The role of anxiety and hormonal changes in menopausal hot flashes

2005 ◽  
Vol 12 (3) ◽  
pp. 258-266 ◽  
Author(s):  
Ellen W Freeman ◽  
Mary D Sammel ◽  
Hui Lin ◽  
Clarisa R Gracia ◽  
Shiv Kapoor ◽  
...  
Keyword(s):  
Hot Flashes ◽  
Hormonal Changes

Physiology and Endocrinology of Hot Flashes in Prostate Cancer

2007 ◽  
Vol 1 (1) ◽  
pp. 8-17 ◽  
Author(s):  
Christine A. Engstrom ◽  
Christine E. Kasper
Keyword(s):  
Prostate Cancer ◽  
Treatment Options ◽  
Hot Flashes ◽  
Hormonal Treatment ◽  
Hormonal Changes ◽  
Pancreatic Islet Cell ◽  
Androgen Ablation ◽  
Pancreatic Islet Cell Tumors ◽  
Primary Focus

The purpose of this article is to integrate the physiology of the male reproductive system and the role of hormones in the pathophysiology and treatment of prostate cancer. The primary focus is to review hormonal changes associated with androgen ablation treatment and to integrate the available hormonal data into a hypothesis. This review used a systematic search of Medline references from 1990 to 2006. All sources were critically evaluated to arrive at an understanding of androgen deprivation symptoms, such as hot flushes/flashes, and to identify research needed in this area. Research is needed to explore the physiological mechanisms of hot flashes to develop better therapeutic treatment options to ameliorate side effects of hormonal treatment. Studies are needed to investigate all aspects of hot flashes in populations other than those with breast cancer, such as men with prostate cancer, carcinoid tumors, medullary thyroid tumors, pancreatic islet-cell tumors, renal cell carcinoma, and phenochromocytoma.

THE ROLE OF ESTROGENS IN THE AUTONOMIC REGULATION OF THE CARDIOVASCULAR SYSTEM IN MENOPAUSE

2021 ◽  
pp. 167-173
Author(s):  
Neufeld I.V. ◽  
Kuznetsova M.V. ◽  
Zhirnyakov A.I. ◽  
Bobyleva I.V. ◽  
Rogozhina I.E.
Keyword(s):  
Heart Rate ◽  
Cardiovascular Risk ◽  
Cardiovascular System ◽  
Hot Flashes ◽  
Surrogate Marker ◽  
Estrogen Deficiency ◽  
Autonomic Regulation ◽  
Hormonal Changes ◽  
Psychological Consequences

Hot flashes are known to be associated with a variety of cardiovascular risk factors. There is evidence of a close relationship between hot flashes and autonomic dysfunction, while the parameter - heart rate variability (HRV) - is a surrogate marker for assessing the activity of the autonomic nervous system (ANS). However, changes in HRV can be caused by both aging and hormonal changes. The purpose of this work is to consider the role of endogenous estrogens in the autonomic regulation of the cardiovascular system on the model of "acute estrogen deficiency" in cases of total oophorectomy and "partial estrogen deficiency" - in cases of hysterectomy with / without appendages. 44 women were included, mean age - 46.9 ± 2.2 years, whose HRV was assessed before surgery (1 week before surgery) and after (not less than 4 and not more than 5 weeks after surgery). According to the results obtained, there were no statistically significant changes in both temporal and spectral HRV parameters in patients after hysterectomy (p> 0.05). On the contrary, patients with total oophorectomy in the postoperative period showed decreased HRV parameters characterizing the parasympathetic activity of the ANS, namely SDRR, rMSSD, pNN50, HF and the LF index, reflecting both sympathetic and parasympathetic effects on heart rate. Patients with total oophorectomy have a higher ratio of the sympatovagal LF / HF index; the work shows that this fact is most likely due to the predominance of sympathetic nervous influences induced by "acute" withdrawal of ovarian hormones due to the performed volume of surgery, and not as a result of surgery. as such, or its psychological consequences. Thus, according to the above-described results of the study, patients in cases of total oophorectomy showed a decrease in the parameters of vagal HRV in the direction of sympathetic dominance, which may cause an increase in cardiovascular risk.

scholarly journals Psychobiological risk factors for suicidal thoughts and behaviors in adolescence: a consideration of the role of puberty

2021 ◽  
Author(s):  
Tiffany C. Ho ◽  
Anthony J. Gifuni ◽  
Ian H. Gotlib
Keyword(s):  
Pubertal Timing ◽  
Anterior Cingulate ◽  
Neural Systems ◽  
Hormonal Changes ◽  
Suicidal Thoughts ◽  
Social Stressors ◽  
And Behaviors ◽  
Suicidal Thoughts And Behaviors ◽  
Pubertal Transition

AbstractSuicide is the second leading cause of death among adolescents. While clinicians and researchers have begun to recognize the importance of considering multidimensional factors in understanding risk for suicidal thoughts and behaviors (STBs) during this developmental period, the role of puberty has been largely ignored. In this review, we contend that the hormonal events that occur during puberty have significant effects on the organization and development of brain systems implicated in the regulation of social stressors, including amygdala, hippocampus, striatum, medial prefrontal cortex, orbitofrontal cortex, and anterior cingulate cortex. Guided by previous experimental work in adults, we also propose that the influence of pubertal hormones and social stressors on neural systems related to risk for STBs is especially critical to consider in adolescents with a neurobiological sensitivity to hormonal changes. Furthermore, facets of the pubertal transition, such as pubertal timing, warrant deeper investigation and may help us gain a more comprehensive understanding of sex differences in the neurobiological and psychosocial mechanisms underlying adolescent STBs. Ultimately, advancing our understanding of the pubertal processes that contribute to suicide risk will improve early detection and facilitate the development of more effective, sex-specific, psychiatric interventions for adolescents.

The effect of oestrogen withdrawal on cardiac Ca2+ regulation and the influence of GPER1

2020 ◽  
Vol 41 (Supplement_2) ◽  
Author(s):  
A.J Francis ◽  
J.M Firth ◽  
N Islam ◽  
J Gorelik ◽  
K.T MacLeod
Keyword(s):  
Heart Failure ◽  
Structural Integrity ◽  
Left Ventricular ◽  
Funding Source ◽  
Hormonal Changes ◽  
Ion Conductance ◽  
Developing Heart ◽  
Rapid Stimulation ◽  
Post Menopausal

Abstract Background Post-menopausal women have an enhanced risk of developing heart failure, attributed to declining oestrogen levels during menopause. However, the signalling mechanisms remain undetermined. Purpose We aim to determine the role of G-protein coupled oestrogenic receptor 1 (GPER1) in intracellular Ca2+ regulation and the consequences of hormonal changes that may exacerbate the pathophysiology of heart failure. Methods Ovariectomy (OVx) (mimics menopausal hormone changes) or sham surgeries were conducted on female guinea pigs. Left ventricular cardiomyocytes were isolated 150-days post-operatively for experimental use. Cellular t-tubule network and structural integrity was measured using fluorescent di-8-ANEPPs staining and scanning ion conductance microscopy. GPER1 expression and localisation was measured by Western blot and immunostaining. The role of GPER1 activation was measured using selective agonist G-1 in electrophysiological and Ca2+-sensitive dye fluorescence experiments. Results Following oestrogen withdrawal, the t-tubule network density decreased by 13% and z-groove index reduced by 15%. GPER1 predominantly localised to the peri-nuclear endoplasmic reticulum and its expression increased by 32% in OVx. Action potential duration (APD) prolonged in OVx and following GPER1 activation, APD90 shortened by 11% and 25% in sham and OVx respectively. OVx cells had larger peak inward Ca2+ current (ICaL) (by 22%) and sarcoplasmic reticulum (SR) Ca2+ content (by 13%), compared with sham. While GPER1 activation had little effect on peak ICaL or SR content, it reduced Ca2+ transient amplitude (by 20%), SR fractional release (by 11%) in OVx cells. The frequency of occurrence of spontaneous Ca2+ waves evoked by periods of rapid stimulation reduced by 40% and wave-free survival time prolonged in OVx cells following GPER1 activation. Conclusions In the hearts of an animal species whose electrophysiology and intracellular Ca2+ regulation is akin to humans, we show that following oestrogen deficiency, the t-tubule network is down-regulated and becomes disorganised, GPER1 expression is increased and its activation induces negative inotropic responses in cardiomyocytes. This may limit the adverse changes to Ca2+ signalling reported in OVx that could be pro-arrhythmic and exacerbate the progression to heart failure. Funding Acknowledgement Type of funding source: Foundation. Main funding source(s): British Heart Foundation

scholarly journals Evaluating the role of serotonin in hot flashes after breast cancer using acute tryptophan depletion

2009 ◽  
Vol 16 (4) ◽  
pp. 644-652 ◽  
Author(s):  
Janet S. Carpenter ◽  
Menggang Yu ◽  
Jingwei Wu ◽  
Diane Von Ah ◽  
Jennifer Milata ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Hot Flashes ◽  
Acute Tryptophan Depletion ◽  
Tryptophan Depletion

Role of hypothalamic inputs in maintaining pituitary-adrenal responsiveness in repeated restraint

2003 ◽  
Vol 285 (5) ◽  
pp. E1110-E1117 ◽  
Author(s):  
D. Zelena ◽  
Z. Mergl ◽  
A. Földes ◽  
K. J. Kovács ◽  
Z. Tóth ◽  
...  
Keyword(s):  
Chronic Stress ◽  
Stress Responses ◽  
Mrna Level ◽  
Hormonal Changes ◽  
Mediobasal Hypothalamus ◽  
Hormonal Responses ◽  
Pomc Mrna ◽  
Paraventricular Nucleus Of Hypothalamus ◽  
Pituitary Adrenal Axis

The role of hypothalamic structures in the regulation of chronic stress responses was studied by lesioning the mediobasal hypothalamus or the paraventricular nucleus of hypothalamus (PVH). Rats were acutely (60 min) and/or repeatedly (for 7 days) restrained. In controls, a single restraint elevated the plasma adrenocorticotropin (ACTH), corticosterone, and prolactin levels. Repeated restraint produced all signs of chronic stress, including decreased body and thymus weights, increased adrenal weight, basal corticosterone levels, and proopiomelanocortin (POMC) mRNA expression in the anterior pituitary. Some adaptation to repeated restraint of the ACTH response, but not of other hormonal responses, was seen. Lesioning of the mediobasal hypothalamus abolished the hormonal response and POMC mRNA activation to acute and/or repeated restraint, suggesting that the hypothalamo-pituitary-adrenal axis activation during repeated restraint is centrally driven. PVH lesion inhibited the ACTH and corticosterone rise to the first restraint by ∼50%. In repeatedly restrained rats with PVH lesion, the ACTH response to the last restraint was reduced almost to basal control levels, and the elevation of POMC mRNA level was prevented. PVH seems to be important for the repeated restraint-induced ACTH and POMC mRNA stimulation, but it appears to partially mediate other restraint-induced hormonal changes.

Amamentação na prevenção do câncer de mama: revisão de literatura

2021 ◽  
Vol 5 (9) ◽  
pp. 52-61
Author(s):  
Fernanda Odete Souza Rodrigues ◽  
João Vítor Flores Silveira ◽  
Marina Santos Costa ◽  
Giovanna Nogueira Torres ◽  
Iwens Moreira de Faria
Keyword(s):  
Breast Cancer ◽  
Positive Impact ◽  
Google Scholar ◽  
Cáncer De Mama ◽  
Hormonal Changes ◽  
Milk Supply ◽  
Breastfeeding Rates ◽  
Las Mujeres ◽  
The Relationship

Pouco tem sido estudada a relação entre câncer de mama e amamentação. É possível que a sucção da mama, realizada pelo recém-nascido, promova alterações hormonais que repercutam sobre o desenvolvimento dessa doença. Esta revisão objetivou analisar estudos publicados sobre a influência da prática da amamentação na redução do risco da neoplasia mamária. Os artigos selecionados foram pesquisados nas bases de dados PubMed, LILACS, Scielo e Google Acadêmico e publicados entre os anos 2002 e 2020. Entre os 11 artigos revisados, 10 atestaram o papel da amamentação na redução do surgimento de câncer de mama, tendo esta redução sido maior quanto mais longo o tempo da oferta de leite materno. Apesar dos benefícios, as taxas de aleitamento materno no Brasil ainda são insuficientes. Tendo em vista o impacto positivo dessa prática sobre a redução da incidência do câncer de mama, orientações às gestantes sobre esse processo se fazem necessárias.                                      Descritores: Câncer de Mama, Aleitamento Materno, Lactação. Breastfeeding in breast cancer prevention: literature reviewAbstract: Little has been studied the relationship between breast cancer and breastfeeding. It is possible that breast sucking, performed by the newborn, promotes hormonal changes that affect the development of this disease. This review aimed to analyze published studies on the influence of breastfeeding in reducing the risk of breast cancer. The selected articles were searched in the PubMed, LILACS, Scielo and Google Scholar databases and published between the years 2002 and 2020. Among the 11 reviewed articles, 10 attested to the role of breastfeeding in reducing the appearance of breast cancer, with this reduction greater the longer the time of breast milk supply. Despite the benefits, breastfeeding rates in Brazil are still insufficient. In view of the positive impact of this practice on reducing the incidence of breast cancer, guidance to pregnant women on this process is necessary.Descriptors: Breast Cancer, Breastfeeding, Lactation. Lactancia en la prevención del cáncer de mama: revisión de la literaturaResumen: Poco se ha estudiado la relación entre el cáncer de mama y la lactancia materna. Es posible que la succión de los senos, realizada por el recién nacido, promueva cambios hormonales que afectan el desarrollo de esta enfermedad. Esta revisión tuvo como objetivo analizar los estudios publicados sobre la influencia de la lactancia materna en la reducción del riesgo de cáncer de mama. Los artículos seleccionados se buscaron en las bases de datos PubMed, LILACS, Scielo y Google Scholar y se publicaron entre los años 2002 y 2020. Entre los 11 artículos revisados, 10 atestiguaron el papel de la lactancia materna en la reducción de la aparición de cáncer de mama, con esta reducción mayor es el tiempo de suministro de leche materna. A pesar de los beneficios, las tasas de lactancia materna en Brasil siguen siendo insuficientes. En vista del impacto positivo de esta práctica en la reducción de la incidencia de cáncer de mama, es necesaria una guía para las mujeres embarazadas sobre este proceso.Descriptores: Cáncer de Mama, Amamantamiento, Lactancia.

The role of hyperactivation, stress and hot flashes in insomnia amongst menopausal women

2019 ◽  
Vol 64 ◽  
pp. S21-S22
Author(s):  
O. Ballot ◽  
H. Ivers ◽  
C. Morin
Keyword(s):  
Hot Flashes ◽  
Menopausal Women

Hormonal changes and enforced diving in the harbor seal Phoca vitulina. II. Plasma catecholamines

1982 ◽  
Vol 242 (5) ◽  
pp. R528-R532 ◽  
Author(s):  
A. J. Hance ◽  
E. D. Robin ◽  
J. B. Halter ◽  
N. Lewiston ◽  
D. A. Robin ◽  
...  
Keyword(s):  
Recovery Period ◽  
Control Period ◽  
Plasma Catecholamines ◽  
Harbor Seal ◽  
Phoca Vitulina ◽  
Harbor Seals ◽  
Hormonal Changes ◽  
Inotropic Effects ◽  
Arterial Constriction

Plasma epinephrine and norepinephrine concentrations were measured in five harbor seals, Phoca vitulina, during a control period, during a 6-min dive, and during a 30-min postdiving recovery period. Measurements were performed with and without prior glucose administration. Control epinephrine concentrations [189 +/- 118 (SD) pg/ml] and norepinephrine concentrations (340 +/- 191 pg/ml) were similar to resting values in humans. During diving there are dramatic increases in both epinephrine and norepinephrine concentrations, which returned to control values by 30 min of the postdiving recovery period. A similar pattern was found after glucose infusion. The increased catecholamines were not the primary mechanism responsible for arterial constriction during the dive. Persistent diving bradycardia suggests obliteration of the chronotropic effects of catecholamines during the dive. An unchanged stroke volume suggests obliteration of the inotropic effects of catecholamines during the dive. Catecholamines do not appear to be involved in postdiving hyperglycemia and hyperglucogenemia. Neither the regulatory role of increased catecholamines nor the physiological function of increased catecholamines was apparent from the studies. However, dramatic increases in plasma catecholamines during diving appear to be an important component of the hormonal response to prolonged diving in aquatic mammals.

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