Local Control by Radiofrequency Thermal Ablation Increased Overall Survival in Patients With Refractory Liver Metastases of Colorectal Cancer

Objectives - to optimize the indications for radiofrequency thermal ablation in patients with synchronous multiple metastases of colorectal cancer to the liver on the basis of prognostic treatment results. Material and methods. The study group included 78 patients with colorectal cancer with synchronous multiple bilobar liver metastases, who have underwent combined treatment in the period of 2007- 2015, such as cytoreductive surgery removing the primary intestinal tumor in combination with RFA of metastases in the liver, followed by chemotherapy. Results. A computer program for preoperative risk assessment of disease progression was developed and introduced in clinical practice. It is based on the results of the analysis of the factors, predicting the risk of relapse during the first year after cytoreductive surgery with RFA of synchronous multiple CRC liver metastases. Conclusion. The index of metastatic liver damage (the product of the sum of the diameters of metastatic liver lesions by their number), the mutational status of the KRAS gene, CEA values are significant factors in predicting the progression of the disease, which can optimize indications for radiofrequency thermal ablation in the treatment of patients with stage IV CRC with synchronous metastases to the liver.

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Occlusion of the vein adjacent to colorectal cancer liver metastasis as a way to increase the radicality of percutaneous radiofrequency thermal ablation

Health and Ecology Issues ◽

10.51523/2708-6011.2021-18-3-7 ◽

2021 ◽

pp. 57-63

Author(s):

K. L. Murashko ◽

A. M. Yurkovskiy

Keyword(s):

Colorectal Cancer ◽

Liver Metastasis ◽

Liver Metastases ◽

Lower Incidence ◽

Thermal Ablation ◽

Heat Removal ◽

Residual Tumor ◽

Control Group ◽

Colorectal Cancer Liver Metastasis ◽

Radiofrequency Thermal Ablation

Objective. To evaluate the effectiveness of preoperative coagulation of the vein adjacent to a tumor nodule in sonographically-guided percutaneous radiofrequency thermal ablation of perivascular liver metastases of colorectal cancer.Materials and methods. To address the issue, we compared the results of sonographically-guided percutaneous radiofrequency thermal ablation of perivascular liver metastases of colorectal cancer in 27 patients (aged 60.5 (58; 68) years) without prior coagulation of the adjacent vein (control group) and 26 patients (62.0 (60; 74)) with prior coagulation of the adjacent vein (experimental group).Results. Lower incidence of residual tumor in the ablation area in the patients with prior coagulation of the adjacent vein (14.3 % vs. 29 % of the patients in the control group) and a higher relapse-free survival of such patients (65.2 % vs. 53.6 % and 55.6 % vs. 33.3 %) were reported as compared to the group without prior coagulation of the adjacent vein (after 6 and 12 months, respectively).Conclusion. Preoperative coagulation of the vein adjacent to colorectal cancer liver metastasis allows reducing the effect of heat removal from the RFA zone, thereby contributing to higher radicality of the treatment and resulting both in a lower incidence of residual tumor in the ablation zone and a higher relapse-free survivalof patients, notably without signifcant concomitant changes in the affected part of the liver (segment atrophy).

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Long-term outcome of radiofrequency thermal ablation (RFA) of liver metastases from colorectal cancer (CRC): size as the leading prognostic factor for survival

La radiologia medica ◽

10.1007/s11547-012-0803-3 ◽

2012 ◽

Vol 117 (7) ◽

pp. 1139-1151 ◽

Cited By ~ 18

Author(s):

A. Veltri ◽

T. Guarnieri ◽

C. Gazzera ◽

M. Busso ◽

F. Solitro ◽

...

Keyword(s):

Colorectal Cancer ◽

Prognostic Factor ◽

Liver Metastases ◽

Thermal Ablation ◽

Term Outcome ◽

Long Term Outcome ◽

Radiofrequency Thermal Ablation

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Carbon Ion Radiotherapy for Oligo-Recurrence in the Lung

Pulmonary Medicine ◽

10.1155/2013/219746 ◽

2013 ◽

Vol 2013 ◽

pp. 1-6 ◽

Cited By ~ 5

Author(s):

Naoyoshi Yamamoto ◽

Mio Nakajima ◽

Hirohiko Tsujii ◽

Tadashi Kamada

Keyword(s):

Colorectal Cancer ◽

Lung Cancer ◽

Overall Survival ◽

Survival Rate ◽

Local Control ◽

Local Control Rate ◽

Carbon Ion Radiotherapy ◽

Overall Survival Rate ◽

Carbon Ion ◽

Metastatic Lung

The clinical results after carbon ion radiotherapy for the metastatic lung tumors believed to be in the state of oligo-recurrence were evaluated. One hundred and sixteen lesions in 91 patients with lung cancer metastasis were treated with carbon ion radiotherapy at our institute from April 1997 to February 2011. Regarding the prescribed dose, total dose ranged between 40 gray equivalents (GyE) and 80 GyE, and fraction size ranged from 1 to 16 fractions. After a median followup period of 2.3 years (range, 0.3–13.1 years), the statistical overall survival rate and local control rate were 71.2% and 91.9% at 2 years after treatment, respectively. Treatment-related side effects were not a clinical problem. When classified by the primary organ, there were 49 cases of lung cancer, 20 cases of colorectal cancer, and 22 cases of others. The overall survival rate and local control rate for lung metastasis cases from lung cancer at 2 years after treatment were 81.5% and 92.4%, respectively, and 65.0% and 92.0% regarding lung metastasis from colorectal cancer. Carbon ion beam therapy for the metastatic lung tumors is a safe therapy, and the therapeutic effect is comparable to the outcome obtained from reported surgical resections.

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Higher titer hepatitis B core antibody predicts a higher risk of liver metastases and worse survival in patients with colorectal cancer

World Journal of Surgical Oncology ◽

10.1186/s12957-021-02369-1 ◽

2021 ◽

Vol 19 (1) ◽

Author(s):

Ziyao Li ◽

Shaofei Li ◽

Hangbo Tao ◽

Yixiang Zhan ◽

Kemin Ni ◽

...

Keyword(s):

Colorectal Cancer ◽

Overall Survival ◽

Hepatitis B ◽

Liver Metastases ◽

Cancer Patients ◽

Hepatic Metastasis ◽

High Titer ◽

Poor Overall Survival ◽

Free Survival ◽

Colorectal Cancer Patients

Abstract Background There have been controversial voices on if hepatitis B virus infection decreases the risk of colorectal liver metastases or not. This study aims to the find the association between HBV infection and postoperative survival of colorectal cancer and the risk of liver metastases in colorectal cancer patients. Methods Patients who underwent curative surgical resection for colorectal cancer between January 2011 and December 2012 were included. Patients were grouped according to anti-HBc. Differences in overall survival, time to progress, and hepatic metastasis-free survival between groups and significant predictors were analyzed. Results Three hundred twenty-seven colorectal cancer patients were comprised of 202 anti-HBc negative cases and 125 anti-HBc positive cases, and anti-HBc positive cases were further divided into high-titer anti-HBc group (39) and low-titer anti-HBc group (86). The high-titer anti-HBc group had significantly worse overall survival (5-Yr, 65.45% vs. 80.06%; P < .001), time to progress (5-Yr, 44.26% vs. 84.73%; P < .001), and hepatic metastasis-free survival (5-Yr, 82.44% vs. 94.58%; P = .029) than the low-titer group. Multivariate model showed anti-HBc ≥ 8.8 S/CO was correlated with poor overall survival (HR, 3.510; 95% CI, 1.718–7.17; P < .001), time to progress (HR, 5.747; 95% CI, 2.789–11.842; P < .001), and hepatic metastasis-free survival (HR, 3.754; 95% CI, 1.054–13.369; P = .041) in the anti-HBc positive cases. Conclusions Higher titer anti-HBc predicts a potential higher risk of liver metastases and a worse survival in anti-HBc positive colorectal cancer patients.

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Survival of patients with non-resectable, chemotherapy-resistant colorectal cancer liver metastases undergoing conventional lipiodol-based transarterial chemoembolization (cTACE) palliatively versus neoadjuvantly prior to percutaneous thermal ablation

European Journal of Radiology ◽

10.1016/j.ejrad.2018.03.015 ◽

2018 ◽

Vol 102 ◽

pp. 138-145 ◽

Cited By ~ 5

Author(s):

Thomas J. Vogl ◽

Maximilian Lahrsow ◽

Moritz H. Albrecht ◽

Renate Hammerstingl ◽

Zachary M. Thompson ◽

...

Keyword(s):

Colorectal Cancer ◽

Liver Metastases ◽

Transarterial Chemoembolization ◽

Thermal Ablation ◽

Colorectal Cancer Liver Metastases ◽

Percutaneous Thermal Ablation

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A grading system for predicting the prognosis of gastric cancer with liver metastasis

Japanese Journal of Clinical Oncology ◽

10.1093/jjco/hyab140 ◽

2021 ◽

Author(s):

Soshi Hori ◽

Michitaka Honda ◽

Hiroshi Kobayashi ◽

Hidetaka Kawamura ◽

Koichi Takiguchi ◽

...

Keyword(s):

Colorectal Cancer ◽

Gastric Cancer ◽

Overall Survival ◽

Liver Metastasis ◽

Confidence Interval ◽

Liver Metastases ◽

Hazard Ratio ◽

Maximum Diameter ◽

Grading System ◽

Computed Tomography Images

Abstract Objective The prognosis of patients with liver metastases from gastric cancer is determined using tumor size and number of metastases; this is similar to the factors used for the prediction of liver metastases from colorectal cancer. The relationship between the degree of liver metastasis from gastric cancer and prognosis with reference to the classification of liver metastasis from colorectal cancer was investigated. Methods This was a multi-institutional historical cohort study. Among patients with stage IV gastric cancer, who visited the cancer hospitals in Fukushima Prefecture, Japan, between 2008 and 2015, those with simultaneous liver metastasis were included. Abdominal pretreatment computed tomography images were reviewed and classified into H1 (four or less liver metastases with a maximum diameter of ≤5 cm); H2 (other than H1 and H3) or H3 (five or more liver metastases with a maximum diameter of ≥5 cm). The hazard ratio for overall survival according to the H grade (H1, H2 and H3) was calculated using the Cox proportional hazards model. Results A total of 412 patients were analyzed. Patients with H1, H2 and H3 grades were 118, 162 and 141, respectively, and their median survival time was 10.2, 5.7 and 3.1 months, respectively (log-rank P < 0.001). The adjusted hazard ratio for overall survival was H1: H2: H3 = reference: 1.39 (95% confidence interval: 1.04–1.85): 1.69 (95% confidence interval: 1.27–2.27). Conclusions The grading system proposed in this study was a simple and easy-to-use prognosis prediction index for patients with liver metastasis from gastric cancer.

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A comparison of microwave thermosphere versus radiofrequency thermal ablation in the treatment of colorectal liver metastases

HPB ◽

10.1016/j.hpb.2018.05.012 ◽

2018 ◽

Vol 20 (12) ◽

pp. 1157-1162 ◽

Cited By ~ 11

Author(s):

Hideo Takahashi ◽

Bora Kahramangil ◽

Emin Kose ◽

Eren Berber

Keyword(s):

Liver Metastases ◽

Thermal Ablation ◽

Colorectal Liver Metastases ◽

Radiofrequency Thermal Ablation

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METACHRONOUS COLORECTAL LIVER METASTASES HAS BETTER PROGNOSIS - IS IT TRUE?

Arquivos de Gastroenterologia ◽

10.1590/s0004-2803.201800000-64 ◽

2018 ◽

Vol 55 (3) ◽

pp. 258-263 ◽

Cited By ~ 1

Author(s):

Claudemiro QUIREZE JUNIOR ◽

Andressa Machado Santana BRASIL ◽

Lúcio Kenny MORAIS ◽

Edmond Raymond Le CAMPION ◽

Eliseu José Fleury TAVEIRA ◽

...

Keyword(s):

Colorectal Cancer ◽

Overall Survival ◽

Liver Metastases ◽

Hepatic Metastasis ◽

Colorectal Liver Metastases ◽

Public Health Problem ◽

Recurrence Free Survival ◽

Free Survival ◽

The Mean ◽

Colorectal Hepatic Metastasis

ABSTRACT BACKGROUND: Liver metastases from colorectal cancer are an important public health problem due to the increasing incidence of colorectal cancer worldwide. Synchronous colorectal liver metastasis has been associated with worse survival, but this prognosis is controversial. OBJECTIVE: The objective of this study was to evaluate the recurrence-free survival and overall survival between groups of patients with metachronous and synchronous colorectal hepatic metastasis. METHODS: This was a retrospective analysis of medical records of patients with colorectal liver metastases seen from 2013 to 2016, divided into a metachronous and a synchronous group. The Cox regression model and the Kaplan-Meier method with log-rank test were used to compare survival between groups. RESULTS: The mean recurrence-free survival was 9.75 months and 50% at 1 year in the metachronous group and 19.73 months and 63.3% at 1 year in the synchronous group. The mean overall survival was 20.00 months and 6.2% at 3 years in the metachronous group and 30.39 months and 31.6% at 3 years in the synchronous group. Patients with metachronous hepatic metastasis presented worse overall survival in multivariate analysis. The use of biological drugs combined with chemotherapy was related to the best overall survival prognosis. CONCLUSION: Metachronous colorectal hepatic metastasis was associated with a worse prognosis for overall survival. There was no difference in recurrence-free survival between metachronous and synchronous metastases.

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