Cerebrospinal Fluid Viral Load in HIV-1-Infected Patients Without Antiretroviral Treatment

Author(s):  
Magnus Gisslén ◽  
Lars Hagberg ◽  
Dietmar Fuchs ◽  
Gunnar Norkrans ◽  
Bo Svennerholm
2017 ◽  
Vol 3 (1) ◽  
pp. 34-39 ◽  
Author(s):  
W. Snippenburg ◽  
F.J.B. Nellen ◽  
C. Smit ◽  
A.M.J. Wensing ◽  
M.H. Godfried ◽  
...  

2010 ◽  
Vol 53 (5) ◽  
pp. 668-669 ◽  
Author(s):  
Annemarie E Brouwer ◽  
Praprit Teparrukkul ◽  
Adul Rajanuwong ◽  
Wirongrong Chierakul ◽  
Weera Mahavanakul ◽  
...  

2007 ◽  
Vol 46 (4) ◽  
pp. 508-509 ◽  
Author(s):  
Cristiane M Rocha ◽  
Daisy M Machado ◽  
Maria Cecilia Sucupira ◽  
Regina C Succi

2003 ◽  
Vol 36 (6) ◽  
pp. 689-694 ◽  
Author(s):  
Lauro Ferreira da Silva Pinto Neto ◽  
Nilo F.R. Vieira ◽  
Moacir Soprani ◽  
Carla B. Cunha ◽  
Valéria P. Cabral ◽  
...  

This study was designed to investigate the impact of anti-retroviral therapy on both plasma and seminal HIV-1 viral loads and the correlation between viral loads in these compartments after treatment. Viral load, CD4+ and CD8+ T-cell counts were evaluated in paired plasma and semen samples from 36 antiretroviral therapy-naïve patients at baseline and on days 45, 90, and 180 of treatment. Slopes for blood and seminal viral loads in all treated patients were similar (p = 0.21). Median HIV-1 RNA titers in plasma and semen at baseline were 4.95 log10 and 4.48 log10 copies/ml, respectively. After 180 days of therapy, the median viral load declined to 3.15 log10 copies/ml (plasma) and 3.2 log10 copies/ml (semen). At this timepoint 22 patients presented HIV-1 viral load below 400 copies/ml in either plasma or semen, but only 9 had viral loads below 400 copies/ml in both compartments.


2012 ◽  
Vol 4 (1) ◽  
pp. 30 ◽  
Author(s):  
Diego M. Cecchini ◽  
Ana M. Cañizal ◽  
Haroldo Rojas ◽  
Alicia Arechavala ◽  
Ricardo Negroni ◽  
...  

In order to determine HIV-1 kinetics in cerebrospinal fluid (CSF) and plasma in patients with cryptococcal meningitis (CM), we undertook a prospective collection of paired CSF/plasma samples from antiretroviral therapy- free HIV-infected patients with CM. Samples were obtained at baseline (S1) and at the second (S2) and third (S3) weeks of antifungal therapy. HIV-1 CSF concentrations were significantly lower in both S2 and S3 with respect to S1. Plasma concentrations remained stable. HIV-1 concentrations were higher in plasma than CSF in all cases. Patients who survived the episode of CM (but not those who died) showed a decrease in CSF viral load, what suggests different viral kinetics of HIV-1 in the CSF according to the clinical course of this opportunistic disease.


HIV Medicine ◽  
2015 ◽  
Vol 16 (6) ◽  
pp. 388-392 ◽  
Author(s):  
JM Tiraboschi ◽  
JA Muñoz-Moreno ◽  
MC Puertas ◽  
C Alonso-Villaverde ◽  
A Prats ◽  
...  

AIDS ◽  
1998 ◽  
Vol 12 (7) ◽  
pp. 737-743 ◽  
Author(s):  
Mariantonietta Di Stefano ◽  
Laura Monno ◽  
José R. Fiore ◽  
Giovanni Buccoliero ◽  
Amelia Appice ◽  
...  

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