Effects of Preeclampsia on Maternal Plasma, Cerebrospinal Fluid, and Umbilical Cord Urotensin II Concentrations

2006 ◽  
Vol 50 (4) ◽  
pp. 184-185
Author(s):  
&NA;
Keyword(s):  
Cerebrospinal Fluid ◽  
Umbilical Cord ◽  
Maternal Plasma ◽  
Urotensin Ii

THE CONCENTRATIONS OF ANDROGENS, OESTROGENS, PROGESTERONE AND LUTEINIZING HORMONE IN THE SERUM OF FOETAL CALVES THROUGHOUT THE COURSE OF GESTATION

1974 ◽  
Vol 60 (1) ◽  
pp. 107-115 ◽  
Author(s):  
J. R. G. CHALLIS ◽  
C. K. KIM ◽  
F. NAFTOLIN ◽  
H. L. JUDD ◽  
S. S. C. YEN ◽  
...  
Keyword(s):  
Luteinizing Hormone ◽  
Cord Blood ◽  
Umbilical Cord ◽  
Umbilical Cord Blood ◽  
Maternal Plasma ◽  
Male And Female ◽  
Hormone Levels

SUMMARY The concentrations of luteinizing hormone (LH), progesterone, testosterone, androstenedione, oestrone and oestradiol in mixed umbilical cord blood taken from foetal calves during months 3 to 9 of gestation have been measured by radioimmunoassay. The levels of progesterone were low (compared with those in maternal plasma) and constant during pregnancy. There were large variations in the concentrations of androstenedione, oestrone, oestradiol and LH, with lower values found during months 7 to 8 of gestation. Significant differences (P < 0·05–< 0·001) in hormone levels between male and female foetuses were found for testosterone, LH, and the oestrogens during months 3 to 7, 3 and 4, and 7 and 8, respectively. No significant differences (P > 0·05) between sexes were found at any time between the concentrations of progesterone and androstenedione.

N-terminal pro-C-type natriuretic peptide, but not C-type natriuretic peptide, is greatly elevated in the fetal circulation

2004 ◽  
Vol 106 (5) ◽  
pp. 535-540 ◽  
Author(s):  
Timothy C. R. PRICKETT ◽  
Risto J. KAAJA ◽  
M. Gary NICHOLLS ◽  
Eric A. ESPINER ◽  
A. Mark RICHARDS ◽  
...  
Keyword(s):  
Cord Blood ◽  
Natriuretic Peptide ◽  
Umbilical Cord ◽  
Umbilical Cord Blood ◽  
Plasma Concentrations ◽  
Maternal Plasma ◽  
Fetal Tissues ◽  
Cord Plasma ◽  
Significant Difference ◽  
Gestational Group

We have identified recently a new peptide, NT-proCNP(1–50) (N-terminal pro-C-type natriuretic peptide), in the circulation of humans and sheep. A previous report of an elevated fetal–maternal gradient in immunoreactive CNP raised the possibility that processing and metabolism of proCNP may differ in maternal and fetal tissues. We therefore collected matching peripheral maternal and umbilical cord plasma samples at delivery from women with normotensive and pre-eclamptic pregnancies to investigate the presence and concentrations of CNP and NT-proCNP using HPLC and RIA. Plasma concentrations of NT-proCNP in normotensive umbilical cord plasma were 10-fold higher than maternal venous levels (246±17 compared with 24.3±1.8 pmol/l; P<0.001) and much higher than corresponding levels of CNP (3.6±0.4 compared with 1.8±0.3 pmol/l in the fetal and maternal plasma respectively; P<0.001). Although there was no significant difference between normotensive and pre-eclamptic plasma CNP concentrations in either maternal or umbilical cord blood, NT-proCNP showed a significant statistical interaction (F=5.8, P=0.025) between the source (maternal or fetal) and gestational group (normotensive or pre-eclamptic). Maternal NT-proCNP levels were raised in the pre-eclampsia group, whereas the converse was observed in umbilical cord blood. In conclusion, the greatly elevated ratio of NT-proCNP/CNP in fetal compared with maternal plasma suggests that synthesis, as well as clearance, of CNP (but not NT-proCNP clearance) are markedly increased in fetal tissues.

Unbound cortisol in umbilical cord plasma and maternal plasma: A reinvestigation

1979 ◽  
Vol 135 (8) ◽  
pp. 1104-1108 ◽  
Author(s):  
J. Predine ◽  
L. Merceron ◽  
G. Barrier ◽  
C. Sureau ◽  
E. Milgrom
Keyword(s):  
Umbilical Cord ◽  
Maternal Plasma ◽  
Cord Plasma

scholarly journals Plasma Concentrations and Maternal-Umbilical Cord Plasma Ratios of the Six Most Prevalent Carotenoids across Five Groups of Birth Gestational Age

Antioxidants ◽  
2021 ◽  
Vol 10 (9) ◽  
pp. 1409
Author(s):  
Chelsey McConnell ◽  
Melissa Thoene ◽  
Matthew Van Ormer ◽  
Jeremy D. Furtado ◽  
Zeljka Korade ◽  
...  
Keyword(s):  
Umbilical Cord ◽  
Gestational Age ◽  
Plasma Concentrations ◽  
Newborn Infants ◽  
Maternal Plasma ◽  
P Value ◽  
Limited Information ◽  
Factors Associated ◽  
Cord Plasma ◽  
Β Carotene

Carotenoids are antioxidant nutrients with the potential to provide protection against oxidative stress. Plasma carotenoid concentrations are lower in newborn infants compared to their mothers; however, limited information is available regarding how concentrations differ by gestational age. The objective of this research is to assess maternal and umbilical cord plasma carotenoid concentrations and maternal-umbilical cord plasma ratios across five groups of birth gestational age. Mother-infant dyads were enrolled at delivery for collection of maternal and umbilical cord blood. Plasma carotenoids were analyzed by HPLC and LC-MS/MS. Birth gestational age was categorized into five groups, and the Kruskal–Wallis test compared carotenoid concentrations and maternal-umbilical cord plasma ratios between these groups. A p-value of < 0.05 was considered statistically significant. 370 mother-infant dyads were included, with most infants delivered at early term (20.3%) or term (64.6%). Though maternal plasma concentrations increased with birth gestational age, we observed less variability in umbilical cord plasma concentrations, thus the maternal-umbilical cord plasma ratio also increased with birth CGA groups for lutein + zeaxanthin (p = 0.008), β-cryptoxanthin (p = 0.027), α-carotene (p = 0.030); β-carotene approached significance (p = 0.056). Additional research is needed to determine if carotenoid concentrations were physiologic to varying gestational ages or if they were impacted by factors associated with preterm birth.

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