scholarly journals Toxicity, Deficiency and Dysmetabolism of Trace Elements in Ghanaian Clinically Stable Schizophrenics

2014 ◽  
Vol 2 (2) ◽  
pp. 293-298
Author(s):  
George A. Asare ◽  
Ruth Tetteh ◽  
Elsie Amedonu ◽  
Bernice Asiedu ◽  
Derek Doku
Keyword(s):  
Trace Elements ◽  
Random Sampling ◽  
Test Group ◽  
Psychiatric Hospitals ◽  
Simple Random Sampling ◽  
Serum Levels ◽  
Healthy Controls ◽  
Flame Atomic Absorption Spectroscopy ◽  
Flame Atomic Absorption ◽  
Schizophrenic Patients

AIM: The purpose of the study was to determine the levels of Copper (Cu), selenium (Se), Zinc (Zn), Lead (Pb) and Lithium (Li) in patients in Accra and Pantang Psychiatric Hospitals in Ghana since no data exist.SUBJECTS AND METHODS: Simple random sampling of age-matched subjects was used to recruit 81 schizophrenics and 25 mentally healthy controls in 2012. Serum levels of Cu, Se, Zn, Pb and Li were determined by flame atomic absorption spectroscopy (FAAS). RESULTS: Mean levels were as follows: Cut 766 ± 250 µg/L and Cuc 855 ± 270 µg/L (p = 0.168). Set 149 ± 72 µg/L and Sec 108 ± 61 µg/L (p=0.009). Znt 702 ± 438 µg/L and Znc 1007 ± 593 µg/L (p = 0.028). Pbt 1.38 ± 0.05 µg/L and Pbc 0.10 ± 0.05 µg/L (p = 0.000). Li levels for the test group (Lit) was 4077 ± 2567 µg/L, whiles that of the controls was undetectable < 0.02 µg/L. Se, Pb and Li levels were significantly higher in schizophrenic patients compared to controls. While Zn and Cu levels were lower in the same group.CONCLUSION: Trace elements dysmetabolism exist among Ghanaian schizophrenics and monitoring is essential to avoid the adverse effects of metal overload or deficiency.

scholarly journals Serum levels of Cadmium, Calcium, Lead and Iron in Schizophrenic Patients

1970 ◽  
Vol 5 (1) ◽  
pp. 9-13 ◽  
Author(s):  
Pinky Karim ◽  
Md. Iqbal Hossain ◽  
AFM Nazmus Sadat ◽  
Zabun Nahar ◽  
Md. Khalid Hossain ◽  
...  
Keyword(s):  
Trace Elements ◽  
Serum Concentration ◽  
Prognostic Significance ◽  
Serum Levels ◽  
Schizophrenic Disorder ◽  
Flame Atomic Absorption Spectroscopy ◽  
Flame Atomic Absorption ◽  
Schizophrenic Patients ◽  
Calcium Lead ◽  
Exact Correlation

The serum concentration of cadmium (Cd), lead (Pb), calcium (Ca) and iron (Fe) in 30 schizophrenic patients and 30 normal healthy subjects were analyzed by flame atomic absorption spectroscopy. The concentrations of Cd, Pb and Ca in schizophrenic disorder patients was not increased significantly (P > 0.05) compared to that of the cohort controls. But the concentration of Fe in schizophrenic patients was significantly different from that of the cohort control (p < 0.000). The change in serum concentration of different trace elements may have some prognostic significance for the diagnosis of schizophrenic disorder. However further work is suggested to examine the exact correlation between trace elements level and the degree of disorder in schizophrenic patients. Key words: Schizophrenic patients, trace elements, clinical significance Dhaka Univ. J. Pharm. Sci. Vol.5(1-2) 2006 The full text is of this article is available at the Dhaka Univ. J. Pharm. Sci. website

scholarly journals Serum Iron Levels and Copper-to-Zinc Ratio in Sickle Cell Disease

Medicina ◽  
2019 ◽  
Vol 55 (5) ◽  
pp. 180
Author(s):  
Charles Antwi-Boasiako ◽  
Gifty Dankwah ◽  
Robert Aryee ◽  
Charles Hayfron-Benjamin ◽  
Alfred Doku ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Sickle Cell Disease ◽  
Sickle Cell ◽  
Serum Levels ◽  
Zinc Homeostasis ◽  
Healthy Controls ◽  
Cell Disease ◽  
Flame Atomic Absorption ◽  
Iron Copper ◽  
Copper And Zinc

Background and Objectives: Altered copper and zinc homeostasis may influence the antioxidant defense system and consequently lead to oxidative stress and associated complications in sickle cell disease (SCD) patients. Iron levels have been reported to increase in sickle cell patients due to frequent blood transfusion, chronic intravenous haemolysis and increased absorption of iron from the gastrointestinal tract. These elevated levels of iron may also lead to extensive oxidative damage. The current study evaluated serum levels of iron, copper and zinc in SCD patients and “healthy” controls. Materials and Methods: The study was a cross-sectional one, comprising 90 SCD patients with Haemoglobin SS and Haemoglobin SC genotypes and 50 HbAA “healthy” controls. Serum levels of iron, copper and zinc were measured using a Flame Atomic Absorption Spectrometer (Variant 240FS manufactured by VARIAN Australia Pty Ltd, VIC, Australia). Copper and zinc ratios were calculated and analyzed. Results: Serum levels of iron and copper were significantly elevated in the SCD patients, compared to their “healthy” counterparts (p < 0.001). These levels were further increased in patients with haemoglobin SS in vaso-occlusive crises (HbSS VOCs). Serum zinc levels were, however, significantly lower in the SCD patients, particularly during vaso-occlusion. The copper-to-zinc ratio was also found to be significantly higher in the SCD patients. Conclusion: Elevated copper-to-zinc ratio may be a biomarker of sickle cell oxidative stress and associated complications. The ratio may also be informative for the management of sickle cell oxidative burden. The significantly lower levels of zinc in the SCD patients may warrant zinc supplementation.

Association of serum levels of leptin, ghrelin, and adiponectin in schizophrenic patients and healthy controls

2011 ◽  
Vol 15 (2) ◽  
pp. 106-111 ◽  
Author(s):  
Meng-Chang Tsai ◽  
Chia-Ming Chang ◽  
Chia-Yih Liu ◽  
Pi-Yueh Chang ◽  
Tiao-Lai Huang
Keyword(s):  
Serum Levels ◽  
Healthy Controls ◽  
Schizophrenic Patients

scholarly journals EFEKTIVITAS MODEL PEMBELAJARAN STAY AND STRAY DENGAN MEDIA FLASHCARD TERHADAP HASIL BELAJAR PESERTA DIDIK PADA MATERI SISTEM PERNAPASAN DI KELAS XI IPA SMA NEGERI 5 SEMARANG TAHUN AJARAN 2016/2017

2020 ◽  
Vol 1 (1) ◽  
pp. 47
Author(s):  
Diah Setiawati ◽  
Miswari Miswari ◽  
Saifullah Hidayat
Keyword(s):  
Random Sampling ◽  
Test Group ◽  
Simple Random Sampling ◽  
Group Design ◽  
Post Test

Penelitian ini dilatarbelakangi oleh kurangnya perhatian peserta didik dalam proses pembelajaran biologi. Kreativitas guru dalam mengembangkan model pembelajaran dan media pembelajaran saat proses pembelajaran diperlukan untuk meningkatkan minat, keaktifan dan hasil belajar peserta didik. Penelitian ini bertujuan untuk mengetahui efektivitas model pembelajaran Stay and Stray dengan media Flashcard terhadap hasil belajar peserta didik pada materi sistem pernapasan di kelas XI IPA SMA Negeri 5 Semarang. Penelitian ini menggunakan pendekatan kuantitatif dengan jenis penelitian eksperimen. Desain penelitian ini menggunakan Quasi eksperimen Pre-test and Post-test group design. Teknik pengambilan sampel dilakukan dengan teknik simple random sampling. Pengumpulan data dilakukan pada kelas XI IPA 4 dan XI IPA 8 dengan menggunakan 2 metode, yaitu metode tes dan metode dokumentasi. Hasil penelitian menunjukkan nilai rata-rata posttest kelas eksperimen adalah 93,5 dan kelas kontrol adalah 79,25. Data yang diperoleh adalahthitung = 8,699 dan ttabel= 1,669, karena thitung&gt;ttabel maka Ho ditolak dan Ha diterima. Berdasarkan hasil penelitian tersebut dapat disimpulkan bahwa model pembelajaran Stay and Stray dengan media Flashcard pada materi sistem pernapasan terbukti efektif terhadap hasil belajar siswa kelas XI IPA SMA Negeri 5 Semarang.

scholarly journals Serum Trace Elements in Manic Patients

1970 ◽  
Vol 4 (1) ◽  
Author(s):  
Md Abu Baker ◽  
AFM Nazmus Sadat ◽  
Md Lutfor Rahman ◽  
MMA Shalahuddin Qusar ◽  
SM Imamul Huq ◽  
...  
Keyword(s):  
Trace Elements ◽  
Serum Concentration ◽  
Prognostic Significance ◽  
Flame Atomic Absorption Spectroscopy ◽  
Flame Atomic Absorption ◽  
Human Volunteers ◽  
Copper Manganese ◽  
Serum Trace Elements ◽  
Manic Patients ◽  
Exact Correlation

The serum concentration of zinc, copper, manganese and lead in 30 manic patients and 30 human volunteers were determined by flame atomic absorption spectroscopy. It was observed that the concentration of zinc in manic patients increased significantly (P < 0.05), where as the concentrations of copper, manganese and lead were found to be within the limit (P > 0.05). These concentrations of different trace elements may have some prognostic significance for the diagnosis of manic patients, but more work is suggested to find out the exact correlation between trace elements level & the degree of disorder in manic patients. Key words: Mania, trace elements, serum etc. Dhaka Univ. J. Pharm. Sci. Vol.4(1) 2005 The full text is of this article is available at the Dhaka Univ. J. Pharm. Sci. website

Mekanisme Koping Dan Dukungan Sosial Keluarga Terhadap Kekambuhan Pasien Skizoferenia Di Ruang Wijaya Kusuma Rumah Sakit Jiwa Menur Surabaya

2019 ◽  
Vol 8 (1) ◽  
Author(s):  
Dya Sustrami ◽  
Nur Chabibah ◽  
Muhammad Zul azhri Rustam
Keyword(s):  
Family Support ◽  
Recurrence Rate ◽  
Family Relationships ◽  
Random Sampling ◽  
Simple Random Sampling ◽  
Coping Mechanism ◽  
Cross Sectional ◽  
Care Family ◽  
Schizophrenic Patients ◽  
Negative Coping

ABSTRAKKeluarga terdapat berbagai permasalahan yang harus diselesaikan oleh anggota keluarga, agar tidak menimbulkan konflik dalam hubungan keluarga yang dapat meningkatkan mekanisme koping keluarga tersebut. Keluarga yang memiliki mekanisme koping negatif (mal adaptif) akan memunculkan sikap seperti marah–marah dan merasa terbebani. Dalam pemberian asuhan keperawatan, dukungan keluarga ikut berperan untuk mencegah terjadinya kekambuhan.Metode penelitian ini menggunakan pendekatan cross sectional. Sample penelitian ini adalah pasien yang dirawat di ruang wijaya kusuma Rumah Sakit Jiwa Menur Surabaya sejumlah 25 Orang dengan teknik simple random sampling. Hasil penelitian ini terdapat hubungan mekanisme koping dan dukungan keluarga terhadap tingkat kekambuhan pasien Skizofrenia. beberapa penyebab kemampuan personal kurang baik sehingga menyebabkan strategi koping maladaptif dikarenakan ketidakmampuan pasien untuk selalu fokus dalam menerima informasi. dan dukungan keluarga yang diperoleh menggambarkan tingkat kekambuhan pada pasien skizofrenia tidak bisa maksimal dan akan mempengaruhi tingkat kekambuhan pasien dikarenakan yakni pendidikan, usia, pendapatan, dan tempat tinggal keluarga. Jauhnya tempat tinggal pasien dengan rumah sakit membuat keluarga jarang untuk datang berkunjung. Kata Kunci : Mekanisme Koping, Dukungan Keluarga, Skizofrenia ABSTRACTFamilies have various problems that must be resolved by family members, so as not to cause conflicts in family relationships that can improve the family's coping mechanism. Families that have a negative coping mechanism (adaptive mall) will emerge like anger and feel burdened. In providing nursing care, family support also plays a role in preventing recurrence.This research method uses a cross sectional approach. The sample of this study was 25 patients treated in the wijaya kusuma room in Surabaya Menur Mental Hospital with a simple random sampling technique.The results of this study have a correlation between coping mechanisms and family support for the recurrence rate of Schizophrenic patients. some of the causes of personal abilities are not good, causing maladaptive coping strategies due to the inability of patients to always focus on receiving information. and family support obtained illustrates the recurrence rate in schizophrenic patients cannot be maximal and will affect the patient's recurrence rate due to education, age, income, and family residence. The extent of the patient's residence with the hospital makes it rare for families to come to visit. Keywords: Copping Mechanism, Family Support, Schizophrenia

Soluble IL-6 receptors in the serum and cerebrospinal fluid of paranoid schizophrenic patients

1997 ◽  
Vol 12 (6) ◽  
pp. 294-299 ◽  
Author(s):  
N Müller ◽  
P Dobmeier ◽  
M Empl ◽  
M Riedel ◽  
M Schwarz ◽  
...  
Keyword(s):  
Cerebrospinal Fluid ◽  
Interleukin 6 ◽  
Serum Levels ◽  
Healthy Controls ◽  
Central Action ◽  
Neuroleptic Treatment ◽  
Interleukin 6 Receptor ◽  
Schizophrenic Patients ◽  
Csf Levels ◽  
Paranoid Schizophrenic

SummarySoluble Interleukin-6 receptor (sIL-6R) levels are strongly related to the levels of Interleukin-6 (IL-6), and sIL-6Rs increase the immune activating properties of IL-6. We estimated sIL-6R serum levels in 25 schizophrenic patients and 25 healthy controls. In the patients, SIL-6R-CSF levels were also measured. The psychopathology was rated according to the AMDP system. We found a significant correlation between serum and cerebrospinal fluid (CSF) levels of sIL-6R, suggesting that serum levels may be a meaningful marker for the central action of sIL-6R. Moreover, significant correlations between the paranoid-hallucinatory syndrome and sIL-6R levels both in serum and CSF were observed. This finding suggests that IL-6 plays a role in the paranoid-hallucinatory symptomatology in schizophrenia. This can be understood regarding the influence of IL-6 to the catecholaminergic neurotransmission. The downregulating effects of neuroleptic treatment to sIL-6R demonstrate that the sIL-6R levels are decreased in the whole group of schizophrenic patients compared to controls.

scholarly journals Analysis of serum trace elements, macro-minerals, antioxidants, malondialdehyde and immunoglobulins in seborrheic dermatitis patients: A case-control investigation

2020 ◽  
Author(s):  
Ishrat Jahan ◽  
Md. Rabiul Islam ◽  
Md. Reazul Islam ◽  
Rubaiya Ali ◽  
S. M. Matiur Rahman ◽  
...  
Keyword(s):  
Trace Elements ◽  
Vitamin E ◽  
Atomic Absorption ◽  
Fungal Infections ◽  
Seborrheic Dermatitis ◽  
Serum Levels ◽  
Case Control ◽  
Uv Spectrophotometry ◽  
Predictive Tool ◽  
Flame Atomic Absorption

AbstractBackgroundThere are many theories abound; the exact mechanism for the pathophysiology of seborrheic dermatitis (SD) remains unknown. Neuropsychiatric disorders, stress, weakened or irregular immune responses, fungal infections, etc. are thought to be associated with the development of SD. The present study aimed to determine the serum levels of trace elements (TEs), macro-minerals (MMs), antioxidant vitamins, malondialdehyde (MDA), and immunoglobulins in SD patients to explore their role in the disease progression.MethodsThis prospective case-control study recruited 75 SD patients and 76 healthy controls (HCs) matched by age and gender. Serum TEs and MMs were analyzed by the flame atomic absorption spectroscopy and graphite furnace atomic absorption spectrometry. RP-HPLC was used to determine the serum levels of vitamin A and E. Serum MDA levels were measured by UV spectrophotometry as a marker of lipid peroxidation, whereas the turbidimetric method was used to quantify the serum levels of immunoglobulins.ResultsWe found significantly higher concentrations of serum copper, manganese, and iron, calcium, and magnesium in SD patients compared to HCs. Serum levels of vitamin E significantly decreased and serum levels of MDA significantly increased in SD patients. Besides, the lower concentrations of immunoglobulin A, G, and M were observed in SD patients when compared to HCs. The present study also found a positive correlation between serum Zn and Ca levels (r = 0.365, p = 0.009) in SD patients; whereas a negative relation was detected between serum Cu and Ca levels (r = -0.298, p = 0.035).ConclusionsThe present study suggests that increased levels of TEs, MMs, MDA, and decreased levels of immunoglobulins and vitamin E are strongly associated with the pathophysiology of SD. Moreover, these alterations may provide a predictive tool for the assessment and management of SD patients.

scholarly journals Resilience affecting the recurrence rate of schizophrenia patients in health community centre, Gamping 2, Sleman, Yogyakarta

2021 ◽  
Vol 9 (1) ◽  
pp. 16
Author(s):  
Fiki Aji Nurcahyati ◽  
Mulyanti Ners ◽  
Rosma Fyki Kamala
Keyword(s):  
Random Sampling ◽  
Quantitative Research ◽  
Demographic Data ◽  
Sampling Technique ◽  
Simple Random Sampling ◽  
Cross Sectional ◽  
Health Community ◽  
Schizophrenic Patients ◽  
Cross Sectional Design ◽  
Community Centre

<p><strong><em>Background: </em></strong><em>The rate of recurrence level in schizophrenia patients is still high. Schizophrenic patients experience various decreases in cognitive, emotional, social behavior, and brain functions, so that an optimal attitude of resilience is needed. </em><em>Schizophrenic patients with good resilience can reduce the risk of recurrence.</em><em></em></p><p><strong><em>Objectives: </em></strong><em>The aim of this study is to analyze the relationship between resilience and recurrence rate of schizophrenia patients in Health Community Centre, Gamping 2, Sleman.</em></p><p><strong><em>Methods: </em></strong><em>This research was a quantitative research with a cross sectional design. Sampling technique used is simple random sampling. There were 44 schizophrenic patients for the sample in Health Community Centre, Gamping 2, Sleman, Yogyakarta. The instrument used was demographic data to measure recurrence, the CD-RISC10 questionnaire with the Kendall Tau test.</em><em></em></p><p><strong><em>Results: </em></strong><em>This research was a quantitative research with a cross sectional design. Sampling technique used is simple random sampling. There were 44 schizophrenic patients for the sample in Health Community Centre, Gamping 2, Sleman, Yogyakarta. The instrument used was demographic data to measure recurrence, the CD-RISC10 questionnaire with the Kendall Tau test.</em><em></em></p><strong><em>Conclusions: </em></strong><em>There is a relationship between resilience and recurrence on schizophrenia patients in  Health Community Centre, Gamping 2, Sleman</em>

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