Electrocardiogram Derived QRS Duration >120 ms is Associated With Elevated Plasma Homocysteine Levels in a Rural Australian Cross-Sectional Population

Objectives: To determine the frequency of elevated plasma homocysteine (Hcy) levels among type 2 diabetes mellitus (T2DM) patients. Study Design: Cross sectional study. Setting: Department of Medicine, Abbasi Shaheed Hospital, Karachi. Period: From 28 September 2012 to 26 March 2015. Material & Methods: Type 2 Diabetic patients fulfilling inclusion criteria were enrolled. Patients with conditions known to cause altered homocysteine levels were excluded. Patients’ HbA1c and fasting serum homocysteine levels were obtained. Level >15 μmol/L was labeled as elevated. Data was collected with the help of Performa. Data was analyzed using SPSS version 21. Results: (90) ninety patients were enrolled in this study during study period with mean age of 61.5±7.3 years. Of (90) ninety patients, 45 (50%) were male and 45 (50%) were female with male to female ratio of 1:1. Mean duration of diabetes was 6.9±1.7 years. 40 (44.44%) cases were of controlled diabetes and 43 (47.7%) were on treatment. Of 90 patients 36 (40%) patients had Homocysteinemia. Homocysteine levels were found to be significantly raised in males 51.1% v/s 28.8% (p<0.03), older patients (>60 years of age) 55.5% v/s 16.6% (p<0.001), having diabetes for > 7 years, 59.2% v/s 17%(p<0.00004), in 21% v/s 57.4% cases who were and were not on treatment respectively (p<0.0004), in 22.5% patients with controlled diabetes and 54% patients with uncontrolled diabetes respectively (p<0.002). Conclusion: Hyperhomocystenemia is prevalent (40%) in type 2 diabetics with statistically significant raised levels in males, >60 years of age, non-compliant diabetics, have long duration diabetes, and uncontrolled disease.

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Plasma Homocysteine and Autonomic Nervous Dysfunction: Association and Clinical Relevance in OSAS

Disease Markers ◽

10.1155/2020/4378505 ◽

2020 ◽

Vol 2020 ◽

pp. 1-6

Author(s):

Lei Liu ◽

Qiansheng Wu ◽

Hong Yan ◽

Xilong Zheng ◽

Qiang Zhou

Keyword(s):

Nervous System ◽

Autonomic Nervous System ◽

Clinical Relevance ◽

Sleep Apnea Syndrome ◽

Plasma Homocysteine ◽

Elevated Plasma ◽

Cross Sectional ◽

Autonomic Nervous ◽

Obstructive Sleep ◽

Echocardiographic Parameters

Objective. Elevated plasma homocysteine (Hcy) is an independent risk factor for cardiovascular diseases, but the precise mechanism of Hcy in cardiovascular disease remains elusive. This study is aimed at evaluating the association between Hcy levels and autonomic nervous system and at investigating their clinical relevance in obstructive sleep apnea syndrome (OSAS). Methods. A total of 191 subjects with OSAS were enrolled for this cross-sectional study. Heart rate variability (HRV) represents the status of the autonomic nervous system and is a well-known index that allows studying the autonomic modulation. HRV and polysomnography parameters were collected based on Holter monitors and polysomnography system. The software computed all the basic HRV parameters including SDANN, SDNN and pNN50. Correlation analyses between Hcy and HRV parameters and echocardiographic parameters were performed. Results. Compared with the mild-moderate OSAS group, the prevalence of male and smoking and Hcy levels were considerably higher in the severe OSAS group (P=0.01, P=0.02, and P=0.01, respectively). Also, there were significant linear relationships between Hcy quartiles with the proportion of severe OSAS (P=0.01 for the trend). Interesting, there is a negative linear correlation between SDANN and Hcy quartiles (P=0.02 for the trend). Spearman’s correlation analysis showed a significant negative correlation between SDANN and Hcy levels (r=−0.17, P=0.02). Interestingly, the relationship of it remains significant after adjustment for clinical covariates (r=−0.15, P=0.04). However, echocardiographic parameters were not significantly correlated with Hcy or HRV parameters (all P>0.05). Conclusions. Elevated plasma Hcy level is linearly correlated with cardiac autonomic nervous function disorders in patients with OSAS.

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Effect of daily vitamin B12 and folic acid supplementation on fracture incidence in elderly with an elevated plasma homocysteine level: B-PROOF, a randomized controlled trial

Bone Abstracts ◽

10.1530/boneabs.3.oc2.2 ◽

2014 ◽

Author(s):

Wijngaarden JP van ◽

KMA Swart ◽

AW Enneman ◽

RAM Dhonukshe-Rutten ◽

Dijk SC van ◽

...

Keyword(s):

Randomized Controlled Trial ◽

Folic Acid ◽

Vitamin B12 ◽

Homocysteine Level ◽

Controlled Trial ◽

Folic Acid Supplementation ◽

Plasma Homocysteine ◽

Elevated Plasma ◽

Plasma Homocysteine Level ◽

Randomized Controlled

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Diet, total plasma homocysteine concentrations and mortality rates in broiler chickens

Canadian Journal of Animal Science ◽

10.4141/a02-029 ◽

2003 ◽

Vol 83 (3) ◽

pp. 601-604 ◽

Cited By ~ 1

Author(s):

S. E. Samuels

Keyword(s):

Cardiovascular Disease ◽

Sudden Death ◽

Broiler Chickens ◽

Independent Risk Factor ◽

Total Mortality ◽

Mortality Rates ◽

Plasma Homocysteine ◽

Sudden Death Syndrome ◽

Total Plasma ◽

Elevated Plasma

The aim of this study was to determine if total plasma homocysteine (HCY) concentrations and mortality rates due to ascites syndrome and (AS) sudden death syndrome (SDS) in broiler chickens could be lowered by diet. Elevated plasma HCY is an independent risk factor for cardiovascular disease in humans. A total of 828 day-old male broiler chickens (Arbor Acre) were fed, for 6 wk, either a basal practical diet or one supplemented with excess vitamins B6 and B12, folic acid and betaine to stimulate the degradation of HCY. The supplemented diet decreased plasma HCY by 17% (P < 0.05; n = 16 per diet). Total mortality due to AS and SDS was 18% lower in the supplemented diet but this difference was not statistically significant. Key words: Homocysteine, folate, chickens, cardiovascular disease, ascites, sudden death syndrome

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