scholarly journals Generation of a cleaned dataset listing Avon Longitudinal Study of Parents And Children peer-reviewed publications to 2015

2018 ◽  
Vol 3 ◽  
pp. 161 ◽  
Author(s):  
Oliver Butters ◽  
Amran Ismail ◽  
Sue Thompson ◽  
Rebecca Wilson
Keyword(s):  
Longitudinal Study ◽  
Cohort Studies ◽  
Birth Cohort ◽  
Research Data ◽  
Data Set ◽  
Parents And Children ◽  
Bibliometric Research ◽  
The Impact ◽  
Avon Longitudinal Study ◽  
Accurate Reporting

Birth cohort studies generate huge amounts of data, and as a consequence are a source of many peer reviewed publications. We have taken the list of publications from the Avon Longitudinal Study of Parents and Children UK birth cohort, filtered, de-duplicated and cleaned it to generate a bibliographic research data set. This dataset could be used for accurate reporting and monitoring of the impact of the study as well as bibliometric research.

scholarly journals Parental suicide attempt and offspring educational attainment during adolescence in the Avon Longitudinal Study of Parents and Children (ALSPAC) birth cohort

2016 ◽  
Vol 46 (10) ◽  
pp. 2097-2107 ◽  
Author(s):  
G. Geulayov ◽  
C. Metcalfe ◽  
D. Gunnell
Keyword(s):  
Longitudinal Study ◽  
Suicide Attempt ◽  
Educational Attainment ◽  
Educational Level ◽  
Parental Education ◽  
Attempted Suicide ◽  
Parental Suicide ◽  
Parents And Children ◽  
The Impact ◽  
Avon Longitudinal Study

BackgroundFew studies have investigated the impact of parental suicide attempt (SA) on offspring outcomes other than mental health. We investigated the association of parental SA with offspring educational attainment in the Avon Longitudinal Study of Parents and Children (ALSPAC).MethodParental SA was prospectively recorded from pregnancy until the study children were 11 years old. National school test results (ages 11–16 years) were obtained by record linkage. Multilevel regression models quantified the association between parental SA and offspring outcomes.ResultsData were available for 6667 mother–child and 3054 father–child pairs. Adolescents whose mothers had attempted suicide were less likely than their peers to achieve the expected educational level by age 14 years [adjusted odds ratio (aOR) 0.63, 95% confidence interval (CI) 0.41–0.95] in models controlling for relevant confounders, including parental education and depression. At age 16 years, adolescents whose mothers had attempted suicide were less likely to obtain the expected educational level (five or more qualifications at grade A*–C) (aOR 0.66, 95% CI 0.43–1.00) in models controlling for relevant confounders and parental education; however, after additionally controlling for maternal depression the results were consistent with chance (aOR 0.74, 95% CI 0.48–1.13). Findings in relation to paternal SA were consistent with those of maternal SA but power was limited due to lower response rate amongst fathers.ConclusionsMaternal SA was associated with diminished educational performance at age 14 years. Educational attainment during adolescence can have substantial effect on future opportunities and well-being and these offspring may benefit from interventions.

scholarly journals The Avon Longitudinal Study of Parents and Children - A resource for COVID-19 research: Generation 2 questionnaire data capture May-July 2020

2021 ◽  
Vol 5 ◽  
pp. 278
Author(s):  
Daniel Smith ◽  
Kate Northstone ◽  
Claire Bowring ◽  
Nicholas Wells ◽  
Michael Crawford ◽  
...  
Keyword(s):  
Longitudinal Study ◽  
School Attendance ◽  
Population Based ◽  
Children's Health ◽  
Children’S Health ◽  
Questionnaire Data ◽  
Contact Patterns ◽  
Parents And Children ◽  
The Impact ◽  
Avon Longitudinal Study

The Avon Longitudinal Study of Parents and Children (ALSPAC) is a prospective population-based cohort study which recruited pregnant women in 1990-1992 from the Bristol area (UK). ALSPAC has followed these women, their partners (Generation 0; G0) and their offspring (Generation 1; G1) ever since. From 2012, ALSPAC has identified G1 participants who were pregnant (or their partner was) or had become parents, and enrolled them, their partners, and children in the ALSPAC-Generation 2 (ALSPAC-G2) study, providing a unique multi-generational cohort. At present, approximately 1,100 G2 children (excluding those in utero) from 810 G1 participants have been enrolled. In response to the COVID-19 pandemic, ALSPAC rapidly deployed two online questionnaires; one during the initial lockdown phase in 2020 (9th April-15th May), and another when national lockdown restrictions were eased (26th May-5th July). As part of this second questionnaire, G1 parents completed a questionnaire about each of their G2 children. This covered: parental reports of children’s feelings and behaviour since lockdown, school attendance, contact patterns, and health. A total of 289 G1 participants completed this questionnaire on behalf of 411 G2 children. This COVID-19 G2 questionnaire data can be combined with pre-pandemic ALSPAC-G2 data, plus ALSPAC-G1 and -G0 data, to understand how children’s health and behaviour has been affected by the pandemic and its management. Data from this questionnaire will be complemented with linkage to health records and results of biological testing as they become available. Prospective studies are necessary to understand the impact of this pandemic on children’s health and development, yet few relevant studies exist; this resource will aid these efforts. Data has been released as: 1) a freely-available dataset containing participant responses with key sociodemographic variables; and 2) an ALSPAC-held dataset which can be combined with existing ALSPAC data, enabling bespoke research across all areas supported by the study.

scholarly journals Joint associations of parental personality traits and socioeconomic position with trajectories of offspring depression: findings from up to 6925 families in a UK birth cohort.

2020 ◽  
Author(s):  
Tim Cadman ◽  
Alex Siu Fung Kwong ◽  
Paul Moran ◽  
Heather O'Mahen ◽  
Iryna Culpin ◽  
...  
Keyword(s):  
Depressive Symptoms ◽  
Longitudinal Study ◽  
Personality Traits ◽  
Birth Cohort ◽  
Socioeconomic Position ◽  
Effect Modification ◽  
Absolute Increase ◽  
Parents And Children ◽  
Parental Personality ◽  
The Impact

Background: Parental personality may influence the course of offspring depression but this is unclear. It is also unknown whether the impact of parental personality on offspring depression is moderated by socioeconomic position (SEP). Our aims were to describe trajectories of depressive symptoms across adolescence for offspring of parents with and without maladaptive personality traits and to test for effect modification by SEP. Methods: A longitudinal study in the Avon Longitudinal Study of Parents and Children birth cohort (ALSPAC; ns= 3054 to 7046). Exposures were binary measures of maladaptive parental personality traits and the outcome was depressive symptoms ages 11 to 24 (SMFQ; range 0 to 26). Results: Offspring of mothers with high maladaptive traits showed higher levels of depressive symptoms at all ages (SMFQ difference at age 10 = 0.66, CI 0.25, 1.28, p = 0.02; age 22 = 1.00, CI 0.51, 1.50, p < 0.001). There was weaker evidence of an association between paternal maladaptive personality traits and offspring depressive symptoms (SMFQ difference at age 10 = 0.21, CI -0.58, - 0.99, p = 0.60; age 22 = 0.02, CI -0.94, 0.90, p= 0.97). We found no consistent evidence of effect modification by SEP. Conclusions: Offspring of mothers with high levels of maladaptive personality traits show evidence of greater depressive symptoms throughout adolescence although the absolute increase in symptoms is small. Evidence for the effect of fathers personality was weaker. Socioeconomic position and maladaptive personality traits appear to be independent risk factors.

scholarly journals The Avon Longitudinal Study of Parents and Children - A resource for COVID-19 research: Questionnaire data capture April-May 2020

2020 ◽  
Vol 5 ◽  
pp. 127 ◽  
Author(s):  
Kate Northstone ◽  
Simown Howarth ◽  
Daniel Smith ◽  
Claire Bowring ◽  
Nicholas Wells ◽  
...  
Keyword(s):  
Longitudinal Study ◽  
Sociodemographic Factors ◽  
Population Based ◽  
Online Questionnaire ◽  
Health Records ◽  
Parents And Children ◽  
Seasonal Flu ◽  
The Impact ◽  
Avon Longitudinal Study

The Avon Longitudinal Study of Parents and Children (ALSPAC) is a prospective population-based cohort study which recruited pregnant women in 1990-1992. The resource provides an informative and efficient setting for collecting data on the current coronavirus 2019 (COVID-19) pandemic. In early March 2020, a questionnaire was developed in collaboration with other longitudinal population studies to ensure cross-cohort comparability. It targeted retrospective and current COVID-19 infection information (exposure assessment, symptom tracking and reported clinical outcomes) and the impact of both disease and mitigating measures implemented to manage the COVID-19 crisis more broadly. Data were collected on symptoms of COVID-19 and seasonal flu, travel prior to the pandemic, mental health and social, behavioural and lifestyle factors. The online questionnaire was deployed across the parent and offspring generations between the 9th April and 15th May 2020. 6807 participants completed the questionnaire (2706 original mothers, 1014 original fathers/partners, 2973 offspring (mean age ~28 years) and 114 partners of offspring). Eight (0.01%) participants (4 G0 and 4 G1) reported a positive test for COVID-19, 77 (1.13%; 28 G0 and 49 G1) reported that they had been told by a doctor they likely had COVID-19 and 865 (12.7%; 426 G0 and 439 G1) suspected that they have had COVID-19.  Using algorithmically defined cases, we estimate that the predicted proportion of COVID-19 cases fell between 1.03% - 4.19% depending on timing of measurement during the period of reporting. Data from this first questionnaire will be complemented with at least two more follow-up questionnaires, linkage to health records and results of biological testing as they become available. Data has been released as: 1) a standard dataset containing all participant responses with key sociodemographic factors and 2) as a composite release coordinating data from the existing resource, thus enabling bespoke research across all areas supported by the study.

scholarly journals Early Childhood General Anesthesia and Neurodevelopmental Outcomes in the Avon Longitudinal Study of Parents and Children Birth Cohort

2020 ◽  
Vol 133 (5) ◽  
pp. 1007-1020
Author(s):  
Graham J. Walkden ◽  
Hannah Gill ◽  
Neil M. Davies ◽  
Alethea E. Peters ◽  
Ingram Wright ◽  
...  
Keyword(s):  
Early Childhood ◽  
Longitudinal Study ◽  
General Anesthesia ◽  
Birth Cohort ◽  
Dynamic Balance ◽  
Statistical Significance ◽  
P Value ◽  
Neurodevelopmental Outcomes ◽  
Parents And Children ◽  
Avon Longitudinal Study

Background Most common anesthetic agents have been implicated in causing neurodegeneration in the developing animal brain, leading to warnings regarding their use in children. The hypothesis of this study was that exposure to general anesthesia and surgery before 4 yr would associate with adverse neurodevelopmental outcomes at age 7 to 16 yr. Methods This cohort study comprised 13,433 children enrolled in the Avon Longitudinal Study of Parents and Children, a prospective, population-based birth cohort born between 1991 and 1993 in southwest England. Children were grouped by none, single, or multiple exposures to general anesthesia and surgery by 4 yr. Motor, cognitive, linguistic, educational, social, and behavioral developmental outcomes were evaluated at 7 to 16 yr using school examination results, validated parent/teacher questionnaires, or clinic assessments. Continuous outcomes were z-scored. P-value thresholds were corrected using false discovery rate procedures. Results This study compared 46 neurodevelopmental outcomes in 13,433 children: 8.3% (1,110) exposed singly and 1.6% (212) exposed multiply to general anesthesia and surgery. Of these, the following reached predefined levels of statistical significance (corrected P &lt; 0.00652): dynamic balance scores were 0.3 SD (95% CI, 0.1, 0.5; P &lt; 0.001) lower in multiply exposed children; manual dexterity performance was 0.1 SD (95% CI, 0.0, 0.2; P = 0.006) lower in singly and 0.3 SD (95% CI, 0.1, 0.4; P &lt; 0.001) lower in multiply exposed children; and social communication scores were 0.1 SD (95% CI, 0.0, 0.2; P = 0.001) and 0.4 SD (95% CI, 0.3, 0.5; P &lt; 0.001) lower in singly and multiply exposed children, respectively. General anesthesia and surgery were not associated with impairments in the remaining neurodevelopmental measures including: general cognitive ability; attention; working memory; reading, spelling, verbal comprehension and expression; behavioral difficulties; or national English, mathematics, and science assessments (all ≤0.1 SD; corrected P ≥ 0.00652). Conclusions Early childhood general anesthesia and surgery were not associated with a global picture of clinically and statistically significant neurodegenerative effects, providing reassurance about the neurotoxic potential of general anesthesia. Exposure to anesthesia and surgery was associated with significantly lower motor and social linguistic performance. Editor’s Perspective What We Already Know about This Topic What This Article Tells Us That Is New

Sign in / Sign up

Export Citation Format

Share Document