scholarly journals Relationship between dietary choline intake and diabetes mellitus in the National Health and Nutrition Examination Survey 2007-2010

Author(s):  
Long Zhou ◽  
Xiang Li ◽  
Shuhong Li ◽  
Xiaoxiao Wen ◽  
Yaguang Peng ◽  
...  

Background: Previous studies have shown that elevated trimethylamine N-oxide (TMAO) was associated with a higher risk of diabetes mellitus (DM). Little is known about the relationship between dietary intake of choline, which is a major dietary precursor for gut microbiome-derived TMAO, and DM in the general population. Objective: The present study aims to explore the relationship between dietary choline intakes and DM in the United States (US) adult population. Design: Cross-sectional data were derived from the National Health and Nutrition Examination Survey (NHANES) 2007-2010 of 8621 individuals aged 20 years or older. Multivariable logistic regression models were used to determine odds ratios (ORs) and 95% confidence intervals (CIs) for DM of each quartile category of energy-adjusted choline intakes. The restricted cubic spline model was used for the dose-response analysis. The receiver operating characteristic (ROC) curve was used to determine the optimal cut-off value of choline intake for predicting DM. Results: A linear dose-response relationship between dietary choline intakes and the odds of DM was found after adjustment for multiple potential confounding factors, p for linear =0.0002. With the lowest quartile category of choline as the reference, the multivariable-adjusted ORs and 95% CIs of the second, third, and highest quartile categories were 1.22 (0.98, 1.52), 1.26 (1.01, 1.56), and 1.42 (1.15, 1.77), respectively, p for trend =0.0024. Per 100 mg/d increase in energy-adjusted choline resulted in 15% (95% CI: 7%, 22%) higher odds of DM. The ROC analysis identified an energy-adjusted choline of 331.7 mg/d as the optimal cut-off value for predicting DM, with 52.5% sensitivity and 60.7% specificity. Conclusion: This study supports a positive and linear relationship between dietary choline intake and DM in the US adult population. Further studies are warranted to replicate our findings in other populations and elucidate the potential mechanisms.




2016 ◽  
Vol 26 (2) ◽  
pp. 123-127 ◽  
Author(s):  
Sally K. Guthrie ◽  
Steven R. Erickson

The use of dietary supplements was compared between a cohort of committed exercisers, U.S. Masters Swimming (USMS) members (n = 1,042), and the general U.S. population, exemplified by respondents to the National Health and Nutrition Examination Survey (NHANES) from 2009 to 2010 (n = 6,209). USMS swimmers were significantly more likely to take dietary supplements (62%) than the general U.S. adult population, as represented by the NHANES population (37%). Those taking dietary supplements were older, more likely to be female and Caucasian, and more highly educated and affluent than those not taking supplements (p < .001 for all). When adjusted for age, race, gender, annual income, and education, masters swimmers were still more likely (p < .001) to use dietary supplements than the NHANES cohort. In addition, masters swimmers were significantly more likely (p < .001) to use either creatine or dehydroepiandrosterone or testosterone than those in the NHANES cohort.



2006 ◽  
Vol 1 (5) ◽  
pp. 301-307 ◽  
Author(s):  
Kwok Leung Ong ◽  
Bernard M.Y. Cheung ◽  
Yu Bun Man ◽  
Louisa Y.F. Wong ◽  
Nelson M.S. Wat ◽  
...  


2021 ◽  
Vol 30 (1) ◽  
pp. 110-121
Author(s):  
Sung-hyun Hong ◽  
Ji-yong Byeon ◽  
Ji-hee Min ◽  
Dong-hyuk Park ◽  
Won-hee Cho ◽  
...  

PURPOSE: The study aimed to examine whether handgrip strength (HGS) expressed as absolute or relative to body weight is associated with fasting glucose (FG), hemoglobin A1c (HbA1c) and the prevalence of diabetes mellitus (DM) in different age categories.METHODS:A total of 28,129 adults from the Korea National Health and Nutrition Examination Survey of 2014-2018 was analyzed. To examine the relationship between HGS and variables related to DM, participants were categorized into three groups according to their HGS (Tertile). Then, participants were further categorized into six groups according to their age. One-way ANOVA and logistic regression analyses were performed.RESULTS: Compared with participants in the upper tertile of absolute handgrip strength (AHGS), those in the lower tertile were older, shorter and heavier and also had higher FG and HbA1c. When age was adjusted, the prevalence of DM was 1.19 times (95% CI: 1.03-1.38) higher among men in the lowest tertile of AHGS. On the other hand, compared with participants in the highest tertile of relative handgrip strength (RHGS), those in the lowest tertile had 2.10 times (95% CI: 1.87-2.41) and 2.42 times (95% CI: 2.08-2.81) higher prevalence of DM in men and women, respectively. When the associations were examined according to age subcategories, significant associations between AHGS and the prevalence of DM were seen only in men in their 50s and 60s, but not seen in women in all age groups, with the exception of the 60s. However, significant associations between RHGS and the prevalence of DM were seen in all age subcategories.CONCLUSIONS:We concluded that the association between HGS and the prevalence of DM was dependent on age and RHGS is a stonger measure than AHGS.



PLoS ONE ◽  
2014 ◽  
Vol 9 (4) ◽  
pp. e94479 ◽  
Author(s):  
Kwok-Leung Ong ◽  
Matthew A. Allison ◽  
Bernard M. Y. Cheung ◽  
Ben J. Wu ◽  
Philip J. Barter ◽  
...  


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