Does cannabis use in adolescence increase the risk of developing psychotic disorder as an adult?

2021 ◽  
Vol Publish Ahead of Print ◽  
Author(s):  
Jessica Waters Davis ◽  
Anne Mounsey
Keyword(s):  
Psychotic Disorder ◽  
Cannabis Use

scholarly journals Age at onset of non-affective psychosis in relation to cannabis use, other drug use and gender

2012 ◽  
Vol 42 (9) ◽  
pp. 1903-1911 ◽  
Author(s):  
N. Dekker ◽  
J. Meijer ◽  
M. Koeter ◽  
W. van den Brink ◽  
N. van Beveren ◽  
...  
Keyword(s):  
Regression Analysis ◽  
Drug Use ◽  
Psychotic Disorder ◽  
Age At Onset ◽  
Cannabis Use ◽  
Psychotic Illness ◽  
Affective Psychosis ◽  
The Mean ◽  
And Gender ◽  
Independent Effects

BackgroundCannabis use is associated with an earlier age at onset of psychotic illness. The aim of the present study was to examine whether this association is confounded by gender or other substance use in a large cohort of patients with a non-affective psychotic disorder.MethodIn 785 patients with a non-affective psychotic disorder, regression analysis was used to investigate the independent effects of gender, cannabis use and other drug use on age at onset of first psychosis.ResultsAge at onset was 1.8 years earlier in cannabis users compared to non-users, controlling for gender and other possible confounders. Use of other drugs did not have an additional effect on age at onset when cannabis use was taken into account. In 63.5% of cannabis-using patients, age at most intense cannabis use preceded the age at onset of first psychosis. In males, the mean age at onset was 1.3 years lower than in females, controlling for cannabis use and other confounders.ConclusionsCannabis use and gender are independently associated with an earlier onset of psychotic illness. Our findings also suggest that cannabis use may precipitate psychosis. More research is needed to clarify the neurobiological factors that make people vulnerable to this precipitating effect of cannabis.

Poster #45 DIFFERENCES IN STRUCTURAL BRAIN VOLUMES BETWEEN PATIENTS WITH AN EARLY PSYCHOTIC DISORDER WITH AND WITHOUT COMORBID CANNABIS USE DISORDERS

2012 ◽  
Vol 136 ◽  
pp. S296-S297
Author(s):  
Marise Machielsen ◽  
Floor van der Meer ◽  
Angelique van Gasselt ◽  
Jet Heering ◽  
Dick Veltman ◽  
...  
Keyword(s):  
Psychotic Disorder ◽  
Cannabis Use ◽  
Brain Volumes ◽  
Cannabis Use Disorders ◽  
Structural Brain

A Case of Cannabis Use-Associated Psychotic Disorder Accompanied by Autoscopic Phenomena

2015 ◽  
pp. 46-51
Author(s):  
Mehmet Hanifi Kokaçya ◽  
◽  
Ümit Sertan Çöpoğlu ◽  
Musa Şahpolat ◽  
Mustafa Arı ◽  
...  
Keyword(s):  
Psychotic Disorder ◽  
Cannabis Use

scholarly journals The contribution of cannabis use to variation in the incidence of psychotic disorder across Europe (EU-GEI): a multicentre case-control study

2019 ◽  
Vol 6 (5) ◽  
pp. 427-436 ◽  
Author(s):  
Marta Di Forti ◽  
Diego Quattrone ◽  
Tom P Freeman ◽  
Giada Tripoli ◽  
Charlotte Gayer-Anderson ◽  
...  
Keyword(s):  
Psychotic Disorder ◽  
Case Control Study ◽  
Case Control ◽  
Cannabis Use ◽  
Control Study

scholarly journals Implicit and explicit affective associations towards cannabis use in patients with recent-onset schizophrenia and healthy controls

2009 ◽  
Vol 40 (8) ◽  
pp. 1325-1336 ◽  
Author(s):  
N. Dekker ◽  
A. M. Smeerdijk ◽  
R. W. Wiers ◽  
J. H. Duits ◽  
G. van Gelder ◽  
...  
Keyword(s):  
Psychotic Disorder ◽  
Treatment Strategies ◽  
Cannabis Use ◽  
Implicit Associations ◽  
Healthy Controls ◽  
Recent Onset ◽  
Important Mediator ◽  
Single Category ◽  
Affective Associations ◽  
Implicit And Explicit

BackgroundCannabis use is common in patients with recent-onset schizophrenia and this is associated with poor disease outcome. More insight in the cognitive-motivational processes related to cannabis use in schizophrenia may inform treatment strategies. The present study is the first known to compare implicit and explicit cannabis associations in individuals with and without psychotic disorder.MethodParticipants consisted of 70 patients with recent-onset psychotic disorder and 61 healthy controls with various levels of cannabis use. Three Single-Category Implicit Association Tests (SC-IAT) were used to assess ‘relaxed’, ‘active’ and ‘negative’ implicit associations towards cannabis use. Explicit expectancies of cannabis use were assessed with a questionnaire using the same words as the SC-IAT.ResultsThere were no differences in implicit associations between patients and controls; however, patients scored significantly higher on explicit negative affect expectancies than controls. Both groups demonstrated strong negative implicit associations towards cannabis use. Explicit relaxed expectancies were the strongest predictors of cannabis use and craving. There was a trend for implicit active associations to predict craving.ConclusionsThe findings indicate that patients suffering from schizophrenia have associations towards cannabis similar to controls, but they have stronger negative explicit cannabis associations. The strong negative implicit associations towards cannabis could imply that users of cannabis engage in a behaviour they do not implicitly like. Explicit relaxing expectancies of cannabis might be an important mediator in the continuation of cannabis use in patients and controls.

scholarly journals Evidence that the presence of psychosis in non-psychotic disorder is environment-dependent and mediated by severity of non-psychotic psychopathology

2015 ◽  
Vol 45 (11) ◽  
pp. 2389-2401 ◽  
Author(s):  
S. Guloksuz ◽  
M. van Nierop ◽  
R. Lieb ◽  
R. van Winkel ◽  
H.-U. Wittchen ◽  
...  
Keyword(s):  
Psychotic Disorder ◽  
Help Seeking ◽  
Psychotic Disorders ◽  
Developmental Stages ◽  
Contrast Ratio ◽  
Environmental Exposures ◽  
Cannabis Use ◽  
Relational Model ◽  
Compulsive Disorder ◽  
Help Seeking Behaviour

BackgroundEvidence suggests that in affective, non-psychotic disorders: (i) environmental exposures increase risk of subthreshold psychotic experiences (PEs) and strengthen connectivity between domains of affective and subthreshold psychotic psychopathology; and (ii) PEs are a marker of illness severity.MethodIn 3021 adolescents from the Early Developmental Stages of Psychopathology cohort, we tested whether the association between PEs and presence of DSM-IV mood disorder (MD)/obsessive–compulsive disorder (OCD) would be moderated by risk factors for psychosis (cannabis use, childhood trauma and urbanicity), using the interaction contrast ratio (ICR) method. Furthermore, we analysed whether the interaction between environment and PEs was mediated by non-psychotic psychopathology.ResultsThe association between PEs and MD/OCD was moderated by urbanicity (ICR = 2.46, p = 0.005), cannabis use (ICR = 3.76, p = 0.010) and, suggestively, trauma (ICR = 1.91, p = 0.063). Exposure to more than one environmental risk factor increased the likelihood of co-expression of PEs in a dose–response fashion. Moderating effects of environmental exposures were largely mediated by the severity of general non-psychotic psychopathology (percentage explained 56–68%, all p < 0.001). Within individuals with MD/OCD, the association between PEs and help-seeking behaviour, as an index of severity, was moderated by trauma (ICR = 1.87, p = 0.009) and urbanicity (ICR = 1.48, p = 0.005), but not by cannabis use.ConclusionsIn non-psychotic disorder, environmental factors increase the likelihood of psychosis admixture and help-seeking behaviour through an increase in general psychopathology. The findings are compatible with a relational model of psychopathology in which more severe clinical states are the result of environment-induced disturbances spreading through a psychopathology network.

scholarly journals Changes over time in prevalence rates of past-year cannabis use by men and women with a psychotic disorder

2020 ◽  
Vol 224 ◽  
pp. 198-200
Author(s):  
Anna Waterreus ◽  
Patsy Di Prinzio ◽  
Johanna C. Badcock ◽  
Mathew T. Martin-Iverson ◽  
Vera A. Morgan
Keyword(s):  
Psychotic Disorder ◽  
Cannabis Use ◽  
Prevalence Rates ◽  
Men And Women ◽  
Changes Over Time ◽  
Over Time

Cannabis Use is Not Associated With the Development of Psychosis in an ‘Ultra’ High-Risk Group

2002 ◽  
Vol 36 (6) ◽  
pp. 800-806 ◽  
Author(s):  
Lisa J Phillips ◽  
Christina Curry ◽  
Alison R Yung ◽  
Hok Pan Yuen ◽  
Steven Adlard ◽  
...  
Keyword(s):  
Risk Factor ◽  
High Risk ◽  
Psychotic Disorder ◽  
Risk Group ◽  
High Risk Group ◽  
Cannabis Use ◽  
Psychotic Symptoms ◽  
First Episode ◽  
Psychotic Episode ◽  
Ultra High Risk

Background: The association between cannabis use and the development of a first psychotic episode was studied in a group of 100 young people identified as being at very high risk for the onset of psychosis. Method: The ‘ultra’ high risk cohort was identified by the presence of subthreshold psychotic symptoms, or a combination of first-degree relative with a psychotic disorder and recent functional decline. Thirty-two per cent of the cohort developed an acute psychotic episode over the 12-month period after recruitment. As a component of a larger research study, the level of cannabis use by participants in the year prior to enrolment in the study was assessed at intake. Results: Cannabis use or dependence in the year prior to recruitment to this study was not associated with a heightened risk of developing psychosis over the following 12-month period and therefore did not appear to contribute to the onset of a psychotic disorder. Conclusion: The results of this study suggest that cannabis use may not play an integral role in the development of psychosis in a high-risk group. While this study does not support a role for cannabis in the development of first-episode psychosis, we cannot conclude that cannabis use should be completely ignored as a candidate risk factor for onset of psychosis. A number of weaknesses of the study (the low level of cannabis use in the current sample, the lack of monitoring of cannabis use after intake) suggest that it may be premature to dismiss cannabis use as a risk factor for the development of psychosis and further research is urged in this area.

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