scholarly journals Analysis of serum trace elements, macro-minerals, antioxidants, malondialdehyde and immunoglobulins in seborrheic dermatitis patients: A case-control investigation

2020 ◽  
Author(s):  
Ishrat Jahan ◽  
Md. Rabiul Islam ◽  
Md. Reazul Islam ◽  
Rubaiya Ali ◽  
S. M. Matiur Rahman ◽  
...  
Keyword(s):  
Trace Elements ◽  
Vitamin E ◽  
Atomic Absorption ◽  
Fungal Infections ◽  
Seborrheic Dermatitis ◽  
Serum Levels ◽  
Case Control ◽  
Uv Spectrophotometry ◽  
Predictive Tool ◽  
Flame Atomic Absorption

AbstractBackgroundThere are many theories abound; the exact mechanism for the pathophysiology of seborrheic dermatitis (SD) remains unknown. Neuropsychiatric disorders, stress, weakened or irregular immune responses, fungal infections, etc. are thought to be associated with the development of SD. The present study aimed to determine the serum levels of trace elements (TEs), macro-minerals (MMs), antioxidant vitamins, malondialdehyde (MDA), and immunoglobulins in SD patients to explore their role in the disease progression.MethodsThis prospective case-control study recruited 75 SD patients and 76 healthy controls (HCs) matched by age and gender. Serum TEs and MMs were analyzed by the flame atomic absorption spectroscopy and graphite furnace atomic absorption spectrometry. RP-HPLC was used to determine the serum levels of vitamin A and E. Serum MDA levels were measured by UV spectrophotometry as a marker of lipid peroxidation, whereas the turbidimetric method was used to quantify the serum levels of immunoglobulins.ResultsWe found significantly higher concentrations of serum copper, manganese, and iron, calcium, and magnesium in SD patients compared to HCs. Serum levels of vitamin E significantly decreased and serum levels of MDA significantly increased in SD patients. Besides, the lower concentrations of immunoglobulin A, G, and M were observed in SD patients when compared to HCs. The present study also found a positive correlation between serum Zn and Ca levels (r = 0.365, p = 0.009) in SD patients; whereas a negative relation was detected between serum Cu and Ca levels (r = -0.298, p = 0.035).ConclusionsThe present study suggests that increased levels of TEs, MMs, MDA, and decreased levels of immunoglobulins and vitamin E are strongly associated with the pathophysiology of SD. Moreover, these alterations may provide a predictive tool for the assessment and management of SD patients.

scholarly journals Determination of Some Trace Elements in Breast Cancer Serum by Atomic Absorption Spectroscopy

2016 ◽  
Vol 9 (1) ◽  
pp. 1 ◽  
Author(s):  
Safaa Sabri Najim
Keyword(s):  
Breast Cancer ◽  
Trace Elements ◽  
Atomic Absorption ◽  
Cancer Patients ◽  
Absorption Spectroscopy ◽  
Atomic Absorption Spectroscopy ◽  
Serum Levels ◽  
Control Group ◽  
Breast Cancer Patients ◽  
Flame Atomic Absorption

In the breast cancer significant differences occurs in the normal distribution of the trace elements, playing an important role in carcinogenic process. The aim of this study was to investigate the serum levels of some trace elements (Chromium, Cadmium, Manganese, Cobalt, Nickel, Selenium, Zinc, Iron, Copper and Magnesium) by using flame atomic absorption spectroscopy (FAAS). The present study included 150 females, the participates were divided into two main groups, control group which consisted of 75 apparently healthy females, 75patients with breast cancer group .The serum levels of Chromium (tcal2.9631 ,ttab1.960), Cadmium (tcal2.0798 ,ttab1.960), Manganese (tcal18.5676, ttab1.960), Selenium (tcal2.2759,ttab1.960), Iron (tcal2.9296,ttab1.960), Copper (tcal4.0869, ttab1.960),Magnesium (tcal2.6648, ttab1.960), Cobalt (tcal3.8615 , ttab1.960) and Zinc (tcal7.0160, ttab1.960) were statistically significant higher in the breast cancer patients group than the control group. Similarly, Nickel (tcal1.5988,ttab1.960) levels showed significant lower level in breast cancer patients group. On the other hand, the higher levels of trace elements could lead to formation of free radicals or other reactive oxygen species. The evaluation of these trace elements in serum maybe used as helpful tool in diagnosis of the breast cancer.

scholarly journals Serum levels of Cadmium, Calcium, Lead and Iron in Schizophrenic Patients

1970 ◽  
Vol 5 (1) ◽  
pp. 9-13 ◽  
Author(s):  
Pinky Karim ◽  
Md. Iqbal Hossain ◽  
AFM Nazmus Sadat ◽  
Zabun Nahar ◽  
Md. Khalid Hossain ◽  
...  
Keyword(s):  
Trace Elements ◽  
Serum Concentration ◽  
Prognostic Significance ◽  
Serum Levels ◽  
Schizophrenic Disorder ◽  
Flame Atomic Absorption Spectroscopy ◽  
Flame Atomic Absorption ◽  
Schizophrenic Patients ◽  
Calcium Lead ◽  
Exact Correlation

The serum concentration of cadmium (Cd), lead (Pb), calcium (Ca) and iron (Fe) in 30 schizophrenic patients and 30 normal healthy subjects were analyzed by flame atomic absorption spectroscopy. The concentrations of Cd, Pb and Ca in schizophrenic disorder patients was not increased significantly (P > 0.05) compared to that of the cohort controls. But the concentration of Fe in schizophrenic patients was significantly different from that of the cohort control (p < 0.000). The change in serum concentration of different trace elements may have some prognostic significance for the diagnosis of schizophrenic disorder. However further work is suggested to examine the exact correlation between trace elements level and the degree of disorder in schizophrenic patients. Key words: Schizophrenic patients, trace elements, clinical significance Dhaka Univ. J. Pharm. Sci. Vol.5(1-2) 2006 The full text is of this article is available at the Dhaka Univ. J. Pharm. Sci. website

Online Preconcentration System Using 6-(2-Thienyl)-2-Pyridine Carboxaldehyde Functionalized Amberlite XAD-4 Resin for the Determination of Trace Elements in Waters by Flame Atomic Absorption Spectrometry

2013 ◽  
Vol 96 (3) ◽  
pp. 642-649 ◽  
Author(s):  
Cennet Karadaş ◽  
Derya Kara
Keyword(s):  
Trace Elements ◽  
Atomic Absorption Spectrometry ◽  
Atomic Absorption ◽  
Flame Atomic Absorption Spectrometry ◽  
Water Samples ◽  
Certified Reference Materials ◽  
Absorption Spectrometry ◽  
Rice Flour ◽  
Flame Atomic Absorption

Abstract An online flow injection method was developed for the determination of trace elements in waters using 6-(2-thienyl)-2-pyridinecarboxaldehyde functionalized Amberlite XAD-4 resin. The metals were eluted with 1.0 M HNO3 directly to a flame atomic absorption spectrometry determination system. The sorption capacities of the resin for metal ions were 74.6, 113.7, 48.3, 131.6, and 88.6 μmol/g for Cd(II), Ni(II), Pb(II), Co(II), and Cu(II), respectively. The resin was found to be very stable and capable of being used for more than 250 retention and elution cycles without major loss of performance. Detection limits (3SD) were determined to be 0.14 μg/L for Cd, 0.39 μg/L for Cu, 0.82 μg/L for Ni, 0.88 μg/L for Co, and 2.54 μg/L for Pb using 10 mL sample loading. The accuracy of the proposed method was checked using different certified reference materials [estuarine water (SLEW-3), riverine water (SRLS-5), 19-element aqueous standard (QCS-19), wheat flour (NBS 1567 a), and rice flour unpolished high level Cd (NIES 10c)]. Results were in agreement with certified values. The proposed method was applied to the determination of Cu, Ni, Co, Cd, and Pb in natural water samples. The recovery values for spiked water samples were between 91.9 and 107.4%.

scholarly journals Toxicity, Deficiency and Dysmetabolism of Trace Elements in Ghanaian Clinically Stable Schizophrenics

2014 ◽  
Vol 2 (2) ◽  
pp. 293-298
Author(s):  
George A. Asare ◽  
Ruth Tetteh ◽  
Elsie Amedonu ◽  
Bernice Asiedu ◽  
Derek Doku
Keyword(s):  
Trace Elements ◽  
Random Sampling ◽  
Test Group ◽  
Psychiatric Hospitals ◽  
Simple Random Sampling ◽  
Serum Levels ◽  
Healthy Controls ◽  
Flame Atomic Absorption Spectroscopy ◽  
Flame Atomic Absorption ◽  
Schizophrenic Patients

AIM: The purpose of the study was to determine the levels of Copper (Cu), selenium (Se), Zinc (Zn), Lead (Pb) and Lithium (Li) in patients in Accra and Pantang Psychiatric Hospitals in Ghana since no data exist.SUBJECTS AND METHODS: Simple random sampling of age-matched subjects was used to recruit 81 schizophrenics and 25 mentally healthy controls in 2012. Serum levels of Cu, Se, Zn, Pb and Li were determined by flame atomic absorption spectroscopy (FAAS). RESULTS: Mean levels were as follows: Cut 766 ± 250 µg/L and Cuc 855 ± 270 µg/L (p = 0.168). Set 149 ± 72 µg/L and Sec 108 ± 61 µg/L (p=0.009). Znt 702 ± 438 µg/L and Znc 1007 ± 593 µg/L (p = 0.028). Pbt 1.38 ± 0.05 µg/L and Pbc 0.10 ± 0.05 µg/L (p = 0.000). Li levels for the test group (Lit) was 4077 ± 2567 µg/L, whiles that of the controls was undetectable < 0.02 µg/L. Se, Pb and Li levels were significantly higher in schizophrenic patients compared to controls. While Zn and Cu levels were lower in the same group.CONCLUSION: Trace elements dysmetabolism exist among Ghanaian schizophrenics and monitoring is essential to avoid the adverse effects of metal overload or deficiency.

Determination of Several Element Levels in Hardaliye Beverages Using Flame Atomic Absorption Spectrometry After Ultrasound-Probe Extraction

2017 ◽  
Vol 100 (5) ◽  
pp. 1531-1538
Author(s):  
Dilek Bakircioglu ◽  
Nukte Topraksever ◽  
Yasemin Bakircioglu Kurtulus
Keyword(s):  
Trace Elements ◽  
Atomic Absorption Spectrometry ◽  
Atomic Absorption ◽  
Flame Atomic Absorption Spectrometry ◽  
Absorption Spectrometry ◽  
Ultrasound Probe ◽  
Experimental Conditions ◽  
Extraction Procedures ◽  
Flame Atomic Absorption

Abstract In the present study, concentrations of calcium (Ca), copper (Cu), magnesium (Mg), manganese (Mn), sodium (Na), and zinc (Zn) in hardaliye samples produced in Turkey were determined by flame atomic absorption spectrometry after ultrasound probe extraction (UPE), microwave-assisted extraction (MAE), and wet extraction procedures. At present, there is limited work in the literature on UPE for the determination of trace elements in beverage samples. Our single-correlation analysis showed that the elements studied with the UPE method in hardaliye were strongly correlated with the MAE procedure. The parameters affecting the UPE experimental conditions—such as ultrasound amplitude, sonication time, sample amount, extractant type, and volume—were studied. Optimal experimental conditions for the extraction of the metals with the UPE procedure were as follows: 2 min of sonication; 30% amplitude; 3 mL sample volume;5% HNO3 extraction solution; and 1 mL extractant volume for Ca, Cu, Mg, Mn, Na, and Zn in thehardaliye samples. The results in the hardaliye samples in minimum–maximum mg/L with the UPE procedure were 33–63 for Ca, 0.10–0.27 forCu, 3.9–14.4 for Mg, 1.0–3.2 for Mn,32–58 for Na, and 0.39–1.1 for Zn. LODs were 0.0032, 0.012, 0.013, 0.009, 0.011, and 0.008 mg/L for Ca, Cu, Mg, Mn, Na, and Zn, respectively. The accuracy of the method was verified with a recovery test (in which recoveries between 95 and 110% wereobserved) and application to a NIST 1643e certified sample (trace elements in water). The UPE procedure was found to be fast, accurate, and simple, with fewer contaminants and lower concentrated reagent consumption in comparison with conventional extraction procedures.

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