scholarly journals Phylogeographical particularity of the Mycobacterium tuberculosis Beijing family in South Korea based on international comparison with surrounding countries

2010 ◽  
Vol 59 (10) ◽  
pp. 1191-1197 ◽  
Author(s):  
Hee Yoon Kang ◽  
Takayuki Wada ◽  
Tomotada Iwamoto ◽  
Shinji Maeda ◽  
Yoshiro Murase ◽  
...  
Keyword(s):  
Mycobacterium Tuberculosis ◽  
Population Structure ◽  
Spanning Tree ◽  
Minimum Spanning Tree ◽  
Variable Number ◽  
Genomic Region ◽  
Beijing Family ◽  
Eastern Asia ◽  
The Republic ◽  
Far Eastern

To understand the domestic population structure of Mycobacterium tuberculosis clinical isolates in the Republic of Korea, we genotypically analysed 80 isolates obtained from various geographical origins in the country. Of these, 64 (80.0 %) isolates were identified as Beijing family strains. It is particularly interesting that their phylogenetic classification, based on the ancient/modern separation and the presence/absence of the genomic region RD181, revealed a majority of the ancient (RD181+) subfamily in the population. The 15 loci of variable number of tandem repeat(s) of mycobacterial interspersed repetitive units (15-MIRU-VNTR) were also analysed. Combination with the previous VNTR data reported from surrounding countries revealed that the topology of the minimum spanning tree was linked tightly not to the geographical origins of the patients but to the phylogenetic characteristics of the isolates. These results show that the phylogeographical distribution of the M. tuberculosis Beijing family around far-eastern Asia could be estimated using international accumulation and comparison of VNTR genotyping data.

scholarly journals Population structure of drug-resistant Mycobacterium tuberculosis in Central Asia

2019 ◽  
Vol 19 (1) ◽  
Author(s):  
Anna Engström ◽  
Uladzimir Antonenka ◽  
Abdylat Kadyrov ◽  
Gulmira Kalmambetova ◽  
Katharina Kranzer ◽  
...  
Keyword(s):  
Mycobacterium Tuberculosis ◽  
Population Structure ◽  
Central Asia ◽  
Tandem Repeats ◽  
Relative Size ◽  
Multidrug Resistant ◽  
Variable Number ◽  
Health Concern ◽  
Drug Resistant ◽  
Recent Emergence

Abstract Background Drug-resistant tuberculosis (TB) is a major public health concern threathing the success of TB control efforts, and this is particularily problematic in Central Asia. Here, we present the first analysis of the population structure of Mycobacterium tuberculosis complex isolates in the Central Asian republics Uzbekistan, Tajikistan, and Kyrgyzstan. Methods The study set consisted of 607 isolates with 235 from Uzbekistan, 206 from Tajikistan, and 166 from Kyrgyzstan. 24-loci MIRU-VNTR (Mycobacterial Interspersed Repetitive Units - Variable Number of Tandem Repeats) typing and spoligotyping were combined for genotyping. In addition, phenotypic drug suceptibility was performed. Results The population structure mainly comprises strains of the Beijing lineage (411/607). 349 of the 411 Beijing isolates formed clusters, compared to only 33 of the 196 isolates from other clades. Beijing 94–32 (n = 145) and 100–32 (n = 70) formed the largest clusters. Beijing isolates were more frequently multidrug-resistant, pre-extensively resistant (pre-XDR)- or XDR-TB than other genotypes. Conclusions Beijing clusters 94–32 and 100–32 are the dominant MTB genotypes in Central Asia. The relative size of 100–32 compared to previous studies in Kazakhstan and its unequal geographic distribution support the hypothesis of its more recent emergence in Central Asia. The data also demonstrate that clonal spread of resistant TB strains, particularly of the Beijing lineage, is a root of the so far uncontroled MDR-TB epidemic in Central Asia.

scholarly journals Evolution of Drug Resistance in Different Sublineages of Mycobacterium tuberculosis Beijing Genotype

2006 ◽  
Vol 50 (8) ◽  
pp. 2820-2823 ◽  
Author(s):  
Igor Mokrousov ◽  
Wei Wei Jiao ◽  
Gui Zhi Sun ◽  
Jia Wen Liu ◽  
Violeta Valcheva ◽  
...  
Keyword(s):  
Drug Resistance ◽  
Mycobacterium Tuberculosis ◽  
Population Structure ◽  
Selective Pressure ◽  
Beijing Genotype ◽  
Beijing Family ◽  
Antituberculosis Drugs ◽  
Beijing Area ◽  
Resistance Patterns ◽  
Mechanisms Of Adaptation

ABSTRACT We compared the population structure and drug resistance patterns of the Mycobacterium tuberculosis strains currently circulating in the Beijing area of China. One hundred thirteen of 123 strains belonged to the Beijing family genotypes defined by spoligotyping. The Beijing genotype strains were further subdivided into old and modern sublineages on the basis of NTF locus analysis. A stronger association with resistance to the more recently introduced antituberculosis drugs has been observed for old versus modern strains of the Beijing genotype, suggesting that its different sublineages may differ in their mechanisms of adaptation to drug selective pressure.

scholarly journals The population structure of Beijing family of Mycobacterium tuberculosis in Western Siberia

2020 ◽  
Vol 98 (5) ◽  
pp. 32-36
Author(s):  
A. A. Vyazovaya ◽  
O. A. Pasechnik ◽  
A. A. Gerasimova ◽  
I. V. Mokrousov
Keyword(s):  
Mycobacterium Tuberculosis ◽  
Population Structure ◽  
Western Siberia ◽  
Beijing Family

scholarly journals Enhancing the differentiation of specific genotypes in Mycobacterium tuberculosis population

2019 ◽  
Vol 9 (1) ◽  
Author(s):  
Shima Hadifar ◽  
Mansour Kargarpour Kamakoli ◽  
Abolfazl Fateh ◽  
Seyed Davar Siadat ◽  
Farzam Vaziri
Keyword(s):  
Mycobacterium Tuberculosis ◽  
Minimum Spanning Tree ◽  
Variable Number Tandem Repeat ◽  
Allelic Diversity ◽  
Variable Number ◽  
Discriminatory Power ◽  
Discrimination Power ◽  
High Discrimination ◽  
High Discriminatory Power ◽  
Selection Of

AbstractToday, significant attention is directed towards the global lineages and sublineages of Mycobacterium tuberculosis (Mtb). NEW-1 (SIT 127) and CAS1-Delhi (SIT 26) strains are recognized as growing and circulating Mtb genotypes, especially in Asian countries. It is crucial to develop or enhance Mtb genotyping methods for a more accurate and simple differentiation of these families. We used 24-loci mycobacterial interspersed repetitive unit-variable number tandem repeat (MIRU-VNTR) typing for genotyping 217 Mtb isolates. To select the optimal MIRU-VNTR loci, we calculated the Hunter-Gaston discriminatory index (HGDI), allelic diversity, and accumulation of percentage differences (APDs) between the strains among different groups of genotypes (NEW-1 and non-NEW-1; CAS1-Delhi and non-CAS). Finally, the minimum spanning tree was constructed for clustering analysis. In the NEW-1 population, loci with APD > 60% were found to have a high discriminatory power. VNTR loci with APD > 50% showed high discrimination power for the CAS population. Our findings suggest that APDs, which are valuable for the selection of VNTR loci sets, may improve the discriminatory power of MIRU-VNTR typing for identification of Mtb genotypes in specific regions.

scholarly journals EPIDEMIOLOGIC SITUATION FOR TUBERCULOSIS IN THE FAR EASTERN FEDERAL DISTRICT AND THE REPUBLIC OF SAKHA (YAKUTIA)

2016 ◽  
pp. 28-34 ◽  
Author(s):  
E. D. Savilov ◽  
V. A. Astafiev ◽  
M. K. Vinokurova ◽  
O. B. Ogarkov ◽  
S. N. Zhdanova ◽  
...  
Keyword(s):  
Mycobacterium Tuberculosis ◽  
Federal District ◽  
The Arctic ◽  
Beijing Genotype ◽  
Arctic Zone ◽  
The North ◽  
Magadan Region ◽  
Complex Evaluation ◽  
The Republic ◽  
Far Eastern

Aim. Complex evaluation of epidemiologic situation for tuberculosis on the territory of the Far Eastern Federal District (FEFD) and the Republic of Sakha (Yakutia). Materials and methods. Data (morbidity, prevalence, mortality, genotypes of Mycobacterium tuberculosis), characterizing, epidemiologic situation for tuberculosis from 2002 - 2014 were used. Results. The highest parameters of tuberculosis morbidity from all the regions of Russian Federation were registered in FEFD, and from all the territories of the region the highest levels were registered in Primorsky Region and Jewish Autonomous Region (166.3±6.2 %ooo and 166.1±4,8 °/oooo, respectively), and lowest - in Magadan Region and Yakutia (76.0±2.1 °/oooo and 78.6±1,9 70000, respectively). In the regions, located in the arctic zone of the Republic of Yakutia, epidemiologic situation is characterized as non-welfare. Moreover, the highest parameters of moibidity for tuberculosis were registered among low-number peoples of the north. Conclusion. Integral evaluation of the main epidemiologic parameters allows to conduct a more in-depth comparative evaluation of the epidemiologic situation. Taking into account such an approach, in the FEFD the most non-welfare situation was established to be registered in Primorsky Region, and in Yakutia the most welfare occurs. Monitoring of the circulation of genotypes of Mycobacterium tuberculosis allows to assume a possibility of displacement of genotype S by more aggressive (transmissive) subtypes of Beijing genotype.

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