Admission for Isolated Low-Grade Solid Organ Injury May Not Be Necessary in Pediatric Patients

2021 ◽  
Vol 28 (5) ◽  
pp. 283-289
Author(s):  
Erin Butt ◽  
Meera Kotagal ◽  
Kaaren Shebesta ◽  
Allison Bailey ◽  
Suzanne Moody ◽  
...  
2020 ◽  
pp. bmjmilitary-2019-001374
Author(s):  
James Ashcroft ◽  
M Khan

IntroductionThis systematic review aimed to evaluate early ambulation protocols implemented for traumatic solid organ injury.MethodsThe electronic databases PubMed, Medline (Ovid), Embase and Cochrane Library were searched without time constraint to identify prospective and retrospective analyses, randomised controlled trials, cohort studies, and case series that investigated early ambulation in solid organ trauma.ResultsSix studies met the predefined inclusion criteria and were reviewed. Three studies investigated early ambulation protocols in direct comparison with bed rest. The remaining three studies were early ambulation case series. In all studies there was no convincing evidence to suggest differences in clinical outcomes between early ambulation and bed rest protocols. In all studies early ambulation resulted in a reduced length of hospitalisation and decreased cost to national healthcare services.ConclusionsThis systematic review has found preliminary evidence that suggests bed rest has no clinical benefit in those with low-grade to mid-grade (grades 1–2) solid organ injury. Further studies are required to inform guidance to improve trauma patient outcomes.


2019 ◽  
Vol 4 (1) ◽  
pp. e000318 ◽  
Author(s):  
Allen K Chen ◽  
David Jeffcoach ◽  
John C Stivers ◽  
Kyle A McCullough ◽  
Rachel C Dirks ◽  
...  

BackgroundThe obese (body mass index, BMI > 30) have been identified as a subgroup of patients in regards to traumatic injuries. A recent study found that high-grade hepatic injuries were more common in obese than non-obese pediatric patients. This study seeks to evaluate whether similar differences exist in the adult population and examine differences in operative versus non-operative management between the obese and non-obese in blunt abdominal trauma.MethodsPatient with trauma evaluated at an American College of Surgeons verified Level I trauma center from February 2013 to November 2016 were retrospectively reviewed. All patients aged >18 years with blunt mechanism of injury and a BMI listed in the trauma registry were included. Patients were excluded for incomplete data, including BMI or inability to grade hepatic or splenic injury. Data collected included age, gender, BMI, injury severity score, hospital length of stay, procedures on liver or spleen, and mortality. Organ injuries were scored using the American Association for the Surgery of Trauma grading scales, and were determined by either imaging or intraoperative findings. Obesity was classified as BMI > 30 compared with non-obese with BMI < 30.ResultsDuring the study period, 9481 patients were included. There were 322 spleen injuries and 237 liver injuries, with 64 patients sustaining both liver and splenic injuries. No differences existed in the percentage of high-grade hepatic or splenic injuries between the obese and non-obese. Obese patients with liver injuries were more likely to have procedural intervention than non-obese liver injuries and had higher rates of mortality. No differences were found in intervention for splenic injury between obese and non-obese.ConclusionsContrary to prior studies on adult and pediatric patients with trauma, this study found no difference between obese and non-obese patients in severity of solid organ injury after blunt abdominal trauma in the adult population. However, there was an increased rate of procedural intervention and mortality for obese patients with liver injuries.Level of Evidence3.


2021 ◽  
Vol Publish Ahead of Print ◽  
Author(s):  
Lauren L. Evans ◽  
Regan F. Williams ◽  
Chengshi Jin ◽  
Leah Plumblee ◽  
Bindi Naik-Mathuria ◽  
...  

2016 ◽  
Vol 51 (3) ◽  
pp. 499-502 ◽  
Author(s):  
Arash Safavi ◽  
Erik D. Skarsgard ◽  
Peter Rhee ◽  
Bardiya Zangbar ◽  
Narong Kulvatunyou ◽  
...  

Author(s):  
Robert A Tessler ◽  
Vivian H Lyons ◽  
Judith C Hagedorn ◽  
Monica S Vavilala ◽  
Adam Goldin ◽  
...  

2018 ◽  
Vol 84 (4) ◽  
pp. 606-612 ◽  
Author(s):  
Robert A. Tessler ◽  
Vivian H. Lyons ◽  
Judith C. Hagedorn ◽  
Monica S. Vavilala ◽  
Adam Goldin ◽  
...  

2021 ◽  
Vol 12 (8) ◽  
Author(s):  
Li Ning ◽  
Xiong Rui ◽  
Wang Bo ◽  
Geng Qing

AbstractHistone deacetylase 3 (HDAC3) plays a crucial role in chromatin remodeling, which, in turn, regulates gene transcription. Hence, HDAC3 has been implicated in various diseases, including ischemic injury, fibrosis, neurodegeneration, infections, and inflammatory conditions. In addition, HDAC3 plays vital roles under physiological conditions by regulating circadian rhythms, metabolism, and development. In this review, we summarize the current knowledge of the physiological functions of HDAC3 and its role in organ injury. We also discuss the therapeutic value of HDAC3 in various diseases.


Author(s):  
Makoto Aoki ◽  
Toshikazu Abe ◽  
Shuichi Hagiwara ◽  
Daizoh Saitoh ◽  
Kiyohiro Oshima

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