scholarly journals Harvest strategies for the elimination of low prevalence wildlife diseases

2021 ◽  
Vol 8 (3) ◽  
Author(s):  
Atle Mysterud ◽  
Hildegunn Viljugrein ◽  
Christer M. Rolandsen ◽  
Aniruddha V. Belsare
Keyword(s):  
Disease Surveillance ◽  
Rangifer Tarandus ◽  
Time Window ◽  
Disease Prevalence ◽  
Management Approach ◽  
Wildlife Diseases ◽  
Demographic Groups ◽  
Short Time Window ◽  
Transmission Period ◽  
Low Prevalence

The intensive harvesting of hosts is often the only practicable strategy for controlling emerging wildlife diseases. Several harvesting approaches have been explored theoretically with the objective of lowering transmission rates, decreasing the transmission period or specifically targeting spatial disease clusters or high-risk demographic groups. Here, we present a novel model-based approach to evaluate alternative harvest regimes, in terms of demographic composition and rates, intended to increase the probability to remove all infected individuals in the population during the early phase of an outbreak. We tested the utility of the method for the elimination of chronic wasting disease based on empirical data for reindeer ( Rangifer tarandus ) in Norway, in populations with (Nordfjella) and without (Hardangervidda) knowledge about exact disease prevalence and population abundance. Low and medium harvest intensities were unsuccessful in eliminating the disease, even at low prevalence. High-intensity harvesting had a high likelihood of eliminating the disease, but probability was strongly influenced by the disease prevalence. We suggest that the uncertainty about disease prevalence can be mitigated by using an adaptive management approach: forecast from models after each harvest season with updated data, derive prevalence estimates and forecast further harvesting. We identified the problems arising from disease surveillance with large fluctuations in harvesting pressure and hence sample sizes. The elimination method may be suitable for pathogens that cause long-lasting infections and with slow epidemic growth, but the method should only be attempted if there is a low risk of reinfection, either by a new disease introduction event (e.g. dispersing hosts) or due to environmental reservoirs. Our simulations highlighted the short time window when such a strategy is likely to be successful before approaching near complete eradication of the population.

scholarly journals 231 A SHORT TIME WINDOW TO PROFIT FROM IL-4 PLUS IL-10 ADDITION TO PROTECT CARTILAGE FROM BLOOD-INDUCED DAMAGE IN VITRO

2011 ◽  
Vol 19 ◽  
pp. S113
Author(s):  
M.E. van Meegeren ◽  
N.W. Jansen ◽  
G. Roosendaal ◽  
S.C. Mastbergen ◽  
F.P. Lafeber
Keyword(s):  
Time Window ◽  
Short Time Window ◽  
Short Time

scholarly journals 383. Feasibility of Specimen Self-collection in Young Children Undergoing SARS-CoV-2 Surveillance for In-person Learning

2021 ◽  
Vol 8 (Supplement_1) ◽  
pp. S293-S293
Author(s):  
Jonathan Altamirano ◽  
Grace Tam ◽  
Marcela Lopez ◽  
India Robinson ◽  
Leanne Chun ◽  
...  
Keyword(s):  
Young Children ◽  
Time Window ◽  
School Administrators ◽  
Error Rates ◽  
Independent Observer ◽  
Specimen Collection ◽  
Timing Data ◽  
Short Time Window ◽  
Short Time ◽  
Over Time

Abstract Background While pediatric cases of COVID-19 are at low risk for adverse events, schoolchildren should be considered for surveillance as they can become infected at school and serve as sources of household or community transmission. Our team assessed the feasibility of young children self-collecting SARS-CoV-2 samples for surveillance testing in an educational setting. Methods Students at a K-8 school were tested weekly for SARS-CoV-2 from September 2020 - June 2021. Error rates were collected from September 2020 - January 2021. Clinical staff provided all students with instructions for anterior nares specimen self-collection and then observed them to ensure proper technique. Instructions included holding the sterile swab while making sure not to touch the tip, inserting the swab into their nostril until they start to feel resistance, and rubbing the swab in four circles before repeating the process in their other nostril. An independent observer timed random sample self-collections from April - June 2021. Results 2,590 samples were collected from 209 students during the study period when data on error rates were collected. Errors occurred in 3.3% of all student encounters (n=87). Error rates over time are shown in Figure 1, with the highest rate occurring on the first day of testing (n=20/197, 10.2%) and the lowest in January 2021 (n=1/202, 0.5%). 2,574 visits for sample self-collection occurred during the study period when independent timing data was collected (April - June 2021). Of those visits, 7.5% (n=193) were timed. The average duration of each visit was 70 seconds. Figure 1. Swab Error Rates Over Time Conclusion Pediatric self-collected lower nasal swabs are a viable and easily tolerated specimen collection method for SARS-CoV-2 surveillance in school settings, as evidenced by the low error rate and short time window of sample self-collection during testing. School administrators should expect errors to drop quickly after implementing testing. Disclosures All Authors: No reported disclosures

Dual origin of the floor plate in the avian embryo

Development ◽  
2002 ◽  
Vol 129 (20) ◽  
pp. 4785-4796 ◽  
Author(s):  
Jean-Baptiste Charrier ◽  
Françoise Lapointe ◽  
Nicole M. Le Douarin ◽  
Marie-Aimée Teillet
Keyword(s):  
Time Window ◽  
Gene Expression Pattern ◽  
Floor Plate ◽  
Avian Embryo ◽  
Plate Formation ◽  
Unknown Factor ◽  
Short Time Window ◽  
Neural Ectoderm ◽  
Dual Origin ◽  
Short Time

Molecular analysis carried out on quail-chick chimeras, in which quail Hensen’s node was substituted for its chick counterpart at the five- to six-somite stage (ss), showed that the floor plate of the avian neural tube is composed of distinct areas: (1) a median one (medial floor plate or MFP) derived from Hensen’s node and characterised by the same gene expression pattern as the node cells (i.e. expression of HNF3β and Shh to the exclusion of genes early expressed in the neural ectoderm such as CSox1); and (2) lateral regions that are differentiated from the neuralised ectoderm (CSox1 positive) and form the lateral floor plate (LFP). LFP cells are induced by the MFP to express HNF3β transiently, Shh continuously and other floor-plate characteristic genes such as Netrin. In contrast to MFP cells, LFP cells also express neural markers such as Nkx2.2 and Sim1. This pattern of avian floor-plate development presents some similarities to floor-plate formation in zebrafish embryos. We also demonstrate that, although MFP and LFP have different embryonic origins in normal development, one can experimentally obtain a complete floor plate in the neural epithelium by the inductive action of either a notochord or a MFP. The competence of the neuroepithelium to respond to notochord or MFP signals is restricted to a short time window, as only the posterior-most region of the neural plate of embryos younger than 15 ss is able to differentiate a complete floor plate comprising MFP and LFP. Moreover, MFP differentiation requires between 4 and 5 days of exposure to the inducing tissues. Under the same conditions LFP and SHH-producing cells only induce LFP-type cells. These results show that the capacity to induce a complete floor plate is restricted to node-derived tissues and probably involves a still unknown factor that is not SHH, the latter being able to induce only LFP characteristics in neuralised epithelium.

REGULAR ARTICLES / ARTICLES RÉGULIERSFactors affecting the distribution and transmission of Elaphostrongylus rangiferi (Protostrongylidae) in caribou (Rangifer tarandus caribou) of Newfoundland, Canada

2001 ◽  
Vol 79 (7) ◽  
pp. 1265-1277 ◽  
Author(s):  
Mark C Ball ◽  
Murray W Lankester ◽  
Shane P Mahoney
Keyword(s):  
Rangifer Tarandus ◽  
Climatic Factors ◽  
Rangifer Tarandus Caribou ◽  
Intermediate Hosts ◽  
Parasite Abundance ◽  
Annual Minimum Temperature ◽  
Transmission Period ◽  
Summer Temperatures ◽  
Elaphostrongylus Rangiferi ◽  
Dual Infections

Elaphostrongylus rangiferi was introduced to caribou (Rangifer tarandus caribou) of Newfoundland by infected reindeer (R. t. tarandus) from Norway and has caused at least two epizootics of cerebrospinal elaphostrongylosis (CSE), a debilitating neurologic disease. In an attempt to understand the conditions necessary for such outbreaks, we examined the effects of herd density and climatic factors on parasite abundance. The abundance of E. rangiferi was represented by counts of first-stage larvae in feces collected from young caribou (calves and yearlings) in 7 distinct caribou herds in Newfoundland. Abundance of E. rangiferi was highest in February and in the Avalon (632 ± 14 (mean ± SE)) and St. Anthony (526 ± 145) herds, the 2 herds in which CSE was most frequently reported. Mean abundance in February samples from young animals correlated positively with mean annual minimum temperature (rS = 0.829, df = 6, P = 0.04) and the number of days per year above 0°C (rS = 0.812, df = 6, P = 0.05) and negatively with mean summer temperatures (rS = –0.830, df = 6, P = 0.04). Results suggest that abundance of E. rangiferi and the likelihood of cases of CSE are increased by moderate summer temperatures suitable for the activity and infection of gastropod intermediate hosts and by mild winters with little snow that extend the transmission period. Abundance of larvae was not correlated with herd density. Animals in all 7 herds also had the muscle worm Parelaphostrongylus andersoni, a related nematode with similar dorsal-spined larvae. In 2 additional herds (Cape Shore and Bay de Verde), P. andersoni occurred alone and larvae were passed only by young caribou. In herds with dual infections, numbers of P. andersoni larvae were depressed, declined more quickly in young animals, and were considered to be present in only low numbers in February samples used for E. rangiferi analysis. Upon initial infection, young caribou develop a resistance to E. rangiferi that prevents or reduces reinfection later in life. This was demonstrated by examining the brains of caribou for recently acquired worms, which must develop there for up to 90 days before continuing their tissue migration into the skeletal muscles. Recent infections were detected in only calves and yearlings in all herds with E. rangiferi except the Avalon herd, where developing worms were also found on the brains of older caribou. The infection of older animals in the Avalon herd may reflect a lower immunocompetence of a naive herd that has only recently been exposed to E. rangiferi.

scholarly journals A New Method for Automated Clearcut Disturbance Detection in Mediterranean Coppice Forests Using Landsat Time Series

2020 ◽  
Vol 12 (22) ◽  
pp. 3720 ◽  
Author(s):  
Francesca Giannetti ◽  
Raffaello Pegna ◽  
Saverio Francini ◽  
Ronald E. McRoberts ◽  
Davide Travaglini ◽  
...  
Keyword(s):  
Time Series ◽  
Sustainable Forest Management ◽  
Time Window ◽  
Detection Algorithm ◽  
Forest Disturbances ◽  
Forest Change ◽  
Short Time Window ◽  
Short Time ◽  
Automated Procedures ◽  
Disturbance Detection

A Landsat time series has been recognized as a viable source of information for monitoring and assessing forest disturbances and for continuous reporting on forest dynamics. This study focused on developing automated procedures for detecting disturbances in Mediterranean coppice forests which are characterized by rapid regrowth after a cut. Specifically, new methods specific to Mediterranean coppice forests are needed for mapping clearcut disturbances over time and for estimating related indicators in the context of Sustainable Forest Management and Biodiversity International monitoring frameworks. The aim of this work was to develop a new change detection algorithm for mapping clearcut disturbances in Mediterranean coppice forests with Landsat time series (LTS) using a short time window. Accuracy for the new algorithm, characterized as the Two Thresholds Method (TTM), was evaluated using an independent clearcut reference dataset over a temporal period of the 13 years between 2001 and 2013. TTM was also evaluated against two benchmark approaches: (i) LandTrendr, and (ii) the forest loss category of the Global Forest Change Map. Overall Accuracy for LandTrendr and TTM were greater than 0.94. Meanwhile, smaller accuracies were always obtained for the GFC. In particular, Producer’s Accuracy ranged between 0.45 and 0.84 for TTM and between 0.49 and 0.83 for LT, while for the GFC, PA ranged between 0 and 0.38. User’s Accuracy ranged between 0.86 and 0.96 for TTM and between 0.73 and 0.91 for LT, while for the GFC UA ranged between 0.19 and 1.00. Moreover, to illustrate the utility of TTM for mapping clearcut disturbances in Mediterranean coppice forests, we applied TTM to a Landsat scene that covered almost the entirety of the Tuscany region in Italy.

Parameters of Spike Trains Observed in a Short Time Window

2008 ◽  
Vol 20 (5) ◽  
pp. 1325-1343 ◽  
Author(s):  
Zbyněk Pawlas ◽  
Lev B. Klebanov ◽  
Martin Prokop ◽  
Petr Lansky
Keyword(s):  
Coefficient Of Variation ◽  
Point Processes ◽  
Interspike Interval ◽  
Time Window ◽  
Time Windows ◽  
Time Interval ◽  
Short Time Interval ◽  
Target Neuron ◽  
Short Time Window ◽  
Short Time

We study the estimation of statistical moments of interspike intervals based on observation of spike counts in many independent short time windows. This scenario corresponds to the situation in which a target neuron occurs. It receives information from many neurons and has to respond within a short time interval. The precision of the estimation procedures is examined. As the model for neuronal activity, two examples of stationary point processes are considered: renewal process and doubly stochastic Poisson process. Both moment and maximum likelihood estimators are investigated. Not only the mean but also the coefficient of variation is estimated. In accordance with our expectations, numerical studies confirm that the estimation of mean interspike interval is more reliable than the estimation of coefficient of variation. The error of estimation increases with increasing mean interspike interval, which is equivalent to decreasing the size of window (less events are observed in a window) and with decreasing the number of neurons (lower number of windows).

scholarly journals Market volatility modeling for short time window

2011 ◽  
Vol 390 (20) ◽  
pp. 3444-3453 ◽  
Author(s):  
Paulo S.G. de Mattos Neto ◽  
David A. Silva ◽  
Tiago A.E. Ferreira ◽  
George D.C. Cavalcanti
Keyword(s):  
Time Window ◽  
Market Volatility ◽  
Volatility Modeling ◽  
Short Time Window ◽  
Short Time

scholarly journals Interaction between Workers during a Short Time Window Is Required for Bacterial Symbiont Transmission in Acromyrmex Leaf-Cutting Ants

PLoS ONE ◽  
2014 ◽  
Vol 9 (7) ◽  
pp. e103269 ◽  
Author(s):  
Sarah E. Marsh ◽  
Michael Poulsen ◽  
Adrián Pinto-Tomás ◽  
Cameron R. Currie
Keyword(s):  
Time Window ◽  
Bacterial Symbiont ◽  
Short Time Window ◽  
Symbiont Transmission ◽  
Leaf Cutting ◽  
Short Time

scholarly journals A three-minute test of implicit language processing for large sample sizes: Proof-of-concept application in a public science event

2020 ◽  
Author(s):  
Gwen Brekelmans ◽  
Claudia Bruns ◽  
Vanessa Meitanis ◽  
Michael Coleman ◽  
Vitor Zimmerer
Keyword(s):  
Language Processing ◽  
Native Speakers ◽  
Time Window ◽  
Proof Of Concept ◽  
Monitoring Methods ◽  
Public Science ◽  
Monitoring Task ◽  
Significant Difference ◽  
Short Time Window ◽  
Short Time

Research into human language processing is challenged by its implicit nature of processes, the short time-window in which they take place, and heterogeneity within the population. We used a word monitoring task to measure implicit sensitivity to grammar, semantics, and the strength of word collocations, when listening to natural spoken sentences. We report substantial and novel adjustments to the paradigm, which allowed a participant to be tested in about three minutes, and data from a proof-of-concept study for which we recruited 125 visitors of different backgrounds to a science event. Linear mixed-effects models suggest that participants’ response time to target words was 45ms slower when words were less predictable in their grammatical, semantic, or collocational context (p = .034). There was no significant difference between language conditions. However, in non-native speakers, grammatical manipulation was less effective than manipulations of semantics and word collocations (p < .08), which is consistent with theories of shallow language processing in non-native speakers. There was no significant effect of age on language sensitivity. Effects generally replicated findings based on standard word-monitoring methods, suggesting that the novel adjustments can be applied in situations where participants’ time is limited, e.g. at events, in schools or online.

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