A little walk from physical to biological complexity: protein folding and stability
Keyword(s):
As an example of topic where biology and physics meet, we present the issue of protein folding and stability, and the development of thermodynamics-based bioinformatics tools that predict the stability and thermal resistance of proteins and the change of these quantities upon amino acid substitutions. These methods are based on knowledge-driven statistical potentials, derived from experimental protein structures using the inverse Boltzmann law.
1999 ◽
Vol 34
(3)
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pp. 356-368
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2007 ◽
Vol 76
(10)
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pp. 104801
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Amino acid substitutions preserve protein folding by conserving steric and hydrophobicity properties
1997 ◽
Vol 10
(3)
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pp. 187-196
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2003 ◽
Vol 16
(9)
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pp. 665-671
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