Assessing the Impact of EQ-5D Country-specific Value Sets on Cost-utility Outcomes

Medical Care ◽  
2020 ◽  
Vol 59 (1) ◽  
pp. 82-90
Author(s):  
Johanna M. van Dongen ◽  
Ângela Jornada Ben ◽  
Aureliano P. Finch ◽  
Milou M.M. Rossenaar ◽  
Karolien E.M. Biesheuvel-Leliefeld ◽  
...  
Keyword(s):  
Cost Utility ◽  
Value Sets ◽  
The Impact ◽  
Country Specific

scholarly journals Cultural Values: Can They Explain Differences in Health Utilities between Countries?

2019 ◽  
Vol 39 (5) ◽  
pp. 605-616 ◽  
Author(s):  
Bram Roudijk ◽  
A. Rogier T. Donders ◽  
Peep F. M. Stalmeier ◽  
Nan Luo ◽  
Rosalie Viney ◽  
...  
Keyword(s):  
Cultural Values ◽  
Multilevel Models ◽  
Research Question ◽  
Intraclass Correlation ◽  
Health States ◽  
Health Utilities ◽  
Cultural Variables ◽  
Value Sets ◽  
The Impact ◽  
Country Specific

Introduction. Health utilities are widely used in health care. The distributions of utilities differ between countries; some countries more often report worse than dead health states, while mild states are valued more or less the same. We hypothesize that cultural values explain these country-related utility differences. Research Question. What is the effect of sociodemographic background, methodological factors, and cultural values on differences in health utilities? Methods and Analyses. Time tradeoff data from 28 EQ-5D valuation studies were analyzed, together with their sociodemographic variables. The dependent variable was [Formula: see text], the utility difference between mild and severe states. Country-specific cultural variables were taken from the World Values Survey. Multilevel models were used to analyze the effect of sociodemographic background, methodology (3L v. 5L), and cultural values on [Formula: see text]. Intraclass correlation (ICC) for country variation was used to assess the impact of the predicting variables on the variation between countries. Results. Substantial variation in [Formula: see text] was found between countries. Adding cultural values did not reduce ICCs for country variation. Sociodemographic background variables were only weakly associated with [Formula: see text] and did not affect the ICC. [Formula: see text] was 0.118 smaller for EQ-5D-5L studies. Discussion. [Formula: see text] varies between countries. These differences were not explained by national cultural values. In conclusion, despite correction for various variables, utility differences between countries remain substantial and unexplained. This justifies the use of country-specific value sets for instruments such as the EQ-5D.

scholarly journals Should the Preference-based Index Set of Values Be Country- or Disease-specific? An Analysis Using Data From Women With Symptoms of Overactive Bladder

2022 ◽  
Author(s):  
Ana Paula Rodrigues Rocha ◽  
Luiz Augusto Brusaca ◽  
Ana Jéssica dos Santos Sousa ◽  
Ana Beatriz Oliveira ◽  
Patricia Driusso
Keyword(s):  
Overactive Bladder ◽  
Short Form ◽  
Cost Utility ◽  
Index Set ◽  
Cross Sectional ◽  
King’S Health Questionnaire ◽  
Utility Index ◽  
Value Sets ◽  
Post Hoc ◽  
Country Specific

Abstract Background: Overactive bladder (OAB) and urinary incontinence (UI) are common conditions among women. However, no studies have evaluated the utility value of this population using different country-specific value sets. We aimed to 1) verify the difference between the preference-based index extracted from the Short Form six dimensions (SF-6Dv1) questionnaire in women with OAB using different country-specific value sets; 2) translate and cross-culturally adapt the King's Health Questionnaire Five Dimension (KHQ-5D) into Brazilian Portuguese; and 3) examine the association between utility index obtained by the SF-6Dv1 and KHQ-5D. Methods: This cross-sectional study included 387 women over 18 years of age with OAB symptoms, divided into groups with and without UI. All participants answered the sociodemographic questionnaire, KHQ, KHQ-5D, and SF-6Dv1. To the statistical analysis a two-way mixed ANOVA was applied to verify the interaction between the presence of UI and utility index obtained from different country-specific value sets. Post-hoc multiple comparisons were applied following the main analysis. Spearman’s test was applied to verify the correlation between the utility values of SF-6Dv1 and KHQ-5D. The significance level was set at 5%. Results: We evaluated 298 women classified according to the presence of UI (119 without UI vs. 179 with UI). The main analysis showed a statistically significant interaction between the presence of UI and the utility index obtained from the different countries (p = 0.005, Cohen’s d= 0.02). The post-hoc analyses showed that there was a statistically significant main effect of the utility index obtained from different countries (p <0.001, d = 0.63) and in the presence of UI (p = 0.012, d = 0.02). The correlations between the utility indices obtained from different countries using the SF-6Dv1 and KHQ-5D were significant, positive, and small. Conclusions: The differences between the indices obtained in different countries and groups with and without UI, assessed using the SF-6Dv1, are shown. The correlation between general and specifics preference-based measures was small; therefore, the SF-6Dv1 should be used with caution in cost-utility studies for this population. We recommend that in women with OAB, the value set for GPBM be obtained in countries where cost utility is applied.

scholarly journals The Impact of Country-Specific Utility Tariffs on the Outcome of Cost-Utility Analyses; A Case Study

2016 ◽  
Vol 19 (7) ◽  
pp. A386
Author(s):  
JE Bosmans ◽  
MM Rossenaar ◽  
JM van Dongen ◽  
MW van Tulder
Keyword(s):  
Cost Utility ◽  
The Impact ◽  
Country Specific

The impact of blacklists on external deposits: one size does not fit all

2021 ◽  
Vol ahead-of-print (ahead-of-print) ◽  
Author(s):  
Michael Jonsson ◽  
Jan Pettersson ◽  
Christian Nils Larson ◽  
Nir Artzi
Keyword(s):  
Growth Rate ◽  
Design Methodology ◽  
Descriptive Statistics ◽  
Comparable Data ◽  
Patriot Act ◽  
Content Type ◽  
Probable Impact ◽  
The Impact ◽  
Practical Implications ◽  
Country Specific

Purpose This study aims to measure the impact of the Non-Cooperative Countries and Territories, Organization for Economic Cooperation and Development and US PATRIOT Act Section 311 blacklists on external deposits from blacklisted jurisdictions into BIS reporting countries in 1996–2008, a period when anti-money laundering-related actions were consistently less stringent than post-2010, to see whether they had an effect even absent the threat of sizable financial fines. Design/methodology/approach The study uses descriptive statistics and bivariate and multivariate regressions to analyze the probable impact from blacklists on non-bank external deposits. The country sample is divided into offshore financial centers (OFCs) and non-OFCs and includes 158 non-listed countries. The impact of the blacklists is tested both jointly and individually for the respective blacklists. Findings The authors find mixed impact from jurisdictions being blacklisted on the growth rate of stocks of deposits into BIS reporting countries. Effects are often zero, negative in several cases and positive in some cases. This is consistent with the “stigma effect” and the “stigma paradox” in the literature. An overall impact from blacklisting is difficult to discern. Different blacklists had different effects, and the same blacklist impacted countries differently, illustrating the importance of disaggregating the analysis by individual countries. Research limitations/implications Interpretation of these data is limited by the absence of comparable data on non-resident deposits in blacklisted jurisdictions. Practical implications The impact of a blacklist depends in part on the structure of the listed jurisdictions’ economies, implying that country-specific sanctions may be more effective than blacklists. Originality/value This is one of the very few papers to date to rigorously test the impact of blacklists on external deposits.

scholarly journals Estimating post-release mortality of European sea bass based on experimental angling

2018 ◽  
Vol 75 (4) ◽  
pp. 1483-1495 ◽  
Author(s):  
Wolf-Christian Lewin ◽  
Harry Vincent Strehlow ◽  
Keno Ferter ◽  
Kieran Hyder ◽  
Jan Niemax ◽  
...  
Keyword(s):  
Stock Assessment ◽  
Sea Bass ◽  
Specific Information ◽  
Experimental Conditions ◽  
European Sea Bass ◽  
Air Exposure ◽  
Cumulative Impact ◽  
The Impact ◽  
Mortality Estimates ◽  
Country Specific

Abstract European sea bass (Dicentrarchus labrax) is an important target species for recreational and commercial fisheries. In recent years, the spawning stock biomass has declined markedly in some areas, and strict management measures have been introduced. However, the development of appropriate stock assessment and fisheries management has been hampered by a lack of information on post-release mortality. This study investigated post-release mortality of sea bass captured with common recreational fishing gear under experimental conditions in an aquaculture facility over 10 d. Three experiments investigated: (i) the effects of different bait types; (ii) the impact of prolonged air exposure; and (iii) the impact of deep hooking on post-release mortality. By combining the experimental results with country-specific information on sea bass angling practices, estimates of post-release mortality are provided for the northern sea bass stock. No mortality was observed for sea bass captured on artificial baits. The use of natural baits resulted in a mortality of 13.9% (95% CI = 4.7–29.5%), which was associated with deep hooking, hooking injuries, and prolonged air exposure. The use of artificial baits and short air exposure (≤30 s) increased survival probability, whereas deep hooking resulted in 76.5% (95% CI = 50.0–93.2%) mortality. Depending on country-specific angling practices, post-release mortality estimates ranged from 2.8% to 9.1% (mean = 5.0%, 95% CI = 1.7–14.4%) for northern sea bass. Despite these relatively low mortality estimates, post-release mortality should be considered in stock assessments as its cumulative impact may be high. Moreover, post-release mortality can be reduced by implementing species-specific best practice guidelines.

INTERNATIONAL OUTPUT AND INFLATION UNCERTAINTY AND THEIR IMPACT ON COUNTRIES' MACROECONOMIC PERFORMANCE. EVIDENCE FROM A DYNAMIC FACTOR GARCH-IN-MEAN MODEL

2018 ◽  
Vol 22 (5) ◽  
pp. 1113-1133 ◽  
Author(s):  
Tino Berger ◽  
Sibylle Grabert
Keyword(s):  
Factor Model ◽  
Output Growth ◽  
Dynamic Factor ◽  
International Level ◽  
Macroeconomic Performance ◽  
Inflation Uncertainty ◽  
Inflation Rates ◽  
Oil Crisis ◽  
The Impact ◽  
Country Specific

We identify international output and inflation uncertainty and analyze their impact on individual countries' macroeconomic performance. Output and inflation uncertainty on an international level is measured through the conditional variances of common factors in inflation and output growth, estimated from a bivariate dynamic factor model with GARCH errors. The impact of international and country-specific uncertainty is analyzed by including the conditional variances as regressors. We find increases in uncertainty during the first and second oil crisis, the 1980s and 1990s recessions as well as the recent Great Recession to be confined to the international level. The effect of international uncertainty results to be highly significant and unambiguously negative on countries' output growth and inflation rates whereas the impact of country-specific uncertainty is very mixed.

scholarly journals Individual solutions to collective problems: the paradoxical treatment of environmental issues on Mexican and French YouTubers' videos

2021 ◽  
Vol 20 (07) ◽  
pp. A07
Author(s):  
Cecilia Lartigue ◽  
Guillaume Carbou ◽  
Muriel Lefebvre
Keyword(s):  
Social Construction ◽  
Environmental Issues ◽  
Streaming Video ◽  
Environmental Discourse ◽  
Country Comparison ◽  
The Social ◽  
Environmental Discourses ◽  
Cross Country ◽  
The Impact ◽  
Country Specific

The impact of human activity on our planet is undeniable. However, this matter of fact is not fully understandable without analyzing the narratives through which people make sense of it. In this study, we aim to describe the narratives present in environmental discourses of Mexican and French YouTubers' videos. This corpus is intended to show how environmental issues are framed in the ever-growing discursive arena of entertainment and “influencing” streaming video. We set out to perform a cross-country comparison, with the purpose of contributing to the discussion of whether environmental discourse is country-specific or shared by various nations and, possibly, even global. Our study contributes to the understanding of the social construction of the environment via these discourses. Our main result points to a paradoxical treatment of environmental issues: the YouTubers of our sample represent them as collectively induced problems, but seem to mainly believe that individual-based solutions would resolve them. More broadly, our study suggests a tendency to the individualization and, therefore, the depoliticization of environmental issues as well as a globalization of the environmental discourses in YouTubers' videos.

OP56 Rehabilitation Of Memory In Brain Injury: A Cost-Utility Analysis

2018 ◽  
Vol 34 (S1) ◽  
pp. 20-21
Author(s):  
Shaun Harris ◽  
Deborah Fitzsimmons ◽  
Roshan das Nair ◽  
Lucy Bradshaw
Keyword(s):  
Usual Care ◽  
Cost Effective ◽  
Cost Utility ◽  
Sensitivity Analyses ◽  
Base Case ◽  
Utility Analysis ◽  
Considerable Uncertainty ◽  
Memory Rehabilitation ◽  
The Impact

Introduction:People with traumatic brain injuries (TBIs) commonly report memory impairments which are persistent, debilitating, and reduce quality of life. As part of the Rehabilitation of Memory in Brain Injury trial, a cost-effectiveness analysis was undertaken to examine the comparative costs and effects of a group memory rehabilitation program for people with TBI.Methods:Individual-level cost and outcome data were collected. Patients were randomized to usual care (n=157) or usual care plus memory rehabilitation (n=171). The primary outcome for the economic analysis was the EuroQol-5D quality of life score at 12 months. A UK NHS costing perspective was used. Missing data was addressed by multiple imputation. One-way sensitivity analyses examined the impact of varying different parameters, and the impact of available cases, on base case findings whilst non-parametric bootstrapping examined joint uncertainty.Results:At 12 months, the intervention was GBP 26.89 (USD 35.76) (SE 249.15) cheaper than usual care; but this difference was statistically non-significant (p=0.914). At 12 months, a QALY loss of −0.007 was observed in the intervention group confidence interval (95% CI: −0.025–0.012) and a QALY gain seen in the usual care group 0.004 (95% CI: -0.017–0.025). This difference was not statistically significant (p=0.442). The base case analysis gave an ICER of GBP 2,445 (USD 3,252) reflecting that the intervention was less effective and less costly compared to usual care. Sensitivity analyses illustrated considerable uncertainty. When joint uncertainty was examined, the probability of the intervention being cost-effective at a willingness-to-pay threshold of GBP 20,000 per QALY gain was 29 percent and 24 percent at GBP 30,000.Conclusions:Our cost-utility analysis indicates that memory rehabilitation was cheaper but less effective than usual care but these findings must be interpreted in the light of small statistically non–significant differences and considerable uncertainty was evident. The ReMemBrIn intervention is unlikely to be considered cost-effective for people with TBI.

scholarly journals Incorporating Household Spillovers in Cost Utility Analysis: A Case Study Using Behavior Change in COPD

2019 ◽  
Vol 35 (03) ◽  
pp. 212-220
Author(s):  
Arjun Bhadhuri ◽  
Hareth Al-Janabi ◽  
Sue Jowett ◽  
Kate Jolly
Keyword(s):  
Cost Effectiveness ◽  
Behavior Change ◽  
Health Effects ◽  
Cost Utility ◽  
Outcome Data ◽  
Cost Utility Analysis ◽  
Household Member ◽  
Utility Analysis ◽  
Household Members ◽  
The Impact

AbstractObjectivesIt is important to capture all health effects of interventions in cost-utility analyses conducted under a societal or healthcare perspective. However, this is rarely done. Household spillovers (health effects on patients’ other household members) may be particularly likely in the context of technologies and interventions to change behaviors that are interdependent in the household. Our objective was to prospectively collect outcome data from household members and illustrate how these can be included in a cost-utility analysis of a behavior change intervention in chronic obstructive pulmonary disease (COPD).MethodsData were collected from patients’ household members (n = 153) alongside a randomized controlled trial of a COPD self-management intervention. The impact of the intervention on household members’ EQ-5D-5L scores (primary outcome), was evaluated. Analyses were then carried out to estimate household members’ quality-adjusted life-years (QALYs) and assess the impact of including these QALYs on cost-effectiveness.ResultsThe intervention had a negligible spillover on household members’ EQ-5D-5L scores (−0.007; p = .75). There were also no statistically significant spillovers at the 5 percent level in household member secondary outcomes. In the base-case model, the inclusion of household member QALYs in the incremental cost-effectiveness ratio (ICER) denominator marginally increased the ICER from GBP 10,271 (EUR 13,146) to GBP 10,991 (EUR 14,068) per QALY gained.ConclusionsThis study demonstrates it is feasible to prospectively collect and include household members’ outcome data in cost utility analysis, although the study highlighted several methodological issues. In this case, the intervention did not impact significantly on household members’ health or health behaviors, but inclusion of household spillovers may make a difference in other contexts.

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