scholarly journals Occlusion of the vein adjacent to colorectal cancer liver metastasis as a way to increase the radicality of percutaneous radiofrequency thermal ablation

2021 ◽  
pp. 57-63
Author(s):  
K. L. Murashko ◽  
A. M. Yurkovskiy
Keyword(s):  
Colorectal Cancer ◽  
Liver Metastasis ◽  
Liver Metastases ◽  
Lower Incidence ◽  
Thermal Ablation ◽  
Heat Removal ◽  
Residual Tumor ◽  
Control Group ◽  
Colorectal Cancer Liver Metastasis ◽  
Radiofrequency Thermal Ablation

Objective. To evaluate the effectiveness of preoperative coagulation of the vein adjacent to a tumor nodule in sonographically-guided percutaneous radiofrequency thermal ablation of perivascular liver metastases of colorectal cancer.Materials and methods. To address the issue, we compared the results of sonographically-guided percutaneous radiofrequency thermal ablation of perivascular liver metastases of colorectal cancer in 27 patients (aged 60.5 (58; 68) years) without prior coagulation of the adjacent vein (control group) and 26 patients (62.0 (60; 74)) with prior coagulation of the adjacent vein (experimental group).Results. Lower incidence of residual tumor in the ablation area in the patients with prior coagulation of the adjacent vein (14.3 % vs. 29 % of the patients in the control group) and a higher relapse-free survival of such patients (65.2 % vs. 53.6 % and 55.6 % vs. 33.3 %) were reported as compared to the group without prior coagulation of the adjacent vein (after 6 and 12 months, respectively).Conclusion. Preoperative coagulation of the vein adjacent to colorectal cancer liver metastasis allows reducing the effect of heat removal from the RFA zone, thereby contributing to higher radicality of the treatment and resulting both in a lower incidence of residual tumor in the ablation zone and a higher relapse-free survivalof patients, notably without signifcant concomitant changes in the affected part of the liver (segment atrophy).

scholarly journals Histologically Verified Biliary Invasion was Associated with Impaired Liver Recurrence-Free Survival in Resected Colorectal Cancer Liver Metastases

2018 ◽  
Vol 108 (3) ◽  
pp. 201-209 ◽  
Author(s):  
P. Reijonen ◽  
P. Österlund ◽  
H. Isoniemi ◽  
J. Arola ◽  
A. Nordin
Keyword(s):  
Colorectal Cancer ◽  
Overall Survival ◽  
Liver Metastasis ◽  
Liver Metastases ◽  
Recurrence Free Survival ◽  
Colorectal Cancer Liver Metastases ◽  
Free Survival ◽  
Colorectal Cancer Liver Metastasis ◽  
Liver Recurrence ◽  
Disease Free

Background and Aims: The impact of biliary invasion on recurrence and survival, after resection of colorectal cancer liver metastases, is not well known as publications are limited to small patient series. The aim was to investigate if biliary invasion in liver resected patients associated with liver relapses and recurrence-free survival. Secondary endpoints included association with other prognostic factors, disease-free survival and overall survival. Materials and Methods: All patients with histologically verified biliary invasion (n = 31, 9%) were identified among 344 patients with liver resection between January 2009 and March 2015. Controls (n = 78) were selected from the same time period and matched for, among others, size and number of colorectal cancer liver metastasis. Results: Median liver recurrence-free survival was significantly shorter in patients with biliary invasion than in controls (15.3 months versus not reached; p = 0.031) and more relapses were noted in the liver (61.3% versus 33.3%; p = 0.010), respectively. In univariate analyses for liver recurrence-free survival, biliary invasion was the only significant prognostic factor; p = 0.034. There were no statistical differences in disease-free and overall survival between the groups. Conclusion: Biliary invasion was associated with higher liver recurrence rates and shorter liver recurrence-free survival in patients with resected colorectal cancer liver metastasis.

Osteopontin Induced by Macrophages Contribute to Metachronous Liver Metastases in Colorectal Cancer

2011 ◽  
Vol 77 (11) ◽  
pp. 1515-1520 ◽  
Author(s):  
Motohiro Imano ◽  
Kiyotaka Okuno ◽  
Tatsuki Itoh ◽  
Takao Satou ◽  
Eizaburo Ishimaru ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Liver Metastasis ◽  
Liver Metastases ◽  
Microvascular Density ◽  
Stage Ii ◽  
Stage Iii ◽  
Control Group ◽  
Cancer Tissue ◽  
Metachronous Liver Metastasis ◽  
Density Control

Even after radical surgery for stage II and stage III colorectal cancer, metachronous liver metastasis is frequently observed. The aim of this study was to identify the risk of metachronous liver metastasis with retrospective clinicopathological study. Immunohistochemistry was performed to evaluate the expression of Osteopontin (OPN), CD-68, and CD105 in 41 cases of stage II and stage III colorectal cancer tissue. Stage II and stage III colorectal cancer patients who had undergone R0 resection were classified into two groups: with metachronous liver metastasis (m-LM; n = 17) and without liver metastases (control; n = 24). Additionally, double-immunofluorescence staining was performed using antibodies to OPN and CD68. OPN-positive cells were frequently colocalized with CD68 immunoreactivity. OPN and microvascular density expression in the central area were significantly higher in the m-LM (OPN; control 4.3 ± 0.56, m-LV 10.8 ± 1.48, P < 0.05; microvascular density control 18.5 ± 2.86, m-LV 31.4 ± 4.39, P < 0.05), while CD68 expression in the invasive margin was significantly higher in the control group (control 98.9 ± 7.31, m-LV 28.2 ± 3.18, P < 0.05). These results suggest that the risk of metachronous liver metastasis could be well predicted by immunohistochemical staining of OPN in the central areas, and CD68 in the invasive margins of tumors.

scholarly journals Claudin-2 promotes colorectal cancer liver metastasis and is a biomarker of the replacement type growth pattern

2021 ◽  
Vol 4 (1) ◽  
Author(s):  
Sébastien Tabariès ◽  
Matthew G. Annis ◽  
Anthoula Lazaris ◽  
Stephanie K. Petrillo ◽  
Jennifer Huxham ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Liver Metastasis ◽  
Liver Metastases ◽  
Growth Pattern ◽  
Treatment Strategies ◽  
Immunohistochemical Analysis ◽  
Colorectal Cancer Liver Metastases ◽  
Colorectal Cancer Liver Metastasis ◽  
Breast Cancer Liver Metastasis ◽  
Colorectal Cancer Patients

AbstractClaudin-2 promotes breast cancer liver metastasis by enabling seeding and early cancer cell survival. We now demonstrate that Claudin-2 is functionally required for colorectal cancer liver metastasis and that Claudin-2 expression in primary colorectal cancers is associated with poor overall and liver metastasis-free survival. We have examined the role of Claudin-2, and other claudin family members, as potential prognostic biomarkers of the desmoplastic and replacement histopathological growth pattern associated with colorectal cancer liver metastases. Immunohistochemical analysis revealed higher Claudin-2 levels in replacement type metastases when compared to those with desmoplastic features. In contrast, Claudin-8 was highly expressed in desmoplastic colorectal cancer liver metastases. Similar observations were made following immunohistochemical staining of patient-derived xenografts (PDXs) that we have established, which faithfully retain the histopathology of desmoplastic or replacement type colorectal cancer liver metastases. We provide evidence that Claudin-2 status in patient-derived extracellular vesicles may serve as a relevant prognostic biomarker to predict whether colorectal cancer patients have developed replacement type liver metastases. Such a biomarker will be a valuable tool in designing optimal treatment strategies to better manage patients with colorectal cancer liver metastases.

scholarly journals Prognosis of the combination therapy results in patients with synchronous metastases of colorectal cancer

2019 ◽  
Vol 4 (3) ◽  
pp. 60-64
Author(s):  
S. V Kozlov ◽  
O. I Kaganov ◽  
A. A Moryatov ◽  
A. M Kozlov ◽  
A. P Borisov
Keyword(s):  
Colorectal Cancer ◽  
Liver Metastases ◽  
Cytoreductive Surgery ◽  
Thermal Ablation ◽  
Combined Treatment ◽  
Stage Iv ◽  
Radiofrequency Thermal Ablation ◽  
Mutational Status ◽  
Synchronous Metastases ◽  
Metastatic Liver

Objectives - to optimize the indications for radiofrequency thermal ablation in patients with synchronous multiple metastases of colorectal cancer to the liver on the basis of prognostic treatment results. Material and methods. The study group included 78 patients with colorectal cancer with synchronous multiple bilobar liver metastases, who have underwent combined treatment in the period of 2007- 2015, such as cytoreductive surgery removing the primary intestinal tumor in combination with RFA of metastases in the liver, followed by chemotherapy. Results. A computer program for preoperative risk assessment of disease progression was developed and introduced in clinical practice. It is based on the results of the analysis of the factors, predicting the risk of relapse during the first year after cytoreductive surgery with RFA of synchronous multiple CRC liver metastases. Conclusion. The index of metastatic liver damage (the product of the sum of the diameters of metastatic liver lesions by their number), the mutational status of the KRAS gene, CEA values are significant factors in predicting the progression of the disease, which can optimize indications for radiofrequency thermal ablation in the treatment of patients with stage IV CRC with synchronous metastases to the liver.

scholarly journals Radiomics and Radiogenomics in Evaluation of Colorectal Cancer Liver Metastasis

2022 ◽  
Vol 11 ◽  
Author(s):  
Yun Wang ◽  
Lu-Yao Ma ◽  
Xiao-Ping Yin ◽  
Bu-Lang Gao
Keyword(s):  
Colorectal Cancer ◽  
Liver Metastasis ◽  
Liver Metastases ◽  
Texture Features ◽  
Biological Properties ◽  
Imaging Features ◽  
Current Application ◽  
Colorectal Cancer Liver Metastases ◽  
Colorectal Cancer Liver Metastasis ◽  
Non Invasive

Colorectal cancer is one common digestive malignancy, and the most common approach of blood metastasis of colorectal cancer is through the portal vein system to the liver. Early detection and treatment of liver metastasis is the key to improving the prognosis of the patients. Radiomics and radiogenomics use non-invasive methods to evaluate the biological properties of tumors by deeply mining the texture features of images and quantifying the heterogeneity of metastatic tumors. Radiomics and radiogenomics have been applied widely in the detection, treatment, and prognostic evaluation of colorectal cancer liver metastases. Based on the imaging features of the liver, this paper reviews the current application of radiomics and radiogenomics in the diagnosis, treatment, monitor of disease progression, and prognosis of patients with colorectal cancer liver metastases.

scholarly journals Gut Microbiota Alteration Influences Colorectal Cancer Metastasis to the Liver By Remodeling the Liver Immune Microenvironment

2021 ◽  
Author(s):  
na yuan ◽  
Xiaoyan Li ◽  
Meng Wang ◽  
Zhilin Zhang ◽  
Lu Qiao ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Liver Metastasis ◽  
Gut Microbiota ◽  
Liver Metastases ◽  
Cancer Metastasis ◽  
Pearson Correlation ◽  
Control Group ◽  
Immune Microenvironment ◽  
Rdna Sequencing ◽  
Key Factor

Abstract Background: The gut microbiota regulates the liver immune microenvironment in colorectal cancer (CRC) through gut-liver axis. Kupffer cells (KCs) contribute significantly to the formation of pre-metastatic niches (PMNs) for CRC liver metastasis. The aim of our study was to explore the effect of gut microbiota regulating KCs in CRC liver metastasis. Results: Mice treated with different antibiotics were divided into Control group, vancomycin (Vanc) group, colistin (Coli) group, and a group of ampicillin, streptomycin and colistin (ASC). Fewer liver metastases were identified in mice in the ASC group and Coli group than in those in the Control group (P = 0.003, P = 0.041, respectively). An increased proportion of Parabacteroides_goldsteinii, Bacteroides_vulgatus, Bacteroides_ thetaiotaomicron, Bacteroides_uniformis in mice of the Coli group were observed in 16S rDNA sequencing. Consistent with the Tax4Fun functional prediction, a prominent expansion of hepatic KCs was identified in mice in the ASC and Coli groups compared to those in the Control group (P = 0.001, P = 0.038, separately). Meanwhile, Bacteroides_vulgatus was a positive correlation with KCs contents (P = 0.011, r = 0.705). On the other hand, more liver metastases were observed in mice of the Vanc group than those in the Control group (P = 0.028). An increased abundance of Parabacteroides_distasonis, Proteus_mirabilis and a remarkable reduction of hepatic KCs were observed in mice in the Vanc group (P = 0.027). Pearson correlation analysis showed Proteus_mirabilis was a negative related to KCs contents (P = 0.028, r = 0.632). Conclusions: An increased abundance of Proteus_mirabilis and a decreased abundance of Bacteroides_vulgatus may be a key factor in CRC liver metastasis, which may be related to the reduction of KCs in the liver.

scholarly journals Local Control by Radiofrequency Thermal Ablation Increased Overall Survival in Patients With Refractory Liver Metastases of Colorectal Cancer

Medicine ◽  
2016 ◽  
Vol 95 (14) ◽  
pp. e3338 ◽  
Author(s):  
Po-Chih Yang ◽  
Been-Ren Lin ◽  
Yi-Chang Chen ◽  
Yu-Lin Lin ◽  
Hong-Shiee Lai ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Overall Survival ◽  
Liver Metastases ◽  
Local Control ◽  
Thermal Ablation ◽  
Radiofrequency Thermal Ablation

scholarly journals Biliothoracic Fistula after Microwave Ablation of Liver Metastasis : Literature Review

2021 ◽  
Vol 2021 ◽  
pp. 1-5
Author(s):  
Valentina Tassi ◽  
Claudia Mosillo ◽  
Massimiliano Mutignani ◽  
Roberto Cirocchi ◽  
Mark Ragusa ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Liver Metastasis ◽  
Literature Review ◽  
Thermal Ablation ◽  
Microwave Ablation ◽  
Conservative Approach ◽  
Colorectal Cancer Liver Metastasis ◽  
Percutaneous Thermal Ablation ◽  
Hepatic Lesions ◽  
Glue Embolization

Microwave ablation is a safe and effective interventional approach, widely used in the treatment of unresectable primary or metastatic hepatic lesions. Thoracobiliary fistula is a rare postablation complication that can be treated with a conservative or surgical approach. We reviewed aetiology, pathogenesis, clinical picture, diagnostic possibilities, and therapeutic options for biliothoracic fistula developed after microwave ablation of liver metastasis. Furthermore, we reported our experience of successful conservative management of a nonhealing thoracobiliary fistula occurred after percutaneous thermal ablation of colorectal cancer liver metastasis. Our case supports a conservative approach based on percutaneous biliary system decompression and synthetic glue embolization for the treatment of combined biliopleural and biliobronchial fistula.

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