A MENDELIAN RANDOMIZATION APPROACH TO ASSESS THE CAUSAL RELATIONSHIP OF GAMMA-GLUTAMYL TRANSFERASE WITH BLOOD PRESSURE AND INSULIN: PP.17.124

2010 ◽  
Vol 28 ◽  
pp. e288
Author(s):  
D Conen ◽  
P Vollenweider ◽  
V Rousson ◽  
P Marques-Vidal ◽  
F Paccaud ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Causal Relationship ◽  
Mendelian Randomization ◽  
Gamma Glutamyl Transferase ◽  
Gamma Glutamyl ◽  
Glutamyl Transferase ◽  
Relationship Of

Obstructive Sleep Apnea and Cardiovascular Risk Markers (Fibrinogen & Gamma Glutamyl Transferase) in Obese Males

2021 ◽  
Vol 15 (12) ◽  
pp. 3312-3314
Author(s):  
Shagufta Khaliq ◽  
Mudassar Ali Roomi ◽  
Shaheena Naz ◽  
Komal Iqbal ◽  
Muhammad Imran Ashraf ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Blood Pressure ◽  
Obstructive Sleep Apnea ◽  
Sleep Apnea ◽  
Gamma Glutamyl Transferase ◽  
Strong Positive Correlation ◽  
Positive Correlation ◽  
Gamma Glutamyl ◽  
Obstructive Sleep ◽  
Glutamyl Transferase

Aim: To determine and compare gamma glutamyl transferase (GGT) and fibrinogen among obese males with and without obstructive sleep apnea (OSA). Second objective was to investigate correlation between blood pressure and GGT. Methodology: Sixty-four obese males aged 20-45 years with BMI > 25kg/m2 were included by convenience sampling. The study was conducted, after obtaining ethical approval from IRB, at the Department of Physiology, Post Graduate Medical Institute, Lahore from August 2014 to May 2015. Participants having acute or chronic inflammatory conditions were excluded. Participants were screened for OSA by Berlin and STOP BANG questionnaires. Diagnosis of OSA was made by overnight portable pulse oximetry. The participants were divided into two groups. Group I had 32 obese males with OSA. Group II contained 32 obese males without OSA. After an overnight fasting of 10-12 hours blood samples were drawn. Serum fibrinogen and GGT were measured by spectrophotometer. The data was analyzed using SPSS-22. Quantitative variables were compared between the two groups by Mann-Whitney U test. Spearman correlation was used to correlate blood pressure and GGT among the participants. Results: Fibrinogen was significantly raised (p=0.015) in obese males with OSA. Systolic blood pressure (p=0.003), diastolic blood pressure (p=0.001) and mean arterial blood pressure (p<0.001) showed strong positive correlation with GGT in obese males with OSA. Conclusion: Proinflammatory, procoagulant and proatherogenic marker fibrinogen levels were significantly raised in obese otherwise healthy males with OSA. Oxidative stress marker GGT showed strong positive correlation with blood pressure in obese males with OSA. Keywords: Fibrinogen, gamma glutamyl transferase, inflammation, obstructive sleep apnea, oxidative stress

scholarly journals Serum gamma-glutamyl transferase and risk of type 2 diabetes in the general Korean population: a Mendelian randomization study

2016 ◽  
Vol 25 (17) ◽  
pp. 3877-3886 ◽  
Author(s):  
Youn Sue Lee ◽  
Yoonsu Cho ◽  
Stephen Burgess ◽  
George Davey Smith ◽  
Caroline L. Relton ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Mendelian Randomization ◽  
Korean Population ◽  
Gamma Glutamyl Transferase ◽  
Gamma Glutamyl ◽  
Glutamyl Transferase

scholarly journals Gamma-Glutamyl Transferase Levels in Patients with Acute Ischemic Stroke

2014 ◽  
Vol 2014 ◽  
pp. 1-4 ◽  
Author(s):  
Nurbanu Gurbuzer ◽  
Eren Gozke ◽  
Zeliha Ayhan Basturk
Keyword(s):  
Ischemic Stroke ◽  
Acute Ischemic Stroke ◽  
Gamma Glutamyl Transferase ◽  
Gamma Glutamyl ◽  
Cerebrovascular Risk ◽  
The Mean ◽  
And Gender ◽  
Glutamyl Transferase ◽  
Relationship Of ◽  
The Relationship

Objective. The aim of this study was to investigate the relationship between gamma-glutamyl transferase (GGT) levels, cerebrovascular risk factors, and distribution of cerebral infarct areas in patients with acute ischemic stroke (AIS). Patients and Methods. Sixty patients with AIS and 44 controls who had not cerebrovascular disease were included in the study. The patients were divided into four groups according to the location of the infarct area and evaluated as for GGT levels and the presence of diabetes mellitus (DM), hypertension (HT), and hyperlipidemia (HL). Results. The frequency of DM, HT, and HL and gender distributions were similar. The mean GGT levels were significantly higher in patients with AIS and those with relatively larger areas of infarction (P<0.05). Increased mean GGT levels were found in the subgroup with hypertension, higher LDL-cholesterol, and triglyceride levels among cases with AIS (P<0.05). Conclusion. Higher GGT levels in AIS patients reinforce the relationship of GGT with inflammation and oxidative stress. The observation of higher GGT levels in patients with relatively larger areas of infarction is indicative of a positive correlation between increases in infarct areas and elevated GGT levels.

A18709 Mendelian Randomization study of causal relationship of height on blood pressure and arterial stiffness

2018 ◽  
Vol 36 ◽  
pp. e91-e92
Author(s):  
Li En Tan ◽  
Andrea Llano ◽  
Alisha Aman ◽  
Anna F Dominiczak ◽  
Sandosh Padmanabhan
Keyword(s):  
Blood Pressure ◽  
Arterial Stiffness ◽  
Causal Relationship ◽  
Mendelian Randomization ◽  
Relationship Of

scholarly journals DIFFERENCES OF GAMMA GLUTAMYL TRANSFERASE IN CORONARY HEART DISEASE PATIENTS WITH MORE THAN EQUAL 70% OCCLUSION AND LESS THAN 70% OCCLUSION

2020 ◽  
pp. 1-3
Author(s):  
Dahlan Siahaan ◽  
Burhanuddin Nasution ◽  
Nizam Zikri Akbar
Keyword(s):  
Coronary Heart Disease ◽  
Heart Disease ◽  
Causes Of Death ◽  
Gamma Glutamyl Transferase ◽  
Cross Sectional ◽  
Heart Attacks ◽  
Gamma Glutamyl ◽  
Artery Disease ◽  
Glutamyl Transferase ◽  
Relationship Of

Background: Coronary heart disease (CHD) is a cumulation of plaque in the heart arteries that can cause heart attacks. CHD is one of the main and rst causes of death in developed and developing countries, including Indonesia. It is estimated that throughout the world, CHD in 2020 became the rst most frequent killer of 36% of all deaths, twice as high as cancer deaths. Currently Gamma Glutamyl Transferase (GGT) is a prognostic marker of death and reinfarction in patients with patients Coronary Artery Disease (CAD) and there is a relationship of GGT with the prognosis of CAD patients undergoing angiography. Methods: The study was conducted by cross sectional method. The study subjects were 60 male and female CHD patients who were treated and treated at the hospital in the Department of Cardiology FK-USU / H. Adam Malik Hospital Medan, which was enforced by history, physical examination, angiography and laboratory and underwent coronary angiography. GGT examination uses Architect c8000. Results: A total of 60 CHD patients in this study found that GGT values were greater in the ≥70% group compared with occlusions <70% with p = 0.003. Conclusions: This study showed a signicant difference in the values of GGT with occlusion ≥70% and <70% occlusion.

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