scholarly journals A feedback control architecture for bioelectronic devices with applications to wound healing

2021 ◽  
Vol 18 (185) ◽  
Author(s):  
Bashir Hosseini Jafari ◽  
Ksenia Zlobina ◽  
Giovanny Marquez ◽  
Mohammad Jafari ◽  
John Selberg ◽  
...  
Keyword(s):  
Wound Healing ◽  
Feedback Control ◽  
Sliding Mode ◽  
Biological Response ◽  
Control Architecture ◽  
Target Area ◽  
Modular Control ◽  
Accelerate Wound Healing ◽  
Information Tracking ◽  
Bioelectronic Device

Bioelectronic devices can provide an interface for feedback control of biological processes in real-time based on sensor information tracking biological response. The main control challenges are guaranteeing system convergence in the presence of saturating inputs into the bioelectronic device and complexities from indirect control of biological systems. In this paper, we first derive a saturated-based robust sliding mode control design for a partially unknown nonlinear system with disturbance. Next, we develop a data informed model of a bioelectronic device for in silico simulations. Our controller is then applied to the model to demonstrate controlled pH of a target area. A modular control architecture is chosen to interface the bioelectronic device and controller with a bistable phenomenological model of wound healing to demonstrate closed-loop biological treatment. External pH is regulated by the bioelectronic device to accelerate wound healing, while avoiding chronic inflammation. Our novel control algorithm for bioelectronic devices is robust and requires minimum information about the device for broad applicability. The control architecture makes it adaptable to any biological system and can be used to enhance automation in bioengineering to improve treatments and patient outcomes.

A Continuous First-Order Sliding Mode Control Law

2017 ◽  
Author(s):  
Keyvan Mohammadi ◽  
Andrea L’Afflitto
Keyword(s):  
Feedback Control ◽  
Sliding Mode Control ◽  
Closed Loop ◽  
Sliding Mode ◽  
Nonlinear Differential Equations ◽  
Nonlinear Observer ◽  
Control Architecture ◽  
Control Law ◽  
Control Laws ◽  
Mode Control

Sliding mode control is a technique to design robust feedback control laws. In its classical formulation, this approach involves discontinuous controls that arise several theoretical and practical challenges, such as the existence of non-unique solutions of nonlinear differential equations and chattering. Numerous variations of the sliding mode control architecture, such as the higher-order sliding mode method, have been presented to overcome these issues. In this paper, we present an alternative sliding mode control architecture that involves Hölder continuous feedback control laws, is simpler to implement than other non-classical nonlinear robust control techniques, guarantees robustness and uniform asymptotic stability of the closed-loop system, and ensures both existence and uniqueness of the closed-loop system’s trajectory. Our results are applied to design a robust nonlinear observer in the same form as the Walcott and Żak observer. Moreover, a numerical example illustrates our theoretical results and compares the proposed control law to the classical sliding mode control, the second order sliding mode control, and the super-twisting control.

Phytotherapy for wound healing: The most important herbal plants in wound healing based on Iranian etnobotanical documents

2020 ◽  
Vol 20 ◽  
Author(s):  
Kamal Solati ◽  
Mehrdad Karimi ◽  
Mahmoud Rafieian-Kopaei ◽  
Naser Abbasi ◽  
Saber Abbaszadeh ◽  
...  
Keyword(s):  
Wound Healing ◽  
Medicinal Plants ◽  
Aloe Vera ◽  
Datura Stramonium ◽  
New Drugs ◽  
Mentha Pulegium ◽  
Accelerate Wound Healing ◽  
Healing Tissue ◽  
Herbal Plants ◽  
Echium Amoenum

: Wound healing is a process which starts with inflammatory response after damage occurrence. This process happens by restoring the wound surface coating tissue, migrating fibroblasts to form the needed collagen, forming a healing tissue and finally contortion and extraction of the wound. Today, various drugs are used to heal the wound. However, the used drugs to repair wounds have some defects and side effects. In spite of all attempts to accelerate wound healing definitely, no safe drug has been introduced for this purpose. Therefore, the necessity of identifying herbal plants in ethnopharmacology and ethnobotany documents with healing effect is felt essential. In this article we tried to review and present Iranian effective medicinal plants and herbal compounds used for wound healing. Searching was performed on databases including ISI Web of Science, PubMed, PubMed Central, Scopus, ISC, SID, Magiran and some other databases. The keywords used included wound healing, skin treatment, medicinal plants, ethnobotany, and phytotherapy. In this regard, 139 effective medicinal plants on wound healing were identified based on ethnopharmacology and ethnobotanical sources of Iran. Medicinal plants such as Salvia officinalis, Echium amoenum, Verbascum spp., G1ycyrrhiza glabra, Medicago sativa, Mentha pulegium, Datura stramonium L., Alhagi spp., Aloe vera, Hypericum perforatum, Pistacia atlantica and Prosopis cineraria were the most important and effective medicinal plants on wound healing in Iran. These native Iranian medicinal plants are full of antioxidants and biological compounds and might be used for wound healing and preparation of new drugs.

Statistical Feedback Control Architecture for Layered Manufacturing

1999 ◽  
Vol 7 (4) ◽  
pp. 391-404 ◽  
Author(s):  
TONG FANG ◽  
MOHSEN A. JAFARI ◽  
AHMAD SAFARI ◽  
STEPHEN C. DANFORTH
Keyword(s):  
Feedback Control ◽  
Layered Manufacturing ◽  
Control Architecture

scholarly journals Development of a Topical Insulin Polymeric Nanoformulation for Skin Burn Regeneration: An Experimental Approach

2021 ◽  
Vol 22 (8) ◽  
pp. 4087
Author(s):  
Maria Quitério ◽  
Sandra Simões ◽  
Andreia Ascenso ◽  
Manuela Carvalheiro ◽  
Ana Paula Leandro ◽  
...  
Keyword(s):  
Wound Healing ◽  
Healing Process ◽  
In Vitro Release ◽  
Peptide Hormone ◽  
Plga Nanoparticles ◽  
Wound Healing Process ◽  
Target Area ◽  
Encapsulation Process

Insulin is a peptide hormone with many physiological functions, besides its use in diabetes treatment. An important role of insulin is related to the wound healing process—however, insulin itself is too sensitive to the external environment requiring the protective of a nanocarrier. Polymer-based nanoparticles can protect, deliver, and retain the protein in the target area. This study aims to produce and characterize a topical treatment for wound healing consisting of insulin-loaded poly-DL-lactide/glycolide (PLGA) nanoparticles. Insulin-loaded nanoparticles present a mean size of approximately 500 nm and neutral surface charge. Spherical shaped nanoparticles are observed by scanning electron microscopy and confirmed by atomic force microscopy. SDS-PAGE and circular dichroism analysis demonstrated that insulin preserved its integrity and secondary structure after the encapsulation process. In vitro release studies suggested a controlled release profile. Safety of the formulation was confirmed using cell lines, and cell viability was concentration and time-dependent. Preliminary safety in vivo assays also revealed promising results.

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