scholarly journals Serum levels of sLOX‐1 and Lp‐PLA2 can predict the prognosis of acute cerebral infarction with a high specificity

2022 ◽  
Vol 10 (1) ◽  
Author(s):  
Ping Yan ◽  
Jing Cao ◽  
Yajun Zhou ◽  
Xia Zhou ◽  
Zhongwu Sun ◽  
...  
Keyword(s):  
Cerebral Infarction ◽  
High Specificity ◽  
Serum Levels ◽  
Acute Cerebral Infarction

scholarly journals Comparative study of intravenous thrombolysis with rt-PA and urokinase for patients with acute cerebral infarction

2020 ◽  
Vol 48 (5) ◽  
pp. 030006051989535
Author(s):  
Fan Sun ◽  
Heng Liu ◽  
Hui-xiao Fu ◽  
Shuo Zhang ◽  
Xu-dong Qian ◽  
...  
Keyword(s):  
Cerebral Infarction ◽  
Time Window ◽  
Intravenous Thrombolysis ◽  
Cerebral Haemorrhage ◽  
Recombinant Tissue Plasminogen Activator ◽  
Serum Levels ◽  
Acute Cerebral Infarction ◽  
Bleeding Complications ◽  
Therapeutic Effects ◽  
Clinical Trial Evidence

Objective Cerebral infarction has a poor prognosis and causes a serious burden on families and society. Recombinant tissue plasminogen activator (rt-PA) and urokinase (UK) are commonly used thrombolytic agents in the clinic. However, direct and powerful clinical trial evidence to determine the therapeutic effect of rt-PA and UK on intravenous thrombolysis is lacking. Methods In this study, 180 patients with acute cerebral infarction were treated with rt-PA or UK. The National Institutes of Health Stroke Scale (NIHSS) scores, Barthel index, bleeding complications, and biomarkers were evaluated. Results No significant differences in NIHSS or Barthel scores were found between the groups. However, UK increased the risk of intracranial haemorrhage compared with rt-PA. rt-PA had increased activity in reducing serum levels of MMP-9 than UK. Conclusion Intravenous thrombolysis with rt-PA and UK in the time window of acute cerebral infarction can achieve similar therapeutic effects, but rt-PA can further reduce the risk of cerebral haemorrhage and is relatively safer than UK.

scholarly journals Correlation Between Serum C-Reactive Protein And Cystatin C In Patients With Acute Cerebral Infarction And Carotid Artery Stenosis

2018 ◽  
Vol 7 (1) ◽  
Author(s):  
Tao Zhang ◽  
Xiaowen Yang ◽  
Hui Wang ◽  
Jie Luo ◽  
Anrong Li ◽  
...  
Keyword(s):  
Carotid Artery ◽  
Cerebral Infarction ◽  
Carotid Artery Stenosis ◽  
Serum Levels ◽  
Artery Stenosis ◽  
Acute Cerebral Infarction ◽  
Control Group ◽  
Case Group ◽  
Reactive Protein ◽  
Serum Crp

<p><em>To investigate the correlation between serum C-reactive protein (CRP) and serum cystatin C (Cys-C) levels in patients with acute cerebral infarction and carotid artery stenosis. Methods: From January 2015 to December 2016 admitted to our hospital new acute cerebral infarction parallel neck vascular color Doppler ultrasound examination showed 121 cases of carotid stenosis as the case group; select the same period of hospitalized patients with non-cerebrovascular disease in 50 cases As a control group. Fasting venous blood was collected on the third day after onset of the disease and serum levels of CRP and Cys-C were measured and compared. Results: Serum levels of CRP and Cys-C in case group were significantly higher than those in control group (P &lt;0.05). The correlation between serum CRP and Cys-C was found in any pairwise comparison (r = 0.4732). The level of CRP and Cys-C were closely related to the degree of carotid artery stenosis (P &lt;0.05). Conclusion: The combined detection of serum CRP and Cys-C levels can be used to evaluate the degree of carotid artery stenosis in patients with acute cerebral infarction and provide a reference for the next carotid endarterectomy.</em><em></em></p>

scholarly journals High Serum Levels of Resistin is Associated With Acute Cerebral Infarction

2021 ◽  
Vol Publish Ahead of Print ◽  
Author(s):  
Kee Ook Lee ◽  
Kyung-Yul Lee ◽  
Cheol-Young Lee ◽  
Ji Hoon Kim ◽  
Jaeku Kang ◽  
...  
Keyword(s):  
Cerebral Infarction ◽  
Serum Levels ◽  
High Serum ◽  
Acute Cerebral Infarction

scholarly journals Serum anti-SERPINE1 antibody as a potential biomarker of acute cerebral infarction

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Masaaki Kubota ◽  
Yoichi Yoshida ◽  
Eiichi Kobayashi ◽  
Tomoo Matsutani ◽  
Shu-Yang Li ◽  
...  
Keyword(s):  
Ischemic Stroke ◽  
Cerebral Infarction ◽  
Intima Media Thickness ◽  
Serum Levels ◽  
Acute Cerebral Infarction ◽  
Expression Cloning ◽  
Healthy Donors ◽  
Potential Biomarker ◽  
Ischemic Attack ◽  
Antibody Levels

AbstractThe presence of disease-specific antigens and autoantibodies in the sera of patients with atherosclerosis-related diseases has been widely reported and is considered to result from inflammation of the arterial wall and the involvement of immune factors. The aim of this study was to identify a novel antibody in patients with ischemic stroke by serological identification of antigens using recombinant cDNA expression cloning from patients who had a transient ischemic attack (TIA). We identified the serpin peptidase inhibitor, clade E member 1 (SERPINE1), as a candidate antigen. The serum anti-SERPINE1 antibody levels quantified using amplified luminescent proximity homogeneous assay-linked immunosorbent assay were significantly higher in patients with ischemic stroke, including those with acute cerebral infarction (aCI), TIA, and chronic cerebral infarction, than in healthy donors. The antibody levels were strongly associated with old age, female sex, and presence of hypertension, diabetes mellitus, and cardiovascular disease. Age and intima-media thickness of the carotid artery were positively correlated with antibody levels, which suggests that SERPINE1 may reflect the progression of atherosclerosis. In a multivariate analysis, SERPINE1 antibody level was an independent predictor of aCI. Thus, the serum levels of anti-SERPINE1 antibody could potentially serve as a biomarker of atherothrombotic infarction.

Intra-carotid urokinase thrombolytic therapy in acute cerebral infarction: a preliminary study

1990 ◽  
Vol 26 (4) ◽  
pp. 609
Author(s):  
H K Cho ◽  
T S Chung ◽  
D I Kim ◽  
J H Suh ◽  
B I Lee ◽  
...  
Keyword(s):  
Cerebral Infarction ◽  
Thrombolytic Therapy ◽  
Acute Cerebral Infarction ◽  
Preliminary Study
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