scholarly journals Account of the dissection of a human fætus, in which the circulation of the blood was carried on without a heart

Mr. Brodie was induced to draw up the account of this case, although other instances are already recorded, because the child differed much less from the natural formation than usual. Twins were produced, both still-born, at the seventh month of pregnancy. The placenta was not preserved; but it was remarked that the chords belonging to the two children were, at their attachment, distant about three inches from each other. In one of these children nothing preternatural was observed. The other was distended, and disfigured with fluid contained in two cysts under the common integuments of the neck and thorax; but when the fluid was evacuated, the form was nearly natural, with the exception of a hare lip, and a deficiency of some of the toes and fingers. In the brain also, and nervous system, nothing unusual was observed. But in the thorax there was no heart, thymus gland, or pleura; and the substances corresponding to lungs, on each side, at the bifurcation of the trachea, were no more than one third of an inch in diameter, the thorax being filled with a dense cellular substance.

1814 ◽  
Vol 104 ◽  
pp. 102-106 ◽  

In a paper formerly communicated to this Society by Sir Everard Home, and since published in the Philosophical Transactions for the year 1809, some facts were stated which render it probable that the various animal secretions are dependent on the influence of the nervous system, and this opinion seemed to derive support from some physiological experiments which were afterwards instituted by myself, and in which it was observed, that after the functions of the brain had been destroyed, although the action of the heart continued, and the circulation of the blood was maintained as under ordinary circumstances, the secreting organs invariably ceased to perform their office. It has been attempted by former physiologists to determine how far the nerves are necessary to secretion, but there are considerable obstacles in the way of this inquiry, and no observations, that have been hitherto made, appear to throw a great deal of light on the subject. The only method, which can be devised, of ascertaining by direct experiment, whether the nerves are really necessary to secretion, is that of dividing the nervous branches by which the glands are supplied. But this, with respect to the greater number of the glands, is an experiment impossible to perform; and, with respect to others, can not be executed without so much disturbance and injury to the other parts, as must render it extremely difficult to arrive at any positive results. Perhaps in future investigations, some circumstances may arise, which will enable us to determine more satisfactorily this important physiological question. In the mean time, as the labours of physiologists have hitherto contributed so little to this purpose, any facts that tend to its elucidation may deserve to be recorded, and I am therefore induced to lay before the Society the following experiments, which afford one example of a secretion being dependent on the influence of the nerves.


Author(s):  
Walter Ott

Descartes’s treatment of perception in the Optics, though published before the Meditations, contains a distinct account of sensory experience. The end of the chapter suggests some reasons for this oddity, but that the two accounts are distinct is difficult to deny. Descartes in the present work topples the brain image from its throne. In its place, we have two mechanisms, one purely causal, the other inferential. Where the proper sensibles are concerned, the ordination of nature suffices to explain why a given sensation is triggered on the occasion of a given brain motion. The same is true with regard to the common sensibles. But on top of this purely causal story, Descartes re-introduces his doctrine of natural geometry.


2008 ◽  
Vol 24 (3) ◽  
pp. 419-429 ◽  
Author(s):  
Anthony Landreth ◽  
John Bickle

We briefly describe ways in which neuroeconomics has made contributions to its contributing disciplines, especially neuroscience, and a specific way in which it could make future contributions to both. The contributions of a scientific research programme can be categorized in terms of (1) description and classification of phenomena, (2) the discovery of causal relationships among those phenomena, and (3) the development of tools to facilitate (1) and (2). We consider ways in which neuroeconomics has advanced neuroscience and economics along each line. Then, focusing on electrophysiological methods, we consider a puzzle within neuroeconomics whose solution we believe could facilitate contributions to both neuroscience and economics, in line with category (2). This puzzle concerns how the brain assigns reward values to otherwise incomparable stimuli. According to the common currency hypothesis, dopamine release is a component of a neural mechanism that solves comparability problems. We review two versions of the common currency hypothesis, one proposed by Read Montague and colleagues, the other by William Newsome and colleagues, and fit these hypotheses into considerations of rational choice.


Hypertension ◽  
2020 ◽  
Vol 76 (3) ◽  
pp. 622-628
Author(s):  
Daniela Carnevale

The nervous system and the immune system share the common ability to exert gatekeeper roles at the interfaces between internal and external environment. Although interaction between these 2 evolutionarily highly conserved systems has been recognized for long time, the investigation into the pathophysiological mechanisms underlying their crosstalk has been tackled only in recent decades. Recent work of the past years elucidated how the autonomic nervous system controls the splenic immunity recruited by hypertensive challenges. This review will focus on the neural mechanisms regulating the immune response and the role of this neuroimmune crosstalk in hypertension. In this context, the review highlights the components of the brain-spleen axis with a focus on the neuroimmune interface established in the spleen, where neural signals shape the immune response recruited to target organs of high blood pressure.


The intention of the author in the present paper, is, not to bring forwards any new facts, but to take a general review of the inferences deducible from the series of facts detailed by him in previous papers communicated to this Society. He divides the nerves into two classes, essentially differing in their functions. The first comprehends those nerves, which, proceeding directly from the brain and spinal cord to other parts, convey in the one case to those parts the influence of those organs only from which they originate, and thus excite to con­traction the muscles of voluntary motion ; and in the other case transmit to the sensorium impressions made on the parts to which they are distributed. The second class comprises what may betermed the Ganglionic nerves, or those which enter ganglions, pro­perly so called; that term being limited to such protuberances only as receive branches of nerves proceeding from the brain and spiral cord. These nerves are distributed more especially to the vital or­ gans, as the thoracic and abdominal viscera, and to the muscles sub­servient to their functions. The nerves belonging to this class also convey impressions to the sensorium, and occasionally excite the muscles of involuntary motion, which, in common with all muscles, possess an inherent power of contractility dependent solely on their own mechanism, and which in ordinary cases are excited by stimuli peculiar to themselves. But the most important function of the gan­glionic nerves, is that of supporting the processes of secretion and assimilation, which require for their performance the combined influ­ence of the whole brain and spinal cord. Viewed as a whole, the system of ganglionic nerves, therefore, constitutes, in the strictest sense, a vital organ. Thus the sensorium, though connected by means of the cerebral and spinal nerves only partially with the organs of sense and voluntary motion, is, by means of the ganglionic nerves, connected generally with all the functions of the animal body. Hence affections of the stomach and other vital organs extend their influence over every part of the frame; while those of a muscle of voluntary motion, or even of an organ of sense, although possessing greater sensibility, are confined to the injured part. From a due consideration of the phenomena of the nervous system, it would appear that they imply the operation of more than one prin­ciple of action. The sensorial power is wholly distinct from the ner­vous power; the former residing chiefly in the brain, while the latter belongs equally to the spinal cord and brain, and may be exercised independently of the sensorial power. In like manner, the muscular power resides in the muscles, and may be called into action by various irritations independently of the nervous power, though fre­quently excited by the action of that power. The muscles of volun­tary motion are subjected to the sensorial power through the inter­vention of the nervous system; and those of involuntary motion are also, under certain circumstances, capable of being excited through the nerves by the sensorial power, particularly when under the influ­ence of the passions. The same observation applies also to other actions which properly belong to the nervous power, such as the evolution of caloric from the blood, and the various processes of se­cretion and of assimilation. That the nervous power is in these instances merely the agent of other powers, and is independent of the peculiar organization of the nerves, is proved by the same effects being produced by galvanism, transmitted through conductors diffe­rent from the nerves. The successive subordination of these several powers is shown during death, when the sensorial functions are the first to cease, and the animal no longer feels or wills, but yet the nervous power still continues to exist, as is proved by the nerves be­ing capable, when stimulated, of exciting contractions in the muscles, both of voluntary and of involuntary motion,of producing the evolution of caloric and of renewing the processes of secretion. In like manner the power of contraction, inherent in the muscular fibre, survives the destniction of both the sensorial and nervous powers, having an existence independent of either, although in the entire state of the functions they are subjected to the entire influence of both.


2020 ◽  
Vol 57 (3) ◽  
pp. 288-292
Author(s):  
K. Taira ◽  
M. Takechi ◽  
H. K. Ooi

SummaryMigration of Baylisascaris potosis larvae in different mouse strains were compared, and infectivity of the persisting larvae in mice tissues were investigated. Five strains of mice, BALB/c, C57BL/6, AKR, B10.BR, and ICR were inoculated with 1,000 B. potosis eggs/mouse, and necropsied at week 13 post inoculation (PI). The other uninfected ICR mice (secondary host) were inoculated with 43 larvae/ mouse recovered from mice at week 13 PI with eggs, and necropsied at day 21 PI. Larvae in organs or tissues were counted at necropsy. One AKR mouse showed torticollis and circling at day 56 PI. At necropsy at week 13 PI, larvae were recovered from all mice. A mean total larvae recovered were 124.1 (n=40). Majority of larvae were found in the carcass (mean 113.9) and some in the viscera (mean 9.9). Zero to 1 larva were found in the brain or eyes of some mice. There were no differences among the mouse strains in the number of larvae, except in the viscera; more larvae were seen in BALB/c or ICR than in B10.BR mice. No larvae were found in the secondary host mice. Present study demonstrated that B. potosis larvae migrate well in the carcass of any strains of mice, however, the tissue larvae did not infect the secondary host. Results of our present study suggest that B. potosis larvae is less aggressive for the nervous tissue migration than that of B. procyonis larvae which is commonly known to migrate in central nervous system of mammals and birds.


1880 ◽  
Vol 26 (114) ◽  
pp. 201-215 ◽  
Author(s):  
W. G. Davies

That there are two methods by which to approach the study of mind—the one inward and reflective, the other outward and transitive, including more especially the anatomy and physiology of the brain and nervous system—is by high authorities, even in physical and biological science, now generally admitted.


1809 ◽  
Vol 99 ◽  
pp. 161-168 ◽  

An opportunity lately occurred to me of examining a human fœtus, in which the heart was wanting, and the circulation of the blood was carried on by the action of the vessels only. There have been some other instances of this remarkable deviation from the natural structure; but in that to which I allude the growth of the child had been natural, and it differed much less from the natural formation than in any of those, which are on record, and I have therefore been induced to draw up the following account of it. A woman was delivered of twins in the beginning of the seventh month of pregnancy. There was a placenta with two umbilical chords, which had their origin about three inches distant from each other. The placenta was not preserved, but Mr. Adams, who attended the mother in her lying-in, observed nothing unusual in its appearance. Both fœtuses were born dead. They were nearly of the same size. One of them in no respect differed from the ordinary formation; the other had an unusual appearance, and Mr. Adams thought it deserving of examination. Through Dr. Hooper it was put into my hands for this purpose.


CNS Spectrums ◽  
2011 ◽  
Vol 16 (5) ◽  
pp. 121-126 ◽  
Author(s):  
J. Douglas Miles ◽  
Laurie McWilliams ◽  
Wendy Liu ◽  
David C. Preston

AbstractWegener granulomatosis (WG) is an uncommon, idiopathic disorder that is characterized by granulomatous inflammation of the upper and lower respiratory tract, disseminated vasculitis involving small and medium-sized vessels, and focal segmental glomerulonephritis. Approximately 25% to 50% of patients have nervous system involvement. The brain is less frequently involved. We report a case of a 74 year-old previously well woman who presented with rapidly progressing WG that culminated in subarachnoid hemorrhage. Only six cases of subarachnoid hemorrhage in the setting of WG have previously been reported. We review the common presenting signs and symptoms, diagnosis, treatment, and complications of WG.


1990 ◽  
Vol 148 (1) ◽  
pp. 313-324 ◽  
Author(s):  
PETER BRÄUNIG

Paired peripheral ganglia within the locust mandibular segment are described. Each mandibular ganglion contains the cell bodies of 22–25 neurones. Four of these are sensory neurones which innervate the receptor strand of one of the mandibular proprioceptors. The other neurones connect the suboesophageal ganglion with the tritocerebral lobes of the brain, and with the first ganglion of the stomatogastric nervous system, the frontal ganglion.


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