scholarly journals Μελέτη λιποκυτοκινών στην παιδική παχυσαρκία

2012 ◽  
Author(s):  
Δήμητρα Μεθενίτη
Keyword(s):  
Vitamin D ◽  
Children And Adolescents ◽  
Morbidly Obese ◽  
Central Adiposity ◽  
Lipocalin 2 ◽  
Z Score ◽  
Obese Children ◽  
The Metabolic Syndrome ◽  
Increased Risk ◽  
Female Children

Childhood obesity is one of the biggest public health challenges of the 21st centurywhich has doubled over the last 20 years and is now an epidemic. Obese children andadolescents, especially those with central adiposity, are more likely to developglucose intolerance, insulin resistance, dyslipidemia as well as high blood pressure,conditions that consist the metabolic syndrome. The above comorbidities have beenlinked with an increased risk for diabetes type 2 and cardiovascular disease in laterlife.Hypovitaminosis D has been associated with adult obesity, while recent data havealso shown low vitamin D concentrations in obese children and adolescents. Retinolbindingprotein-4 and lipocalin-2 are altered in obese individuals. The aim of thisstudy was to examine circulating 25-(OH) D3 concentrations in female children andadolescents, according to BMI status, and to associate 25-(OH) D3 with RBP-4 andlipocalin-2 concentrations.Seventy-nine (79) female children and adolescents, aged 8-16 years, were studied.The children were divided into four groups according to their obesity status: 19 lean(mean BMI z-score <1.24), 20 overweight (mean BMI z-score 1.92 ± 0.58), 20 obese(mean BMI z-score 2.625 ± 0.225) and 20 morbidly obese (mean BMI z-score >3).Overweight and obese children were derived from the Obesity Clinic of ourDepartment. Plasma 25-(OH) D3, RBP-4 and lipocalin-2 concentrations weremeasured with specific assays.Plasma 25-(OH) D3 concentrations were decreased significantly in the morbidlyobese (p=0.005) and marginally in the obese group (p=0.05). In the entire BMI range, Spearman correlations revealed positive associations between 25-(OH) D3 and RBP-4(r=0.349, p=0.002) and between 25-(OH) D3 and lipocalin-2 (r=0.338, p=0.003).Decreased 25-(OH) D3 concentrations are present in female obese children andadolescents. 25-(OH) D3 concentrations are associated with other markers ofchildhood obesity, such as RBP-4 and lipocalin-2. These associations may reveal newnutritional interventions in childhood and adolescent obesity.Further investigation and research of larger groups of obese young individuals, takinginto account broader parameters is therefore adamant . The aim is to reveal atimeframe and a homeostatic pattern, in which the hormonal mechanisms fail andsubsequently result in the elevation of Vitamin D and the possible compensatoryresponses of RBP4 and NGAL. These associations may reveal new nutritionalinterventions in childhood and adolescent obesity.

scholarly journals Vitamin D Deficiency in Children and Adolescents: Role of Puberty and Obesity on Vitamin D Status

2021 ◽  
Vol 14 ◽  
pp. 117863882110187
Author(s):  
Hedyeh Saneifard ◽  
Marjan Shakiba ◽  
Ali Sheikhy ◽  
Leila Baniadam ◽  
Fatemeh Abdollah Gorji ◽  
...  
Keyword(s):  
Vitamin D ◽  
Children And Adolescents ◽  
Vitamin D Deficiency ◽  
Tanner Stage ◽  
Additional Risk Factor ◽  
Healthy Children ◽  
Vitamin D Status ◽  
Obese Children ◽  
Increased Risk ◽  
Vitamin D Levels

Background: Vitamin D deficiency is common among children and adolescents and can be affected by several factors such as puberty and obesity. Objective: The aim of this study was to evaluate vitamin D status in children and adolescents and to analyse the influence of puberty and obesity on its level. Method: A cross-sectional study was carried-out, in which clinical and biochemical data were gathered from 384 healthy children and adolescents between May 2019 to May 2020. Results: 220 females and 164 males were enrolled (aged 7-16 years; mean ± SD: 11 ± 2.5). Vitamin D deficiency was found in 49% of the total cases and was significantly more prevalent in females than males (33.1% in female; 15.9% in male, P < .001). Mean vitamin D level was lower in obese children compared with non-obese ( P < .001). Non-obese group had significantly higher levels of vitamin D in Tanner stage IV of puberty than obese individuals (20.1 ± 17.0 vs 5.4 ± 2.0) ( P = .03). Vitamin D levels were significantly lower in females than males only in Tanner stage II (12.3 ± 9.0 vs 19.6 ± 16.6) ( P = .005). The lowest level of Vitamin D was in Tanner stage Ⅳ-Ⅴ in boys and in Tanner stage Ⅱ-Ⅲ in girls ( P < .001). Conclusion: Puberty is an additional risk factor for vitamin D deficiency especially in girls and obese children. This increased risk, together with the fact that most important time for building a proper skeleton is during childhood and adolescent, makes it essential to monitor vitamin D in these age groups.

Increased Risk of Blount Disease in Obese Children and Adolescents With Vitamin D Deficiency

2010 ◽  
Vol 30 (8) ◽  
pp. 879-882 ◽  
Author(s):  
Corey O. Montgomery ◽  
Karen L. Young ◽  
Mark Austen ◽  
Chan-Hee Jo ◽  
Robert Dale Blasier ◽  
...  
Keyword(s):  
Vitamin D ◽  
Children And Adolescents ◽  
Vitamin D Deficiency ◽  
Obese Children ◽  
Increased Risk ◽  
Blount Disease

Sleep-associated breathing disorders in morbidly obese children and adolescents

1989 ◽  
Vol 115 (6) ◽  
pp. 892-897 ◽  
Author(s):  
George B. Mallory ◽  
Debra H. Fiser ◽  
Rithea Jackson
Keyword(s):  
Children And Adolescents ◽  
Morbidly Obese ◽  
Obese Children ◽  
Breathing Disorders

scholarly journals Is there a benefit of vitamin D supplementation in deficient children and adolescents suffering from obesity? A meta-analysis

QJM ◽  
2020 ◽  
Vol 113 (Supplement_1) ◽  
Author(s):  
M F Nassar ◽  
E K Emam ◽  
M F Allam
Keyword(s):  
Vitamin D ◽  
Children And Adolescents ◽  
Vitamin D Deficiency ◽  
Meta Analysis ◽  
Vitamin D Supplementation ◽  
Obese Children ◽  
Intramuscular Dose ◽  
Vitamin D Levels ◽  
Pubmed Search ◽  
Lower Vitamin

Abstract Background and objectives Both childhood obesity and vitamin D deficiency are common in the Middle East. This systematic review/meta-analysis aims to highlight the effect of vitamin D supplementation in deficient children suffering from obesity. Methods Published clinical studies on vitamin D supplementation in obese children and adolescents with vitamin D deficiency were identified through a comprehensive MEDLINE/PubMed search (from July 1966 to November 2017). Outcomes intended after vitamin D supplementation were improvements in vitamin D status, BMI alterations and appetite changes. The inclusion criteria were children aged 2 to 18 years of both sexes in clinical trials that specified the oral and/or intramuscular dose of vitamin D supplementation. Results Ten studies were retrieved, but only six were relevant. First, supplemented obese children and adolescents were compared to non-obese controls; thereafter, supplemented obese children and adolescents were compared to matching obese peers given placebo. Pooled risks from the two studies that evaluated the number of obese and non-obese children and adolescents who improved upon vitamin D supplementation revealed that obesity poses a risk for not benefiting from the vitamin D supplementation regardless of the dose and the duration of supplementation. Pooled results from the six retrieved studies that compared supplemented obese children and adolescents to matching non-obese or obese peers given placebo revealed significantly lower vitamin D levels in obese participants than in non-obese peers. Conclusion Vitamin D levels are significantly lower in obese children and adolescents with obesity, posing a risk for not benefiting from vitamin D supplementation regardless of the dose and duration of supplementation. Our results suggest that only with simultaneous weight adjustment strategies, vitamin D sufficiency would be achieved more effectively. Vitamin D supplementation in deficient children suffering from obesity.

Allelic variations in the vitamin D receptor gene, insulin secretion and parents' heights are independently associated with height in obese children and adolescents

Metabolism ◽  
2012 ◽  
Vol 61 (10) ◽  
pp. 1413-1421 ◽  
Author(s):  
Daniela A.F. Ferrarezi ◽  
Naïma Bellili-Muñoz ◽  
Christiane Nicolau ◽  
Nadir Cheurfa ◽  
Isabel C. Guazzelli ◽  
...  
Keyword(s):  
Vitamin D ◽  
Insulin Secretion ◽  
Children And Adolescents ◽  
Vitamin D Receptor ◽  
Receptor Gene ◽  
Vitamin D Receptor Gene ◽  
Obese Children ◽  
Allelic Variations

Changes in physical fitness of a home-based physical exercise program in childhood obesity: A quasi-experimental uncontrolled study

2017 ◽  
Vol 21 (2) ◽  
pp. 153-161 ◽  
Author(s):  
Juan Francisco Lisón ◽  
Alejandro Bruñó-Soler ◽  
Isabel Torró ◽  
Eva Segura-Ortí ◽  
Julio Alvarez-Pitti
Keyword(s):  
Childhood Obesity ◽  
Physical Exercise ◽  
Physical Fitness ◽  
Children And Adolescents ◽  
Body Fat ◽  
Fat Free Mass ◽  
Z Score ◽  
Obese Children ◽  
Percentage Of Body Fat ◽  
Home Based

Few studies have evaluated the changes in physical fitness (PF) of obese children and adolescents of a physical activity program for the treatment of obesity, and even fewer have explored the modality of home-based physical exercise. The objective of this study is to evaluate the changes in PF and body composition (BC) of a home-based physical exercise for treating childhood obesity. Thirty-three overweight/obese children and adolescents participated for six months in a home-based intervention that combined aerobics and muscular strength exercises. The results were compared, before and after the intervention, for the different PF components (VO2max, abdominal muscle resistance strength, and lower body explosive strength) and BC (body mass index Z-score (BMI-Z), percentage of body fat, and fat-free mass) variables. A significant reduction was observed in the percentage of body fat (4.7%) and the BMI- Z score (.23), and there was an increase in the fat-free mass of 2.9 kg ( p < .001). In addition, the VO2max showed a significant increase ( p < .05). The results of the different strength tests also showed significant improvements ( p < .05). Our findings support the effectiveness of this program improving not only BC but also PF. However, our results should be interpreted with caution due to lack of control group.

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