Inflammatory and oxidative parameters in cord blood as diagnostic of early-onset neonatal sepsis: A case-control study

Abstract Background: Early-onset neonatal sepsis (EOS) is difficult to diagnose clinically because the semiology of premature newborns is poor during the first days of life. This study aimed to identify predictive factors of EOS in neonates less than 37 weeks gestational age in neonatal care at Louis Mourier Hospital. Method: This was a case-control study of all newborns <37 weeks of gestational age diagnosed and managed for EOS from January 1 to December 31, 2019. The main parameters studied were demographic characteristics, risk factors, biological and bacteriological characteristics. At the benchmarking level, the statistical tests used were the Mac Nemar test for qualitative variables and the paired Student's test for quantitative variables. Results: A total of 50 mother-child pairs were included in this study (25 cases and 25 matched controls). The results showed a statistically significant relationship between the birth of a child suffering from an EOS and between a premature rupture of membranes (PRM)> 18 h (68% of cases versus 36% of controls ( p: 0.042)); a positive culture of the placenta (p: 0.0002); a CRP> 6 mg / l (88% of cases against 20% of controls (p: 0.001)); a PCT> 0.6 ng / ml (72% of cases vs. 16% of controls (p: 0.001)). Grams negative including E. coli (44.5%) and Haemophilus Influenzae (14.8%) were the most common bacteria found. Conclusion: The search for risk factors must be systematic. The dosage of PCT must be coupled with that of CRP and the clinic must remain at the center of the diagnostic process.

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Is There an Association Between Fetal Scalp Electrode Application and Early-Onset Neonatal Sepsis in Term and Late Preterm Pregnancies? A Case–Control Study

Journal of Obstetrics and Gynaecology Canada ◽

10.1016/s1701-2163(16)35130-1 ◽

2012 ◽

Vol 34 (1) ◽

pp. 29-33 ◽

Cited By ~ 4

Author(s):

Nao Nakatsuka ◽

Venu Jain ◽

Khalid Aziz ◽

Robert Verity ◽

Manoj Kumar

Keyword(s):

Neonatal Sepsis ◽

Early Onset ◽

Case Control Study ◽

Case Control ◽

Late Preterm ◽

Scalp Electrode ◽

Fetal Scalp ◽

Control Study

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Multiple vaginal examinations and early neonatal sepsis

International Journal of Reproduction Contraception Obstetrics and Gynecology ◽

10.18203/2320-1770.ijrcog20190848 ◽

2019 ◽

Vol 8 (3) ◽

pp. 876 ◽

Cited By ~ 1

Author(s):

Usha Christopher ◽

Goldy S. J. ◽

Bewin Oral J. ◽

Adlin Rose C.

Keyword(s):

Risk Factor ◽

Neonatal Sepsis ◽

Early Onset ◽

Case Control Study ◽

Case Control ◽

Control Group ◽

P Value ◽

Maternal Risk Factors ◽

Maternal Risk ◽

Control Study

Background: Early onset neonatal sepsis (EONS) is caused mainly by organisms present in the genital tract. Maternal risk factors increase the incidence of EONS. This study was done to find out the association between one such risk factor i.e., multiple vaginal examinations and EONS.Methods: Case control study. 114 patients with three or more vaginal examinations after rupture of membranes were taken as cases and 114 patients with less than three vaginal examinations after rupture of membranes were taken as controls. All these babies were followed up for the development of EONS.Results: Of the 114 cases, 6 babies developed EONS. None of the babies in the control group developed EONS. So, 3 or more vaginal examinations after rupture of membranes in labour is significantly associated with early onset neonatal sepsis with p-value of 0.01305.Conclusions: Multiple vaginal examinations after rupture of membranes is a risk factor for early onset neonatal sepsis.

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Predictors of Early Onset Neonatal Sepsis among Neonates in Dodoma, Tanzania: A Case Control Study

Journal of Tropical Pediatrics ◽

10.1093/tropej/fmz062 ◽

2019 ◽

Vol 66 (3) ◽

pp. 257-266

Author(s):

Pendo P Masanja ◽

Stephen M Kibusi ◽

Mkhoi L Mkhoi

Keyword(s):

Neonatal Sepsis ◽

Early Onset ◽

Case Control Study ◽

Perinatal Asphyxia ◽

Case Control ◽

Normal Birth ◽

History Of ◽

Mother’S Age ◽

Poor Outcomes ◽

Control Study

Abstract Objective To assess the predictors of early onset neonatal sepsis (EONS) among neonates in Dodoma Tanzania. Methods A hospital-based case-control study of randomly selected 105 cases and 217 controls in three hospitals in Dodoma region. Cases were neonates diagnosed with neonatal sepsis. Controls were matched to the cases by mother’s age and parity at a ratio of 1 case to 2 controls. A semi-structured questionnaire was used to collect data on the potential mother, neonate and interventional predictors of EONS. Both descriptive and inferential statistical analysis were employed to test for independent association Results Most (92.5%) of neonates were born at term (≥37 weeks) and 84% had normal birth weight of ≥3 kg. After adjusting for confounders, the maternal factors which showed significant association with EONS were maternal history of chorioamnionitis [adjusted odds ratios (AOR) = 1.910, p = 0.042, 95% confidence interval (CI): 1.0223.56], HIV status (AOR = 2.909, p = 0.012, 95% CI: 1.020–8.296), prolonged rupture of membrane (AOR = 2.857, p = 0.014, 95% CI: 1.233–6.619) and multiple digital vaginal examinations during labor (AOR = 5.178, p = 0.026, 95% CI: 1.220–21.986). The neonatal history of perinatal asphyxia was observed to have a significant association with EONS (AOR = 6.781, p = 0.006, 95% CI: 1.725–26.652). Conclusion Both maternal and neonatal predictors had significant contribution to EONS. Results shed light on critical factors for consideration to prevent this disease and poor outcomes.

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