Behavioral Quantitation Is More Sensitive Than Cognitive Testing in Frontotemporal Dementia

Frontotemporal dementia (FTD) is an uncommon cause of behavioural change in adults under the age of 50. A 44-year-old man presented with progressive neuropsychiatric disturbance characterised by social withdrawal, apathy, loss of empathy, motor stereotypies and hyperorality. Cognitive testing identified severe impairment, including executive dysfunction. MR scan of the brain showed bilateral symmetrical frontal atrophy. There was no relevant family history, and targeted genetic testing for FTD-associated variants in MAPT, GRN and C9orf72 genes proved negative. He became more withdrawn with disinhibited behaviour; his condition progressively worsened and he died 6 years later. The pathological diagnosis was frontotemporal lobar degeneration with fused-in-sarcoma (FUS) pathology, a rare sporadic cause of FTD, accounting for only 5%–10% of cases, its characteristic features including very young onset, motor stereotypies and hyperorality.

Download Full-text

DOUBLE JEOPARDY: UNTANGLING DEPRESSION, PARKINSON'S DISEASE & FRONTOTEMPORAL DEMENTIA IN CLINICAL PRACTICE WITH BEDSIDE COGNITIVE TESTING

American Journal of Geriatric Psychiatry ◽

10.1016/j.jagp.2020.01.124 ◽

2020 ◽

Vol 28 (4) ◽

pp. S99-S100 ◽

Cited By ~ 1

Author(s):

Jose Grijalva ◽

Jacob Delgado ◽

Ricardo Salazar

Keyword(s):

Parkinson’S Disease ◽

Parkinson's Disease ◽

Clinical Practice ◽

Frontotemporal Dementia ◽

Cognitive Testing ◽

Double Jeopardy

Download Full-text

Quantitative Measurements of Motor Function in Alzheimer’s Disease, Frontotemporal Dementia, and Dementia with Lewy Bodies: A Proof-of-Concept Study

Dementia and Geriatric Cognitive Disorders ◽

10.1159/000492860 ◽

2018 ◽

Vol 46 (3-4) ◽

pp. 168-179 ◽

Cited By ~ 3

Author(s):

Frederikke Jeppesen Kragh ◽

Marie Bruun ◽

Esben Budtz-Jørgensen ◽

Lena Elisabeth Hjermind ◽

Robin Schubert ◽

...

Keyword(s):

Alzheimer’S Disease ◽

Alzheimer's Disease ◽

Frontotemporal Dementia ◽

Dementia With Lewy Bodies ◽

Lewy Bodies ◽

Cross Sectional Study ◽

Cognitive Testing ◽

Motor Dysfunction ◽

Cross Sectional ◽

Quantitative Measurements

Background: This study examines the efficacy of using quantitative measurements of motor dysfunction, compared to clinical ratings, in Alzheimer’s disease (AD), frontotemporal dementia (FTD), and dementia with Lewy bodies (DLB). Methods: In this cross-sectional study, 49 patients with a diagnosis of AD (n = 17), FTD (n = 19), or DLB (n = 13) were included and underwent cognitive testing, clinical motor evaluation, and quantitative motor tests: pronation/supination hand tapping, grasping and lifting, and finger and foot tapping. Results: Our results revealed significantly higher Q-Motor values in pronation/supination and in grip lift force assessment in AD, FTD, and DLB compared to healthy controls (HC). Q-Motor values detected significant differences between AD and HC, while clinical ratings did not. Conclusion: Our results suggest that quantitative measurements provide more objective and sensitive measurements of motor dysfunction in dementia.

Download Full-text

A remote smartphone cognitive testing battery for frontotemporal dementia: Completion rate, reliability, and validity

Alzheimer s & Dementia ◽

10.1002/alz.056136 ◽

2021 ◽

Vol 17 (S6) ◽

Author(s):

Adam M. Staffaroni ◽

Jack C Taylor ◽

Annie L Clark ◽

Hilary W. Heuer ◽

Leah K. Forsberg ◽

...

Keyword(s):

Frontotemporal Dementia ◽

Reliability And Validity ◽

Completion Rate ◽

Cognitive Testing

Download Full-text

When behavioral assessment detects frontotemporal dementia and cognitive testing does not: data from the Frontal Behavioral Inventory

International Journal of Geriatric Psychiatry ◽

10.1002/gps.1697 ◽

2007 ◽

Vol 22 (3) ◽

pp. 266-267 ◽

Cited By ~ 4

Author(s):

Graziella Milan ◽

Alessandro Iavarone ◽

Elisa Lorè ◽

Sara Vitaliano ◽

Francesco Lamenza ◽

...

Keyword(s):

Frontotemporal Dementia ◽

Behavioral Assessment ◽

Cognitive Testing

Download Full-text

The Impact of Subjective and Objective Hearing Loss on Cognition and Memory in Older Adults

Perspectives on Gerontology ◽

10.1044/gero20.2.49 ◽

2015 ◽

Vol 20 (2) ◽

pp. 49-57 ◽

Cited By ~ 1

Author(s):

Yvonne Rogalski ◽

Amy Rominger

Keyword(s):

Older Adults ◽

Hearing Loss ◽

Reading Aloud ◽

Cognitive Testing ◽

Professional Collaboration ◽

Cognitive Screening ◽

Speech Language Pathologist ◽

Text Passage ◽

The Impact ◽

Audiologic Evaluation

For this exploratory cross-disciplinary study, a speech-language pathologist and an audiologist collaborated to investigate the effects of objective and subjective hearing loss on cognition and memory in 11 older adults without hearing loss (OAs), 6 older adults with unaided hearing loss (HLOAs), and 16 young adults (YAs). All participants received cognitive testing and a complete audiologic evaluation including a subjective questionnaire about perceived hearing difficulty. Memory testing involved listening to or reading aloud a text passage then verbally recalling the information. Key findings revealed that objective hearing loss and subjective hearing loss were correlated and both were associated with a cognitive screening test. Potential clinical implications are discussed and include a need for more cross-professional collaboration in assessing older adults with hearing loss.

Download Full-text

Reflections on the Cognitive Interviewing Reporting Framework

Methodology ◽

10.1027/1614-2241/a000074 ◽

2013 ◽

Vol 9 (3) ◽

pp. 123-128 ◽

Cited By ~ 1

Author(s):

Gordon Willis ◽

Hennie Boeije

Keyword(s):

Research Design ◽

Cognitive Testing ◽

Level Of Detail ◽

Cognitive Interviewing ◽

Research Groups ◽

Research Project ◽

Reporting Framework ◽

Full Explanation ◽

Key Steps

Based on the experiences of three research groups using and evaluating the Cognitive Interviewing Reporting Framework (CIRF), we draw conclusions about the utility of the CIRF as a guide to creating cognitive testing reports. Authors generally found the CIRF checklist to be usable, and that it led to a more complete description of key steps involved. However, despite the explicit direction by the CIRF to include a full explanation of major steps and features (e.g., research objectives and research design), the three cognitive testing reports tended to simply state what was done, without further justification. Authors varied in their judgments concerning whether the CIRF requires the appropriate level of detail. Overall, we believe that current cognitive interviewing practice will benefit from including, within cognitive testing reports, the 10 categories of information specified by the CIRF. Future use of the CIRF may serve to direct the overall research project from the start, and to further the goal of evaluation of specific cognitive interviewing procedures.

Download Full-text