Increase in plasma atrial natriuretic factor and right atrial area during endogenous and exogenous volume loading in healthy volunteers

1988 ◽  
Vol 6 (4) ◽  
pp. S314-316 ◽  
Author(s):  
Winfried Wingender ◽  
Dieter Neuser ◽  
Horst Weber ◽  
Frank-Joachim Morich ◽  
Rolf Horstmann ◽  
...  
Keyword(s):  
Healthy Volunteers ◽  
Atrial Natriuretic Factor ◽  
Right Atrial ◽  
Volume Loading ◽  
Natriuretic Factor ◽  
Right Atrial Area ◽  
Atrial Area ◽  
Atrial Natriuretic

Control of atrial natriuretic factor by right and left atrial distension in pregnant sheep

1995 ◽  
Vol 268 (6) ◽  
pp. R1411-R1417
Author(s):  
D. Javeshghani ◽  
S. Mukaddam-Daher ◽  
L. Fan ◽  
Z. Guan ◽  
J. Gutkowska ◽  
...  
Keyword(s):  
Atrial Natriuretic Factor ◽  
Left Atrial ◽  
Atrial Pressure ◽  
Right Atrial ◽  
Natriuretic Factor ◽  
Pregnant Sheep ◽  
Vascular Catheters ◽  
The Right ◽  
Left Atrial Distension ◽  
Atrial Natriuretic

Previous studies of the atrial stretch-atrial natriuretic factor (ANF) relationship during pregnancy have employed volume expansion and measured only right atrial pressure (RAP). Consequently, we studied nonpregnant (n = 7) and 115- to 125-day pregnant (n = 7) sheep and assessed the ANF response to changes of RAP and left atrial pressure (LAP) induced by graded balloon inflation. Ewes prepared with vascular catheters and atrial balloons were studied after recovery from preparatory surgical procedures. The basal levels of mean arterial pressure (MAP, 83 +/- 3 mmHg), RAP (2.1 +/- 0.7 mmHg), LAP (4.7 +/- 0.9 mmHg), and heart rate (HR, 102 +/- 6 beats/min) were similar in nonpregnant and pregnant sheep. Pregnancy also resulted in elevation of ANF concentration from 25 +/- 6 to 57 +/- 4 fmol/ml. With right atrial distension, the RAP-ANF relationships were similar in both nonpregnant and pregnant sheep, with a 10-mmHg increase in RAP increasing ANF by an average of 95 +/- 9 fmol/ml. In nonpregnant sheep, the LAP-ANF relationship was more responsive than RAP-ANF because a 10-mmHg increase in LAP resulted in a 193 +/- 10 fmol/ml increase in ANF. Moreover, during pregnancy, the LAP-ANF relationship was significantly more sensitive because a 10-mmHg increase in LAP resulted in a 433 +/- 15 fmol/ml elevation of ANF. These data demonstrate that plasma ANF levels are more responsive to distension of the left atria than to the right. More importantly, the ANF response to left, but not right, atrial distension is enhanced by pregnancy.

Effects of clonidine and dihydralazine on atrial natriuretic factor and cGMP in humans

1989 ◽  
Vol 67 (3) ◽  
pp. 938-944 ◽  
Author(s):  
M. Wehling ◽  
T. Muller ◽  
J. M. Heim ◽  
R. Lorenz ◽  
H. Witzgall ◽  
...  
Keyword(s):  
Atrial Natriuretic Factor ◽  
Soluble Guanylate Cyclase ◽  
Normal Subjects ◽  
Treated Group ◽  
Base Line ◽  
Hemodynamic Effects ◽  
Volume Loading ◽  
Natriuretic Factor ◽  
Basal Plasma ◽  
Atrial Natriuretic

The effects of a 1-wk treatment with clonidine (75 micrograms/day twice a day) and dihydralazine (25 mg/day twice a day) on base-line levels of plasma atrial natriuretic factor (ANF) and plasma and urinary guanosine 3′,5′-cyclic monophosphate (cGMP) and their changes by acute saline infusion (2 liters) in eight normal subjects were evaluated. Basal ANF was decreased to 65% in the clonidine group compared with both the control and dihydralazine groups. Volume loading increased plasma ANF levels by 30–40% of base-line values in the control and the dihydralazine groups and by 15% in the clonidine group. Basal plasma and urinary cGMP levels were raised by 30 and 90% in the dihydralazine group compared with both other groups. Volume loading increased plasma cGMP levels by 40% in the control and clonidine-treated groups and by 25% in the dihydralazine-treated group. It is concluded that ANF may contribute to hemodynamic effects of clonidine but not to those of dihydralazine. Dihydralazine increases plasma and urinary cGMP, supposedly by direct activation of the soluble guanylate cyclase.

Atrial dynamics, atrial natriuretic factor, tachycardia, and blood volume in anesthetized rabbits

1991 ◽  
Vol 261 (1) ◽  
pp. H22-H28 ◽  
Author(s):  
K. A. King ◽  
J. R. Ledsome
Keyword(s):  
Blood Volume ◽  
Atrial Natriuretic Factor ◽  
Left Atrial ◽  
Wall Stress ◽  
Atrial Pressure ◽  
Right Atrial ◽  
Right Atrial Pressure ◽  
Atrial Wall ◽  
Natriuretic Factor ◽  
Atrial Natriuretic

The effects of tachycardia and a slow (1%/min) 20% reduction and elevation of blood volume (BV) on right atrial pressure (RAP), right atrial dimension (RAD), and plasma immunoreactive atrial natriuretic factor (IR-ANF) were examined in anesthetized rabbits. Plasma IR-ANF was significantly increased during pacing at 6 Hz in the presence of high BV but not at low BV. Mean RAP increased with expansion of BV, but this change was not associated with significant changes in IR-ANF. There were no statistically significant changes in systolic or diastolic RAD with alterations in BV or with tachycardia. Tachycardia had no effect on left atrial dimension. Diastolic right atrial wall stress (DRAS) and minute DRAS increased with a 20% increase in BV, but changes in BV did not affect systolic right atrial wall stress (SRAS) or minute SRAS. Tachycardia decreased DRAS at high BV and significantly increased SRAS and minute SRAS. The increases in SRAS and minute SRAS were greater during tachycardia at high BV, suggesting that an interaction between BV and tachycardia results in potentiation of SRAS and minute SRAS. The results suggest that systolic RAS is a significant factor in ANF release during tachycardia at high BV.

Right atrial appendectomy reduces the renal response to acute hypervolemia in the rat

1984 ◽  
Vol 247 (3) ◽  
pp. R610-R613 ◽  
Author(s):  
A. T. Veress ◽  
H. Sonnenberg
Keyword(s):  
Atrial Natriuretic Factor ◽  
Control Period ◽  
Atrial Appendage ◽  
Right Atrial ◽  
Blood Flows ◽  
Natriuretic Factor ◽  
Right Atrial Appendage ◽  
The Right ◽  
Experimental Group ◽  
Atrial Natriuretic

We have shown previously that an extract of atrial tissue from rat heart contains a potent natriuretic factor. In this study anesthetized rats were connected to a respirator and the right atrial appendage was either excised, using a loop ligature (experimental group), or the loop was placed around the appendage and then removed (sham-operated group). After equilibration and control urine collection periods an isooncotic Ringers-albumin solution was infused intravenously (25% of estimated blood volume), and renal function was monitored over the next hour. There were no differences between groups in control period arterial or central venous pressures, heart rates, cardiac outputs, renal blood flows, or filtration rates. However, the diuretic and natriuretic responses to infusion in the experimental group were only one half of those in the sham-operated series (vol = 23.4 +/- 6.2 vs. 68.2 +/- 11.0 microliter X min-1 X g kidney wt-1, UNa V = 2,731 +/- 856 vs. 6,504 +/- 962 nmol X min-1 X g kidney wt-1). These differences were not affected by prior bilateral vagotomy. Administration of homologous atrial natriuretic factor or furosemide resulted in identical renal responses in both groups. We conclude therefore that acute hypervolemia is associated with release of atrial natriuretic factor into the bloodstream and that removal of the atrial appendage reduces the amount available for such release.

EVIDENCE FOR FENTANYL ALTERATION OF PLASHA ATRIAL NATRIURETIC FACTOR - RIGHT ATRIAL PRESSURE (RELATIONSHIP AFTEH CARDIAC SURGERY

1986 ◽  
Vol 65 (Supplement 3A) ◽  
pp. A511 ◽  
Author(s):  
D. M. PAYEN ◽  
D. LECLERC ◽  
J. J. CARACO ◽  
I. VIOSSAT ◽  
E. CHABRIER ◽  
...  
Keyword(s):  
Cardiac Surgery ◽  
Atrial Natriuretic Factor ◽  
Atrial Pressure ◽  
Right Atrial ◽  
Right Atrial Pressure ◽  
Natriuretic Factor ◽  
Atrial Natriuretic

Release of atrial natriuretic factor from heart-lung preparations of inbred Dahl rats

1987 ◽  
Vol 253 (5) ◽  
pp. H1044-H1052 ◽  
Author(s):  
M. O. Onwochei ◽  
R. M. Snajdar ◽  
J. P. Rapp
Keyword(s):  
Atrial Natriuretic Factor ◽  
Left Atrial ◽  
Isolated Heart ◽  
Strain Difference ◽  
Atrial Pressure ◽  
Right Atrial ◽  
Bicarbonate Buffer ◽  
Natriuretic Factor ◽  
Salt Hypertension ◽  
Atrial Natriuretic

Isolated heart-lung preparations from hypertensive inbred Dahl salt-hypertension sensitive (S) and normotensive inbred Dahl salt-hypertension resistant (R) rats were perfused using 15% washed rat red blood cells in Krebs-Ringer bicarbonate buffer. Atrial pressures were increased by increasing venous return (preload) or by increasing the arterial resistance (afterload). Increases in preload at a constant afterload produced increases in the right and left atrial pressures equivalent between S and R strains. Atrial natriuretic factor (ANF) release was linearly related to right atrial pressure (RAP) or left atrial pressure (LAP) in either strain, but S released more ANF at each level of preload, and the slope of the line relating ANF release to RAP was significantly greater in S than R. When the heart-lung preparations were subjected to changes in afterload at a constant preload, LAP was significantly increased in R but not in S rats, and concomitantly ANF increased in R but not in S. In the afterload experiments, as in the preload studies, S released more ANF than R for comparable LAP. It is concluded that 1) at any atrial pressure, hearts of hypertensive S rats release more ANF than hearts of normotensive R rats, 2) this strain difference is probably a consequence of hypertension, and 3) the observed relationships between ANF release and atrial pressures support the contention that atrial distention stimulates the release of ANF.

Atrial natriuretic factor and right atrial pressure in patients undergoing chronic haemodialysis

1992 ◽  
Vol 29 (3-4) ◽  
pp. 273-277
Author(s):  
G. Tonolo ◽  
V. Scardaccio ◽  
M. La Rocca ◽  
A. Soro ◽  
M. G. Melis ◽  
...  
Keyword(s):  
Atrial Natriuretic Factor ◽  
Atrial Pressure ◽  
Right Atrial ◽  
Right Atrial Pressure ◽  
Chronic Haemodialysis ◽  
Natriuretic Factor ◽  
Atrial Natriuretic

Hemodynamic and plasma atrial natriuretic factor responses to cardiac volume loading in young versus older normotensive humans

1992 ◽  
Vol 70 (12) ◽  
pp. 1549-1554 ◽  
Author(s):  
Louis Legault ◽  
Paul van Nguyen ◽  
Donna L. Holliwell ◽  
Frans H. H. Leenen
Keyword(s):  
Heart Rate ◽  
Cardiac Index ◽  
Atrial Natriuretic Factor ◽  
Venous Pressure ◽  
Central Venous ◽  
Volume Loading ◽  
Cardiac Volume ◽  
Volume Load ◽  
Natriuretic Factor ◽  
Atrial Natriuretic

To assess the effects of age on responsiveness of atrial natriuretic factor (ANF) release, and the possible contribution of cardiac sympathetic activity, in young (n = 8) and older normotensives (n = 7), the effects of cardiac volume load on plasma ANF, central venous pressure, and general hemodynamics were evaluated. Studies were performed after pretreatment with placebo or 80 mg propranolol. Cardiac volume loading increased central venous pressure by 3–5 mmHg (1 mmHg = 133.3 Pa); β-blockade did not affect this response. Cardiac volume load caused significant increases in heart rate (10–15 beats/min) and cardiac index (by 0.7–0.8 L∙min−1∙m−2) and decreases in plasma catecholamines. Propranolol attenuated the increases in heart rate and cardiac index. These hemodynamic responses did not differ significantly between the two groups of subjects. Cardiac volume load significantly increased plasma ANF, by 87 ± 21 pg/mL in the young normotensives and by 212 ± 33 pg/mL in the older normotensives (p < 0.01, young vs. older). β-Blockade did not affect this different response. Our results show that the plasma ANF response to volume loading is potentiated by aging. Although differences in atrial stretch cannot be excluded, this effect may relate to the decrease in clearance of plasma ANF occurring with aging.Key words: cardiac volume load, atrial natriuretic factor, aging, β-blockade.

Cardiac secretion of atrial natriuretic factor with exercise in chronic congestive heart failure patients

1992 ◽  
Vol 73 (4) ◽  
pp. 1637-1643 ◽  
Author(s):  
R. J. Cody ◽  
S. H. Kubo ◽  
J. H. Laragh ◽  
S. A. Atlas
Keyword(s):  
Heart Failure ◽  
Congestive Heart Failure ◽  
Right Ventricular ◽  
Atrial Natriuretic Factor ◽  
Physiological Stress ◽  
Right Atrial ◽  
Peak Exercise ◽  
Chronic Congestive Heart Failure ◽  
Natriuretic Factor ◽  
Atrial Natriuretic

We have previously reported a fivefold increase of plasma atrial natriuretic factor (ANF) in patients with congestive heart failure (CHF) compared with normal subjects. However, given the marked increase of ANF under basal conditions, the extent to which ANF secretion can further increase under physiological stress is not been clarified in CHF. We therefore evaluated ANF secretion during ergometric exercise in 11 patients with CHF, with peripheral venous ANF samples obtained at rest and peak exercise. In seven patients, simultaneous peripheral venous and right ventricular ANF samples were obtained to estimate myocardial ANF secretion. Hemodynamic characteristics of exercise included a significant increase of heart rate, mean arterial pressure, and cardiac output (all P < 0.01); reduction of systemic vascular resistance (P < 0.001); and increase of right atrial and pulmonary wedge pressures (P < 0.001). ANF was abnormally elevated at baseline (108 +/- 58 fmol/ml) yet increased further to 183 +/- 86 fmol/ml with exercise (P < 0.003). A step-up of right ventricular ANF, particularly during exercise, was consistent with active myocardial secretion, despite elevated baseline ANF levels.

Transcription, storage and release of atrial natriuretic factor in the failing human heart

1991 ◽  
Vol 80 (4) ◽  
pp. 285-291 ◽  
Author(s):  
Thomas A. Fischer ◽  
Markus Haass ◽  
Rainer Dietz ◽  
Roland C. Willenbrock ◽  
Werner Saggau ◽  
...  
Keyword(s):  
Plasma Levels ◽  
Atrial Natriuretic Factor ◽  
Human Heart ◽  
Artery Bypass ◽  
Plasma Concentrations ◽  
Left Ventricular ◽  
Right Atrial ◽  
Heart Catheterization ◽  
Natriuretic Factor ◽  
Atrial Natriuretic

1. In this study the relationship between the synthesis of atrial natriuretic factor at the level of atrial natriuretic factor mRNA and the atrial storage and circulating plasma levels of atrial natriuretic factor were investigated in 15 patients with heart failure. The patients underwent right and left heart catheterization before cardiac surgery for valve replacement or coronary artery bypass grafting. 2. Plasma concentrations of atrial natriuretic factor were correlated to atrial levels of atrial natriuretic factor mRNA. Atrial levels of atrial natriuretic factor mRNA and plasma concentrations of atrial natriuretic factor exhibited a close correlation to both pulmonary artery pressure and left atrial pressure. No relationship, however, could be found between the right atrial content of atrial natriuretic factor and both the expression of atrial natriuretic factor mRNA in the atria and the plasma levels of atrial natriuretic factor. 3. From these data it may be concluded that increased plasma levels of atrial natriuretic factor in the pressure-and/or volume-overloaded heart are associated with an elevated level of atrial natriuretic factor mRNA. We suggest that not only plasma levels of atrial natriuretic factor but also the expression of atrial natriuretic factor in the atria are related to left ventricular filling pressures in the failing human heart.

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