scholarly journals Bridging the gap – Spontaneous fluctuations shape stimulus-evoked spectral power

2020 ◽  
Author(s):  
Soren Wainio-Theberge ◽  
Annemarie Wolff ◽  
Georg Northoff
Keyword(s):  
Neural Activity ◽  
Large Scale ◽  
Spectral Power ◽  
Low Frequency ◽  
Positive Interaction ◽  
Scale Free ◽  
The Time Domain ◽  
Low Frequency Power ◽  
Spontaneous Fluctuations ◽  
Frequency Power

AbstractSpontaneous fluctuations of neural activity have been shown to influence trial-by-trial variation in perceptual, cognitive, and behavioural outcomes. This implies that these fluctuations affect stimulus-related neural processes, and hence should affect stimulus-evoked neural activity. However, the mechanisms by which spontaneous neural activity shapes stimulus-evoked neural activity have rarely been examined. Employing a large-scale magnetoencephalographic dataset, as well as an electroencephalographic replication dataset, we observed that for high-frequency power, high pre-stimulus activity leads to greater evoked desynchronization (negative interaction); in contrast, for low-frequency power, high pre-stimulus activity induces greater event-related synchronization (positive interaction). We show that both positive and negative interactions are manifest primarily in cortical oscillations, rather than scale-free activity, and can also be observed in the time domain. In summary, we demonstrate positive and negative spontaneous-evoked interaction in multiple electrophysiological processes; these mechanisms “bridge the gap” between spontaneous and evoked activity and provide novel insights into how spontaneous activity influences behaviour and cognition.

scholarly journals In search of Universal Cortical Power Changes Linked to NMDA-Antagonist based Anesthetic Induced Reductions in Consciousness

2019 ◽  
Author(s):  
Andria Pelentritou ◽  
Levin Kuhlmann ◽  
John Cormack ◽  
Steven Mcguigan ◽  
Will Woods ◽  
...  
Keyword(s):  
Spectral Power ◽  
Low Frequency ◽  
Nmda Antagonist ◽  
Alpha Power ◽  
Source Imaging ◽  
Source Power ◽  
Gamma Range ◽  
Anesthetic Agents ◽  
Low Frequency Power ◽  
Frequency Power

B. AbstractBackground.Despite their intriguing nature, investigations of the neurophysiology of N-methyl-D-aspartate (NMDA)-antagonists Xenon (Xe) and nitrous oxide (N2O) are limited and have revealed inconsistent frequency-dependent alterations, in spectral power and functional connectivity. Discrepancies are likely due to using low resolution electroencephalography restricted to sensor level changes, concomitant anesthetic agent administration and dosage. Our intention was to describe the effects of equivalent stepwise levels of Xe and N2O administration on oscillatory source power using a crossover design, to explore universal mechanisms of NMDA-based anesthesia.Methods.22 healthy males participated in a study of simultaneous magnetoencephalography and electroencephalography recordings. In separate sessions, equivalent subanesthetic doses of gaseous anesthetic agents N2O and Xe (0.25, 0.50, 0.75 equi MAC-awake) and 1.30 MAC-awake Xe (for Loss of Responsiveness) were administered. Source power in various frequency bands was computed and statistically assessed relative to a conscious baseline.Results.Delta (l-4Hz) and theta (4-8Hz) band power was significantly increased at the highest Xe concentration (42%, 1.30 MAC-awake) relative to baseline for both magnetoencephalography and electroencephalography source power (p<0.005). A reduction in frontal alpha (8-13 Hz) power was observed upon N2O administration, and shown to be stronger than equivalent Xe dosage reductions (p=0.005). Higher frequency activity increases were observed in magnetoencephalographic but not encephalographic signals for N2O alone with occipital low gamma (30-49Hz) and widespread high gamma (51-99Hz) rise in source power.Conclusions.Magnetoencephalography source imaging revealed unequivocal and widespread power changes in dissociative anesthesia, which were divergent to source electroencephalography. Loss of Responsiveness anesthesia at 42% Xe (1.30 MAC-awake) demonstrated, similar to inductive agents, low frequency power increases in frontal delta and global theta. N2O sedation yielded a rise in high frequency power in the gamma range which was primarily occipital for lower gamma bandwidth (3049 Hz) and substantially decreased alpha power, particularly in frontal regions.Clinical trial number and Registry URLNot applicable.Prior PresentationsPelentritou Andria, Kuhlmann Levin; Lee Heonsoo; Cormack John; Mcguigan Steven; Woods Will; Sleigh Jamie; Lee UnCheol; Muthukumaraswamy Suresh; Liley David. Searching For Universal Cortical Power Changes Linked To Anesthetic Induced Reductions In Consciousness. The Science of Consciousness April 4th2018. Tucson, Arizona, USA.Summary StatementNot applicable.

scholarly journals Toward asleep DBS: cortico-basal ganglia spectral and coherence activity during interleaved propofol/ketamine sedation mimics NREM/REM sleep activity

2021 ◽  
Vol 7 (1) ◽  
Author(s):  
Jing Guang ◽  
Halen Baker ◽  
Orilia Ben-Yishay Nizri ◽  
Shimon Firman ◽  
Uri Werner-Reiss ◽  
...  
Keyword(s):  
Basal Ganglia ◽  
Rem Sleep ◽  
Standard Procedure ◽  
Low Frequency ◽  
Nrem Sleep ◽  
Sleep Cycle ◽  
Advanced Parkinson’S Disease ◽  
Low Frequency Power ◽  
The Brain ◽  
Frequency Power

AbstractDeep brain stimulation (DBS) is currently a standard procedure for advanced Parkinson’s disease. Many centers employ awake physiological navigation and stimulation assessment to optimize DBS localization and outcome. To enable DBS under sedation, asleep DBS, we characterized the cortico-basal ganglia neuronal network of two nonhuman primates under propofol, ketamine, and interleaved propofol-ketamine (IPK) sedation. Further, we compared these sedation states in the healthy and Parkinsonian condition to those of healthy sleep. Ketamine increases high-frequency power and synchronization while propofol increases low-frequency power and synchronization in polysomnography and neuronal activity recordings. Thus, ketamine does not mask the low-frequency oscillations used for physiological navigation toward the basal ganglia DBS targets. The brain spectral state under ketamine and propofol mimicked rapid eye movement (REM) and Non-REM (NREM) sleep activity, respectively, and the IPK protocol resembles the NREM-REM sleep cycle. These promising results are a meaningful step toward asleep DBS with nondistorted physiological navigation.

Cortical low‐frequency power correlates with behavioral impairment in animal model of focal limbic seizures

Epilepsia ◽  
2021 ◽  
Author(s):  
Abhijeet Gummadavelli ◽  
Reese Martin ◽  
Derek Goshay ◽  
Lim‐Anna Sieu ◽  
Jingwen Xu ◽  
...  
Keyword(s):  
Animal Model ◽  
Low Frequency ◽  
Behavioral Impairment ◽  
Limbic Seizures ◽  
Low Frequency Power ◽  
Frequency Power

scholarly journals Dynamic relationships between spontaneous and evoked electrophysiological activity

2021 ◽  
Vol 4 (1) ◽  
Author(s):  
Soren Wainio-Theberge ◽  
Annemarie Wolff ◽  
Georg Northoff
Keyword(s):  
Neural Activity ◽  
Large Scale ◽  
Behavioral Outcomes ◽  
Low Frequencies ◽  
Scale Free ◽  
Non Invasive ◽  
Spontaneous Neural Activity ◽  
Electrophysiological Signals ◽  
Evoked Activity ◽  
Dynamic Relationships

AbstractSpontaneous neural activity fluctuations have been shown to influence trial-by-trial variation in perceptual, cognitive, and behavioral outcomes. However, the complex electrophysiological mechanisms by which these fluctuations shape stimulus-evoked neural activity remain largely to be explored. Employing a large-scale magnetoencephalographic dataset and an electroencephalographic replication dataset, we investigate the relationship between spontaneous and evoked neural activity across a range of electrophysiological variables. We observe that for high-frequency activity, high pre-stimulus amplitudes lead to greater evoked desynchronization, while for low frequencies, high pre-stimulus amplitudes induce larger degrees of event-related synchronization. We further decompose electrophysiological power into oscillatory and scale-free components, demonstrating different patterns of spontaneous-evoked correlation for each component. Finally, we find correlations between spontaneous and evoked time-domain electrophysiological signals. Overall, we demonstrate that the dynamics of multiple electrophysiological variables exhibit distinct relationships between their spontaneous and evoked activity, a result which carries implications for experimental design and analysis in non-invasive electrophysiology.

scholarly journals A Novel Methodology for Adaptive Coordination of Multiple Controllers in Electrical Grids

Mathematics ◽  
2021 ◽  
Vol 9 (13) ◽  
pp. 1474
Author(s):  
Ruben Tapia-Olvera ◽  
Francisco Beltran-Carbajal ◽  
Antonio Valderrabano-Gonzalez ◽  
Omar Aguilar-Mejia
Keyword(s):  
Power Systems ◽  
Power System ◽  
Electric Power ◽  
Large Scale ◽  
Short Circuit ◽  
Dynamic Performance ◽  
Low Frequency ◽  
Electric Power System ◽  
Design Stage ◽  
Positive Interaction

This proposal is aimed to overcome the problem that arises when diverse regulation devices and controlling strategies are involved in electric power systems regulation design. When new devices are included in electric power system after the topology and regulation goals were defined, a new design stage is generally needed to obtain the desired outputs. Moreover, if the initial design is based on a linearized model around an equilibrium point, the new conditions might degrade the whole performance of the system. Our proposal demonstrates that the power system performance can be guaranteed with one design stage when an adequate adaptive scheme is updating some critic controllers’ gains. For large-scale power systems, this feature is illustrated with the use of time domain simulations, showing the dynamic behavior of the significant variables. The transient response is enhanced in terms of maximum overshoot and settling time. This is demonstrated using the deviation between the behavior of some important variables with StatCom, but without or with PSS. A B-Spline neural networks algorithm is used to define the best controllers’ gains to efficiently attenuate low frequency oscillations when a short circuit event is presented. This strategy avoids the parameters and power system model dependency; only a dataset of typical variable measurements is required to achieve the expected behavior. The inclusion of PSS and StatCom with positive interaction, enhances the dynamic performance of the system while illustrating the ability of the strategy in adding different controllers in only one design stage.

Low-frequency heating of doublets

1981 ◽  
Vol 25 (1) ◽  
pp. 133-143 ◽  
Author(s):  
T. H. Jensen ◽  
F. W. McClain ◽  
H. Grad
Keyword(s):  
Physical Model ◽  
Linear Theory ◽  
Low Frequency ◽  
Plasma Temperature ◽  
Auxiliary Heating ◽  
Power Sources ◽  
Axisymmetric Mode ◽  
Low Frequency Power ◽  
Frequency Power ◽  
Frequency Heating

Heating of a doublet plasma by driving an axisymmetric mode at low frequency may be an attractive means for auxiliary heating. The attractiveness of the method stems from (1) the low technology required for low-frequency power sources, (2) the fact that the field-shaping coils required for doublets may also be used as the antennae for transmitting the power, (3) the possibility of transmitting the power through a resistive vacuum wall, (4) the insensitivity to the plasma temperature and density and (5) the relative simplicity of the physical model. The utility of the concept depends on the existence of a special axisymmetric eigenmode in the resistive M.HD approximation which is used. This mode has nodes through the elliptic axes of the doublet equilibrium and an antinode at the hyperbolic axis. It is remarkable that the dissipation per cycle of this mode remains large at low plasma resistivity. This paper describes a linear theory for such heating.

Preeclamptic pregnancy is associated with increased sympathetic and decreased parasympathetic control of HR

2000 ◽  
Vol 278 (4) ◽  
pp. H1269-H1273 ◽  
Author(s):  
Cheryl C. H. Yang ◽  
Te-Chang Chao ◽  
Terry B. J. Kuo ◽  
Chang-Sheng Yin ◽  
Hsing I. Chen
Keyword(s):  
Heart Rate ◽  
Low Frequency ◽  
Normal Pregnancy ◽  
Frequency Domain Analysis ◽  
Natural Logarithm ◽  
Sympathetic Regulation ◽  
History Of ◽  
Low Frequency Power ◽  
Normalized Units ◽  
Frequency Power

Previous work from our laboratory using heart rate variability (HRV) has demonstrated that women before menopause have a more dominant parasympathetic and less effective sympathetic regulations of heart rate compared with men. Because it is still not clear whether normal or preeclamptic pregnancy coincides with alternations in the autonomic functions, we evaluated the changes of HRV in 17 nonpregnant, 17 normotensive pregnant, and 11 preeclamptic women who were clinically diagnosed without history of diabetic neuropathy, cardiac arrhythmia, and other cardiovascular diseases. Frequency-domain analysis of short-term, stationary R-R intervals was performed to evaluate the total variance, low-frequency power (LF; 0.04–0.15 Hz), high-frequency power (HF; 0.15–0.40 Hz), ratio of LF to HF (LF/HF), and LF in normalized units (LF%). Natural logarithm transformation was applied to variance, LF, HF, and LF/HF for the adjustment of the skewness of distribution. We found that the normal pregnant group had a lower R-R value and HF but had a higher LF/HF and LF% compared with the nonpregnant group. The preeclamptic group had lower HF but higher LF/HF compared with either the normal pregnant or nonpregnant group. Our results suggest that normal pregnancy is associated with a facilitation of sympathetic regulation and an attenuation of parasympathetic influence of heart rate, and such alterations are enhanced in preeclamptic pregnancy.

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