scholarly journals The effect of acute and chronic iodine excess on thyroid profile and reproductive function of women using Lipiodol during hysterosalpingography and the potential impact on thyroid function of their offspring: The SELFI study protocol

2021 ◽  
Vol 2 (8) ◽  
pp. e0148
Author(s):  
Divya M. Mathews ◽  
Jane M. Peart ◽  
Robert G. Sim ◽  
Neil P. Johnson ◽  
Susannah O'Sullivan ◽  
...  
Keyword(s):  
Thyroid Function ◽  
Study Protocol ◽  
Reproductive Function ◽  
Iodine Excess ◽  
Potential Impact ◽  
Thyroid Profile

Effects of iodine excess on serum thyrotropin-releasing hormone levels and type 2 deiodinase in the hypothalamus of Wistar rats

2021 ◽  
pp. 1-30
Author(s):  
Ying Sun ◽  
Xin Du ◽  
Zhongyan Shan ◽  
Weiping Teng ◽  
Yaqiu Jiang
Keyword(s):  
Thyroid Function ◽  
Wistar Rats ◽  
Iodine Intake ◽  
Thyrotropin Releasing Hormone ◽  
High Iodine ◽  
Releasing Hormone ◽  
Iodine Excess ◽  
Excessive Iodine ◽  
Thyroid Hormone Biosynthesis

Abstract Iodine is an important element in thyroid hormone biosynthesis. Thyroid function is regulated by the hypothalamic-pituitary-thyroid axis (HPT). Excessive iodine leads to elevated thyroid stimulating hormone (TSH) levels, but the mechanism is not yet clear. Type 2 deiodinase (Dio2) is a selenium-containing protease that plays a vital role in thyroid function. The purpose of this study was to explore the role of hypothalamus Dio2 in regulating TSH increase caused by excessive iodine and to determine the effects of iodine excess on thyrotropin-releasing hormone (TRH) levels. Male Wistar rats were randomized into five groups and administered different iodine dosages (folds of physiological dose): normal iodine (NI), 3-fold iodine (3HI), 6-fold iodine (6HI), 10-fold iodine (10HI), and 50-fold iodine (50HI). Rats were euthanized at 4, 8, 12, or 24 weeks after iodine administration. Serum TRH, TSH, total thyroxine (TT4), and total triiodothyronine (TT3) were determined. Hypothalamus tissues were frozen and sectioned to evaluate expression of Dio2, Dio2 activity, and monocarboxylate transporter 8 (MCT8). Prolonged high iodine intake significantly increased TSH expression (p < 0.05), but did not affect TT3 and TT4 levels. Prolonged high iodine intake decreased serum TRH levels in the hypothalamus (p < 0.05). Dio2 expression and activity in the hypothalamus exhibited an increasing trend compared at each time point with increasing iodine intake (p < 0.05). Hypothalamic MCT8 expression was increased in rats with prolonged high iodine intake(p < 0.05). These results indicate that iodine excess affects the levels of Dio2, TRH, and MCT8 in the hypothalamus.

Testicular Trauma: Potential Impact on Reproductive Function

1996 ◽  
Vol 156 (5) ◽  
pp. 1643-1646 ◽  
Author(s):  
Ashok N. Kukadia ◽  
Cesar J. Ercole ◽  
Paul Gleich ◽  
Hugh Hensleigh ◽  
Jon L. Pryor
Keyword(s):  
Reproductive Function ◽  
Testicular Trauma ◽  
Potential Impact

scholarly journals A prospective study for the assessment of thyroid function by pre and post supervised exercise protocol in newly diagnosed patients of subclinical hypothyroidism

2019 ◽  
Vol 6 (2) ◽  
pp. 253
Author(s):  
Dharmendra Jhavar ◽  
Naresh K. Patel ◽  
V. P. Pandey
Keyword(s):  
Physical Exercise ◽  
Thyroid Function ◽  
Subclinical Hypothyroidism ◽  
Thyroid Function Test ◽  
Exercise Group ◽  
P Value ◽  
Newly Diagnosed ◽  
Function Test ◽  
Thyroid Profile ◽  
Regular Physical Exercise

Background: The presence of raised serum TSH with serum free T4 and T3 within the reference range falls in subclinical hypothyroidism. It is a well-known fact that exercise affects the activity of thyroid glands and the production of their hormones. Author studied the effect of regular exercise in patients of newly diagnosed subclinical hypothyroidism. Pre and post-exercise thyroid function tests were evaluated to decide about the necessity to start thyroid replacement therapy or to adopt wait and watch policy.Methods: Study enrolled 100 newly diagnosed subclinical hypothyroidism patients attending this tertiary care hospital and randomised them in two groups, one group was subjected to regular physical exercise of 45-60 minutes daily along with supervised treadmill exercise stage 0 for 45-60 minutes once weekly followed by re-evaluation of thyroid function test after 30 days and second group was re-evaluated for thyroid function test without exercise after 30 days.Results: Thyroid profile parameters were compared and analysed by paired ‘t’ test, statistically significant increase in serum T3 (p value <0.05) and serum T4 (p value <0.05), along with significant reduction in TSH level (p value <0.05) were found in exercise group, while in non-exercise group changes in thyroid profile parameters were statistically not significant. There was significant reduction in mean weight in exercise group (p value <0.05), while in non-exercise group changes in weight were not significant.Conclusions: Present study concluded that regular physical exercise can improve thyroid function in patients of newly diagnosed subclinical hypothyroidism and convert them to euthyroid state.

Experimental study on the effects of chronic iodine excess on thyroid function, structure, and autoimmunity in autoimmune-prone NOD.H-2h4 mice

2008 ◽  
Vol 9 (1) ◽  
pp. 51-59 ◽  
Author(s):  
Xiaochun Teng ◽  
Zhongyan Shan ◽  
Weiping Teng ◽  
Chenling Fan ◽  
Hong Wang ◽  
...  
Keyword(s):  
Experimental Study ◽  
Thyroid Function ◽  
Function Structure ◽  
Iodine Excess

scholarly journals Thyroid Profile abnormalities of RHGH treated children

QJM ◽  
2020 ◽  
Vol 113 (Supplement_1) ◽  
Author(s):  
W A Mouharam ◽  
D A Soliman
Keyword(s):  
Growth Hormone ◽  
Thyroid Function ◽  
Optimal Growth ◽  
Hormone Treatment ◽  
Hormone Deficiency ◽  
Height Velocity ◽  
Free T4 ◽  
Thyroid Profile ◽  
The Impact ◽  
Rhgh Treatment

Abstract Objective Normal thyroid function is important for optimal growth. Contradictory studies are available on the impact of rhGH treatment on thyroid function. Study aim is to evaluate the effect of rhGH treatment on thyroid function. Methods Study involved 102 euthyroid, prepubertal patients with growth hormone deficiency treated with rhGH. For all children, basal thyroid function, height, height velocity after 1 year of treatment, thyroid function every 3 months during the first year of treatment, all were performed. Results At 3 months of treatment 12 patients had elevated TSH, with or without low free T4. The remaining patients had normal free T4 (but lower than the basal one in most of the patients), with no TSH difference. The latter results were normalized at 1 year. Growth velocity was significantly lower in patients with hypothyroidism. Conclusion Thyroid profile may be affected in patients with short stature on growth hormone treatment which may negatively impact treatment response.

scholarly journals Relationship between thyroid function and ICU mortality (sick euthyroid syndrome)

2017 ◽  
Vol 4 (5) ◽  
pp. 1266
Author(s):  
Priyadarsini Bose ◽  
Ramesh Dasarathan ◽  
Arun Shivaraman Mulaur Murugesan ◽  
K. S. Chenthil
Keyword(s):  
Critical Illness ◽  
Thyroid Hormone ◽  
Thyroid Function ◽  
Apache Ii ◽  
Apache Ii Score ◽  
Thyroid Function Tests ◽  
Icu Patients ◽  
Thyroid Profile ◽  
A Prospective Study ◽  
Sick Euthyroid

Background: Sick euthyroid syndrome refers to alterations that occur in thyroid hormone levels in response to any critical illness like sepsis, ARDS, patients on mechanical ventilation and also any ICU patients. This study aimed at the relationship between thyroid hormone level changes and critical illness in ICU patients and predict the mortality based on thyroid hormone levels.Methods: A prospective study was designed to carry out in intensive care unit (ICU), Institute of internal medicine, Rajiv Gandhi government general hospital, Chennai for six months from May to August 2015. A total of 40 patients were selected who fulfilled the selection criteria.Results: APACHE II scores were calculated for all the 40 patients to assess whether thyroid function tests could independently predict the outcome of the patients. Again, the thyroid profile was compared with APACHE II scores in predicting the outcome. Values showed statistically significance.Conclusions: Thyroid profile can be used as an independent factor in predicting the outcome of the patients. Thyroid profile can also increase the sensitivity of APACHE II score in predicting the outcome.

The non-thyroidal illness syndrome after coronary artery bypass grafting: a 6-month follow-up study

2005 ◽  
Vol 43 (3) ◽  
Author(s):  
Alfredo Giuseppe Cerillo ◽  
Simona Storti ◽  
Massimiliano Mariani ◽  
Enkel Kallushi ◽  
Stefano Bevilacqua ◽  
...  
Keyword(s):  
Coronary Artery ◽  
Coronary Artery Bypass Grafting ◽  
Coronary Artery Bypass ◽  
Thyroid Function ◽  
Artery Bypass ◽  
Bypass Grafting ◽  
Artery Bypass Grafting ◽  
Follow Up Study ◽  
Thyroid Profile

AbstractThe non-thyroidal illness syndrome (NTIS) is considered a transient and completely reversible phenomenon, but it has been shown that it may last for several days postoperatively after coronary artery bypass grafting (CABG) surgery. This study was undertaken to assess thyroid function 6 months after uncomplicated CABG. The thyroid profile was evaluated in 40 consecutive patients undergoing CABG preoperatively, at 0, 12, 48, and 120h postoperatively, and at 6-month follow-up. Triiodothyronine (T

scholarly journals Paediatric Constipation;Think Beyond Thyroid Causes

2016 ◽  
Vol 36 (2) ◽  
pp. 143-146
Author(s):  
Ekta Malik Debnath ◽  
Rashmi Rasi Datta ◽  
Pinaki Ranjan Debnath ◽  
Anju Jain
Keyword(s):  
Thyroid Function ◽  
Medical Records ◽  
Clinical Laboratory ◽  
Functional Constipation ◽  
Reference Ranges ◽  
Thyroid Function Tests ◽  
Radiologic Evaluation ◽  
Paediatric Patients ◽  
Clinical Biochemistry Laboratory ◽  
Thyroid Profile

Introduction: This study was designed to evaluate the importance of proper detailed history and examination of the patient as well as to determine the prevalence of unrecognized hypothyroidism among the paediatric patients with constipation attending the outpatient paediatric units in our hospital.Material and Methods: A retrospective review of medical records of paediatric patients ordered for thyroid function tests between July 2014 and June 2015 was performed. Total of 2210 paediatric patients were included in the study. A complete review of the medical records of these patients were performed which included indications for ordering thyroid tests, medical history, drug history, radiologic evaluation, other laboratory tests and subspeciality consultation.The samples were analyzed in the hormone unit of the Clinical Biochemistry Laboratory by a fully automated analyzer (Cobas e411, Roche). Data analysis was done using SPSS statistical software. Clinical diagnosis was made according to the paediatric reference ranges used in our clinical laboratory. Results: Out of all patients, 149 had history of constipation and 11 patients out of 149 had abnormal thyroid function. Repeat measurements after three months showed normal results for nine, while only two patients had results suggestive of hypothyroidism.Conclusion: Functional constipation is a condition which is to be diagnosed only by history or clinical examination. Thyroid profile where necessary is to be done after proper examination, to reduce the burden of cost to laboratory and society as well as exposing the pediatric patient to trauma.J Nepal Paediatr Soc 2016;36(2):143-146

scholarly journals Effect of Isotretinoin on Thyroid Function Test in Acne Patients

2020 ◽  
Author(s):  
Amruta Morey ◽  
Bhushan Madke ◽  
Adarshlata Singh
Keyword(s):  
Thyroid Function ◽  
Acne Vulgaris ◽  
Thyroid Stimulating Hormone ◽  
Endocrine Function ◽  
Common Side Effect ◽  
P Value ◽  
Thyroid Function Tests ◽  
Oral Isotretinoin ◽  
The Difference ◽  
Thyroid Profile

Introduction: With the rising popularity of Isotretinoin for acne vulgaris treatment, the interest in knowing the effect of oral Isotretinoin on endocrine function and the metabolic processes has increased considerably. Aim: To study the effect of Isotretinoin on serum thyroid hormone levels in acne patients and to study side effects of Isotretinoin, if any. Materials and Methods: In this interventional from September 2018-August 2019, using purposive method, 30 patients (Twenty males and Ten females) between age group 15-30 years-old having grade 3 (20 patients) and 4 (10 patients) acne vulgaris (according to standard system of grading) were enrolled and were started on oral capsule Isotretinoin 0.5 mg/kg/day for at least three months. A baseline thyroid profile which includes serum Triiodothyronine (T3), serum Thyroxine (T4) and Thyroid Stimulating Hormone (TSH) was performed on all subjects before and after three months of continued treatment. p-value <0.05 was considered as significant. Results: After three months of continuous oral Isotretinoin administration, it was observed that serum T3 and T4 values were raised while serum TSH was slightly reduced as compared to baseline values but the difference was not statistically significant. It was also observed that lip cheilitis was the most common side effect manifesting in 28 out of 30 patients. Conclusion: In the study, minor alteration in thyroid profile was observed but the difference was statistically not significant. Thus, it can be concluded that Isotretinoin can be safely given upto three months without any disturbance in thyroid function tests.

Sign in / Sign up

Export Citation Format

Share Document