THE ROLE OF ESTROGENS IN THE AUTONOMIC REGULATION OF THE CARDIOVASCULAR SYSTEM IN MENOPAUSE

2021 ◽  
pp. 167-173
Author(s):  
Neufeld I.V. ◽  
Kuznetsova M.V. ◽  
Zhirnyakov A.I. ◽  
Bobyleva I.V. ◽  
Rogozhina I.E.
Keyword(s):  
Heart Rate ◽  
Cardiovascular Risk ◽  
Cardiovascular System ◽  
Hot Flashes ◽  
Surrogate Marker ◽  
Estrogen Deficiency ◽  
Autonomic Regulation ◽  
Hormonal Changes ◽  
Psychological Consequences

Hot flashes are known to be associated with a variety of cardiovascular risk factors. There is evidence of a close relationship between hot flashes and autonomic dysfunction, while the parameter - heart rate variability (HRV) - is a surrogate marker for assessing the activity of the autonomic nervous system (ANS). However, changes in HRV can be caused by both aging and hormonal changes. The purpose of this work is to consider the role of endogenous estrogens in the autonomic regulation of the cardiovascular system on the model of "acute estrogen deficiency" in cases of total oophorectomy and "partial estrogen deficiency" - in cases of hysterectomy with / without appendages. 44 women were included, mean age - 46.9 ± 2.2 years, whose HRV was assessed before surgery (1 week before surgery) and after (not less than 4 and not more than 5 weeks after surgery). According to the results obtained, there were no statistically significant changes in both temporal and spectral HRV parameters in patients after hysterectomy (p> 0.05). On the contrary, patients with total oophorectomy in the postoperative period showed decreased HRV parameters characterizing the parasympathetic activity of the ANS, namely SDRR, rMSSD, pNN50, HF and the LF index, reflecting both sympathetic and parasympathetic effects on heart rate. Patients with total oophorectomy have a higher ratio of the sympatovagal LF / HF index; the work shows that this fact is most likely due to the predominance of sympathetic nervous influences induced by "acute" withdrawal of ovarian hormones due to the performed volume of surgery, and not as a result of surgery. as such, or its psychological consequences. Thus, according to the above-described results of the study, patients in cases of total oophorectomy showed a decrease in the parameters of vagal HRV in the direction of sympathetic dominance, which may cause an increase in cardiovascular risk.

scholarly journals Abnormal Cardiac Autonomic Regulation in Mice Lacking ASIC3

2014 ◽  
Vol 2014 ◽  
pp. 1-8 ◽  
Author(s):  
Ching-Feng Cheng ◽  
Terry B. J. Kuo ◽  
Wei-Nan Chen ◽  
Chao-Chieh Lin ◽  
Chih-Cheng Chen
Keyword(s):  
Heart Rate ◽  
Autonomic Function ◽  
Physiological Role ◽  
Autonomic Regulation ◽  
Pcr Analysis ◽  
Baseline Heart Rate ◽  
Cardiac Autonomic Function ◽  
Sympathetic Function ◽  
Cardiac Autonomic Regulation

Integration of sympathetic and parasympathetic outflow is essential in maintaining normal cardiac autonomic function. Recent studies demonstrate that acid-sensing ion channel 3 (ASIC3) is a sensitive acid sensor for cardiac ischemia and prolonged mild acidification can open ASIC3 and evoke a sustained inward current that fires action potentials in cardiac sensory neurons. However, the physiological role of ASIC3 in cardiac autonomic regulation is not known. In this study, we elucidate the role of ASIC3 in cardiac autonomic function usingAsic3−/−mice.Asic3−/−mice showed normal baseline heart rate and lower blood pressure as compared with their wild-type littermates. Heart rate variability analyses revealed imbalanced autonomic regulation, with decreased sympathetic function. Furthermore,Asic3−/−mice demonstrated a blunted response to isoproterenol-induced cardiac tachycardia and prolonged duration to recover to baseline heart rate. Moreover, quantitative RT-PCR analysis of gene expression in sensory ganglia and heart revealed that no gene compensation for muscarinic acetylcholines receptors and beta-adrenalin receptors were found inAsic3−/−mice. In summary, we unraveled an important role of ASIC3 in regulating cardiac autonomic function, whereby loss of ASIC3 alters the normal physiological response to ischemic stimuli, which reveals new implications for therapy in autonomic nervous system-related cardiovascular diseases.

Acute Effect of Insulin on Autonomic Regulation of the Cardiovascular System: A Study by Heart Rate Spectral Analysis

1996 ◽  
Vol 13 (8) ◽  
pp. 709-714 ◽  
Author(s):  
F. Bellavere ◽  
V. Cacciatori ◽  
P. Moghetti ◽  
M.L. Gemma ◽  
A. Dellera ◽  
...  
Keyword(s):  
Heart Rate ◽  
Spectral Analysis ◽  
Cardiovascular System ◽  
Acute Effect ◽  
Autonomic Regulation ◽  
System A

scholarly journals The State of the Cardiovascular System of Qualified Table Tennis Athletes at the Stage of Competitive Activity

2021 ◽  
Vol 6 (4) ◽  
pp. 231-236
Author(s):  
Ulizko V. M. ◽  
◽  
V. R. Kryzhanivsky ◽  
T. M. Zakharkevich ◽  
I. L. Belyavsky
Keyword(s):  
Physical Activity ◽  
Heart Rate ◽  
Cardiovascular System ◽  
High Frequency ◽  
Heart Rhythm ◽  
Frequency Component ◽  
The State ◽  
Autonomic Regulation ◽  
The Body ◽  
High Frequency Component

The condition of the cardiovascular system is one of the important criteria for assessing the impact of sports training on the human body. According to the indicators characterizing the state of the cardiovascular system, it is possible to trace the changes associated with fluctuations in the level of training, as well as to identify signs of overload as early as possible. The study of adaptive reactions of the cardiovascular system in athletes under physical activity is an important indicator for sports practice. The purpose of the study was to investigate the quantitative criteria for assessing the state of the cardiovascular system and approaches to correct the functional state of qualified athletes specializing in table tennis. Materials and methods. Studies of heart rate variability, quantitative and qualitative indicators that sufficiently reflect the autonomic functions of the body were used in order to assess the state of autonomic regulation in highly qualified athletes. Systematic physical activity causes a significant restructuring of the cardiovascular system and leads to morphofunctional changes in the mechanisms of the heart. Depending on the autonomic regulation of heart rhythm, there are different ways of myocardial adaptation processes. The balance of sympathetic and parasympathetic links of autonomic rhythm regulation is reflected in the activation of the left ventricle. Results and discussion. Adaptive changes of the cardiovascular system to competitive and training loads in the competitive period in qualified athletes are characterized by a significant decrease in heart rate (from 84.75±1.74 beats / min to 74.8±0.38 beats / min). In addition, a significantly faster process of restoring heart rate was established after exercise in the group of qualified athletes, compared with athletes of the category 1 at 4 (p >0.05) and 5 (p >0.05) minutes, respectively. According to the indicators of autonomic regulation of heart rhythm, activation of the parasympathetic link prevails in athletes of the category 1 in comparison with qualified athletes activation (according to high-frequency component, p <0.05). Significantly higher rates of individual parts of the body compared to low-skilled athletes were found out: the hormonal system (the indicator responsible for the hormonal part of the body – very low-frequency component) and the nervous system (indicators of the sympathetic nervous system – low frequency component). There are significantly higher values of the magnitude of the heart rate spectrum and high-frequency component at p <0.05, which indicates a higher power of all units of the parasympathetic regulation in the category 1 in relation to masters of sports and candidates masters of sports. Conclusion. Systematic physical activity causes a significant restructuring of the cardiovascular system and leads to morphofunctional changes in the mechanisms of the heart. Depending on the autonomic regulation of heart rhythm, there are different ways of myocardial adaptation processes. The balance of sympathetic and parasympathetic links of autonomic rhythm regulation is reflected in the activation of the left ventricle. The analysis showed that the spectral characteristics of heart rate variability significantly differ between groups of athletes with different dominance that are observed only in terms of high-frequency component, which in turn led to a change in the sympathetic-vagal balance

The role of anxiety and hormonal changes in menopausal hot flashes

2005 ◽  
Vol 12 (3) ◽  
pp. 258-266 ◽  
Author(s):  
Ellen W Freeman ◽  
Mary D Sammel ◽  
Hui Lin ◽  
Clarisa R Gracia ◽  
Shiv Kapoor ◽  
...  
Keyword(s):  
Hot Flashes ◽  
Hormonal Changes

What role do adrenoreceptor polymorphisms play in modifying cardiovascular responses in obstructive sleep apnoea?

2005 ◽  
Vol 110 (1) ◽  
pp. 89-91 ◽  
Author(s):  
Nigel Mcardle
Keyword(s):  
Blood Pressure ◽  
Heart Rate ◽  
Cardiovascular Risk ◽  
Diastolic Blood Pressure ◽  
Obstructive Sleep Apnoea ◽  
Cardiovascular Responses ◽  
Sleep Apnoea ◽  
Cpap Treatment ◽  
Obstructive Sleep

OSA (obstructive sleep apnoea) is a common condition that is strongly associated with cardiovascular disease. It is remains unclear what role OSA plays in determining cardiovascular risk. The immediate physiological changes that occur during upper airway obstruction are potential contributors to cardiovascular risk in OSA. These changes include increased sympathetic activity, which is responsive to treatment of OSA with CPAP (continuous positive airway pressure). In this issue of Clinical Science, the possible role of a common polymorphism in the β1-adrenoreceptor [R389G (Arg389Gly)] has been investigated by Börgel and co-workers. Measurements of heart rate and blood pressure in untreated OSA patients were not related to the R389G polymorphism. There were changes in heart rate and diastolic blood pressure with CPAP treatment that were related to this polymorphism. Reduction in heart rate with CPAP treatment was associated with the R389R genotype. By contrast, a reduction in diastolic blood pressure was associated with the Gly389 carriers. These findings are intriguing, but difficult to fully explain. Further study is needed to determine if there is an important role of the R389G polymorphism in modifying cardiovascular responses among OSA patients.

scholarly journals Non-hormonal options for the relief of menopausal disorders

2022 ◽  
pp. 190-196
Author(s):  
O. V. Yakushevskaya
Keyword(s):  
Large Scale ◽  
Estrogen Deficiency ◽  
Alternative Methods ◽  
Main Function ◽  
Hormonal Changes ◽  
Social Self ◽  
Number Of Patients ◽  
Wide Range ◽  
Long Time

Woman’s nature is unique. Taking into account some historical milestones, it can be noted that the role of women in society has undergone large-scale changes. The woman took a confident position in society. Its main function remains unchanged and it consists in procreation and procreation. A woman’s activity is consistent with the work of her reproductive system (RS). The gradual decrease, and then the cessation of the work of the ovaries, contributes to the life order and health of the fair sex. Menopause is a natural stage in a woman’s life, which corresponds to the peak of social self-realization. However, in some cases, hormonal changes characteristic of this period can serve as a favorable background for the formation of a number of pathological changes. The growing estrogen deficiency is becoming a pathogenetic impetus for the development of a wide range of climacteric disorders. Vasomotor symptoms and hyperhidrosis are the most frequent companions of women during the perimenopausal transition and early postmenopause. Maintaining optimal activity and the full quality of life of patients should be the goal of correcting the negative manifestations of estrogen deficiency and the complications associated with it. Compensating for estrogen deficiency with menopausal hormone therapy (HRT) is the benchmark for menopausal problems. However, there are a number of patients who have contraindications to prescribing HRT or who refuse to receive it for some reason. For this category of patients, alternative methods of diet correction. Combinations of plant extracts with vitamins and minerals have been successfully used in clinical practice for a long time. The article will provide information on the most studied phytoestrogens contained in soy.

Cardiovascular Consequences of a Mutant Thyroid Hormone Receptor α1

2010 ◽  
Vol 6 (2) ◽  
pp. 51 ◽  
Author(s):  
Jens Mittag ◽  
Keyword(s):  
Heart Rate ◽  
Nervous System ◽  
Autonomic Nervous System ◽  
Thyroid Hormone ◽  
Cardiovascular System ◽  
Hormone Receptor ◽  
Thyroid Hormone Receptor ◽  
Cardiac Activity ◽  
Autonomic Nervous

Thyroid hormone has long been known for its profound direct effects on the cardiovascular system, but its interactions with the autonomic nervous system controlling cardiac activity still remain enigmatic. Recently, mice heterozygous for a mutant thyroid hormone receptor α1 (TRα1+/m) have been generated and their analysis has provided new insights into the actions of thyroid hormone on the cardiovascular system. The mutant TRα1 caused many symptoms resembling hypothyroidism, such as bradycardia, as well as reduced contraction and delayed relaxation time of isolated cardiomyocytes. While no abnormalities were detected in the autonomic regulation of the basal heart rate using pharmacological denervation, an impaired adjustment of the autonomic nervous system could be observed in TRα1+/m mice on activity, stress or increased temperature. The results thus confirm the important role of TRα1 in maintaining the intrinsic properties of the heart and demonstrate a novel role for TRα1 in the adaptations of the autonomic nervous system controlling the heart rate under non-baseline conditions.

Cardiovascular Consequences of a Mutant Thyroid Hormone Receptor α1

2011 ◽  
Vol 07 (01) ◽  
pp. 55
Author(s):  
Jens Mittag ◽  
Keyword(s):  
Heart Rate ◽  
Nervous System ◽  
Autonomic Nervous System ◽  
Thyroid Hormone ◽  
Cardiovascular System ◽  
Hormone Receptor ◽  
Thyroid Hormone Receptor ◽  
Cardiac Activity ◽  
Autonomic Nervous

Thyroid hormone has long been known for its profound direct effects on the cardiovascular system, but its interactions with the autonomic nervous system controlling cardiac activity still remain enigmatic. Recently, mice heterozygous for a mutant thyroid hormone receptor 〈1 (TR〈1+/m) have been generated and their analysis has provided new insights into the actions of thyroid hormone on the cardiovascular system. The mutant TR〈1 caused many symptoms resembling hypothyroidism, such as bradycardia, as well as reduced contraction and delayed relaxation time of isolated cardiomyocytes. While no abnormalities were detected in the autonomic regulation of the basal heart rate using pharmacologic denervation, an impaired adjustment of the autonomic nervous system could be observed in TR〈1+/m mice on activity, stress, or increased temperature. The results thus confirm the important role of TR〈1 in maintaining the intrinsic properties of the heart and demonstrate a novel role for TR〈1 in the adaptations of the autonomic nervous system controlling the heart rate under non-baseline conditions.

scholarly journals Dynamic Aerobic Exercise Induces Baroreflex Improvement in Diabetic Rats

2012 ◽  
Vol 2012 ◽  
pp. 1-5 ◽  
Author(s):  
Luciana Jorge ◽  
Demilto Y. da Pureza ◽  
Danielle da Silva Dias ◽  
Filipe Fernandes Conti ◽  
Maria-Cláudia Irigoyen ◽  
...  
Keyword(s):  
Heart Rate ◽  
Cardiovascular Risk ◽  
Arterial Pressure ◽  
Aerobic Exercise ◽  
Wistar Rats ◽  
Baroreflex Sensitivity ◽  
Diabetic Rats ◽  
Male Wistar Rats

The objective of the present study was to investigate the effects of an acute aerobic exercise on arterial pressure (AP), heart rate (HR), and baroreflex sensitivity (BRS) in STZ-induced diabetic rats. Male Wistar rats were divided into control (n=8) and diabetic (n=8) groups. AP, HR, and BRS, which were measured by tachycardic and bradycardic (BR) responses to AP changes, were evaluated at rest (R) and postexercise session (PE) on a treadmill. At rest, STZ diabetes induced AP and HR reductions, associated with BR impairment. Attenuation in resting diabetes-induced AP (R:103±2versus PE:111±3 mmHg) and HR (R:290±7versus PE:328±10 bpm) reductions and BR dysfunction (R:-0.70±0.06versus PE:-1.21±0.09 bpm/mmHg) was observed in the postexercise period. In conclusion, the hemodynamic and arterial baro-mediated control of circulation improvement in the postexercise period reinforces the role of exercise in the management of cardiovascular risk in diabetes.

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