The role of genetics in the diagnosis and treatment of haemorrhagic diathesis

SummaryThe rôle of the clotting system in the pathogenesis of the generalized Shwartzman reaction (gSr) has been stressed in recent years. The clotting system is activated ubiquitously and as a result of it, fibrin is deposited intravascularly and a haemorrhagic diathesis develops. Evidence is presented herein, that endotoxin does not activate purified prothrombin, nor does endotoxin influence the convertion of prothrombin when it is activated in the presence of purified platelet-factor 3 (or caephalin) purified Ac-G (factor V) and Ca-ions.The trigger mechanism of the gSr also seems to be in the so-called prephase of clotting mechanism. Data are presented, which show that endotoxin activates the Hageman factor in vitro. The importance of this clotting factor and of platelet-factor 3 is discussed. Also the rôle played by the RES and cardiodynamic and vascular components are taken in consideration in the discussion.

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Neuromyelitis optica spectrum: novel concept of pathogenesis, diagnosis and treatment of Devic’s disease

Orvosi Hetilap ◽

10.1556/oh.2009.28724 ◽

2009 ◽

Vol 150 (46) ◽

pp. 2101-2109 ◽

Cited By ~ 1

Author(s):

Péter Csécsei ◽

Anita Trauninger ◽

Sámuel Komoly ◽

Zsolt Illés

Keyword(s):

Neuromyelitis Optica ◽

Water Channel ◽

Diagnostic Procedures ◽

Diagnosis And Treatment ◽

Clinical Settings ◽

Permanent Disability ◽

Therapeutic Decisions ◽

Novel Concept ◽

The Brain

The identification of autoantibodies generated against the brain isoform water channel aquaporin4 in the sera of patients, changed the current diagnostic guidelines and concept of neuromyelitis optica (NMO). In a number of cases, clinical manifestation is spatially limited to myelitis or relapsing optic neuritis creating a diverse. NMO spectrum. Since prevention of relapses provides the only possibility to reduce permanent disability, early diagnosis and treatment is mandatory. In the present study, we discuss the potential role of neuroimaging and laboratory tests in differentiating the NMO spectrum from other diseases, as well as the diagnostic procedures and therapeutic options. We also present clinical cases, to provide examples of different clinical settings, diagnostic procedures and therapeutic decisions.

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Role of exosomes in diagnosis and therapy of prostate cancer

I P Pavlov Russian Medical Biological Herald ◽

10.23888/pavlovj2020283399-405 ◽

2020 ◽

Vol 28 (3) ◽

pp. 399-405

Author(s):

Fabrizio Fontana ◽

Olga A. Babenko

Keyword(s):

Prostate Cancer ◽

Cancer Cells ◽

Tumor Cells ◽

Biological Fluids ◽

Diagnosis And Treatment ◽

Diagnosis And Therapy ◽

The Future ◽

Important Direction ◽

Potential Biomarkers

Aim of this letter is to attract the attention of journal readers to the study of exosomes as an important direction in the development of Oncology, in particular, in the diagnosis and treatment of prostate cancer. Exosomes are produced by tumor cells and regulate proliferation, metastasis, and the development of chemoresistance. Their extraction from biological fluids allows further use of these vesicles as potential biomarkers of prostate cancer. In the future, exosomes can be successfully used in the delivery of drugs and other anti-tumor substances to cancer cells.

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The Role of Laparoscopic Technology in the Diagnosis and Treatment of Acute Surgical Pathologies of the Abdominal Cavity Organs

Ukraïnsʹkij žurnal medicini bìologìï ta sportu ◽

10.26693/jmbs03.02.175 ◽

2018 ◽

Vol 3 (2) ◽

pp. 175-180

Author(s):

F. G. Jamalov ◽

◽

M. M. Abdullaev ◽

E. V. Nabieva ◽

Т. P. Jamalova ◽

...

Keyword(s):

Abdominal Cavity ◽

Diagnosis And Treatment

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Dementia with Lewy bodies

V M BEKHTEREV REVIEW OF PSYCHIATRY AND MEDICAL PSYCHOLOGY ◽

10.31363/2313-7053-2018-2-11-21 ◽

2018 ◽

pp. 11-21

Author(s):

O. S. Levin ◽

E. E. Vasenina ◽

A. Sh. Chimagomedova ◽

N. G. Dudchenko

Keyword(s):

Parkinson’S Disease ◽

Dementia With Lewy Bodies ◽

Cholinesterase Inhibitors ◽

Lewy Bodies ◽

Diagnosis And Treatment ◽

Modern Concept ◽

Historical Aspect ◽

Neurodegenerative Process ◽

Icd 10

Te lecture presents modern concept of the symptoms, diagnosis and treatment of dementia with Lewy bodies (DLB), which accounts for about 10% of cases of dementia. Te nosological status of DLB and the problem of ratio of DLB and Parkinson’s disease which, apparently, represent two phenotypic variants of one neurodegenerative process («diseases with Lewy bodies») are considered in historical aspect. Approaches to the diagnosis and coding of DLB in accordance with ICD-10 are proposed. Te role of cholinesterase inhibitors, antipsychotics, levodopa, rasagiline and other drugs in the treatment of patients with DLB is аnalyzed.

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