The Cerebral Metabolic Consequences of Nitric Oxide Synthase Deficiency: Glucose Utilization in Endothelial and Neuronal Nitric Oxide Synthase Null Mice
1999 ◽
Vol 19
(2)
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pp. 144-148
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Keyword(s):
Nitric oxide has multiple physiologic roles in the CNS. Inhibiting nitric oxide synthesis might therefore alter functional activity within the brain. We used [14C]-2-deoxyglucose in vivo autoradiography to measure local CMRglc in “knockout” mice lacking the genes for either the endothelial (eNOS) or neuronal (nNOS) isoforms of nitric oxide synthase, and in the progenitor strains (SV129, CS7B1/6). Glucose utilization levels did not significantly differ between nNOS and eNOS knockout mice and C57B1/6 mice in any of the 48 brain regions examined, but were relatively lower in some subcortical regions in SV129 mice.
2000 ◽
Vol 72
(6)
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pp. 1001-1006
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Keyword(s):
1996 ◽
Vol 70
(11)
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pp. 7678-7685
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Localization of the cGMP-dependent protein kinases in relation to nitric oxide synthase in the brain
1999 ◽
Vol 17
(1)
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pp. 45-55
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Keyword(s):
2001 ◽
Vol 132
(3)
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pp. 677-684
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2011 ◽
Vol 301
(3)
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pp. H721-H729
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1995 ◽
Vol 181
(1)
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pp. 63-70
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