Long-Term Follow-Up of Patients with Untreated Scoliosis A Study of Mortality, Causes of Death, and Symptoms

Spine ◽  
1992 ◽  
Vol 17 (9) ◽  
pp. 1091-1096 ◽  
Author(s):  
Kerstin Pehrsson ◽  
Sven Larsson ◽  
Anders Oden ◽  
Alf Nachemson
Keyword(s):  
Causes Of Death ◽  
Long Term Follow Up ◽  
Mortality Causes

Long-term morbidity and mortality in Whipple’s disease: a single-center experience over 20 years

2020 ◽  
Vol 15 (10) ◽  
pp. 847-854
Author(s):  
Annalisa Schiepatti ◽  
Maria Luisa Nicolardi ◽  
Piero Marone ◽  
Federico Biagi
Keyword(s):  
Causes Of Death ◽  
Morbidity And Mortality ◽  
Whipple’S Disease ◽  
Whipple's Disease ◽  
Single Center Experience ◽  
Long Term Follow Up ◽  
Life Threatening ◽  
Neoplastic Disorders

Background: Little is known about long-term morbidity and mortality in Whipple’s disease (WD). Aim: To describe morbidity and mortality in patients with WD on a long-term follow-up. Materials & methods: Comorbidities, mortality and causes of death were retrospectively registered. Results: A total of 35 patients with WD (9F, 54 ± 11 years) were followed-up for a median of 104 months. Nine patients developed ten complications; three patients died. A total of 31 severe comorbidities apparently unrelated to WD were found in 20 patients: preneoplastic/neoplastic disorders in seven, thromboembolic and cardiovascular events in seven, pneumonia in four, candidiasis in ten patients. Conclusion: WD is frequently complicated by potentially life-threatening infectious, neoplastic and thromboembolic disorders, thus highlighting the need for a life-long multidisciplinary follow-up.

scholarly journals The association between deaths from infection and mutations of the BRAF, FBXW7, NRAS and XPO1 genes: a report from the LRF CLL4 trial

Leukemia ◽  
2021 ◽  
Author(s):  
Monica Else ◽  
Stuart J. Blakemore ◽  
Jonathan C. Strefford ◽  
Daniel Catovsky
Keyword(s):  
Cause Of Death ◽  
Causes Of Death ◽  
Lymphocytic Leukaemia ◽  
Gene Mutations ◽  
Randomised Trials ◽  
Long Term Follow Up ◽  
11Q Deletion ◽  
Careful Management

AbstractCauses of death, in particular deaths due to infection, have not been widely studied in randomised trials in chronic lymphocytic leukaemia. With long-term follow-up (median 13 years) we examined the cause of death in 600/777 patients in the LRF CLL4 trial. Blood samples, taken at randomisation from 499 patients, were available for identifying gene mutations. Infection was a cause of death in 258 patients (43%). Patients dying of infection were more likely than those who died of other causes to have received ≥2 lines of treatment (194/258 [75%] versus 231/342 [68%], P = 0.04) and to have died in the winter months (149/258 [58%] versus 166/342 [49%], P = 0.03), respectively. In patients with mutation data, the factors significantly associated with death from infection versus all other deaths were 11q deletion (47/162 [29%] versus 40/209 [19%], P = 0.03) and mutations of the BRAF, FBXW7, NRAS and XPO1 genes. Death was caused by an infection in 46/67 assessable patients (69%) who had a mutation of one or more of these four genes versus only 129/333 patients (39%) without any of these mutations (odds ratio: 3.46 [95% CI 1.98–6.07] P < 0.0001). Careful management of infection risk, including prophylaxis against infection, may be important in patients who carry these mutations.

scholarly journals A long-term follow-up study of Japanese diabetic patients: Mortality and causes of death

Diabetologia ◽  
1983 ◽  
Vol 25 (4) ◽  
Author(s):  
A. Sasaki ◽  
M. Uehara ◽  
N. Horiuchi ◽  
K. Hasagawa
Keyword(s):  
Causes Of Death ◽  
Diabetic Patients ◽  
Follow Up Study ◽  
Long Term Follow Up

Long-term Follow up in Chronic Hemofiltration

1983 ◽  
Vol 6 (3) ◽  
pp. 115-120 ◽  
Author(s):  
E. Quellhorst
Keyword(s):  
Blood Pressure ◽  
Blood Flow ◽  
Renal Insufficiency ◽  
Causes Of Death ◽  
Artificial Kidney ◽  
Favourable Effect ◽  
Long Term Follow Up ◽  
Access Problems

The course of treatment is demonstrated in 72 patients with chronic renal insufficiency who were undergoing regular hemofiltration for more than 6 months. 29 patients were treated for more than 5 years and 8 for more than 6 years with hemofiltration exclusively, total experience comprising 2,985 patient months. Thus, 16% of all patients accepted for artificial kidney treatment were selected for this form of therapy. Main reasons for transfer from hemodialysis to hemofiltration were hypotension, hypertension and/or repeated episodes of overhydration. In 12 patients with severe drug- and dialysis-resistant hypertension, blood pressure was normalized within 6 weeks after transfer to hemofiltration. Whereas some parameters of lipid and bone metabolism showed a tendency towards normalization, a favourable effect of hemofiltration on neuropathy was not observed. Main causes of death were encephalomalacia and cardiac infarction. Contraindications for post-dilution hemofiltration are vascular access problems resulting in a reduced blood flow and severe catabolism with accumulation of low molecular protein metabolities or potassium.

scholarly journals A long-term follow-up study of diabetic patients in Osaka, Japan: Mortality and causes of death.

1983 ◽  
Vol 141 (Suppl) ◽  
pp. 639-644 ◽  
Author(s):  
AKIRA SASAKI ◽  
MASUKO UEHARA ◽  
NARUTO HORIUGHI ◽  
KYOIOHI HASEGAWA
Keyword(s):  
Causes Of Death ◽  
Diabetic Patients ◽  
Follow Up Study ◽  
Long Term Follow Up
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