Long-term Outcomes of Endoscopic Resection for Gastric Subepithelial Tumors

Background Prospectively collected long-term data of patients undergoing endoscopic resection for superficial esophageal squamous cell carcinoma (ESCC) are limited. The aim of this study was to determine the prospectively collected long-term outcomes of endoscopic resection for ESCC as a secondary analysis of the Japan Esophageal Cohort (JEC) study. Methods Patients who underwent endoscopic resection of intramucosal ESCC at 16 institutions between September 2005 and May 2010 were enrolled in the JEC study. All patients underwent endoscopic examination with iodine staining at 3 and 6 months after resection, and every 6 months thereafter. We investigated clinical courses after endoscopic resection, survival rates, and cumulative incidence of metachronous ESCC. Results 330 patients (mean age 67.0 years) with 396 lesions (mean size 20.4 mm) were included in the analysis. Lesions were diagnosed as high-grade intraepithelial neoplasia in 17.4 % and as squamous cell carcinoma in 82.6 % (limited to epithelium in 28.4 %, to lamina propria in 55.4 %, and to muscularis mucosa in 16.2 %). En bloc resection was achieved in 291 (73.5 %). The median follow-up period was 49.4 months. Local recurrences occurred in 13 patients (3.9 %) and were treated by endoscopic procedures. Lymph node metastasis occurred in two patients (0.6 %) after endoscopic resection. The 5-year overall, disease-specific, and metastasis-free survival rates were 95.1 %, 99.1 %, and 94.6 %, respectively. The 5-year cumulative incidence rate of metachronous ESCC was 25.7 %. Conclusions Our study demonstrated that endoscopic resection is an effective treatment for intramucosal ESCC, with favorable long-term outcomes.

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Long-term Outcomes of Endoscopic Resection for Premalignant and Early Malignant Lesions of the Esophagus: Comparison Between EMR and ESD Method

The American Journal of Gastroenterology ◽

10.14309/00000434-201010001-01431 ◽

2010 ◽

Vol 105 ◽

pp. S532

Author(s):

Hwoon-Yong Jung ◽

Do Hoon Kim ◽

Kee Don Choi ◽

Ho June Song ◽

Gin Hyug Lee ◽

...

Keyword(s):

Endoscopic Resection ◽

Long Term Outcomes ◽

Malignant Lesions

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Mo1638 ENDOSCOPIC RESECTION FOLLOWED BY SURGERY IN T1 COLORECTAL CANCER WITH HIGH RISK HISTOLOGICAL FEATURES DOES NOT AFFECT CANCER-RELATED LONG-TERM OUTCOMES

Gastrointestinal Endoscopy ◽

10.1016/j.gie.2020.03.2506 ◽

2020 ◽

Vol 91 (6) ◽

pp. AB430-AB431

Author(s):

Eun Hye Oh ◽

Jeongseok Kim ◽

Namseok Ham ◽

Sang Hyoung Park ◽

Dong-Hoon Yang ◽

...

Keyword(s):

Colorectal Cancer ◽

High Risk ◽

Endoscopic Resection ◽

Long Term Outcomes ◽

Histological Features ◽

T1 Colorectal Cancer

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Long-term Outcomes of Primary Endoscopic Resection vs Surgery for T1 Colorectal Cancer: A Systematic Review and Meta-analysis

Clinical Gastroenterology and Hepatology ◽

10.1016/j.cgh.2020.05.060 ◽

2020 ◽

Vol 18 (12) ◽

pp. 2813-2823.e5 ◽

Cited By ~ 2

Author(s):

Jen-Hao Yeh ◽

Cheng-Hao Tseng ◽

Ru-Yi Huang ◽

Chih-Wen Lin ◽

Ching-Tai Lee ◽

...

Keyword(s):

Colorectal Cancer ◽

Systematic Review ◽

Endoscopic Resection ◽

Meta Analysis ◽

Long Term Outcomes ◽

T1 Colorectal Cancer

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Long-term outcomes of a primary complete endoscopic resection strategy for short-segment Barrett’s esophagus with high-grade dysplasia and/or early esophageal adenocarcinoma

Gastrointestinal Endoscopy ◽

10.1016/j.gie.2015.04.044 ◽

2016 ◽

Vol 83 (1) ◽

pp. 68-77 ◽

Cited By ~ 20

Author(s):

Farzan F. Bahin ◽

Mahesh Jayanna ◽

Luke F. Hourigan ◽

Reginald V. Lord ◽

David Whiteman ◽

...

Keyword(s):

Barrett’S Esophagus ◽

Esophageal Adenocarcinoma ◽

Endoscopic Resection ◽

Barrett's Esophagus ◽

High Grade Dysplasia ◽

High Grade ◽

Long Term Outcomes ◽

Short Segment

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Efficacy and safety of endoscopic resection for gastric subepithelial tumors.

Journal of Clinical Oncology ◽

10.1200/jco.2016.34.4_suppl.107 ◽

2016 ◽

Vol 34 (4_suppl) ◽

pp. 107-107

Author(s):

Kyoungwon Jung ◽

Ji Yong Ahn ◽

Do Hoon Kim ◽

Eun Jeong Gong ◽

Charles J. Cho ◽

...

Keyword(s):

Endoscopic Resection ◽

Medical Center ◽

Wedge Resection ◽

Endoscopic Management ◽

Severe Bleeding ◽

Related Factors ◽

Pathologic Evaluation ◽

Gastric Subepithelial Tumors ◽

The Mean ◽

Subepithelial Tumors

107 Background: Because small gastric subepithelial tumors (SETs) less than 2.0 cm might have malignant potential, ambiguous cases should be removed for optimal diagnosis and treatment. With the recent advances in endoscopic technique, endoscopic resection (ER) has been attempted for pathologic confirmation of gastric SETs. Herein, we aim to investigate the clinical usefulness and safety of ER of gastric SETs. Methods: A total of 115 subjects who underwent ER for gastric SETs from January 2005 to December 2014 were eligible for the study at the Asan Medical Center, Seoul, Korea. Patient’s demographic status, tumor related factors, procedure related factors, and clinical outcomes were retrospectively reviewed by using electronic medical record. Results: Among the 115 patients, 53 were male (46.1%) and the mean age was 51.59 ± 14.59 years. The mean size of all tumors was 18.58 ± 10.71 mm. Complete endoscopic resection was achieved in 108 of 115 tumors (93.9%). The final histopathologic diagnoses included 38 gastrointestinal stromal tumors (GISTs) (33.0%), 21 heterotopic pancreas (18.3%), 18 neuroendocrine tumors (15.7%), 11 leiomyoma (9.6%), 10 inflammatory fibroid polyp (8.7%), and others tumors (n = 17, 14.8%). Perforations occurred in 12 patients (10.4%) and they were successfully managed with endoscopic clipping. Severe bleeding during endoscopic resection occurred in 13 patients (11.3%) and they were treated by endoscopic management. Six patients underwent sequential wedge resection or gastrectomy of stomach because of non-curative resection and the pathologic evaluation revealed residual tumors in 3 patients. There was no recurrence or metastasis during mean follow-up of 44.96 ± 32.62 months (range 3-120.7 months). The rate for complete resection in relation to the final pathology was lower in GISTs (86.8%) than others (97.4%, p = 0.026). The rate of perforation was significantly higher for the fundus (66.7%) than for other locations (0% for the cardia, 16.7% for high body, 8.3% for mid body and 8.3% for antrum) (p < 0.001). Conclusions: ER of gastric SETs may be feasible and safe method for pathologic confirmation and further strategy.

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