scholarly journals Early Childhood General Anesthesia and Neurodevelopmental Outcomes in the Avon Longitudinal Study of Parents and Children Birth Cohort

2020 ◽  
Vol 133 (5) ◽  
pp. 1007-1020
Author(s):  
Graham J. Walkden ◽  
Hannah Gill ◽  
Neil M. Davies ◽  
Alethea E. Peters ◽  
Ingram Wright ◽  
...  
Keyword(s):  
Early Childhood ◽  
Longitudinal Study ◽  
General Anesthesia ◽  
Birth Cohort ◽  
Dynamic Balance ◽  
Statistical Significance ◽  
P Value ◽  
Neurodevelopmental Outcomes ◽  
Parents And Children ◽  
Avon Longitudinal Study

Background Most common anesthetic agents have been implicated in causing neurodegeneration in the developing animal brain, leading to warnings regarding their use in children. The hypothesis of this study was that exposure to general anesthesia and surgery before 4 yr would associate with adverse neurodevelopmental outcomes at age 7 to 16 yr. Methods This cohort study comprised 13,433 children enrolled in the Avon Longitudinal Study of Parents and Children, a prospective, population-based birth cohort born between 1991 and 1993 in southwest England. Children were grouped by none, single, or multiple exposures to general anesthesia and surgery by 4 yr. Motor, cognitive, linguistic, educational, social, and behavioral developmental outcomes were evaluated at 7 to 16 yr using school examination results, validated parent/teacher questionnaires, or clinic assessments. Continuous outcomes were z-scored. P-value thresholds were corrected using false discovery rate procedures. Results This study compared 46 neurodevelopmental outcomes in 13,433 children: 8.3% (1,110) exposed singly and 1.6% (212) exposed multiply to general anesthesia and surgery. Of these, the following reached predefined levels of statistical significance (corrected P < 0.00652): dynamic balance scores were 0.3 SD (95% CI, 0.1, 0.5; P < 0.001) lower in multiply exposed children; manual dexterity performance was 0.1 SD (95% CI, 0.0, 0.2; P = 0.006) lower in singly and 0.3 SD (95% CI, 0.1, 0.4; P < 0.001) lower in multiply exposed children; and social communication scores were 0.1 SD (95% CI, 0.0, 0.2; P = 0.001) and 0.4 SD (95% CI, 0.3, 0.5; P < 0.001) lower in singly and multiply exposed children, respectively. General anesthesia and surgery were not associated with impairments in the remaining neurodevelopmental measures including: general cognitive ability; attention; working memory; reading, spelling, verbal comprehension and expression; behavioral difficulties; or national English, mathematics, and science assessments (all ≤0.1 SD; corrected P ≥ 0.00652). Conclusions Early childhood general anesthesia and surgery were not associated with a global picture of clinically and statistically significant neurodegenerative effects, providing reassurance about the neurotoxic potential of general anesthesia. Exposure to anesthesia and surgery was associated with significantly lower motor and social linguistic performance. Editor’s Perspective What We Already Know about This Topic What This Article Tells Us That Is New

scholarly journals Generation of a cleaned dataset listing Avon Longitudinal Study of Parents And Children peer-reviewed publications to 2015

2018 ◽  
Vol 3 ◽  
pp. 161 ◽  
Author(s):  
Oliver Butters ◽  
Amran Ismail ◽  
Sue Thompson ◽  
Rebecca Wilson
Keyword(s):  
Longitudinal Study ◽  
Cohort Studies ◽  
Birth Cohort ◽  
Research Data ◽  
Data Set ◽  
Parents And Children ◽  
Bibliometric Research ◽  
The Impact ◽  
Avon Longitudinal Study ◽  
Accurate Reporting

Birth cohort studies generate huge amounts of data, and as a consequence are a source of many peer reviewed publications. We have taken the list of publications from the Avon Longitudinal Study of Parents and Children UK birth cohort, filtered, de-duplicated and cleaned it to generate a bibliographic research data set. This dataset could be used for accurate reporting and monitoring of the impact of the study as well as bibliometric research.

scholarly journals Association between maternal vitamin D status in pregnancy and neurodevelopmental outcomes in childhood: results from the Avon Longitudinal Study of Parents and Children (ALSPAC)

2017 ◽  
Vol 117 (12) ◽  
pp. 1682-1692 ◽  
Author(s):  
Andrea L. Darling ◽  
Margaret P. Rayman ◽  
Colin D. Steer ◽  
Jean Golding ◽  
Susan A. Lanham-New ◽  
...  
Keyword(s):  
Vitamin D ◽  
Longitudinal Study ◽  
Motor Development ◽  
Vitamin D Status ◽  
Neurodevelopmental Outcomes ◽  
Maternal Vitamin ◽  
Parents And Children ◽  
Maternal Vitamin D Status ◽  
Avon Longitudinal Study ◽  
In Pregnancy

AbstractSeafood intake in pregnancy has been positively associated with childhood cognitive outcomes which could potentially relate to the high vitamin D content of oily fish. However, whether higher maternal vitamin D status (serum 25-hydroxyvitamin D (25(OH)D)) in pregnancy is associated with a reduced risk of offspring suboptimal neurodevelopmental outcomes is unclear. A total of 7065 mother–child pairs were studied from the Avon Longitudinal Study of Parents and Children cohort who had data for both serum total 25(OH)D concentration in pregnancy and at least one measure of offspring neurodevelopment (pre-school development at 6–42 months; ‘Strengths and Difficulties Questionnaire’ scores at 7 years; intelligence quotient (IQ) at 8 years; reading ability at 9 years). After adjustment for confounders, children of vitamin D-deficient mothers (<50·0 nmol/l) were more likely to have scores in the lowest quartile for gross-motor development at 30 months (OR 1·20; 95 % CI 1·03, 1·40), fine-motor development at 30 months (OR 1·23; 95 % CI 1·05, 1·44) and social development at 42 months (OR 1·20; 95 % CI 1·01, 1·41) than vitamin D-sufficient mothers (≥50·0 nmol/l). No associations were found with neurodevelopmental outcomes, including IQ, measured at older ages. However, our results suggest that deficient maternal vitamin D status in pregnancy may have adverse effects on some measures of motor and social development in children under 4 years. Prevention of vitamin D deficiency may be important for preventing suboptimal development in the first 4 years of life.

scholarly journals Why the son-bias in fathering? Testing sex-differences in the associations between paternal caregiving and child outcomes in England (Pre-print)

2018 ◽  
Author(s):  
Emily H Emmott ◽  
Ruth Mace
Keyword(s):  
Early Childhood ◽  
Sex Differences ◽  
Longitudinal Study ◽  
Test Scores ◽  
Child Outcomes ◽  
Ecological Framework ◽  
Parents And Children ◽  
More Care ◽  
Using Data ◽  
Avon Longitudinal Study

Fathers in Western populations tend to provide more care to sons than daughters. Following a Human Behavioural Ecological framework, we hypothesise that son-biases in fathering may (at least in part) be due to differences in the “returns to paternal caregiving” on children’s outcomes by sex. In this study, we investigate possible sex-differences in the associations between paternal caregiving throughout early childhood and children’s outcomes in stable, two-parent families. Using data from the Avon Longitudinal Study of Parents and Children, we test whether paternal caregiving is associated with different effects on children’s school test scores and behavioural difficulty by children’s sex. Overall, we find that paternal caregiving is associated with higher school test scores and lower behavioural difficulty scores, but the association between paternal caregiving and school test scores were stronger for boys. Our findings highlight possible sex-differences in returns to paternal caregiving for certain domains of child outcomes in England.

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