ELEVATED ONE-HOUR POSTLOAD PLASMA GLUCOSE LEVELS IDENTIFY CORONARY HEART DISEASE PATIENTS WITH GREATER SEVERITY OF CORONARY ARTERY LESIONS AND HIGHER RISK OF ONE-YEAR RE-ADMISSION

Objective: To investigate the relationship of 1-h postload plasma glucose during the oral glucose tolerance test with the severity of coronary artery lesions and risk of 1-year re-admission in coronary heart disease patients with normal glucose tolerance. Methods: A total of 266 consecutive coronary heart disease patients who underwent coronary angiography and had normal glucose tolerance confirmed by oral glucose tolerance test during hospitalization were prospectively enrolled and followed in two groups according to the 1-h postload plasma glucose cut-off point (1-h postload plasma glucose <155 mg/dL, n = 149 and 1-h postload plasma glucose ⩾155 mg/dL, n = 117). Angiographic severity was assessed by number of diseased vessels, lesion morphology and Gensini score. The risk of 1-year re-admission with adverse cardiovascular events after discharge was analysed. Results: Subjects with a 1-h postload plasma glucose ⩾155 mg/dL had higher incidence of multivessel disease and complex lesions, Gensini score and risk of 1-year re-admission than subjects with a 1-h postload plasma glucose <155 mg/dL (all p < 0.05). In the stepwise multivariate regression analysis, 1-h postload plasma glucose was the major determinant of the Gensini score. Subgroup analyses by sex showed that men with a 1-h postload plasma glucose ⩾155 mg/dL had higher incidence of complex lesions and risk of 1-year re-admission than men with a 1-h postload plasma glucose <155 mg/dL (all p < 0.05). Conclusion: Coronary heart disease patients with normal glucose tolerance and elevated 1-h postload plasma glucose levels had a greater severity of coronary artery lesions and an increased risk of re-admission with adverse cardiovascular events, particularly in men.

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Fasting Plasma Glucose and Coronary Heart Disease in a Rural Population of North Henan, China

Evidence-based Complementary and Alternative Medicine ◽

10.1155/2020/2348583 ◽

2020 ◽

Vol 2020 ◽

pp. 1-11

Author(s):

Quan Guo ◽

Fei Lin ◽

Yi Liu ◽

Yang Li ◽

Xue-Hui Wang ◽

...

Keyword(s):

Coronary Heart Disease ◽

Heart Disease ◽

Plasma Glucose ◽

Fasting Plasma Glucose ◽

Rural Areas ◽

Odds Ratio ◽

Coronary Artery Lesions ◽

Fasting Plasma ◽

The Relationship ◽

Different Levels

Even in individuals without diabetes, the incidence of coronary heart disease (CHD) increases with the rise in fasting plasma glucose (FPG); however, the threshold of FPG for CHD in rural areas of China is unclear. We retrospectively examined 2,987 people. Coronary angiography records were used to determine the presence of CHD as well as its severity. Risk factors for CHD and the relationship between different levels of FPG and CHD were analyzed. After adjusting for age, hypertension, dyslipidemia, smoking, drinking, chronic kidney disease, and previous ischemic stroke, the incidence of CHD in nondiabetic women began to increase when FPG exceeded 5.2 mmol/L (odds ratio (OR) = 1.438, 95% confidence interval (CI) = 1.099–1.880, p=0.008), and the degree of coronary artery lesions also became more severe (OR = 1.406, 95% CI = 1.107–1.788, p=0.005). However, no such correlations were found in nondiabetic men. In conclusion, among the nondiabetic women in rural areas of northern Henan, both the incidence of CHD and the severity of lesions increased when FPG levels were greater than 5.2 mmol/L, while no significant correlation between FPG and CHD was observed in diabetes-free men.

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P82 THE CLINICAL STUDY OF HEART RATE VARIABILITY AND THE SERIOUS EXTENT OF CORONARY ARTERY LESIONS IN CORONARY HEART DISEASE

Atherosclerosis Supplements ◽

10.1016/s1567-5688(10)70149-5 ◽

2010 ◽

Vol 11 (2) ◽

pp. 33

Author(s):

G. Tian

Keyword(s):

Heart Rate ◽

Coronary Heart Disease ◽

Heart Rate Variability ◽

Heart Disease ◽

Clinical Study ◽

Coronary Artery ◽

Coronary Artery Lesions

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Correlation Between Severity of Coronary Artery Lesions and Risk Factors of Coronary Heart Disease

Journal of Computational and Theoretical Nanoscience ◽

10.1166/jctn.2015.4736 ◽

2015 ◽

Vol 12 (12) ◽

pp. 5916-5919

Author(s):

Jian Shen ◽

Xu Zhang ◽

Zhiming Li ◽

Guiting Xie ◽

Shenxiong Nong ◽

...

Keyword(s):

Risk Factors ◽

Coronary Heart Disease ◽

Heart Disease ◽

Coronary Artery ◽

Coronary Artery Lesions

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Addition of Risk Factors of Coronary Heart Disease in Diagnostic Value of Treadmill Score for Detecting Complexity of Coronary Arterial Lesions

ACI (Acta Cardiologia Indonesiana) ◽

10.22146/aci.40853 ◽

2018 ◽

Vol 4 (2) ◽

pp. 88

Author(s):

Mariyetty K.S. Nasution ◽

Abdullah A. Siregar ◽

Harris Hasan ◽

Zulfikri Mukhtar ◽

Abdul H. Raynaldo ◽

...

Keyword(s):

Risk Factors ◽

Coronary Heart Disease ◽

Heart Disease ◽

Coronary Artery ◽

Stable Angina ◽

Diagnostic Value ◽

Coronary Artery Lesions ◽

Treadmill Test ◽

Chd Risk ◽

Chd Risk Factors

Background: Coronary heart disease (CHD) is still the leading cause of death in the world. There are various risk factors for atherosclerosis leading to CHD. Duke Treadmill Score (DTS) is known to demonstrate prognostic stratification and has a diagnostic value in predicting the number of coronary arteries involved in patient populations with ischemic heart disease. However, DTS does not describe the role of risk factors for coronary heart disease to the complexity of coronary artery lesions. This study aims to add risk factors for coronary heart disease on DTS to detect the complexity of coronary artery lesions with stable angina pectoris.Methods: This study was a cross-sectional study in stable angina pectoris patient who comes to Haji Adam Malik Hospital Medan from January 2017 until February 2018. Patients who have done treadmill test and coronary angiography, and fulfill inclusion and exclusion criteria are included in the study. ECG examination and recording of risk factors for coronary heart disease were done. DTS assessment was performed based on a treadmill test and Syntax score based on coronary angiography results. Diagnostic tests were performed to assess the sensitivity and specificity of the addition of CHD risk factors to detect the complexity of coronary artery lesions.Results: Of the 76 people with stable angina pectoris, 55 people were found with low SYNTAX and 21 people with high Syntax. DTS is divided into 3 groups: mild (> -10), moderate (-10 to - 13.5), and severe (≤-13.6) based on the cut off of the ROC curve. Risk factors for CHD are divided into 3 groups, mild (≤3 CHD risk factors), moderate (4-6 CHD risk factors), and severe (7 CHD risk factors) based on the cut off of the ROC curve, then assessed the relationship with Syntax which has been divided into 2 groups, low Syntax, and high Syntax. Diagnostic test shows the addition of risk factors of CHD to DTS to detect the complexity of coronary artery lesions have greater sensitivity and specificity than DTS without the addition of risk factors of CHD, 95%, and 89%.Conclusion: The addition of risk factors for coronary heart disease on DTS can detect the complexity of coronary artery lesions.

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