scholarly journals Acute Exercise Following Skill Practice Promotes Motor Memory Consolidation in Parkinson’s Disease

2020 ◽  
Author(s):  
Philipp Wanner ◽  
Martin Winterholler ◽  
Heiko Gaßner ◽  
Jürgen Winkler ◽  
Jochen Klucken ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Motor Learning ◽  
Memory Consolidation ◽  
Acute Exercise ◽  
Dopaminergic System ◽  
Exercise Bout ◽  
Whole Body ◽  
Motor Memory ◽  
Offline Learning

AbstractAcute cardiovascular exercise has shown to promote neuroplastic processes, and thus to improve the consolidation of newly acquired motor skills in healthy adults. First results suggest that this concept may be transferred to populations with motor and cognitive dysfunctions. In this context, Parkinson’s disease (PD) is highly relevant since patients demonstrate deficits in motor learning. Hence, in the present study we sought to explore the effect of a single post-practice exercise bout on motor memory consolidation in PD patients.For this purpose, 17 PD patients (Hoehn and Yahr: 1 – 2.5, age: 60.1 ± 7.9 y) practiced a whole-body task followed by either (i) a moderate-intense bout of cycling, or (ii) seated rest for a total of 30 minutes. The motor task required the participants to balance on a tiltable platform (stabilometer) for 30 seconds. During skill practice, patients performed 15 trials followed by a retention test 1 day and 7 days later. We calculated time in balance (platform within ± 5° from horizontal) for each trial and within- and between-group differences in memory consolidation (i.e. offline learning = skill change from last acquisition block to retention tests) were analyzed.Groups revealed similar improvements during skill practice (F4,60 = .316, p = .866), but showed differences in offline learning, which was only evident after 7 days (F1,14 = 5.602, p = .033).Our results suggest that a single post-practice exercise bout is effective in enhancing long-term motor memory consolidation in a population with motor learning impairments. This may point at unique promoting effects of exercise on dopamine neurotransmission involved in memory formation. Future studies should investigate the potential role of exercise-induced effects on the dopaminergic system.HighlightsAcute exercise enhanced motor memory consolidation in PDEffects were evident only at 7-day retentionResults may indicate unique exercise-effects on the dopaminergic systemFindings show promising potential of exercise for motor rehabilitation

scholarly journals Acute exercise following skill practice promotes motor memory consolidation in parkinson’s disease

2020 ◽  
pp. 107366
Author(s):  
Philipp Wanner ◽  
Martin Winterholler ◽  
Heiko Gaßner ◽  
Jürgen Winkler ◽  
Jochen Klucken ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Memory Consolidation ◽  
Acute Exercise ◽  
Motor Memory

scholarly journals Preserved motor memory in Parkinson's disease

2021 ◽  
Author(s):  
Soraya Lahlou ◽  
Ella Gabitov ◽  
Lucy L. W. Owen ◽  
Daphna Shohamy ◽  
Madeleine Sharp
Keyword(s):  
Older Adults ◽  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Motor Learning ◽  
Motor Performance ◽  
Motor Memory ◽  
Motor Sequence ◽  
Younger Adults ◽  
Initial Sequence ◽  
Initial Learning

Patients with Parkinson's disease, who lose the dopaminergic projections to the striatum, are impaired in certain aspects of motor learning. Recent evidence suggests that, in addition to its role in motor performance, the striatum plays a key role in the memory of motor learning. Whether Parkinson's patients have impaired motor memory and whether motor memory is modulated by dopamine at the time of initial learning is unknown. To address these questions, we measured memory of a learned motor sequence in Parkinson's patients who were either On or Off their dopaminergic medications. We compared them to a group of older and younger controls. Contrary to our predictions, motor memory was not impaired in patients compared to older controls, and was not influenced by dopamine state at the time of initial learning. To probe post-learning consolidation processes, we also tested whether learning a new sequence shortly after learning the initial sequence would interfere with later memory. We found that, in contrast to younger adults, neither older adults nor patients were susceptible to this interference. These findings suggest that motor memory is preserved in Parkinson's patients and raise the possibility that motor memory in patients is supported by compensatory non-dopamine sensitive mechanisms. Furthermore, given the similar performance characteristics observed in the patients and older adults and the absence of an effect of dopamine, these results raise the possibility that aging and Parkinson's disease affect motor memory in similar ways.

scholarly journals Acute Exercise and Motor Memory Consolidation: The Role of Exercise Timing

2016 ◽  
Vol 2016 ◽  
pp. 1-11 ◽  
Author(s):  
Richard Thomas ◽  
Mikkel Malling Beck ◽  
Rune Rasmussen Lind ◽  
Line Korsgaard Johnsen ◽  
Svend Sparre Geertsen ◽  
...  
Keyword(s):  
Skill Acquisition ◽  
Memory Consolidation ◽  
High Intensity ◽  
Acute Exercise ◽  
Exercise Bout ◽  
Procedural Memory ◽  
Motor Memory ◽  
Temporal Proximity ◽  
Exercise Timing ◽  
Motor Practice

High intensity aerobic exercise amplifies offline gains in procedural memory acquired during motor practice. This effect seems to be evident when exercise is placed immediately after acquisition, during the first stages of memory consolidation, but the importance of temporal proximity of the exercise bout used to stimulate improvements in procedural memory is unknown. The effects of three different temporal placements of high intensity exercise were investigated following visuomotor skill acquisition on the retention of motor memory in 48 young (24.0 ± 2.5 yrs), healthy male subjects randomly assigned to one of four groups either performing a high intensity (90% Maximal Power Output) exercise bout at 20 min (EX90), 1 h (EX90+1), 2 h (EX90+2) after acquisition or rested (CON). Retention tests were performed at 1 d (R1) and 7 d (R7). At R1 changes in performance scores after acquisition were greater for EX90 than CON (p<0.001) and EX90+2 (p=0.001). At R7 changes in performance scores for EX90, EX90+1, and EX90+2 were higher than CON (p<0.001,p=0.008, andp=0.008, resp.). Changes for EX90 at R7 were greater than EX90+2 (p=0.049). Exercise-induced improvements in procedural memory diminish as the temporal proximity of exercise from acquisition is increased. Timing of exercise following motor practice is important for motor memory consolidation.

scholarly journals The transcription factor BCL11A defines a distinctive subset of dopamine neurons in the developing and adult midbrain

2020 ◽  
Author(s):  
Marianna Tolve ◽  
Ayse Ulusoy ◽  
Khondker Ushna Sameen Islam ◽  
Gabriela O. Bodea ◽  
Ece Öztürk ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Transcription Factor ◽  
Substantia Nigra ◽  
Motor Learning ◽  
Molecular Mechanisms ◽  
Dopaminergic System ◽  
Dopamine Neurons ◽  
Anatomical Changes ◽  
Murine Brain

AbstractMidbrain dopaminergic (mDA) neurons are diverse in their projection targets, impact on behavior and susceptibility to neurodegeneration. Little is known about the molecular mechanisms that establish this diversity in mDA neurons during development. We find that the transcription factor Bcl11a defines a subset of mDA neurons in the developing and adult murine brain. By combining intersectional labeling and viral-mediated tracing we show that Bcl11a-expressing mDA neurons form a highly specific subcircuit within the dopaminergic system. We demonstrate that Bcl11a-expressing mDA neurons in the substantia nigra (SN) are particularly vulnerable to neurodegeneration in an α-synuclein overexpression model of Parkinson’s disease. Inactivation of Bcl11a in developing mDA neurons results in anatomical changes, deficits in motor learning and a dramatic increase in the susceptibility to α-synuclein-induced degeneration in SN-mDA neurons. In summary, we identify an mDA subpopulation with highly distinctive characteristics defined by the expression of the transcription factor Bcl11a already during development.

Cognition and motor learning in a Parkinson’s disease cohort

Neuroreport ◽  
2021 ◽  
Vol Publish Ahead of Print ◽  
Author(s):  
Yu-Chen Chung ◽  
Beth E. Fisher ◽  
James M. Finley ◽  
Aram Kim ◽  
Andrew J. Petkus ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Motor Learning

scholarly journals Tango Therapy: Current Status and the Next Perspective

2018 ◽  
Vol 3 (8) ◽  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Dance Therapy ◽  
Well Being ◽  
Medical Application ◽  
Whole Body ◽  
Current Status ◽  
Argentine Tango ◽  
Systemic Analysis ◽  
Health And Well Being

Dance is basically a complex physical activity which either casually or formally organized in which people take part for fitness, health and well-being, social relationships or competition and a worldwide human activity that involves complex whole body movements through space synchronized to music. Dance-related reviews of evidence have examined the effectiveness of dance therapy on psychological and physical health and well-being outcomes in patients with cancer, for schizophrenia, and on depression. Dance therapy was officially described firstly in 1948. The medical application of dance therapy was well reviewed in neurologic conditions. Dance has been used extensively for the treatment of gait and balance dysfunction in individuals with Parkinson’s disease. Especially, Argentine tango is the most frequently employed dance form in the treatment of Parkinson’s disease. Tango therapy may hold promise as an intervention to improve gait, balance, and mobility in a variety of neurological conditions. Tango therapy was approached from dance therapy to the current status of medical application. A more systemic analysis of tango movement for proper and effective therapeutic application of tango is necessary for medical purposes.

scholarly journals Blunted emotion judgments of body movements in Parkinson’s disease

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Emmanuelle Bellot ◽  
Antoine Garnier-Crussard ◽  
Elodie Pongan ◽  
Floriane Delphin-Combe ◽  
Marie-Hélène Coste ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Mirror Neuron System ◽  
Mirror Neuron ◽  
Emotional Valence ◽  
Whole Body ◽  
Emotional Expressions ◽  
Emotional Facial Expressions ◽  
Body Movements ◽  
Point Light

AbstractSome of the behavioral disorders observed in Parkinson’s disease (PD) may be related to an altered processing of social messages, including emotional expressions. Emotions conveyed by whole body movements may be difficult to generate and be detected by PD patients. The aim of the present study was to compare valence judgments of emotional whole body expressions in individuals with PD and in healthy controls matched for age, gender and education. Twenty-eight participants (13 PD patients and 15 healthy matched control participants) were asked to rate the emotional valence of short movies depicting emotional interactions between two human characters presented with the “Point Light Displays” technique. To ensure understanding of the perceived scene, participants were asked to briefly describe each of the evaluated movies. Patients’ emotional valence evaluations were less intense than those of controls for both positive (p < 0.001) and negative (p < 0.001) emotional expressions, even though patients were able to correctly describe the depicted scene. Our results extend the previously observed impaired processing of emotional facial expressions to impaired processing of emotions expressed by body language. This study may support the hypothesis that PD affects the embodied simulation of emotional expression and the potentially involved mirror neuron system.

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