scholarly journals Clinical Characteristics of Two Human to Human Transmitted Coronaviruses: Corona Virus Disease 2019 versus Middle East Respiratory Syndrome Coronavirus

Author(s):  
Ping Xu ◽  
Guo-Dong Sun ◽  
Zhi-Zhong Li

AbstractAfter the outbreak of the middle east respiratory syndrome (MERS) worldwide in 2012. Currently, a novel human coronavirus has caused a major disease outbreak, and named corona virus disease 2019 (COVID-19). The emergency of MRES-COV and COVID-19 has caused global panic and threatened health security. Unfortunately, the similarities and differences between the two coronavirus diseases remain to be unknown. The aim of this study, therefore, is to perform a systematic review to compare epidemiological, clinical and laboratory features of COVID-19 and MERS-COV population. We searched PubMed, EMBASE and Cochrane Register of Controlled Trials database to identify potential studies reported COVID-19 or MERS-COV. Epidemiological, clinical and laboratory outcomes, the admission rate of intensive cure unit (ICU), discharge rate and fatality rate were evaluated using GraphPad Prism software. Thirty-two studies involving 3770 patients (COVID-19 = 1062, MERS-COV = 2708) were included in this study. The present study revealed that compared with COVID-19 population, MERS-COV population had a higher rate of ICU admission, discharge and fatality and longer incubation time. It pointed out that fever, cough and generalised weakness and myalgia were main clinical manifestations of both COVID-19 and MERS-COV, whereas ARDS was main complication. The most effective drug for MERS-COV is ribavirin and interferon.

2021 ◽  
Vol 3 (3) ◽  
pp. 1027
Author(s):  
Hilda Rodhotul Ainiyah ◽  
Andi Rahmad Rahim ◽  
Sukaris Sukaris ◽  
Ernawati Ernawati

Corona virus Disease-2019 (COVID-19) diketahui menyebabkan infeksi saluran nafas pada manusia mulai dari batuk pilek hingga yang lebih serius seperti Middle East Respiratory Syndrome (MERS) dan Severe Acute Respiratory Syndrome (SARS). Persebaran virus COVID-19 meningkat semakin cepat melalui tetesan air liur atau keluar dari hidung ketika orang yang terinfeksi batuk atau bersin. Akan tetapi, masih sangat minim pemahaman dan kesadaran masyarakat di Desa Kedungrukem Kecamatan Benjeng Kabupaten Gresik yang mematuhi protokol kesehatan saat beraktivitas di luar rumah. Lokasi tersebut merupakan padat penduduk.  Oleh karena itu, perlunya peningkatan pemahaman COVID-19 dan pentingnya mematuhi protokol kesehatan penanggulangan COVID-19. Berdasakan permasalahan tersebut, penulis melakukan pengabdian pada masyarakat melalui kegiatan Kuliah Kerja Nyata (KKN) UMG Era Covid-19. Kegiatan yang dilakukan dengan metode Edukasi COVID-19 secara online Kepada Masyarakat Desa Kedungrukem. Pada program KKN ini dilakukan pembagian masker, pembagian banner tentang bahaya dan cara pencegahan COVID19, edukasi tentang pentingnya menabung dimasa Pandemi COVID19, pembuatan pembukuan laporan keuangan untuk Karangtaruna Dusun Bulak Ploso serta edukasi protokol kesehatan di lingkungan Desa Kedungrukem secara virtual. Telah berhasil disalurkan sebanyak 75 masker, 1 banner tentang bahaya dan cara pencegahan COVID19, video edukasi tentang menabung dan cara pencegahan COVID19.


2020 ◽  
Vol 1 (2) ◽  
pp. 112-125
Author(s):  
Muhammad Miftah ◽  
◽  
Henda Riyana ◽  
Yusup Fikria Erdiana ◽  
Arby Agnia Nurhakim ◽  
...  

Corona virus Disease-2019 (COVID-19) diketahui menyebabkan infeksi saluran nafas pada manusia mulai dari batuk pilek hingga yang lebih serius seperti Middle East Respiratory Syndrome (MERS) dan Severe Acute Respiratory Syndrome (SARS). Umumnya penularan Covid-19 paling banyak terjadi melalui tangan, oleh karena itu masyarakat untuk rajin mencuci tangan sebelum maupun sesudah melakukan kegiatan apa pun. Selain itu pencegahan penularan Covid-19 dengan cara selalu menggunakan masker dan menjaga jarak minimal 1 meter. Akan tetapi masyarakat di Desa Cibatu Kecamatan Cibatu masih mengabaikan terhadap protokol kesehatan pencegahan Covid-19 seperti mencuci tangan pada air yang mengalir maupun himbauan untuk menggunakan masker. Lokasi tersebut merupakan padat penduduk dan banyak masyarakat yang bekerja dan beraktivitas diluar rumah . Oleh karena itu, perlunya pemahaman mengenai protokol kesehatan pencegahan Covid-19. Berdasarkan permasalahan tersebut, penulis melakukan pengabdian pada masyarakat melalui kegiatan Kuliah Kerja Nyata Tematik Pencegahan Covid-19. Kegiatan yang dilakukan dengan metode edukasi tentang Covid-19 kepada warga di Desa Cibatu. Pada kegiatan Kuliah Kerja Nyata ini dilakukan pembuatan Alat Pelindung Diri (APD) berupa masker kain, handsanitizer, dan disinfektan yang di salurkan kepada warga dan kepala Desa Cibatu serta edukasi pencegahan Covid-19 kepada masyarakat secara daring.


2021 ◽  
Vol 3 (3) ◽  
pp. 994
Author(s):  
M. Gerri Setia B ◽  
Nanang Khoirul Umam ◽  
Andi Rahmad Rahim ◽  
Sukaris Sukaris ◽  
Ernawati Ernawati

Corona virus Disease-2019 (COVID-19) diketahui menyebabkan infeksi saluran nafas pada manusia mulai dari batuk pilek hingga yang lebih serius seperti  Middle East Respiratory Syndrome (MERS) dan Severe Acute Respiratory Syndrome (SARS). Persebaran COVID-19 meningkat semakin cepat melalui tetesan air  liur  atau keluar dari hidung ketika orang yang terinfeksi batuk atau bersin. Virus tersebut sangatlah meluas dengan cepat yang berdampak pada seluruh dunia, bukan hanya dalam pandangan kesehatan saja tetapi dalam ekonomi juga terdampak baik ekonomi Negara maupun masyarakatnya. Dimana keuangan masyarakat Desa Cagak Agung Kecamatan Cerme Gresik mengalami guncangan dalam masalah perekonomiannya. Berdasakan permasalahan tersebut, penulis melakukan pengabdian pada masyarakat Desa Cagak Agung kusunya pada Rt 02 Rw 01 melalui kegiatan Kuliah Kerja Nyata (KKN) Mandiri Tahun 2020 Universitas Muhammadiyah Gresik Era Covid-19. Untuk memberikan edukasi bahwasanya masyarakat Desa Cagak Agung Rt 02 Rw 01 banyak sekali yang bekerja di perusahaan kemudian di rumahkan sementara karena dalam masa lockdown, sehingga pemasukan yang dialami oleh masyarakat mengalami penurunan bahkan ada juga yang tidak mencukupi kebutuhannya sehinga banyak masyarakat yang mengeluh akan keadaan dan kondisi seperti ini untuk mencari peluang kerja sangatlah susah dicari, sehingga penulis memberikan sebuah edukasi maupun saran dengan apa yang telah dikeluhkan oleh masyarakat. Pemberian edukasi kepada sasaran penulis ialah salah satu warga budidaya ternak ikan lele dan edukasi yang di salurkan dengan system daring atau via online untuk memberikan edukasi bagaimana pemanfaatan tong bekas untuk dijadikan alat pengiriman agar dapat meminimalisir biaya pengiriman.


Viruses ◽  
2019 ◽  
Vol 11 (4) ◽  
pp. 381 ◽  
Author(s):  
W. Widagdo ◽  
Nisreen M. A. Okba ◽  
Mathilde Richard ◽  
Dennis de Meulder ◽  
Theo M. Bestebroer ◽  
...  

Middle East respiratory syndrome coronavirus (MERS-CoV) transmission from dromedaries to humans has resulted in major outbreaks in the Middle East. Although some other livestock animal species have been shown to be susceptible to MERS-CoV, it is not fully understood why the spread of the virus in these animal species has not been observed in the field. In this study, we used rabbits to further characterize the transmission potential of MERS-CoV. In line with the presence of MERS-CoV receptor in the rabbit nasal epithelium, high levels of viral RNA were shed from the nose following virus inoculation. However, unlike MERS-CoV-infected dromedaries, these rabbits did not develop clinical manifestations including nasal discharge and did shed only limited amounts of infectious virus from the nose. Consistently, no transmission by contact or airborne routes was observed in rabbits. Our data indicate that despite relatively high viral RNA levels produced, low levels of infectious virus are excreted in the upper respiratory tract of rabbits as compared to dromedary camels, thus resulting in a lack of viral transmission.


Medicine ◽  
2020 ◽  
Vol 99 (42) ◽  
pp. e22688
Author(s):  
Jia Xu ◽  
Xue-Ping Ma ◽  
Long Bai ◽  
Miao Wang ◽  
Wu Deng ◽  
...  

2014 ◽  
Vol 14 (2) ◽  
pp. 156-163
Author(s):  
H A M Nazmul Ahasan ◽  
Aparna Das ◽  
Mostofa Kamal Chowdhury ◽  
Baharul Minnat

The Middle East respiratory syndrome coronavirus (MERS-CoV) is a novel coronavirus (nCoV) first reported on 24 September 2012 on ProMED-mail by Egyptian virologist Dr. Ali Mohamed Zaki in Jeddah, Saudi Arabia. He isolated and identified a previously unknown coronavirus from the lungs of a 60-year-old male patient with acute pneumonia and acute renal failure. MERS-CoV is the sixth new type of coronavirus like SARS (but still distinct from it and from the common-cold coronavirus). Until 23 May 2013, MERS-CoV had frequently been referred to as a SARS-like virus, or simply the novel coronavirus, and colloquially on messageboards as “Saudi SARS”. These respiratory viruses are an emerging threat to global health security and have led to worldwide epidemics with substantial morbidity, mortality, and economic consequences. Currently confirmatory testing requires molecular diagnostics including either a positive PCR on at least two specific genomic targets or a single positive target with sequencing on a second. However, the interim recommendations for laboratory testing for MERS-CoV should be consulted for the most recent standard for laboratory confirmation. Hajj and Umrah draws some of the largest crowds in the world, and the large crowds bring some health and safety risks. The virus can spread from person to person when people are touching or very near each other, so pilgrims in crowds may be at risk. Symptoms of MERS include fever, cough, and shortness of breath. Most people infected with MERS have had severe illness and pneumonia, and about half of them have died. If anyone develops a fever and cough or difficulty in breathing within 14 days after returning from trip, must seek medical care. The Embassy of Saudi Arabia recommends that the following groups should postpone their plans for Hajj and Umrah in 2013: the elderly, the terminally ill, pregnant women, and children.DOI: http://dx.doi.org/10.3329/jom.v14i2.19634 J Medicine 2013, 14(2): 156-163


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