scholarly journals A review of an emerging enteric pathogen: enteroaggregative Escherichia coli

2006 ◽  
Vol 55 (10) ◽  
pp. 1303-1311 ◽  
Author(s):  
David B. Huang ◽  
Alakananda Mohanty ◽  
Herbert L. DuPont ◽  
Pablo C. Okhuysen ◽  
Tom Chiang
Keyword(s):  
Escherichia Coli ◽  
Healthcare Workers ◽  
Developed Countries ◽  
Enteric Pathogen ◽  
Host Susceptibility ◽  
Symptomatic Infection ◽  
Single Nucleotide ◽  
Host Interaction ◽  
Contaminated Food ◽  
Developing And Developed Countries

Enteroaggregative Escherichia coli (EAEC) is an increasingly recognized enteric pathogen. It is a cause of both acute and persistent diarrhoea among children, adults and HIV-infected persons, in both developing and developed countries. In challenge studies, EAEC has caused diarrhoeal illness with the ingestion of 1010 c.f.u. Outbreaks of diarrhoeal illness due to EAEC have been reported, and linked to the ingestion of contaminated food. Diarrhoeal illness due to EAEC is the result of a complex pathogen–host interaction. Some infections due to EAEC result in diarrhoeal illness and elicit an inflammatory response, whereas other infections do not result in a symptomatic infection. Many putative virulence genes and EAEC strains that produce biofilm have been identified; however, the clinical significance of these genes and of biofilm production has yet to be defined. A −251 AA single nucleotide polymorphism (SNP) in the interleukin (IL)-8 promoter region is reported to increase host susceptibility to EAEC diarrhoea. Ciprofloxacin and rifaximin continue to be an effective treatment in persons infected with EAEC. This review is intended to provide an updated review for healthcare workers on EAEC, an emerging enteric pathogen.

scholarly journals FUT2, Secretor Status and FUT3 Polymorphisms of Children with Acute Diarrhea Infected with Rotavirus and Norovirus in Brazil

Viruses ◽  
2020 ◽  
Vol 12 (10) ◽  
pp. 1084
Author(s):  
Marco André Loureiro Tonini ◽  
Débora Maria Pires Gonçalves Barreira ◽  
Luciana Bueno de Freitas Santolin ◽  
Lays Paula Bondi Volpini ◽  
José Paulo Gagliardi Leite ◽  
...  
Keyword(s):  
Acute Diarrhea ◽  
Current Knowledge ◽  
Host Susceptibility ◽  
High Rate ◽  
Southeastern Brazil ◽  
Blood Group Antigens ◽  
Nucleotide Polymorphisms ◽  
Symptomatic Infection ◽  
Single Nucleotide ◽  
Secretor Status

Host susceptibility according to human histo-blood group antigens (HBGAs) is widely known for norovirus infection, but is less described for rotavirus. Due to the variable HBGA polymorphism among populations, we aimed to evaluate the association between HBGA phenotypes (ABH, Lewis and secretor status) and susceptibility to rotavirus and norovirus symptomatic infection, and the polymorphisms of FUT2 and FUT3, of children from southeastern Brazil. Paired fecal-buccal specimens from 272 children with acute diarrhea were used to determine rotavirus/norovirus genotypes and HBGAs phenotypes/genotypes, respectively. Altogether, 100 (36.8%) children were infected with rotavirus and norovirus. The rotavirus P[8] genotype predominates (85.7%). Most of the noroviruses (93.8%) belonged to genogroup II (GII). GII.4 Sydney represented 76% (35/46) amongst five other genotypes. Rotavirus and noroviruses infected predominantly children with secretor status (97% and 98.5%, respectively). However, fewer rotavirus-infected children were Lewis-negative (8.6%) than the norovirus-infected ones (18.5%). FUT3 single nucleotide polymorphisms (SNP) occurred mostly at the T59G > G508A > T202C > C314T positions. Our results reinforce the current knowledge that secretors are more susceptible to infection by both rotavirus and norovirus than non-secretors. The high rate for Lewis negative (17.1%) and the combination of SNPs, beyond the secretor status, may reflect the highly mixed population in Brazil.

Norovirus–host interaction: implications for disease control and prevention

2007 ◽  
Vol 9 (19) ◽  
pp. 1-22 ◽  
Author(s):  
Ming Tan ◽  
Xi Jiang
Keyword(s):  
Receptor Binding ◽  
Genetic Relatedness ◽  
Developed Countries ◽  
Side Chain ◽  
Blood Group Antigens ◽  
Host Interaction ◽  
Binding Interface ◽  
Outermost Surface ◽  
Control And Prevention ◽  
Developing And Developed Countries

Noroviruses (NVs) are a major cause of acute gastroenteritis epidemics in both developing and developed countries and affect people of all ages. Three main human histo-blood group antigens (HBGAs) – the ABO, Lewis and secretor families – are involved in NV recognition and eight strain-specific receptor-binding patterns in two major binding groups have been described. The receptor-binding interface is located at the outermost surface of the P domain of the viral capsid. Each interface contains two major binding sites and each site interacts with a carbohydrate side-chain of the HBGAs via multiple hydrogen bonds. Soluble HBGAs in human milk are able to block binding of NV to HBGA receptors, suggesting a potential decoy receptor for the protection of infants from NV infection. Phylogenetic analysis has revealed limited genetic relatedness among NVs with similar receptor-binding patterns. This review summarises and discusses recent advances and highlights implications for future studies in the control and prevention of NV gastroenteritis.

scholarly journals Molecular Characterization and Antimicrobial Resistance of Enteropathogenic Escherichia coli in Children from Ahvaz, Iran

2020 ◽  
Vol 13 (7) ◽  
Author(s):  
Mehrandokht Sirous ◽  
Mohammad Hashemzadeh ◽  
Maryam Keshtvarz ◽  
Mansour Amin ◽  
Nasim Shams ◽  
...  
Keyword(s):  
Escherichia Coli ◽  
Drug Resistance ◽  
Developed Countries ◽  
Therapeutic Strategies ◽  
Beta Lactamase ◽  
Enteropathogenic Escherichia Coli ◽  
Emerging Pathogen ◽  
E Coli ◽  
Atypical Strains ◽  
Developing And Developed Countries

Background: Enteropathogenic Escherichia coli (EPEC) is one of the most important pathogens among young children worldwide. Both eae and bfp genes have been used to identify EPEC strains and categorize them into typical and atypical strains. They may be an emerging pathogen in both developing and developed countries. Objectives: This study was primarily conducted to assess the epidemiology, drug resistance, and β-lactamase distribution of EPEC, as well as the detection of efa1/lifA in atypical strains. Methods: A total of 251 E. coli strains isolated from children with diarrhea were evaluated for their EPEC pathotype by PCR for the presence of eae, stx1, stx2, and bfp genes. Serogrouping with polyvalent antisera was performed to confirm EPEC strains. Atypical EPEC-containing samples were evaluated for the efa1/lifA gene. EPEC isolates were assessed to recognize the antibiotic resistance and screened to detect extended-spectrum β-lactamases (ESBLs). Results: Enteropathogenic E. coli strains were detected in 17 (6.78%) of E. coli isolates by PCR. The prevalence of typical and atypical strains was determined at 35.3% and 64.7%. All strains were completely susceptible to colistin, imipenem, and meropenem. The prevalence of blaCTX-M and blaTEM genes was calculated at 70.58% and 58.82%, respectively. Conclusions: Enteropathogenic E. coli isolates are completely sensitive to carbapenems, and precise therapeutic strategies are required to prevent the spread of these beta-lactamase genes among diarrheagenic E. coli.

Housing Inflation: Policy Guidelines from Shariah Perspective

2019 ◽  
Vol 16 (1) ◽  
pp. 70-81
Author(s):  
Azrul Azlan Iskandar Mirza ◽  
Asmaddy Haris ◽  
Ainulashikin Marzuki ◽  
Ummi Salwa Ahmad Bustamam ◽  
Hamdi Hakiem Mudasir ◽  
...  
Keyword(s):  
Content Analysis ◽  
Housing Prices ◽  
Construction Materials ◽  
Housing Price ◽  
Developed Countries ◽  
Control Element ◽  
Recent Issue ◽  
Analysis Methodology ◽  
The Government ◽  
Developing And Developed Countries

The soaring housing prices in Malaysia is not a recent issue. It is a global phenomenon especially in developing and developed countries, driven by factors including land price, location, construction materials cost, demand, and speculation. This issue demands immediate attention as it affects the younger generation, most of whom could not afford to buy their own house. The government has taken many initiatives and introduced regulations to ensure that housing prices are within the affordable range. This article aims to introduce a housing price control element from the Shariah perspective, as an alternative solution for all parties involved in this issue. It adopts content analysis methodology on policy from Shariah approved sources.

scholarly journals Income, wealth and use of personal protection equipment in the Mekong Delta

2021 ◽  
Author(s):  
Matteo Migheli
Keyword(s):  
Low Income ◽  
Mekong Delta ◽  
Developed Countries ◽  
Household Wealth ◽  
Protective Equipment ◽  
Personal Protection ◽  
Personal Protection Equipment ◽  
Management Techniques ◽  
Using Data ◽  
Developing And Developed Countries

AbstractBoth in developing and developed countries, farmers often do not protect themselves adequately, especially when applying agrochemicals that are dangerous for their health. The issue is relevant because insufficient protection is between the causes leading to intoxication of farmers and workers who handle these products. The literature suggests that both lack of training and information and low income may explain why, especially in developing countries, protective equipment is under-used. Using data from the Mekong Delta, this study addresses the issue of whether income and household wealth may help explaining the use of incomplete protections against pesticides. The results suggest that income, more than wealth, is a reason why Vietnamese farmers operating in the Mekong Delta fail in using adequate protections. In particular, the data suggest that they may prefer to divert resources to increasing the production of their fields or to buying goods that may be used both as protection and as everyday garments. This behaviour leads to underinvestment in some important protective goods. Possible public interventions to mitigate the problem are suggested; in particular, the promotion of integrated pest management techniques could be useful.

scholarly journals Strategies for reducing out of pocket payments in the health system: a scoping review

2021 ◽  
Vol 19 (1) ◽  
Author(s):  
Faride Sadat Jalali ◽  
Parisa Bikineh ◽  
Sajad Delavari
Keyword(s):  
Health System ◽  
Health Systems ◽  
Scoping Review ◽  
Health Financing ◽  
Developed Countries ◽  
Vulnerable Groups ◽  
System A ◽  
Out Of Pocket Payments ◽  
Review Study ◽  
Developing And Developed Countries

Abstract Background Direct out-of-pocket payments (OOP) are among the most important financing mechanisms in many health systems, especially in developing countries, adversely affecting equality and leading vulnerable groups to poverty. Therefore, this scoping review study was conducted to identify the strategies involving OOP reduction in health systems. Methods Articles published in English on strategies related to out-of-pocket payments were Searched and retrieved in the Web of Science, Scopus, PubMed, and Embase databases between January 2000 and November 2020, following PRISMA guidelines. As a result, 3710 papers were retrieved initially, and 40 were selected for full-text assessment. Results Out of 40 papers included, 22 (55%) and 18 (45%) of the study were conducted in developing and developed countries, respectively. The strategies were divided into four categories based on health system functions: health system stewardship, creating resources, health financing mechanisms, and delivering health services.As well, developing and developed countries applied different types of strategies to reduce OOP. Conclusion The present review identified some strategies that affect the OOP payments According to the health system functions framework. Considering the importance of stewardship, creating resources, the health financing mechanisms, and delivering health services in reducing OOP, this study could help policymakers make better decisions for reducing OOP expenditures.

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