Unraveling chronic obstructive pulmonary disease and keeping up with new and avatars of old occupational lung diseases

2016 ◽  
Vol 22 (2) ◽  
pp. 89-90
Author(s):  
Basil Varkey ◽  
Craig S. Glazer
2021 ◽  
pp. 55-68
Author(s):  
Vyacheslav S. Lotkov ◽  
Anton Vladimirovich Glazistov ◽  
Antonina G. Baykova ◽  
Marina Yuryevna Vostroknutova ◽  
Natalia E. Lavrentieva

The formation and progression of chronic dust bronchitis and chronic bronchitis of toxic-chemical etiology, chronic obstructive pulmonary disease is accompanied by an increase in the degree of ventilation disorders, echocardiographic signs of hypertrophy and dilatation of the right ventricle are formed, typical for chronic pulmonary heart disease. The progression of disturbances in the function of external respiration in dusty lung diseases leads to a decrease in myocardial contractility. The detection of hemodynamic disturbances at the early stages of the development of occupational lung diseases indicates the need for individual monitoring of the functional state of the cardiovascular system in the process of contact with industrial aerosols, especially in groups of workers with long-term exposure.


2017 ◽  
Author(s):  
Cora S Sack ◽  
Sverre Vedal ◽  
Joel D Kaufman

Environmental and occupational lung diseases encompass a diverse group of lung diseases caused by the inhalation of potentially harmful substances. Although workplace regulations and the changing economy in the United States have significantly decreased incidence, these diseases remain both common and associated with significant morbidity. In addition, novel exposures continue to be recognized as new causes of disease. This review provides the medical student and clinician with a framework for approaching and categorizing environmental and occupational lung disease. It also presents an in-depth discussion of the epidemiology, biological mechanisms, diagnosis, and clinical care of some of the more commonly encountered diseases. Occupational lung diseases that affect the airways, such as work-related asthma and chronic obstructive pulmonary disease, and malignant neoplasms are covered. This review concludes with general strategies to help prevent disease incidence and progression.     This review contains 1 figure, 5 tables, and 56 references. Key words: bronchiolitis obliterans, chronic obstructive pulmonary disease, irritant-induced occupational asthma, mesothelioma, occupational asthma, occupational lung disease, occupational lung neoplasm, work-related asthma


2017 ◽  
Author(s):  
Cora S Sack ◽  
Sverre Vedal ◽  
Joel D Kaufman

Environmental and occupational lung diseases encompass a diverse group of lung diseases caused by the inhalation of potentially harmful substances. Although workplace regulations and the changing economy in the United States have significantly decreased incidence, these diseases remain both common and associated with significant morbidity. In addition, novel exposures continue to be recognized as new causes of disease. This review provides the medical student and clinician with a framework for approaching and categorizing environmental and occupational lung disease. It also presents an in-depth discussion of the epidemiology, biological mechanisms, diagnosis, and clinical care of some of the more commonly encountered diseases. Occupational lung diseases that affect the airways, such as work-related asthma and chronic obstructive pulmonary disease, and malignant neoplasms are covered. This review concludes with general strategies to help prevent disease incidence and progression.     This review contains 1 figure, 5 tables, and 56 references. Key words: bronchiolitis obliterans, chronic obstructive pulmonary disease, irritant-induced occupational asthma, mesothelioma, occupational asthma, occupational lung disease, occupational lung neoplasm, work-related asthma


2014 ◽  
Vol 11 (Supplement 3) ◽  
pp. S154-S160 ◽  
Author(s):  
M. Bradley Drummond ◽  
A. Sonia Buist ◽  
James D. Crapo ◽  
Robert A. Wise ◽  
Stephen I. Rennard

Cells ◽  
2021 ◽  
Vol 10 (12) ◽  
pp. 3467
Author(s):  
Amel Nasri ◽  
Florent Foisset ◽  
Engi Ahmed ◽  
Zakaria Lahmar ◽  
Isabelle Vachier ◽  
...  

Mesenchymal cells are an essential cell type because of their role in tissue support, their multilineage differentiation capacities and their potential clinical applications. They play a crucial role during lung development by interacting with airway epithelium, and also during lung regeneration and remodeling after injury. However, much less is known about their function in lung disease. In this review, we discuss the origins of mesenchymal cells during lung development, their crosstalk with the epithelium, and their role in lung diseases, particularly in chronic obstructive pulmonary disease.


2015 ◽  
Vol 45 (3) ◽  
pp. 807-827 ◽  
Author(s):  
Silke Meiners ◽  
Oliver Eickelberg ◽  
Melanie Königshoff

Ageing is the main risk factor for major non-communicable chronic lung diseases, including chronic obstructive pulmonary disease, most forms of lung cancer and idiopathic pulmonary fibrosis. While the prevalence of these diseases continually increases with age, their respective incidence peaks at different times during the lifespan, suggesting specific effects of ageing on the onset and/or pathogenesis of chronic obstructive pulmonary disease, lung cancer and idiopathic pulmonary fibrosis. Recently, the nine hallmarks of ageing have been defined as cell-autonomous and non-autonomous pathways involved in ageing. Here, we review the available evidence for the involvement of each of these hallmarks in the pathogenesis of chronic obstructive pulmonary disease, lung cancer, or idiopathic pulmonary fibrosis. Importantly, we propose an additional hallmark, “dysregulation of the extracellular matrix”, which we argue acts as a crucial modifier of cell-autonomous changes and functions, and as a key feature of the above-mentioned lung diseases.


2004 ◽  
Vol 11 (3) ◽  
pp. 185-186
Author(s):  
Nick R. Anthonise

In this issue of theCanadian Respiratory Journal, Almirall and Bégin (pages 195 to 196) make a suggestion aimed at increasing the use of spirometry by primary care physicians, as well as family and general practitioners. The idea is that spirometry should be performed not necessarily to make specific diagnoses, but to rule in or out the possibility of a number of lung diseases, most notably, chronic obstructive pulmonary disease (COPD). If the patient demonstrates normal forced vital capacity and forced expiratory volume in 1 s, then he or she does not have COPD; if the results are not normal, then COPD is a possibility that can be further investigated.


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