Malignant Melanoma of the Spinal Epidural Space Metastasized from the Enucleated Left Eye after Nine Years without Symptoms: Report of a Case

Neurosurgery ◽  
1985 ◽  
Vol 16 (1) ◽  
pp. 79-82
Author(s):  
Yoshimi Yanai ◽  
Tetsuo Wakao ◽  
Akira Fukamachi ◽  
Hideo Kunimine ◽  
Hirochiyo Wada
Keyword(s):  
Malignant Melanoma ◽  
Epidural Space ◽  
Lower Limbs ◽  
Pertinent Literature ◽  
Long Term Follow Up ◽  
Spinal Epidural

Abstract A case of flaccid paraplegia due to a metastatic spinal epidural melanoma is reported. Symptoms occurred approximately 9 years after the enucleation of the left eye. A solid melanotic mass was removed almost totally. Three years after the operation, the patient had not regained the motility of the lower limbs. The need for long term follow-up and management of patients with such problems is discussed, and the pertinent literature is reviewed. (Neurosurgery 16:79–82, 1985)

A randomized trial of levamisole versus placebo as adjuvant therapy in malignant melanoma.

1991 ◽  
Vol 9 (5) ◽  
pp. 736-740 ◽  
Author(s):  
L E Spitler
Keyword(s):  
Malignant Melanoma ◽  
Adjuvant Therapy ◽  
Randomized Trial ◽  
Control Groups ◽  
Disease Free Interval ◽  
Significant Difference ◽  
Long Term Follow Up ◽  
And Control

We conducted a long-term follow-up (median, 10.5 years) of patients included in a randomized trial of levamisole versus placebo as surgical adjuvant therapy in 203 patients with malignant melanoma. Of the patients randomized, 104 received levamisole, and 99 received placebo. The results show that there is no difference between the treatment and control groups with regard to any of the three end points analyzed. These included disease-free interval, time to appearance of visceral metastasis, and survival. Moreover, there was no significant difference between the treatment and control groups after adjusting for age, sex, or stage of disease.

scholarly journals A Case of Late Delayed Metastasis of Malignant Melanoma After 27 Years After First Excision

2020 ◽  
Vol 2 (2) ◽  
pp. 1-2
Author(s):  
Claudio Bravin ◽  
◽  
Carlo Braga ◽  
Gaetana Rizzi ◽  
◽  
...  
Keyword(s):  
Malignant Melanoma ◽  
Histological Examination ◽  
Mitotic Rate ◽  
Skin Tumor ◽  
Melanocytic Lesions ◽  
Long Term Follow Up ◽  
Neoplastic Process ◽  
Abdominal Lesion

We report a case of an ultra-late delayed metastasis of malignant melanoma 27 years after the excision of the first tumor. The patient is a 67 years old Italian woman. She underwent a primary excision of a skin lesion of 1cm in diameter on the lower third of the left leg in 1984 when she was 39. According to the histological examination the lesion was a lentigo malign melanoma with an epithelial histological pattern with intra- and subepidermal diffusion. The lesion was 2.2 mm in thickness (Breslow) and was a Clark level IV melanoma; mitotic rate was 6 mitosis/mm2. No melanocytic lesions were found on excision edges and no lymph nodes were removed and examined. In March 2011, when the woman was 67 years old, an inguinal lymph node and an intraabdominal lesion were considered suspect for neoplastic process during a clinical exam of the GP. A histological examination and an eco-imaging procedure described the lesions as metastasis of malignant melanoma probably related to the first skin tumor. Within a few days she was treated with the excision of the abdominal lesion, the total greater omentectomy and the lymphadenectomy of the left inguinal region. Histological examination confirmed the suspect of metastasis of the first melanoma with a predominant epithelioid growing pattern. This case underlines the need of a long-term follow-up period for patients with melanoma.

scholarly journals Long‐term follow up of nivolumab in previously untreated Japanese patients with advanced or recurrent malignant melanoma

2019 ◽  
Vol 110 (6) ◽  
pp. 1995-2003 ◽  
Author(s):  
Naoya Yamazaki ◽  
Yoshio Kiyohara ◽  
Hisashi Uhara ◽  
Jiro Uehara ◽  
Yasuhiro Fujisawa ◽  
...  
Keyword(s):  
Malignant Melanoma ◽  
Japanese Patients ◽  
Long Term Follow Up

Malignant Melanoma of the Skin: Long-term Follow-up and Time to First Recurrence

2010 ◽  
Vol 35 (3) ◽  
pp. 580-589 ◽  
Author(s):  
Annika M. Hohnheiser ◽  
Olaf Gefeller ◽  
Jonas Göhl ◽  
Gerold Schuler ◽  
Werner Hohenberger ◽  
...  
Keyword(s):  
Malignant Melanoma ◽  
Long Term Follow Up ◽  
First Recurrence

Hemangiopericytomas of the skull base

2011 ◽  
Vol 30 (5) ◽  
pp. E10 ◽  
Author(s):  
Clemens M. Schirmer ◽  
Carl B. Heilman
Keyword(s):  
Skull Base ◽  
Pertinent Literature ◽  
Total Resection ◽  
Secondary Resection ◽  
Free Interval ◽  
Initial Surgery ◽  
Long Term Follow Up ◽  
Cns Neoplasms

Object Intracranial hemangiopericytomas are frequently located along the dural sinuses along the skull base and represent rare, aggressive CNS neoplasms that are difficult to distinguish from meningiomas based on both imaging and gross characteristics. The authors of this study describe 3 patients with these lesions and review the pertinent literature. Methods Two men and 1 woman, whose median age at the time of the initial presentation was 37 years (range 20–53 years), constitute this series. They underwent multimodal treatment consisting of resection, embolization, radiation therapy, and in 1 case chemotherapy. Results Two of the 3 patients treated were alive after a mean follow-up of 93 months (range 4–217 months). One patient died 217 months after the initial diagnosis. The longest tumor progression–free interval after the initial or secondary resection was 43 months (range 4–84 months). Conclusions Hemangiopericytomas have been reclassified as mesenchymal nonmeningothelial tumors. They have an inevitable tendency to recur locally and metastasize distally. The mainstay of therapy remains an aggressive attempt to achieve gross-total resection at the initial surgery. Postoperative adjuvant radiotherapy should be offered to all patients, regardless of the degree of resection achieved. Diligent long-term follow-up is paramount as local recurrences and distal metastases can develop sometimes years after the initial treatment.

scholarly journals Primary extradural hydatid cyst extended to paraspinal muscles

2012 ◽  
Vol 03 (03) ◽  
pp. 358-360 ◽  
Author(s):  
Omar Boulahroud ◽  
B.S. Sharma ◽  
Ibrahim Dao ◽  
Cherif Abad El Asri ◽  
Mohammed Boucetta
Keyword(s):  
Hydatid Cyst ◽  
Early Postoperative Period ◽  
Paraspinal Muscles ◽  
Long Term Follow Up ◽  
Bony Involvement ◽  
Magnetic Resonance Imaging Mri ◽  
Spinal Epidural ◽  
Multiple Cysts

ABSTRACTPrimary spinal epidural hydatid cyst without bony involvement is extremely rare. Authors report the case of a 44-yearold female brought to their attention for a rapidly progressive paraplegia. Magnetic resonance imaging (MRI) revealed extradural multiple cysts with “bunch of grapes” appearance extended to the paraspinal muscles through neural foramina without bony involvement on computed tomography (CT) scan. Histopathologic examination after a surgical approach confirmed the diagnosis of hydatid cyst. The early postoperative period showed a progressive improvement of her neurological deficit. The long-term follow-up under discontinued antihelminthic chemotherapy was uneventful.

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