scholarly journals High Serum Levels of Resistin is Associated With Acute Cerebral Infarction

2021 ◽  
Vol Publish Ahead of Print ◽  
Author(s):  
Kee Ook Lee ◽  
Kyung-Yul Lee ◽  
Cheol-Young Lee ◽  
Ji Hoon Kim ◽  
Jaeku Kang ◽  
...  
Keyword(s):  
Cerebral Infarction ◽  
Serum Levels ◽  
High Serum ◽  
Acute Cerebral Infarction

scholarly journals Non-Survivor Ischemic Stroke Patients Maintain High Serum Caspase-Cleaved Cytokeratin-18 Levels

2020 ◽  
Vol 10 (3) ◽  
pp. 132 ◽  
Author(s):  
Leonardo Lorente ◽  
María M. Martín ◽  
Antonia Pérez-Cejas ◽  
Agustín F González-Rivero ◽  
Rafael Sabatel ◽  
...  
Keyword(s):  
Cerebral Infarction ◽  
Serum Levels ◽  
High Serum ◽  
The Novel ◽  
Midline Shift ◽  
Cytokeratin 18 ◽  
Middle Cerebral Artery Infarction ◽  
Acute Neurological Deterioration ◽  
Diagnosis Criteria ◽  
Scale 8

Objective: Caspase-cleaved cytokeratin (CCCK)-18 could appear in blood during apoptosis. In two different studies, on day 1 of cerebral infarction and at 72 h of cerebral infarction, respectively, higher circulating CCCK-18 levels were found in non-surviving than in surviving patients. The objective of this study was to analyze the ability of these levels to predict mortality at any time during the first week of cerebral infarction. Methods: Patients with malignant middle cerebral artery infarction (MMCAI) were included and the diagnosis criteria were the presence, observed in a computed tomography, of an acute cerebral infarction in at least 50% of this territory and midline shift, and an acute neurological deterioration with a Glasgow Coma Scale ≤ 8. Serum CCCK-18 levels at days 1, 4 and 8 of MMCAI were determined. Results: Serum concentrations of CCCK-18 at days 1, 4 and 8 of MMCAI were higher in non-surviving (n = 34) than in surviving patients (n = 34). Serum CCCK-18 concentrations at days 1, 4 and 8 of MMCAI had an area under curve (95% CI) used to predict a 30-day mortality of 0.83 (0.72 –0.91; p < 0.001), 0.78 (0.65–0.89; p < 0.001) and 0.82 (0.68–0.92; p < 0.001). Conclusions: The novel finding is that serum levels of CCCK-18 levels at any time after the first week of MMCAI could help predict 30-day mortality.

scholarly journals Comparative study of intravenous thrombolysis with rt-PA and urokinase for patients with acute cerebral infarction

2020 ◽  
Vol 48 (5) ◽  
pp. 030006051989535
Author(s):  
Fan Sun ◽  
Heng Liu ◽  
Hui-xiao Fu ◽  
Shuo Zhang ◽  
Xu-dong Qian ◽  
...  
Keyword(s):  
Cerebral Infarction ◽  
Time Window ◽  
Intravenous Thrombolysis ◽  
Cerebral Haemorrhage ◽  
Recombinant Tissue Plasminogen Activator ◽  
Serum Levels ◽  
Acute Cerebral Infarction ◽  
Bleeding Complications ◽  
Therapeutic Effects ◽  
Clinical Trial Evidence

Objective Cerebral infarction has a poor prognosis and causes a serious burden on families and society. Recombinant tissue plasminogen activator (rt-PA) and urokinase (UK) are commonly used thrombolytic agents in the clinic. However, direct and powerful clinical trial evidence to determine the therapeutic effect of rt-PA and UK on intravenous thrombolysis is lacking. Methods In this study, 180 patients with acute cerebral infarction were treated with rt-PA or UK. The National Institutes of Health Stroke Scale (NIHSS) scores, Barthel index, bleeding complications, and biomarkers were evaluated. Results No significant differences in NIHSS or Barthel scores were found between the groups. However, UK increased the risk of intracranial haemorrhage compared with rt-PA. rt-PA had increased activity in reducing serum levels of MMP-9 than UK. Conclusion Intravenous thrombolysis with rt-PA and UK in the time window of acute cerebral infarction can achieve similar therapeutic effects, but rt-PA can further reduce the risk of cerebral haemorrhage and is relatively safer than UK.

scholarly journals Correlation Between Serum C-Reactive Protein And Cystatin C In Patients With Acute Cerebral Infarction And Carotid Artery Stenosis

2018 ◽  
Vol 7 (1) ◽  
Author(s):  
Tao Zhang ◽  
Xiaowen Yang ◽  
Hui Wang ◽  
Jie Luo ◽  
Anrong Li ◽  
...  
Keyword(s):  
Carotid Artery ◽  
Cerebral Infarction ◽  
Carotid Artery Stenosis ◽  
Serum Levels ◽  
Artery Stenosis ◽  
Acute Cerebral Infarction ◽  
Control Group ◽  
Case Group ◽  
Reactive Protein ◽  
Serum Crp

<p><em>To investigate the correlation between serum C-reactive protein (CRP) and serum cystatin C (Cys-C) levels in patients with acute cerebral infarction and carotid artery stenosis. Methods: From January 2015 to December 2016 admitted to our hospital new acute cerebral infarction parallel neck vascular color Doppler ultrasound examination showed 121 cases of carotid stenosis as the case group; select the same period of hospitalized patients with non-cerebrovascular disease in 50 cases As a control group. Fasting venous blood was collected on the third day after onset of the disease and serum levels of CRP and Cys-C were measured and compared. Results: Serum levels of CRP and Cys-C in case group were significantly higher than those in control group (P &lt;0.05). The correlation between serum CRP and Cys-C was found in any pairwise comparison (r = 0.4732). The level of CRP and Cys-C were closely related to the degree of carotid artery stenosis (P &lt;0.05). Conclusion: The combined detection of serum CRP and Cys-C levels can be used to evaluate the degree of carotid artery stenosis in patients with acute cerebral infarction and provide a reference for the next carotid endarterectomy.</em><em></em></p>

scholarly journals Serum anti-SERPINE1 antibody as a potential biomarker of acute cerebral infarction

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Masaaki Kubota ◽  
Yoichi Yoshida ◽  
Eiichi Kobayashi ◽  
Tomoo Matsutani ◽  
Shu-Yang Li ◽  
...  
Keyword(s):  
Ischemic Stroke ◽  
Cerebral Infarction ◽  
Intima Media Thickness ◽  
Serum Levels ◽  
Acute Cerebral Infarction ◽  
Expression Cloning ◽  
Healthy Donors ◽  
Potential Biomarker ◽  
Ischemic Attack ◽  
Antibody Levels

AbstractThe presence of disease-specific antigens and autoantibodies in the sera of patients with atherosclerosis-related diseases has been widely reported and is considered to result from inflammation of the arterial wall and the involvement of immune factors. The aim of this study was to identify a novel antibody in patients with ischemic stroke by serological identification of antigens using recombinant cDNA expression cloning from patients who had a transient ischemic attack (TIA). We identified the serpin peptidase inhibitor, clade E member 1 (SERPINE1), as a candidate antigen. The serum anti-SERPINE1 antibody levels quantified using amplified luminescent proximity homogeneous assay-linked immunosorbent assay were significantly higher in patients with ischemic stroke, including those with acute cerebral infarction (aCI), TIA, and chronic cerebral infarction, than in healthy donors. The antibody levels were strongly associated with old age, female sex, and presence of hypertension, diabetes mellitus, and cardiovascular disease. Age and intima-media thickness of the carotid artery were positively correlated with antibody levels, which suggests that SERPINE1 may reflect the progression of atherosclerosis. In a multivariate analysis, SERPINE1 antibody level was an independent predictor of aCI. Thus, the serum levels of anti-SERPINE1 antibody could potentially serve as a biomarker of atherothrombotic infarction.

scholarly journals Serum levels of sLOX‐1 and Lp‐PLA2 can predict the prognosis of acute cerebral infarction with a high specificity

2022 ◽  
Vol 10 (1) ◽  
Author(s):  
Ping Yan ◽  
Jing Cao ◽  
Yajun Zhou ◽  
Xia Zhou ◽  
Zhongwu Sun ◽  
...  
Keyword(s):  
Cerebral Infarction ◽  
High Specificity ◽  
Serum Levels ◽  
Acute Cerebral Infarction

scholarly journals The Predictive Value of Serum Alkaline Phosphatase Level on the Degree of Neurological Impairment in Patients With Acute Cerebral Infarction

2021 ◽  
Author(s):  
Ji-ming Zou ◽  
Xiao-yu Li ◽  
Chao Han
Keyword(s):  
Cerebral Infarction ◽  
Serum Alkaline Phosphatase ◽  
Pearson Correlation ◽  
Multivariate Regression Analysis ◽  
Neurological Impairment ◽  
Serum Marker ◽  
High Serum ◽  
Acute Cerebral Infarction ◽  
Control Group ◽  
Nihss Score

Abstract ObjectiveTo analyze the correlation between the changes of ALP level and the degree of neurological impairment in patients with acute cerebral infarction. MethodsA total of 267 patients with acute cerebral infarction were selected as the cerebral infarction group, 181 elderly patients who were matched age and gender in the same period with the cerebral infarction group were selected as the control group by the physical examination. All the selected patients were tested for serum ALP, ALT, AST, Cr, BUN,TG, TC, LDL - C and HDL - C after eight hours on an empty stomach. In the 72nd hour of the patient's course of cerebral infarction, the degree of neurological impairment was assessed using NIHSS score. The relationship between serum ALP level and NIHSS score was analyzed. ResultsAccording to NIHSS score, the patients with score of 5~15 were Group A , patients with score of 15~20 were Group B and score of 21~42 were Group C. Pearson correlation analysis showed that the serum ALP level of the three groups was positively correlated with NIHSS score. Multivariate regression analysis results showed that the high serum ALP level of the risk of cerebral infarction is a low serum ALP level 1.58 times. ConclusionsSerum ALP level was increased in patients with acute cerebral infarction and was closely related to the degree of neurological impairment. Perhaps the serum ALP level may be used as a serum marker to predict the degree of neurological impairment in patients.

Sign in / Sign up

Export Citation Format

Share Document