Hospital-Based Intervention is Rarely Needed for Children with Low-Grade Blunt Abdominal Solid Organ Injury

IntroductionThis systematic review aimed to evaluate early ambulation protocols implemented for traumatic solid organ injury.MethodsThe electronic databases PubMed, Medline (Ovid), Embase and Cochrane Library were searched without time constraint to identify prospective and retrospective analyses, randomised controlled trials, cohort studies, and case series that investigated early ambulation in solid organ trauma.ResultsSix studies met the predefined inclusion criteria and were reviewed. Three studies investigated early ambulation protocols in direct comparison with bed rest. The remaining three studies were early ambulation case series. In all studies there was no convincing evidence to suggest differences in clinical outcomes between early ambulation and bed rest protocols. In all studies early ambulation resulted in a reduced length of hospitalisation and decreased cost to national healthcare services.ConclusionsThis systematic review has found preliminary evidence that suggests bed rest has no clinical benefit in those with low-grade to mid-grade (grades 1–2) solid organ injury. Further studies are required to inform guidance to improve trauma patient outcomes.

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Admission for Isolated Low-Grade Solid Organ Injury May Not Be Necessary in Pediatric Patients

Journal of Trauma Nursing ◽

10.1097/jtn.0000000000000604 ◽

2021 ◽

Vol 28 (5) ◽

pp. 283-289

Author(s):

Erin Butt ◽

Meera Kotagal ◽

Kaaren Shebesta ◽

Allison Bailey ◽

Suzanne Moody ◽

...

Keyword(s):

Pediatric Patients ◽

Organ Injury ◽

Low Grade ◽

Solid Organ ◽

Solid Organ Injury

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53 Low-grade isolated blunt paediatric solid organ injury and secondary overtriage in washington state 2005–2014

10.1136/injuryprev-2017-042560.53 ◽

2017 ◽

Author(s):

Robert A Tessler ◽

Vivian H Lyons ◽

Judith C Hagedorn ◽

Monica S Vavilala ◽

Adam Goldin ◽

...

Keyword(s):

Washington State ◽

Organ Injury ◽

Low Grade ◽

Solid Organ ◽

Solid Organ Injury

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Transfer and nontransfer patients in isolated low-grade blunt pediatric solid organ injury

Journal of Trauma and Acute Care Surgery ◽

10.1097/ta.0000000000001777 ◽

2018 ◽

Vol 84 (4) ◽

pp. 606-612 ◽

Cited By ~ 3

Author(s):

Robert A. Tessler ◽

Vivian H. Lyons ◽

Judith C. Hagedorn ◽

Monica S. Vavilala ◽

Adam Goldin ◽

...

Keyword(s):

Organ Injury ◽

Low Grade ◽

Solid Organ ◽

Solid Organ Injury

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The critical roles of histone deacetylase 3 in the pathogenesis of solid organ injury

Cell Death and Disease ◽

10.1038/s41419-021-04019-6 ◽

2021 ◽

Vol 12 (8) ◽

Author(s):

Li Ning ◽

Xiong Rui ◽

Wang Bo ◽

Geng Qing

Keyword(s):

Histone Deacetylase ◽

Chromatin Remodeling ◽

Current Knowledge ◽

Organ Injury ◽

Solid Organ ◽

Solid Organ Injury ◽

Histone Deacetylase 3 ◽

Physiological Conditions ◽

Inflammatory Conditions ◽

Therapeutic Value

AbstractHistone deacetylase 3 (HDAC3) plays a crucial role in chromatin remodeling, which, in turn, regulates gene transcription. Hence, HDAC3 has been implicated in various diseases, including ischemic injury, fibrosis, neurodegeneration, infections, and inflammatory conditions. In addition, HDAC3 plays vital roles under physiological conditions by regulating circadian rhythms, metabolism, and development. In this review, we summarize the current knowledge of the physiological functions of HDAC3 and its role in organ injury. We also discuss the therapeutic value of HDAC3 in various diseases.

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