Impact of diastolic blood pressure threshold for the young population

2019 ◽  
Vol 37 (3) ◽  
pp. 652-653
Author(s):  
Kei Asayama ◽  
Yuki Kinoshita ◽  
Shinya Watanabe ◽  
Takayoshi Ohkubo ◽  
Takashi Ando ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Diastolic Blood Pressure ◽  
Young Population ◽  
Pressure Threshold ◽  
Blood Pressure Threshold

scholarly journals 29: DIASTOLIC BLOOD PRESSURE THRESHOLD DURING PEDIATRIC CPR AND OUTCOMES: A MULTICENTER VALIDATION STUDY

2021 ◽  
Vol 50 (1) ◽  
pp. 15-15
Author(s):  
Robert Berg ◽  
Ryan Morgan ◽  
Ron Reeder ◽  
Kellimarie Cooper ◽  
Kathryn Graham ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Diastolic Blood Pressure ◽  
Validation Study ◽  
Pressure Threshold ◽  
Blood Pressure Threshold ◽  
Multicenter Validation

scholarly journals Extracellular vesicles as a novel diagnostic and research tool for patients with HTN and kidney disease

2019 ◽  
Vol 317 (3) ◽  
pp. F641-F647 ◽  
Author(s):  
Uta Erdbrügger ◽  
Thu H. Le
Keyword(s):  
Blood Pressure ◽  
Cardiovascular Disease ◽  
Kidney Disease ◽  
Extracellular Vesicles ◽  
Organ Damage ◽  
The United States ◽  
End Organ Damage ◽  
Pressure Threshold ◽  
Stage Renal Disease ◽  
Blood Pressure Threshold

Hypertension (HTN) affects one in three adults in the United States and is a major risk factor for cardiovascular disease and kidney failure. There is emerging evidence that more intense blood pressure lowering reduces mortality in patients with kidney disease who are at risk of cardiovascular disease and progression to end-stage renal disease. However, the ideal blood pressure threshold for patients with kidney disease remains a question of debate. Novel tools to more precisely diagnose HTN, tailor treatment, and predict the risk of end-organ damage such as kidney disease are needed. Analysis of circulating and urinary extracellular vesicles (EVs) and their cargo (protein and RNA) has the potential to identify novel noninvasive biomarkers that can also reflect a specific pathological mechanism of different HTN phenotypes. We will discuss the use of extracellular vesicles as markers of HTN severity and explain their profile change with antihypertensive medicine and potential to detect early end-organ damage. However, more studies with enhanced rigor in this field are needed to define the blood pressure threshold to prevent or delay kidney disease progression and decrease cardiovascular risk.

A lower blood pressure threshold to define hypertension

2019 ◽  
Vol 24 (2) ◽  
pp. 78-82
Author(s):  
Min Lai ◽  
Wei Zhou ◽  
Wen-Yin Wang ◽  
Tai-Xuan Wan ◽  
Qiang Peng ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Lower Blood Pressure ◽  
Pressure Threshold ◽  
Lower Blood ◽  
Blood Pressure Threshold

scholarly journals What Is the Ideal Blood Pressure Threshold for the Prevention of Atrial Fibrillation in Elderly General Population?

2020 ◽  
Vol 9 (9) ◽  
pp. 2988 ◽  
Author(s):  
Yoon Jung Park ◽  
Pil-Sung Yang ◽  
Hee Tae Yu ◽  
Tae-Hoon Kim ◽  
Eunsun Jang ◽  
...  
Keyword(s):  
Atrial Fibrillation ◽  
Blood Pressure ◽  
Pressure Threshold ◽  
Hazard Ratios ◽  
Increased Risk ◽  
Clinical Covariates ◽  
Blood Pressure Threshold ◽  
Multivariable Adjustment ◽  
Intensive Blood Pressure

Intensive blood pressure (BP) lowering in patients with hypertension at increased risk of cardiovascular disease has been associated with a lowered risk of incident atrial fibrillation (AF). It is uncertain whether maintaining the optimal BP levels can prevent AF in the general elderly population. We included 115,866 participants without AF in the Korea National Health Insurance Service-Senior (≥60 years) cohort from 2002 to 2013. We compared the influence of BP on the occurrence of new-onset AF between octogenarians (≥80 years) and non-octogenarians (<80 years) subjects. With up to 6.7 ± 1.7 years of follow-up, 4393 incident AF cases occurred. After multivariable adjustment for potentially confounding clinical covariates, the risk of AF in non-octogenarians was significantly higher in subjects with BP levels of <120/<80 and ≥140/90 mm Hg, with hazard ratios of 1.15 (95% confidence interval (CI), 1.03–1.28; p < 0.001) and 1.14 (95% CI, 1.04–1.26; p < 0.001), compared to the optimal BP levels (120–129/<80 mm Hg). In octogenarians, the optimal BP range was 130–139/80–89 mm Hg, higher than in non-octogenarians. A U-shaped relationship for the development of incident AF was evident in non-octogenarians, and BP levels of 120–129/<80 mm Hg were associated the lowest risk of incident AF. Compared to non-octogenarians, the lowest risk of AF was associated with higher BP levels of 130–139/80–89 mm Hg amongst octogenarians.

scholarly journals Intraoperative Hypotension and 1-Year Mortality after Noncardiac Surgery

2009 ◽  
Vol 111 (6) ◽  
pp. 1217-1226 ◽  
Author(s):  
Jilles B. Bijker ◽  
Wilton A. van Klei ◽  
Yvonne Vergouwe ◽  
Douglas J. Eleveld ◽  
Leo van Wolfswinkel ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Regression Tree ◽  
Noncardiac Surgery ◽  
Classification And Regression Tree ◽  
Regression Tree Analysis ◽  
Intraoperative Hypotension ◽  
Pressure Threshold ◽  
Confounding Variables ◽  
Blood Pressures ◽  
Blood Pressure Threshold

Background Intraoperative hypotension (IOH) is frequently associated with adverse outcome such as 1-yr mortality. However, there is no consensus on the correct definition of IOH. The authors studied a number of different definitions of IOH, based on blood pressure thresholds and minimal episode durations, and their association with 1-yr mortality after noncardiac surgery. Methods This cohort study included 1,705 consecutive adult patients who underwent general and vascular surgery. Data on IOH and potentially confounding variables were obtained from electronic record-keeping systems. Mortality data were collected up to 1 yr after surgery. The authors used two different techniques to reduce the influence of confounding variables, multivariable Cox proportional hazard regression modeling and classification and regression tree analysis. Results The mortality within 1 yr after surgery was 5.2% (88 patients). After adjustment for confounding, the Cox regression analysis did not show an association between IOH and the risk of dying within 1 yr after surgery (hazard ratio around 1.00 with high P values for different definitions of IOH). Additional classification and regression tree analysis identified IOH as a predictor for 1-yr mortality in elderly patients. When the blood pressure threshold for IOH was decreased, the duration of IOH at which this association was found was decreased as well. Conclusions This observational study showed no causal relation between IOH and 1-yr mortality after noncardiac surgery for any of the definitions of IOH. Nevertheless, additional analysis suggested that for elderly patients, the mortality risk increases when the duration of IOH becomes long enough. The length of this duration depends on the designated blood pressure threshold, suggesting that lower blood pressures are tolerated for shorter durations. The effect of IOH on 1-yr mortality remains debatable, and no firm conclusions on the lowest acceptable intraoperative blood pressures can be drawn from this study.

scholarly journals Blood Pressure Threshold Violations in the First 24 Hours After Admission for Acute Stroke

Stroke ◽  
2009 ◽  
Vol 40 (2) ◽  
pp. 462-468 ◽  
Author(s):  
Martin A. Ritter ◽  
Peter Kimmeyer ◽  
Peter U. Heuschmann ◽  
Rainer Dziewas ◽  
Ralf Dittrich ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Acute Stroke ◽  
Pressure Threshold ◽  
Blood Pressure Threshold
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