Should the Preference-based Index Set of Values Be Country- or Disease-specific? An Analysis Using Data From Women With Symptoms of Overactive Bladder
Abstract Background: Overactive bladder (OAB) and urinary incontinence (UI) are common conditions among women. However, no studies have evaluated the utility value of this population using different country-specific value sets. We aimed to 1) verify the difference between the preference-based index extracted from the Short Form six dimensions (SF-6Dv1) questionnaire in women with OAB using different country-specific value sets; 2) translate and cross-culturally adapt the King's Health Questionnaire Five Dimension (KHQ-5D) into Brazilian Portuguese; and 3) examine the association between utility index obtained by the SF-6Dv1 and KHQ-5D. Methods: This cross-sectional study included 387 women over 18 years of age with OAB symptoms, divided into groups with and without UI. All participants answered the sociodemographic questionnaire, KHQ, KHQ-5D, and SF-6Dv1. To the statistical analysis a two-way mixed ANOVA was applied to verify the interaction between the presence of UI and utility index obtained from different country-specific value sets. Post-hoc multiple comparisons were applied following the main analysis. Spearman’s test was applied to verify the correlation between the utility values of SF-6Dv1 and KHQ-5D. The significance level was set at 5%. Results: We evaluated 298 women classified according to the presence of UI (119 without UI vs. 179 with UI). The main analysis showed a statistically significant interaction between the presence of UI and the utility index obtained from the different countries (p = 0.005, Cohen’s d= 0.02). The post-hoc analyses showed that there was a statistically significant main effect of the utility index obtained from different countries (p <0.001, d = 0.63) and in the presence of UI (p = 0.012, d = 0.02). The correlations between the utility indices obtained from different countries using the SF-6Dv1 and KHQ-5D were significant, positive, and small. Conclusions: The differences between the indices obtained in different countries and groups with and without UI, assessed using the SF-6Dv1, are shown. The correlation between general and specifics preference-based measures was small; therefore, the SF-6Dv1 should be used with caution in cost-utility studies for this population. We recommend that in women with OAB, the value set for GPBM be obtained in countries where cost utility is applied.