scholarly journals Serological prevalence of SARS-CoV-2 infection and associated factors in health care workers in a “non-COVID” hospital in Mexico City

2020 ◽  
Author(s):  
Esteban Cruz-Arenas ◽  
Elizabeth Cabrera-Ruiz ◽  
Sara Laguna-Barcenas ◽  
Claudia A. Colin-Castro ◽  
Tatiana Chavez ◽  
...  
Keyword(s):  
Health Care ◽  
Mexico City ◽  
Health Care Workers ◽  
Sociodemographic Factors ◽  
Serological Survey ◽  
Rt Pcr ◽  
Factors Associated ◽  
Care Workers ◽  
Study Population ◽  
University Degree

ABSTRACTBackgroundMexico is one of the countries with the highest number of deaths from the COVID-19 pandemic. However, the number of confirmed cases and RT-PCR tests per million population are lower than for other countries, which leads to uncertainty about the actual extent of the pandemic. In Mexico City, health care workers represent an important fraction of individuals with SARS-CoV-2 infection. This work aims to estimate the frequency of antibodies to SARS-CoV-2 in health care workers at a non-COVID hospital, as well as identify factors associated with SARS-CoV-2 infection in this population.MethodsWe conducted a serological survey in a large non-COVID teaching hospital in Mexico City. The study population included all the personnel that works, in any capacity, in the hospital. From this population we selected a representative sample of 300 individuals. Blood samples were collected and questionnaires were applied between August 10th and September 9th, 2020.ResultsELISA results indicate a serological prevalence to SARS-CoV-2 infection of 13.0%. Working in the janitorial and security groups, having an educational level below a university degree, and living with larger numbers of people, were also identified as sociodemographic factors that increase the risk of having SARS-CoV-2 infection.ConclusionsEven though the rate from the official number of confirmed cases in Mexico City is substantially smaller than the seropositive rate identified in this work, even in health care workers there is still a majority of individuals that are seronegative, and thus the risk of continued epidemic waves and mortality remains high.

scholarly journals SARS-CoV-2 RT-PCR Positivity and Antibody Prevalence among Asymptomatic Hospital-Based Health Care Workers

2021 ◽  
pp. 104794
Author(s):  
Christine C. Johnson ◽  
Chad M. Coleman ◽  
Alexandra R. Sitarik ◽  
Joyce E. Leon ◽  
Robert J. Tibbetts ◽  
...  
Keyword(s):  
Health Care ◽  
Health Care Workers ◽  
Rt Pcr ◽  
Antibody Prevalence ◽  
Care Workers

scholarly journals Factors associated with low tuberculosis preventive therapy prescription rates among health care workers in rural South Africa

2021 ◽  
Vol 14 (1) ◽  
Author(s):  
Amiya A. Ahmed ◽  
Megan Grammatico ◽  
Anthony P. Moll ◽  
Sipho Malinga ◽  
Philile Makhunga ◽  
...  
Keyword(s):  
South Africa ◽  
Health Care ◽  
Health Care Workers ◽  
Preventive Therapy ◽  
Rural South ◽  
Factors Associated ◽  
Care Workers ◽  
Prescription Rates ◽  
Rural South Africa

scholarly journals Incidence of COVID-19 Infection in Hospital Workers From March 1, 2020 to May 31, 2021 Routinely Tested, Before and After Vaccination With BNT162B2

2021 ◽  
Author(s):  
Francesca Larese Filon ◽  
Francesca Rui ◽  
Federico Ronchese ◽  
Paola Michieli ◽  
Corrado Negro
Keyword(s):  
Health Care ◽  
Health Care Workers ◽  
Hospital Workers ◽  
Factors Associated ◽  
Care Workers ◽  
Before And After ◽  
Polymerase Chain ◽  
Incident Rate ◽  
Rate Ratios ◽  
Monthly Incidence

Abstract Objective To evaluate the incidence of COVID-19 infection in health care workers from the start of COVID-19 pandemic in NE of Italy, to the vaccination with BNT162b2. Materials and methods This was a retrospective cohort study. Health care workers were routinely tested for SARS-CoV-2 infections using real-time polymerase chain reaction tests in nasopharyngeal swabs. Logistic regression was used to calculate incident rate ratios (IRRs) of factors associated to COVID-19. Results A total of 4251 workers were followed-up and an annual incidence of COVID-19 of 13.6% was found. In March 2021 the incidence of infection was 4.88 and 103.55 cases for 100.000 person-days in vaccinated and non-vaccinated workers, respectively, with an adjusted IRRs of 0.05 (95% CI 0.02–0.08). Conclusions Our study evaluated the monthly incidence in health care workers in Trieste hospitals before and after the vaccination finding the protective effect of BNT162B2 vaccine in 95% of health care workers routinely tested.

scholarly journals Psychological status of healthcare workers during COVID-19 pandemic: a single center observational study from Peshawar

2020 ◽  
Vol 6 (4) ◽  
pp. 03-06
Author(s):  
Wajeeha Qayyum ◽  
Asad Khalil ◽  
Mohammad Jawad ◽  
Seema Ashraf
Keyword(s):  
Health Care ◽  
Health Care Workers ◽  
Tertiary Care Hospital ◽  
Tertiary Care ◽  
Psychological Status ◽  
Anxiety And Depression ◽  
Medical Institute ◽  
Care Hospital ◽  
Factors Associated ◽  
Care Workers

Introduction: Infectious pandemics are a significant health risk to the general population, but much more so for the frontline health care workers tending patients at different locations. The increased workload, stress, fear, and anxiety are the burdens to be coped with by health professionals through resort to resiliency and other mechanisms.Objective: To determine the magnitude of depression / anxiety and factors associated with it in health care workers of a tertiary care hospital during the COVID-19 pandemic in Peshawar, Khyber Pakhtunkhwa, Pakistan.Materials & Methods: This cross sectional study was conducted at Rehman Medical Institute, Peshawar after approval from Rehman Medical Institute Research Ethics Committee. A structured questionnaire consisting of two sections was distributed by convenience sampling to health care workers in the hospital, the first part containing demographic information, and the second part consisting of Hospital Anxiety and Depression Scale (HADS) comprised of 14 scales to assess anxiety and depression. Scoring for Normal, Borderline Abnormal, and Definitive Disorder was done as per standard criteria. Data were analyzed for descriptive statistics by SPSS 22. Results: Total 327 participants were included in the study, having mean age of 30.19 ± 7.82 years, of which 230(70.3%) were males. The majority of health care workers 226(69.1%) were suffering from disturbed mental status either in the form of Anxiety (19.9%), Depression (8%) or Mixed Disorder (41.3%). Factors associated with high disease frequency were female gender, age group 21-30 years, nursing staff, workers of ICU and Hostel residence (p value <0.05). Conclusion: COVID-19 related psychological disturbances significantly affected healthcare staff of a tertiary care hospital of Peshawar, being more evident in females, younger age groups, nurses, and ICU staff on duty.

scholarly journals SARS-CoV-2–Specific Neutralizing Antibody Responses in Norwegian Health Care Workers After the First Wave of COVID-19 Pandemic: A Prospective Cohort Study

2020 ◽  
Author(s):  
Mai-Chi Trieu ◽  
Amit Bansal ◽  
Anders Madsen ◽  
Fan Zhou ◽  
Marianne Sævik ◽  
...  
Keyword(s):  
Health Care ◽  
Cohort Study ◽  
Prospective Cohort Study ◽  
Health Care Workers ◽  
Prospective Cohort ◽  
Neutralizing Antibodies ◽  
Rt Pcr ◽  
Patient Exposure ◽  
Specific Antibodies ◽  
Care Workers

Abstract Background During the coronavirus disease 2019 (COVID-19) pandemic, many countries experienced infection in health care workers (HCW) due to overburdened health care systems. Whether infected HCW acquire protective immunity against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is unclear. Methods In a Norwegian prospective cohort study, we enrolled 607 HCW before and after the first COVID-19 wave. Exposure history, COVID-19–like symptoms, and serum samples were collected. SARS-CoV-2–specific antibodies were characterized by spike-protein IgG/IgM/IgA enzyme-linked immunosorbent and live-virus neutralization assays. Results Spike-specific IgG/IgM/IgA antibodies increased after the first wave in HCW with, but not in HCW without, COVID-19 patient exposure. Thirty-two HCW (5.3%) had spike-specific antibodies (11 seroconverted with ≥4-fold increase, 21 were seropositive at baseline). Neutralizing antibodies were found in 11 HCW that seroconverted, of whom 4 (36.4%) were asymptomatic. Ninety-seven HCW were tested by reverse transcriptase polymerase chain reaction (RT-PCR) during follow-up; 8 were positive (7 seroconverted, 1 had undetectable antibodies). Conclusions We found increases in SARS-CoV-2 neutralizing antibodies in infected HCW, especially after COVID-19 patient exposure. Our data show a low number of SARS-CoV-2–seropositive HCW in a low-prevalence setting; however, the proportion of seropositivity was higher than RT-PCR positivity, highlighting the importance of antibody testing.

Factors Associated with the Treatment of Latent Tuberculosis Infection Among Health-Care Workers at a Midwestern Teaching Hospital

CHEST Journal ◽  
2002 ◽  
Vol 122 (5) ◽  
pp. 1609-1614 ◽  
Author(s):  
Sunita J. Shukla ◽  
David K. Warren ◽  
Keith F. Woeltje ◽  
Carol A. Gruber ◽  
Victoria J. Fraser
Keyword(s):  
Health Care ◽  
Teaching Hospital ◽  
Health Care Workers ◽  
Latent Tuberculosis Infection ◽  
Latent Tuberculosis ◽  
Tuberculosis Infection ◽  
Factors Associated ◽  
Care Workers

scholarly journals Pericarditis and myocarditis long after SARS-CoV-2 infection: a cross-sectional descriptive study in health-care workers

2020 ◽  
Author(s):  
Rocio Eiros ◽  
Manuel Barreiro-Perez ◽  
Ana Martin-Garcia ◽  
Julia Almeida ◽  
Eduardo Villacorta ◽  
...  
Keyword(s):  
Health Care ◽  
Beta Cell ◽  
Health Care Workers ◽  
Immune Cell ◽  
Rt Pcr ◽  
Cross Sectional ◽  
Cell Numbers ◽  
Cell Counts ◽  
Care Workers ◽  
Alpha Beta

Background: Cardiac sequelae of past SARS-CoV-2 infection are still poorly documented. We conducted a cross-sectional study in health-care workers to report evidence of pericarditis and myocarditis after SARS-CoV-2 infection. Methods We studied 139 health-care workers with confirmed past SARS-CoV-2 infection (103 diagnosed by RT-PCR and 36 by serology). Participants underwent clinical assessment, electrocardiography, laboratory tests including immune cell profiling and cardiac magnetic resonance (CMR) imaging. Pericarditis was diagnosed when classical criteria were present, and the diagnosis of myocarditis was based on the updated CMR Lake-Louise-Criteria. Results: Median age was 52 years (IQR 41-57), 100 (72%) were women, and 23 (16%) were previously hospitalized for Covid-19 pneumonia. At examination (10.4 [9.3-11.0] weeks after infection-like symptoms), all participants presented hemodynamic stability. Chest pain, dyspnoea or palpitations were observed in 58 (42%) participants; electrocardiographic abnormalities in 69 (50%); NT-pro-BNP was elevated in 11 (8%); troponin in 1 (1%); and CMR abnormalities in 104 (75%). Isolated pericarditis was diagnosed in 4 (3%) participants, myopericarditis in 15 (11%) and isolated myocarditis in 36 (26%). Participants diagnosed by RT-PCR were more likely to still present symptoms than participants diagnosed by serology (73 [71%] vs 18 [50%]; p=0.027); nonetheless, the prevalence of pericarditis or myocarditis was high in both groups (44 [43%] vs 11 [31%]; p=0.238). Most participants (101 [73%]) showed altered immune cell counts in blood, particularly decreased eosinophil (37 [27%]; p<0.001) and increased CD4-CD8-/loT alpha beta-cell numbers (24 [17%]; p<0.001). Pericarditis was associated with elevated CD4-CD8-/loT alpha beta-cell numbers (p=0.011), while participants diagnosed with myopericarditis or myocarditis had lower (p<0.05) plasmacytoid dendritic cell, NK-cell and plasma cell counts and lower anti-SARS-CoV-2-IgG antibody levels (p=0.027). Conclusions: Pericarditis and myocarditis with clinical stability are frequent long after SARS-CoV-2 infection, even in presently asymptomatic subjects. These observations will probably apply to the general population infected and may indicate that cardiac sequelae might occur late in association with an altered (delayed) innate and adaptative immune response.

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