scholarly journals Co-evolution of cooperation and cognition: the impact of imperfect deliberation and context-sensitive intuition

2017 ◽  
Vol 284 (1851) ◽  
pp. 20162326 ◽  
Author(s):  
Adam Bear ◽  
Ari Kagan ◽  
David G. Rand
Keyword(s):  
Social Dilemmas ◽  
Coordination Games ◽  
Evolution Of Cooperation ◽  
Contextual Cues ◽  
Cognitive Constraints ◽  
Context Sensitive ◽  
Active Selection ◽  
Selection For ◽  
The Impact ◽  
Cognitive Sophistication

How does cognitive sophistication impact cooperation? We explore this question using a model of the co-evolution of cooperation and cognition. In our model, agents confront social dilemmas and coordination games, and make decisions using intuition or deliberation. Intuition is automatic and effortless, but relatively (although not necessarily completely) insensitive to context. Deliberation, conversely, is costly but relatively (although not necessarily perfectly) sensitive to context. We find that regardless of the sensitivity of intuition and imperfection of deliberation, deliberating undermines cooperation in social dilemmas, whereas deliberating can increase cooperation in coordination games if intuition is sufficiently sensitive. Furthermore, when coordination games are sufficiently likely, selection favours a strategy whose intuitive response ignores the contextual cues available and cooperates across contexts. Thus, we see how simple cognition can arise from active selection for simplicity, rather than just be forced to be simple due to cognitive constraints. Finally, we find that when deliberation is imperfect, the favoured strategy increases cooperation in social dilemmas (as a result of reducing deliberation) as the benefit of cooperation to the recipient increases.

scholarly journals Conformity enhances network reciprocity in evolutionary social dilemmas

2015 ◽  
Vol 12 (103) ◽  
pp. 20141299 ◽  
Author(s):  
Attila Szolnoki ◽  
Matjaž Perc
Keyword(s):  
Social Dilemmas ◽  
Interaction Network ◽  
Evolution Of Cooperation ◽  
Effective Surface ◽  
Interaction Range ◽  
Testing Conditions ◽  
Social Animals ◽  
Crowd Behaviour ◽  
Common Strategy ◽  
The Impact

The pursuit of highest payoffs in evolutionary social dilemmas is risky and sometimes inferior to conformity. Choosing the most common strategy within the interaction range is safer because it ensures that the payoff of an individual will not be much lower than average. Herding instincts and crowd behaviour in humans and social animals also compel to conformity in their own right. Motivated by these facts, we here study the impact of conformity on the evolution of cooperation in social dilemmas. We show that an appropriate fraction of conformists within the population introduces an effective surface tension around cooperative clusters and ensures smooth interfaces between different strategy domains. Payoff-driven players brake the symmetry in favour of cooperation and enable an expansion of clusters past the boundaries imposed by traditional network reciprocity. This mechanism works even under the most testing conditions, and it is robust against variations of the interaction network as long as degree-normalized payoffs are applied. Conformity may thus be beneficial for the resolution of social dilemmas.

scholarly journals Identifying Critical Binder Attributes to Facilitate Binder Selection for Efficient Formulation Development in a Continuous Twin Screw Wet Granulation Process

Pharmaceutics ◽  
2021 ◽  
Vol 13 (2) ◽  
pp. 210
Author(s):  
Lise Vandevivere ◽  
Maxine Vangampelaere ◽  
Christoph Portier ◽  
Cedrine de Backere ◽  
Olaf Häusler ◽  
...  
Keyword(s):  
Dissolution Kinetics ◽  
Wet Granulation ◽  
Continuous Manufacturing ◽  
Formulation Development ◽  
Granulation Process ◽  
Low Viscosity ◽  
Twin Screw ◽  
Poorly Soluble ◽  
Selection For ◽  
The Impact

The suitability of pharmaceutical binders for continuous twin-screw wet granulation was investigated as the pharmaceutical industry is undergoing a switch from batch to continuous manufacturing. Binder selection for twin-screw wet granulation should rely on a scientific approach to enable efficient formulation development. Therefore, the current study identified binder attributes affecting the binder effectiveness in a wet granulation process of a highly soluble model excipient (mannitol). For this formulation, higher binder effectiveness was linked to fast activation of the binder properties (i.e., fast binder dissolution kinetics combined with low viscosity attributes and good wetting properties by the binder). As the impact of binder attributes on the granulation process of a poorly soluble formulation (dicalcium phosphate) was previously investigated, this enabled a comprehensive comparison between both formulations in current research focusing on binder selection. This comparison revealed that binder attributes that are important to guide binder selection differ in function of the solubility of the formulation. The identification of critical binder attributes in the current study enables rational and efficient binder selection for twin-screw granulation of well soluble and poorly soluble formulations. Binder addition proved especially valuable for a poorly soluble formulation.

scholarly journals The Impact of Selection using Residual Average Daily Gain and Marbling EPDs on Growth Performance and Carcass Traits in Angus Steers

2019 ◽  
Vol 3 (2) ◽  
Author(s):  
T. R. Krause ◽  
E. R. Moore ◽  
J. Duggin ◽  
J. R. Segers ◽  
T. D. Pringle
Keyword(s):  
Growth Performance ◽  
Feed Efficiency ◽  
Average Daily Gain ◽  
Backfat Thickness ◽  
Feeding Trial ◽  
Body Weights ◽  
Selection For ◽  
Carcass Merit ◽  
The Impact ◽  
Daily Gain

ObjectivesProfitability in the beef industry has narrow margins regulated by revenue from output traits like growth and carcass merit, but profitability is also largely impacted by input expenses like feed costs. Selecting for improvements in feed efficiency during the finishing phase, one of the most feed intensive segments of the industry, can help to mitigate those input costs. This study compared growth performance, feed efficiency, body composition, and carcass characteristics in Angus steers (n = 321) from bulls divergently selected for feed efficiency and marbling.Materials and MethodsAngus sires were selected based on high (10th percentile or better) and low (85th percentile or worse) residual average daily gain (RADG) EPD as well as high (fifth percentile or better) and average (near 50th percentile) marbling (MARB) EPD. These criteria resulted in a 2 × 2 factorial design with four breeding lines: high RADG/high MARB, high RADG/average MARB, low RADG/high MARB, low RADG/average MARB. Data were analyzed using MIXED procedures of SAS with RADG and MARB as main effects. Significance was set at α = 0.05. Generation was also analyzed, where generation one (GEN1) steers were from a selected sire while generation two (GEN2) steers were from a selected sire and a selected dam.ResultsUltrasound and carcass data revealed no differences (P ≥ 0.12) in 12th rib backfat thickness from weaning through slaughter for the RADG EPD groups. Yield grade and dressing percent did not differ (P ≥ 0.56) across RADG or MARB groups. At the beginning and end of the feeding trial, the high RADG (P ≤ 0.02) group had larger ultrasound ribeye area (REA) than the low RADG group. Carcass REA tended (P = 0.08) to be larger in the high versus low RADG steers. During the feedlot trial and through slaughter, body weight was heavier (P ≤ 0.006) for the high versus low RADG steers but did not differ (P ≥ 0.44) across MARB EPD. Feed efficiency measures did not differ (P ≥ 0.32) across RADG or MARB groups apart from the tendency (P = 0.08) for residual feed intake to be lower in the high versus low RADG steers. Marbling scores differed (P ≤ 0.04) across RADG and MARB groups with the low RADG steers and the high MARB steers having improved marbling. The quality grade distribution across MARB EPD revealed that the average MARB steers graded 73% Choice and 25% Prime while the high MARB steers graded 56% and 42%, respectively. Slice shear force did not differ (P ≥ 0.32) across RADG or MARB EPD. Body weights tended (P = 0.06) to be heavier at the start of the feeding trial for GEN1 versus GEN2 steers. Total gain, average daily gain, and feed to gain (F:G) differed by generation (P ≤ 0.007) with increased rates of gain and reduced F:G in the GEN2 versus GEN1 steers. Body weights did not differ (P = 0.72) across GEN at the end of the feeding trial. Backfat thickness at the start and end of the feedlot phase was less (P ≤ 0.03) and marbling score was improved (P = 0.02) in the GEN2 versus GEN1 steers, respectively.ConclusionThese results suggest that selection using RADG EPD has negligible impacts on meat quality; and that progress in selection for efficiency can be achieved while advancing carcass quality and value. Furthermore, continued divergent selection for feed efficiency and marbling has the potential to improve feed efficiency through advancements in the rate of gain, while enhancing carcass merit through marbling.

scholarly journals MicroRNA-203 represses selection and expansion of oncogenic Hras transformed tumor initiating cells

eLife ◽  
2015 ◽  
Vol 4 ◽  
Author(s):  
Kent Riemondy ◽  
Xiao-jing Wang ◽  
Enrique C Torchia ◽  
Dennis R Roop ◽  
Rui Yi
Keyword(s):  
Cell Division ◽  
Skin Cancer ◽  
Mouse Model ◽  
Mouse Models ◽  
Knockout Mouse ◽  
Selection Process ◽  
Tumor Initiating Cells ◽  
Knockout Mouse Model ◽  
Active Selection ◽  
The Impact

In many mouse models of skin cancer, only a few tumors typically form even though many cells competent for tumorigenesis receive the same oncogenic stimuli. These observations suggest an active selection process for tumor-initiating cells. Here, we use quantitative mRNA- and miR-Seq to determine the impact of HrasG12V on the transcriptome of keratinocytes. We discover that microRNA-203 is downregulated by HrasG12V. Using a knockout mouse model, we demonstrate that loss of microRNA-203 promotes selection and expansion of tumor-initiating cells. Conversely, restoration of microRNA-203 using an inducible model potently inhibits proliferation of these cells. We comprehensively identify microRNA-203 targets required for Hras-initiated tumorigenesis. These targets include critical regulators of the Ras pathway and essential genes required for cell division. This study establishes a role for the loss of microRNA-203 in promoting selection and expansion of Hras mutated cells and identifies a mechanism through which microRNA-203 antagonizes Hras-mediated tumorigenesis.

Reward Dominance in Tax-Reporting Experiments: The Role of Context

1999 ◽  
Vol 21 (1) ◽  
pp. 20-31 ◽  
Author(s):  
Martha L. Wartick ◽  
Silvia A. Madeo ◽  
Cynthia C. Vines
Keyword(s):  
Experimental Economics ◽  
Real World ◽  
Psychological Theory ◽  
Role Playing ◽  
Contextual Cues ◽  
Individual Subject ◽  
The Past ◽  
Tax Reporting ◽  
The Impact

During the past decade, the experimental economics method increasingly has been used to study the impact of tax policy on taxpayer behavior. Experimental economics in taxation typically tests tax applications of expected utility and psychological theory by creating a real microeconomy in the laboratory. A key requirement is strict control over the parameters of the experimental setting and subject preferences. One generally accepted procedure to achieve experimental control is to avoid references to real-world phenomena in instructions to subjects. The reasoning underlying this procedure is that if subjects associate the experiment with real-world phenomena, they may make decisions based on values associated with the real-world context instead of the rewards and penalties of the microeconomy. Despite this, several recent tax-reporting experiments that otherwise conform to the experimental economics method have used explicit tax terminology. In discussing the results of these experiments, the authors and commentators stated that the results probably were not affected by the tax context. We conducted an experiment to further examine whether the results of a tax-reporting experiment were affected by context. We found that subjects reported significantly more income when the context of the experiment was tax than when the context was nontax. This effect differed, however, depending on the age of the subjects. While subjects 25 years of age and older reported approximately twice as much income in the tax context as they did in the nontax context, subjects under 25 reported only slightly more in the tax context than in the nontax context. These results provide evidence that role playing based on individual subject characteristics occurred when contextual cues were provided.

Decentralization in European and MENA Countries

2016 ◽  
pp. 1-27
Author(s):  
Francois Vaillancourt ◽  
Richard M. Bird
Keyword(s):  
National Unity ◽  
Mena Region ◽  
Mena Countries ◽  
Context Sensitive ◽  
The Road ◽  
The United Kingdom ◽  
Political Outcomes ◽  
Initial Question ◽  
On The Road ◽  
The Impact

The question considered in this chapter is whether decentralization is likely to hurt or help national unity in “countries at risk.” We begin with a literature review, focusing on three particular questions: the size and number of nations; the determinants of decentralization; and, finally, and bearing most directly on our topic, the links between decentralization and political outcomes. We next set out in capsule form some of the very mixed stories of linkages between decentralization and national unity found in Europe and the Middle East and North Africa (MENA) region, before considering more closely the ongoing discussions of secession in three European countries – Belgium, Spain and the United Kingdom. We conclude that the impact of decentralization on national unity is so complex and context-sensitive that no general answers to our initial question emerge: in some instances, decentralization may be an inducement for regions to stay in a country; in others, however, it may prove to be only a way station on the road to the exit.

scholarly journals Social Trust in the Middle East and North Africa: The Context-Dependent Impact of Citizens’ Socio-Economic and Religious Characteristics

2019 ◽  
Vol 35 (6) ◽  
pp. 894-911 ◽  
Author(s):  
Niels Spierings
Keyword(s):  
Middle East ◽  
North Africa ◽  
Social Trust ◽  
Context Dependency ◽  
Comparative Approach ◽  
Mena Region ◽  
Mena Countries ◽  
Systematic Assessment ◽  
Context Sensitive ◽  
The Impact

Abstract Our knowledge of social trust's drivers in the MENA region is limited and there are good reasons to expect that theories based on Western countries cannot be copied to the MENA one-to-one. Arguing for a broader and at the same time context-sensitive comparative approach, I translate the ‘societal winners’, social capital, and religious beliefs mechanisms explaining trust to the MENA context. Moreover, I acknowledge intraregional diversity and test how the impact of these factors also differs among MENA countries. Empirically, I synchronize 47 surveys from 15 MENA countries, which provides the broadest and most systematic assessment of trust in the MENA to date. The results show that the societal-winner mechanism does not hold: employed, higher education and wealthier citizens are not more trusting. However, higher-educated citizens distrust other citizens more, particularly in the strongest autocracies. Religiosity seems pivotal too. Among others, service-attending citizens are more trusting, mainly where regimes regulate religious affairs. Overall, this study provides insight into what shapes generalized social trust in the Middle East and North Africa and it underscores that at a comparative level we need to consider inter-regional and intra-regional forms of context-dependency were we to formulate a broadly applicable theoretical framework of trust's drivers.

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