scholarly journals Lipoxins: A Novel Regulator in Embryo Implantation

2011 ◽  
Vol 11 ◽  
pp. 235-241 ◽  
Author(s):  
Jing Xiong ◽  
Pan Zeng ◽  
Duyun Ye
Keyword(s):  
Cross Talk ◽  
Leukemia Inhibitory Factor ◽  
Molecular Mechanisms ◽  
Embryo Implantation ◽  
Endometrial Receptivity ◽  
Inhibitory Factor ◽  
Resolution Of Inflammation ◽  
Recent Advances ◽  
Close Relationship

Embryo implantation is essential for mammalian pregnancy, which involves intricate cross-talk between the blastocyst and the maternal endometrium. Recent advances have identified various molecules crucial to implantation and endometrial receptivity, including leukemia inhibitory factor, calcitonin, and homeobox A10. There is a close relationship between implantation and inflammation. Lipoxins, important in the resolution of inflammation, may be a potential regulator in implantation. Here we discuss the hypothesis that lipoxins may work as a novel regulator in embryo implantation and the possible molecular mechanisms.

The role of the leukemia inhibitory factor receptor in embryo implantation and placentation

Placenta ◽  
2021 ◽  
Vol 114 ◽  
pp. 139
Author(s):  
Jumpei Terakawa ◽  
Kazuhiro Matsuo ◽  
Takafumi Namiki ◽  
Kana Ohtomo ◽  
Atsuko Kageyama ◽  
...  
Keyword(s):  
Leukemia Inhibitory Factor ◽  
Embryo Implantation ◽  
Inhibitory Factor ◽  
Leukemia Inhibitory Factor Receptor

Leukemia inhibitory factor: Recent advances and implications in biotechnology

2020 ◽  
Vol 52 ◽  
pp. 25-33 ◽  
Author(s):  
Vanessa Pinho ◽  
Mário Fernandes ◽  
André da Costa ◽  
Raúl Machado ◽  
Andreia C. Gomes
Keyword(s):  
Leukemia Inhibitory Factor ◽  
Inhibitory Factor ◽  
Recent Advances

Levonorgestrel Inhibits Embryo Attachment by Eliminating Uterine Induction of Leukemia Inhibitory Factor

Endocrinology ◽  
2019 ◽  
Vol 161 (2) ◽  
Author(s):  
Mitsunori Matsuo ◽  
Yasushi Hirota ◽  
Yamato Fukui ◽  
Hidetoshi Fujita ◽  
Tomoko Saito-Fujita ◽  
...  
Keyword(s):  
Leukemia Inhibitory Factor ◽  
Embryo Implantation ◽  
Infertility Treatment ◽  
Vehicle Control ◽  
Inhibitory Factor ◽  
Wild Type ◽  
Attachment Sites ◽  
Attachment Inhibition ◽  
Evening Administration ◽  
Embryo Attachment

Abstract Progestogens including progesterone (P4) and levonorgestrel (LNG) are clinically used for multiple purposes such as contraception and infertility treatment. The effects of progestogens on the uterus remains to be elucidated. Here we examine the effect of excessive progestogen administration on embryo implantation focusing on the function of uterine leukemia inhibitory factor (LIF), a cytokine that is induced by estrogen and essential for embryo attachment. Treatment of wild-type (WT) female mice with vehicle (control), LNG at the dose of 300 μg/kg/day and P4 at the dose of 10 mg/day from day 1 to day 4 of pregnancy was conducted. LNG-treated and P4-treated mice showed embryo attachment failure on day 5 of pregnancy (The rate of mice with embryo attachment sites [%MAS], 11% and 13%, respectively), while all the control mice had normal attachment sites. Uterine LIF expression was significantly reduced in LNG-treated and P4-treated mice on day 4 evening. Administration of recombinant LIF (rLIF) at the dose of 24 μg/day on day 4 significantly rescued embryo attachment failure in LNG-treated and P4-treated mice (%MAS, 80% and 75%, respectively). Estradiol (E2) administration also rescued embryo attachment failure in LNG-treated mice (%MAS, 83%). Furthermore, excess P4 treatment before implantation decreased decidual P4 receptor (PGR) expression and induced decidualization defect apart from LIF downregulation. These findings indicate that progestogens cause embryo attachment inhibition through downregulation of uterine LIF expression and compromised decidualization through downregulation of PGR independently of LIF reduction. This study may contribute to a better understanding of contraceptive action of progestogens.

scholarly journals miRNA-181 regulates embryo implantation in mice through targeting leukemia inhibitory factor

2015 ◽  
Vol 7 (1) ◽  
pp. 12-22 ◽  
Author(s):  
Bo Chu ◽  
Liangwen Zhong ◽  
Shuang Dou ◽  
Jun Wang ◽  
Jianmin Li ◽  
...  
Keyword(s):  
Leukemia Inhibitory Factor ◽  
Embryo Implantation ◽  
Inhibitory Factor

scholarly journals Leukemia Inhibitory Factor: Roles in Embryo Implantation and in Nonhormonal Contraception

2014 ◽  
Vol 2014 ◽  
pp. 1-10 ◽  
Author(s):  
Naguib Salleh ◽  
Nelli Giribabu
Keyword(s):  
Leukemia Inhibitory Factor ◽  
Growth And Development ◽  
Immune Modulation ◽  
Embryo Implantation ◽  
Critical Role ◽  
Inhibitory Factor ◽  
Trophoblast Invasion ◽  
Leukaemia Inhibitory Factor ◽  
Multiple Processes

Leukaemia inhibitory factor (LIF) plays an indispensible role in embryo implantation. Aberrant LIF production is linked to implantation failure. LIF regulates multiple processes prior to and during implantation such as uterine transformation into a receptive state, decidualization, blastocyst growth and development, embryo-endometrial interaction, trophoblast invasion, and immune modulation. Due to its critical role, LIF has been a target for a nonhormonal contraception. In this review, we summarize up-to-date information on the role of LIF in implantation and its role in contraception.

scholarly journals Assessment of endometrial receptivity by biomarkers

2012 ◽  
Vol 61 (6) ◽  
pp. 61-67
Author(s):  
Yana Nikolayevna Kravchuk ◽  
Alla Stanislavovna Kalugina
Keyword(s):  
Ovarian Stimulation ◽  
Leukemia Inhibitory Factor ◽  
Endometrial Receptivity ◽  
Inhibitory Factor ◽  
Controlled Ovarian Stimulation ◽  
Αvβ3 Integrin

Endometrial receptivity defect can lead to a recurrent failures in ART. Data on endometrial receptivity assessment by the most studied biomarkers, such as pinopodes, leukemia-inhibitory factor, αVβ3 integrin, mucin MUC 1, are presented. Analysis of controlled ovarian stimulation protocols influence on endometrial receptivity is composed.

Regulation of Notch Signaling by Leukemia Inhibitory Factor in the Murine Uterus During Embryo Implantation.

2010 ◽  
Vol 83 (Suppl_1) ◽  
pp. 81-81
Author(s):  
Gracy Xavier Rosario ◽  
Jianbo Hu Eiichi Hondo ◽  
Jae-Wook Jeong ◽  
Francesco J. DeMayo ◽  
Colin L. Stewart
Keyword(s):  
Notch Signaling ◽  
Leukemia Inhibitory Factor ◽  
Embryo Implantation ◽  
Inhibitory Factor

scholarly journals Optogenetic regulation of embryo implantation in mice using photoactivatable CRISPR-Cas9

2020 ◽  
Vol 117 (46) ◽  
pp. 28579-28581
Author(s):  
Tomoka Takao ◽  
Moritoshi Sato ◽  
Tetsuo Maruyama
Keyword(s):  
Leukemia Inhibitory Factor ◽  
Gene Editing ◽  
Therapeutic Strategy ◽  
Molecular Mechanisms ◽  
Light Emitting Diode ◽  
Embryo Implantation ◽  
Light Emitting ◽  
Spatiotemporal Expression ◽  
Fertilized Egg

Embryo implantation is achieved upon successful interaction between a fertilized egg and receptive endometrium and is mediated by spatiotemporal expression of implantation-associated molecules including leukemia inhibitory factor (LIF). Here we demonstrate, in mice, that LIF knockdown via a photoactivatable CRISPR-Cas9 gene editing system and illumination with a light-emitting diode can spatiotemporally disrupt fertility. This system enables dissection of spatiotemporal molecular mechanisms associated with embryo implantation and provides a therapeutic strategy for temporal control of reproductive functions in vivo.

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