Red cell Distribution Width as a Predictor of Left Atrial Spontaneous Echo Contrast in Echocardiography

Background: Red cell distribution width (RDW) is a quantitative measure of variability in the size of circulating erythrocytes and previously shown to provide information concerning the prothrombotic status or adverse outcome of cardiovascular disease. Left atrial thrombus (LAT) is commonly detected in patients with valvular atrial fibrillation (VAF) due to rheumatic mitral valve stenosis (RMVS) but there is very limited data regarding the predictive value of RDW for the development of LAT in these patients. Aim: To determine the association between RDW and LAT in VAF patients. Methods: A total of 58 patients were included in a retrospective observational study between January 2016 to December 2016 in patients who admitted to Dr. Moewardi General Hospital, due to symptomatic VAF. Blood examination and transthoracic echocardiography were performed to all patients. LAT was defined as a fixed or mobile echogenic mass within left atrium (LA) and left atrial appendage (LAA). The RDW was compared between a patient with LAT or without LAT. Results: There were 28 patients (mean age: 46.2±13.3 years) in LAT(+) group and 30 patients (mean age: 45.6±11.5 years) in LAT(-) group. RDW was significantly higher in LAT(+) group (14.4±1.8% vs. 13.3±1.5%, p=0.010). The RDW was independent predictor of LAT by multivariate analysis (OR 1.619; p=0.020; 95% CI: 1.079-2.429). The cut-off RDW value for LAT was >13.5% with a sensitivity of 73.3% and a specificity of 64.3% (area under curve=0.700; 95% CI: 0.562-0.838; p=0.009). The prevalence of LAT was significantly higher in patient with an RDW >13.5% than in those with an RDW <13.5 % (64.3% and 35.7%, p=0.002), with prevalence ratio 5.91. Conclusion: This study shows that a higher level of RDW has an association with the presence of LAT and an independent risk factor of LAT formation in patients with VAF.

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Preoperative red cell distribution width and neutrophil-to-lymphocyte ratio predict survival in patients with epithelial ovarian cancer

10.26226/morressier.5770e29dd462b80290b4be83 ◽

2016 ◽

Author(s):

Zheng Li

Keyword(s):

Ovarian Cancer ◽

Epithelial Ovarian Cancer ◽

Neutrophil To Lymphocyte Ratio ◽

Red Cell Distribution Width ◽

Red Cell ◽

Cell Distribution ◽

Distribution Width ◽

Lymphocyte Ratio

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Faculty Opinions recommendation of A retrospective cohort study on the association between elevated preoperative red cell distribution width and all-cause mortality after noncardiac surgery.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.737641408.793575041 ◽

2020 ◽

Author(s):

Yuguang Huang ◽

Xiaohan Xu

Keyword(s):

Cohort Study ◽

Retrospective Cohort Study ◽

Retrospective Cohort ◽

Noncardiac Surgery ◽

Red Cell Distribution Width ◽

Red Cell ◽

Cell Distribution ◽

Distribution Width ◽

All Cause Mortality

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Prognostic Value of the Hemoglobin/Red Cell Distribution Width Ratio in Resected Lung Adenocarcinoma

Cancers ◽

10.3390/cancers13040710 ◽

2021 ◽

Vol 13 (4) ◽

pp. 710

Author(s):

Francesco Petrella ◽

Monica Casiraghi ◽

Davide Radice ◽

Andrea Cara ◽

Gabriele Maffeis ◽

...

Keyword(s):

Prognostic Factor ◽

Lung Adenocarcinoma ◽

Disease Free Survival ◽

Red Cell Distribution Width ◽

Red Cell ◽

Cell Distribution ◽

Distribution Width ◽

Free Survival ◽

Node Involvement ◽

Disease Free

Background: The ratio of hemoglobin to red cell distribution width (HRR) has been described as an effective prognostic factor in several types of cancer. The aim of this study was to investigate the prognostic role of preoperative HRR in resected-lung-adenocarcinoma patients. Methods: We enrolled 342 consecutive patients. Age, sex, surgical resection, adjuvant treatments, pathological stage, preoperative hemoglobin, red cell distribution width, and their ratio were recorded for each patient. Results: Mean age was 66 years (SD: 9.0). There were 163 females (47.1%); 169 patients (49.4%) had tumors at stage I, 71 (20.8%) at stage II, and 102 (29.8%) at stage III. In total, 318 patients (93.0%) underwent lobectomy, and 24 (7.0%) pneumonectomy. Disease-free survival multivariable analysis disclosed an increased hazard ratio (HR) of relapse for preoperative HRR lower than 1.01 (HR = 2.20, 95%CI: (1.30–3.72), p = 0.004), as well as for N1 single-node (HR = 2.55, 95%CI: (1.33–4.90), p = 0.005) and multiple-level lymph node involvement compared to N0 for both N1 (HR = 9.16, 95%CI:(3.65–23.0), p < 0.001) and N2 (HR = 10.5, 95%CI:(3.44–32.2, p < 0.001). Conclusion: Pre-operative HRR is an effective prognostic factor of disease-free survival in resected-lung-adenocarcinoma patients, together with the level of pathologic node involvement.

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