scholarly journals Prospective Representations in Rat Orbitofrontal Ensembles

2020 ◽  
Author(s):  
Jingfeng Zhou ◽  
Wenhui Zong ◽  
Chunying Jia ◽  
Matthew P.H. Gardner ◽  
Geoffrey Schoenbaum
Keyword(s):  
Neural Activity ◽  
Activity Patterns ◽  
Positional Information ◽  
Sequence Information ◽  
Neural Encoding ◽  
Reward Contingency ◽  
Common Path ◽  
The Past ◽  
The Common ◽  
Future Outcomes

AbstractThe orbitofrontal cortex (OFC) has been proposed to encode expected outcomes, which is thought to be important for outcome-directed behavior. However, such neural encoding can also often be explained by the recall of information about the recent past. To dissociate the retrospective and prospective aspects of encoding in the OFC, we designed a non-spatial, continuous, alternating odor-sequence task that mimicked a continuous T-maze. The task consisted of two alternating sequences of four odor-guided trials (2 sequences × 4 positions). In each trial, rats were asked to make a “go” or “no-go” action based on a fixed odor-reward contingency. Odors at both the first and last positions were distinct across the two sequences, such that they resembled unique paths in the past and future, respectively; odors at positions in between were the same and thus resembled a common path. We trained classifiers using neural activity to distinguish between either sequences or positions and asked whether the neural activity patterns in the common path were more like the ones in the past or the future. We found a proximal prospective code for sequence information as well as a distal prospective code for positional information, the latter of which was closely associated with rats’ ability to predict future outcomes. This study demonstrates a prospective behaviorally-relevant predictive code in rat OFC.

scholarly journals Operant Behavior in Model Systems

2016 ◽  
Author(s):  
Bjöern Brembs
Keyword(s):  
Neural Activity ◽  
Brain Function ◽  
Activity Patterns ◽  
Sensory Information ◽  
Behavioral Flexibility ◽  
Model Systems ◽  
Multiple Systems ◽  
Behavioral Choice ◽  
The Past ◽  
Fields Of Study

AbstractIn contrast to the long-held assumption that the organization of behavior is best characterized as the perception of a sensory stimulus followed by appropriate response (i.e., “sensorimotor hypothesis”), recent converging evidence from multiple systems and fields of study instead suggests that both ancestral and extant general brain function is best described in operant terms. Rather than specifyng precise behaviors, sensory information - if at all present - interacts with ongoing neural activity to instruct the organism which type of spontaneous, exploratory behavior to generate. Evaluating the ensuing reafferent feedback modifies the nervous system such that ongoing neural activity patterns become biased towards activity that has generated increased appetitive and decreased aversive feedback in the past. The neurobiological mechanisms underlying both the exploratory, spontaneous behaviors as well as those underlying the modifications caused by the feedback are becoming increasingly understood, even on a molecular level. It is straightforward to hypothesize that the constant interaction between ongoing neural activity and the incoming sensory stream allows the organism to balance behavioral flexibility with efficiency to accomplish adaptive behavioral choice in an often unpredictably changing environment.

Beyond Promoter: The Role of Macrophage in Invasion and Progression of Renal Cell Carcinoma

2020 ◽  
Vol 15 (7) ◽  
pp. 588-596
Author(s):  
Haibao Zhang ◽  
Guodong Zhu
Keyword(s):  
Renal Cell Carcinoma ◽  
Tumor Microenvironment ◽  
Cell Carcinoma ◽  
Renal Cell ◽  
Cell Formation ◽  
Biological Behavior ◽  
Tumor Stem Cell ◽  
The Past ◽  
The Common

Renal cell carcinoma (RCC) is one of the common urologic neoplasms, and its incidence has been increasing over the past several decades; however, its pathogenesis is still unknown up to now. Recent studies have found that in addition to tumor cells, other cells in the tumor microenvironment also affect the biological behavior of the tumor. Among them, macrophages exist in a large amount in tumor microenvironment, and they are generally considered to play a key role in promoting tumorigenesis. Therefore, we summarized the recent researches on macrophage in the invasiveness and progression of RCC in latest years, and we also introduced and discussed many studies about macrophage in RCC to promote angiogenesis by changing tumor microenvironment and inhibit immune response in order to activate tumor progression. Moreover, macrophage interactes with various cytokines to promote tumor proliferation, invasion and metastasis, and it also promotes tumor stem cell formation and induces drug resistance in the progression of RCC. The highlight of this review is to make a summary of the roles of macrophage in the invasion and progression of RCC; at the same time to raise some potential and possible targets for future RCC therapy.

Searching for Political Parties in the Past

2017 ◽  
Author(s):  
Piero Ignazi
Keyword(s):  
Eighteenth Century ◽  
Political Parties ◽  
Political Party ◽  
Ancient Greece ◽  
Political Community ◽  
Democratic Politics ◽  
The Political ◽  
The Past ◽  
The Common

Chapter 1 introduces the long and difficult process of the theoretical legitimation of the political party as such. The analysis of the meaning and acceptance of ‘parties’ as tools of expressing contrasting visions moves forward from ancient Greece and Rome where (democratic) politics had first become a matter of speculation and practice, and ends up with the first cautious acceptance of parties by eighteenth-century British thinkers. The chapter explores how parties or factions have been constantly considered tools of division of the ‘common wealth’ and the ‘good society’. The holist and monist vision of a harmonious and compounded society, stigmatized parties and factions as an ultimate danger for the political community. Only when a new way of thinking, that is liberalism, emerged, was room for the acceptance of parties set.

Can Groups Assert That P?

2019 ◽  
pp. 326-344
Author(s):  
Deborah Tollefsen
Keyword(s):  
Common Ground ◽  
Speech Act ◽  
Single Individual ◽  
Constitutive Rule ◽  
The Past ◽  
Group Members ◽  
The Common ◽  
Declarative Statement ◽  
John Macfarlane

When a group or institution issues a declarative statement, what sort of speech act is this? Is it the assertion of a single individual (perhaps the group’s spokesperson or leader) or the assertion of all or most of the group members? Or is there a sense in which the group itself asserts that p? If assertion is a speech act, then who is the actor in the case of group assertion? These are the questions this chapter aims to address. Whether groups themselves can make assertions or whether a group of individuals can jointly assert that p depends, in part, on what sort of speech act assertion is. The literature on assertion has burgeoned over the past few years, and there is a great deal of debate regarding the nature of assertion. John MacFarlane has helpfully identified four theories of assertion. Following Sandy Goldberg, we can call these the attitudinal account, the constitutive rule account, the common-ground account, and the commitment account. I shall consider what group assertion might look like under each of these accounts and doing so will help us to examine some of the accounts of group assertion (often presented as theories of group testimony) on offer. I shall argue that, of the four accounts, the commitment account can best be extended to make sense of group assertion in all its various forms.

scholarly journals A Theoretical Framework on the Determinants of Food Purchasing Behavior of the Elderly: A Bibliometric Review with Scientific Mapping in Web of Science

Foods ◽  
2021 ◽  
Vol 10 (3) ◽  
pp. 688
Author(s):  
Khaled Alhammadi ◽  
Luna Santos-Roldán ◽  
Luis Javier Cabeza-Ramírez
Keyword(s):  
Elderly Population ◽  
Web Of Science ◽  
The Elderly ◽  
Purchasing Behavior ◽  
Food Purchasing ◽  
The Past ◽  
Bibliometric Review ◽  
Food Market ◽  
The Common ◽  
Elderly Consumers

The past few years have seen significant demographic changes in most regions, including an increased elderly population. Subsequently, elderly citizens comprise an important market segment of consumers, with the food industry one of the most affected areas in this context. However, food market managers previously believed that elderly consumers’ needs were stereotyped in nature. The lack of focus on this sector, therefore, left elderly consumers as an untapped market, without realizing the financial independence of this segment regarding their nutrition. This research will attempt to provide the key determinant factors on elderly consumers’ behavior related to food. For that purpose, a complete literature review of more than 123 papers regarding these concepts has been carried out. Once analyzed, we highlight the common insights to give clear guidance for supermarket managers and food manufacturers to have a better knowledge of the reasons behind elderly people’s food acquisitions.

scholarly journals A palace fit for the future: Desirability in temporal work

2021 ◽  
pp. 147612702110120
Author(s):  
Siavash Alimadadi ◽  
Andrew Davies ◽  
Fredrik Tell
Keyword(s):  
Real Time ◽  
Crucial Role ◽  
The Past ◽  
Renewal Program ◽  
The Future ◽  
Depth Study ◽  
Future Events ◽  
Future Outcomes ◽  
Pluralistic Contexts

Research on the strategic organization of time often assumes that collective efforts are motivated by and oriented toward achieving desirable, although not necessarily well-defined, future states. In situations surrounded by uncertainty where work has to proceed urgently to avoid an impending disaster, however, temporal work is guided by engaging with both desirable and undesirable future outcomes. Drawing on a real-time, in-depth study of the inception of the Restoration and Renewal program of the Palace of Westminster, we investigate how organizational actors develop a strategy for an uncertain and highly contested future while safeguarding ongoing operations in the present and preserving the heritage of the past. Anticipation of undesirable future events played a crucial role in mobilizing collective efforts to move forward. We develop a model of future desirability in temporal work to identify how actors construct, link, and navigate interpretations of desirable and undesirable futures in their attempts to create a viable path of action. By conceptualizing temporal work based on the phenomenological quality of the future, we advance understanding of the strategic organization of time in pluralistic contexts characterized by uncertainty and urgency.

scholarly journals B.05 Hemi-laryngopharyngeal spasm (HELPS) syndrome: The discovery, cure, and characterization of a new neurological condition

2017 ◽  
Vol 44 (S2) ◽  
pp. S11-S11
Author(s):  
C Honey ◽  
M Morrison
Keyword(s):  
Surgical Care ◽  
Review Of The Literature ◽  
The Past ◽  
First Case ◽  
Patient Reported ◽  
Operative Outcome ◽  
Small Cohort ◽  
The Common ◽  
Similar Motor

Background: We published the world’s first case of hemi-laryngpharyngeal spasm (HELPS) syndrome cured by microvascular decompression (MVD) of the Xth cranial nerve in 2016. We now present a small cohort of patients (n=3) successfully treated with surgery in order to better delineate the common characteristics of this syndrome, diagnostic tests of choice, nuances of their surgical care and outcomes of their treatment. Methods: The history and physical examination of three patients with HELPS syndrome are presented. Pre-operative laryngoscopy, neuroimaging, response to botox and intra-operative videos are detailed. Post-operative outcome and complications are presented. Results: Each patient reported similar motor (choking) and sensory (coughing) features in their history. Episodic choking relentlessly progressed over the years until it occurred while sleeping and with frightening severity prompting tracheostomy in one patient and intubation in another. A “tickling” sensation deep in the throat triggered episodic coughing that worsened over the years until it occurred while sleeping and with frightening severity (syncope and incontinence). Conclusions: A review of the literature suggests that patients with similar symptoms, often called episodic laryngospasm in the past, have been treated with psychotherapy or antacids. With the recognition that a clearly defined subset of these patients have HELPS syndrome, we can offer them the potential of a neurosurgical cure.

Expanding Evolutionary Psychology: toward a Better Understanding of Violence and Aggression

2003 ◽  
Vol 42 (1) ◽  
pp. 5-50 ◽  
Author(s):  
Iver Mysterud ◽  
Dag Viljen Poleszynski
Keyword(s):  
Evolutionary Psychology ◽  
Food Allergies ◽  
Sociocultural Factors ◽  
The Past ◽  
Physical Chemical ◽  
Reactive Hypoglycemia ◽  
Proximate Factors ◽  
Survival And Reproduction ◽  
The Common ◽  
Habitual Intake

The “mainstream” evolutionary psychology model is currently under criticism from scientists of other persuasions wanting to expand the model or to make it more realistic in various ways. We argue that focusing on the environment as if it consisted only of social (or sociocultural) factors gives too limited a perspective if evolutionary approaches are to understand the behavior of modern humans. Taking the case of violence, we argue that numerous novel environmental factors of nutritional and physical-chemical origin should be considered as relevant proximate factors. The common thesis presented here is that several aspects of the biotic or abiotic environment are able to change brain chemistry, thus predisposing individuals to violence and aggression in given contexts. In the past, aggressive behavior has had a number of useful functions that were of particular importance to our ancestors' survival and reproduction. However, some of the conditions in our novel environment, which either lowered the threshold for aggression or released such behavior in contexts which were adaptive in our evolutionary past, no longer apply. It is high time evolutionary approaches to violence are expanded to include the possibilities that violence may be triggered by nutritionally depleted foods, reactive hypoglycemia caused by habitual intake of foods with a high glycemic index (GI), food allergies/intolerances and exposure to new environmental toxins (heavy metals, synthetic poisons).

Communication Theory and Training Approaches for Multiculturally Diverse Organizations: Have Academics and Practitioners Missed the Connection?

2001 ◽  
Vol 30 (4) ◽  
pp. 445-455 ◽  
Author(s):  
Marguerite Arai ◽  
Maryanne Wanca-Thibault ◽  
Pamela Shockley-Zalabak
Keyword(s):  
Communication Theory ◽  
Diversity Training ◽  
Multicultural Training ◽  
Theory And Practice ◽  
Important Research ◽  
Human Communication ◽  
The Past ◽  
The Common ◽  
Multiculturally Diverse ◽  
And Training

While a number of articles have looked at the importance of multicultural training in the workplace over the past 30 years, there is little concrete agreement that documents the common fundamental elements of a “successful” diversity initiative. A review of the training literature suggests the importance of human communication theory and practice without including important research, methodologies, and practice from the communication discipline. This article examines formal diversity approaches, provides examples from the literature of several successful diversity initiatives in larger organizations, identifies the limited use of communication-based approaches in diversity training, and discusses the importance of integrating communication theory and practice in future training efforts.

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