scholarly journals Rapid inactivation of SARS-CoV-2 on copper touch surfaces determined using a cell culture infectivity assay

2021 ◽  
Author(s):  
Catherine Bryant ◽  
Sandra A. Wilks ◽  
C. William Keevil
Keyword(s):  
Human Coronavirus ◽  
Copper Surfaces ◽  
Infectivity Assay ◽  
Airborne Exposure ◽  
Asymptomatic Patients ◽  
Rapid Inactivation ◽  
A Cell ◽  
The Difference ◽  
Respiratory Droplets ◽  
Human Coronavirus 229E

ABSTRACTCOVID-19, caused by SARS-CoV-2, was first reported in China in 2019 and has transmitted rapidly around the world, currently responsible for 83 million reported cases and over 1.8 million deaths. The mode of transmission is believed principally to be airborne exposure to respiratory droplets from symptomatic and asymptomatic patients but there is also a risk of the droplets contaminating fomites such as touch surfaces including door handles, stair rails etc, leading to hand pick up and transfer to eyes, nose and mouth. We have previously shown that human coronavirus 229E survives for more than 5 days on inanimate surfaces and another laboratory reproduced this for SARS-CoV-2 this year. However, we showed rapid inactivation of Hu-CoV-229E within 10 minutes on different copper surfaces while the other laboratory indicated this took 4 hours for SARS-CoV-2. So why the difference? We have repeated our work with SARS-CoV-2 and can confirm that this coronavirus can be inactivated on copper surfaces in as little as 1 minute. We discuss why the 4 hour result may be technically flawed.

Role of Rasayan Churna in outbreak of Covid -19 as preventive and curative aspect

2020 ◽  
Vol 11 (SPL1) ◽  
pp. 1208-1212
Author(s):  
Amol Madhav Deshpande ◽  
Mayuri Amol Deshpande
Keyword(s):  
Recurrent Infection ◽  
Symptomatic Patient ◽  
H1n1 Influenza ◽  
Drug Of Choice ◽  
Asymptomatic Patients ◽  
Diseased Person ◽  
Anti Cancer ◽  
Anti Oxidant ◽  
Immune Booster ◽  
Respiratory Droplets

In last two decade world suffer with three epidemic diseases like SARS-CoV, H1N1 influenza, MERS –CoV and presently the world under a pandemic of Covid-19, out of these SARS-CoV, MERS –CoV and Covid-19 are form the same virus call as corona, which primary present on bats and transferred from animal to human, and then it transfer from human to human mostly by respiratory droplets or in the direct contact with the diseased person, these recurrent infection of corona virus is the burning issue in the word, so to avoid these recurrent infections good habitual behaviour with regular immune booster medicine should be taken which can be used in both normal and symptomatic patient for this Rasayan churna  is the best drug of choice as it is used for  rejuvenation therapy. From literally study from various recourses it is found that Rasayan churna have property anti-depressant, anti-xylotic, Immunomodulatory, Anti-diabetes, anti hypertensive, anti-inflammatory, Anti-toxic effects, Anti-arthritic, Anti-cancer effects, Anti-microbial effect, and Anti-oxidant which can be useful in preventive aspect of Covid -19 in all phase like normal individual, also can be used in asymptomatic patients and symptomatic patients, clinical study can be performed for the same to evaluate the result.

scholarly journals A protocol for adding knowledge to Wikidata: aligning resources on human coronaviruses

BMC Biology ◽  
2021 ◽  
Vol 19 (1) ◽  
Author(s):  
Andra Waagmeester ◽  
Egon L. Willighagen ◽  
Andrew I. Su ◽  
Martina Kutmon ◽  
Jose Emilio Labra Gayo ◽  
...  
Keyword(s):  
Common Ground ◽  
Knowledge Bases ◽  
Public Knowledge ◽  
Medical Problems ◽  
Human Coronavirus ◽  
Data Schema ◽  
Helping Others ◽  
Human Coronaviruses ◽  
The Right ◽  
Human Coronavirus 229E

Abstract Background Pandemics, even more than other medical problems, require swift integration of knowledge. When caused by a new virus, understanding the underlying biology may help finding solutions. In a setting where there are a large number of loosely related projects and initiatives, we need common ground, also known as a “commons.” Wikidata, a public knowledge graph aligned with Wikipedia, is such a commons and uses unique identifiers to link knowledge in other knowledge bases. However, Wikidata may not always have the right schema for the urgent questions. In this paper, we address this problem by showing how a data schema required for the integration can be modeled with entity schemas represented by Shape Expressions. Results As a telling example, we describe the process of aligning resources on the genomes and proteomes of the SARS-CoV-2 virus and related viruses as well as how Shape Expressions can be defined for Wikidata to model the knowledge, helping others studying the SARS-CoV-2 pandemic. How this model can be used to make data between various resources interoperable is demonstrated by integrating data from NCBI (National Center for Biotechnology Information) Taxonomy, NCBI Genes, UniProt, and WikiPathways. Based on that model, a set of automated applications or bots were written for regular updates of these sources in Wikidata and added to a platform for automatically running these updates. Conclusions Although this workflow is developed and applied in the context of the COVID-19 pandemic, to demonstrate its broader applicability it was also applied to other human coronaviruses (MERS, SARS, human coronavirus NL63, human coronavirus 229E, human coronavirus HKU1, human coronavirus OC4).

scholarly journals Examining the persistence of human Coronavirus 229E on fresh produce

2021 ◽  
pp. 103780
Author(s):  
Madeleine Blondin-Brosseau ◽  
Jennifer Harlow ◽  
Tanushka Doctor ◽  
Neda Nasheri
Keyword(s):  
Fresh Produce ◽  
Human Coronavirus ◽  
Human Coronavirus 229E

Effect of pH and temperature on the infectivity of human coronavirus 229E

1989 ◽  
Vol 35 (10) ◽  
pp. 972-974 ◽  
Author(s):  
Alain Lamarre ◽  
Pierre J. Talbot
Keyword(s):  
Incubation Period ◽  
Storage Conditions ◽  
Viral Infectivity ◽  
Human Coronavirus ◽  
Virus Growth ◽  
The Stability ◽  
And Storage ◽  
Influence Of Ph ◽  
Human Coronavirus 229E

The stability of human coronavirus 229E infectivity was maximum at pH 6.0 when incubated at either 4 or 33 °C. However, the influence of pH was more pronounced at 33 °C. Viral infectivity was completely lost after a 14-day incubation period at 22, 33, or 37 °C but remained relatively constant at 4 °C for the same length of time. Finally, the infectious titer did not show any significant reduction when subjected to 25 cycles of thawing and freezing. These studies will contribute to optimize virus growth and storage conditions, which will facilitate the molecular characterization of this important pathogen.Key words: coronavirus, pH, temperature, infectivity, human coronavirus.

scholarly journals Involvement of the Inconstant Bursa of the Fifth Metatarsophalangeal Joint in Psoriatic Arthritis: A Clinical and Ultrasonographic Study

2014 ◽  
Vol 2014 ◽  
pp. 1-5 ◽  
Author(s):  
Giovanni Ciancio ◽  
Stefania Volpinari ◽  
Maria Fotinidi ◽  
Federica Furini ◽  
Ilaria Farina ◽  
...  
Keyword(s):  
Psoriatic Arthritis ◽  
Healthy Subjects ◽  
Statistical Significance ◽  
Metatarsophalangeal Joint ◽  
Metatarsal Bone ◽  
The Other ◽  
Control Group ◽  
Asymptomatic Patients ◽  
Seronegative Spondyloarthritis ◽  
The Difference

Objective. To evaluate the involvement of the bursa located next to the head of the 5th metatarsal bone in patients with psoriatic arthritis (PsA) in comparison with the other seronegative spondyloarthritis (SpA).Methods. All patients with PsA seen during a period of 24 months were enrolled. The control group included healthy subjects and patients with the other SpA. All subjects underwent clinical and ultrasound (US) examination of the lateral surface of the 5th metatarsal.Results. 150 PsA patients (88 M; 62 F), 172 SpA (107 M; 65 F), and 95 healthy controls (58 M; 37 F) were evaluated. Based on clinical and US evaluation, bursitis was diagnosed in 17/150 (11.3%) PsA patients but in none of the SpA (P<0.0001) and healthy (P=0.0002) controls. In detecting bursitis, US was more sensitive than clinical examination, although the difference did not reach statistical significance (P=0.09).Conclusion. The bursa of the 5th metatarsophalangeal joint appears to be involved in PsA more frequently than by chance. If confirmed by other studies, this finding could be considered as a distinctive clinical sign of PsA, useful for differential diagnosis with the other SpA. In asymptomatic patients, US proved to be more sensitive in the detection of bursitis.

Effect of Bilingualism on Multitasking: A Pilot Study

2015 ◽  
Vol 22 (3) ◽  
pp. 94-101 ◽  
Author(s):  
Li Hsieh
Keyword(s):  
Executive Control ◽  
Positive Impact ◽  
Reaction Times ◽  
Language Experience ◽  
Bilingual Advantage ◽  
Bilingual Speakers ◽  
Proficiency Level ◽  
Linguistic Representations ◽  
A Cell ◽  
The Difference

Bilingual speakers rely on attentional and executive control to continuously inhibit or activate linguistic representations of competing languages, which leads to an increased efficiency known as “bilingual advantage”. Both monolingual and bilingual speakers were asked to perform multiple tasks of talking on a cell phone while simultaneously attending to simulated driving events. This study examined the effect of bilingualism on participants' performance during a dual-task experiment based on 20 monolingual and 13 bilingual healthy adults. The within-subject and between-subject comparisons were conducted on reaction times of a visual event detection task for (a) only driving and (b) driving while simultaneously engaged in a phone conversation. Results of this study showed that bilingual speakers performed significantly faster than monolingual speakers during the multitasking condition, but not during the driving only condition. Further, bilingual speakers consistently showed a bilingual advantage in reaction times during the multitasking condition, despite varying degrees on a bilingual dominance scale. Overall, experiences in more than one language yield bilingual advantage in better performance than monolingual speakers during a multitasking condition, but not during a single task condition. Regardless of the difference in bilingual proficiency level, such language experience reveals a positive impact on bilingual speakers for multitasking.

scholarly journals Picornavirus-Like Cytopathic Effects on RD-18S Cell Lines Were Induced by Human Coronavirus 229E Not Picornaviruses

2015 ◽  
Vol 68 (1) ◽  
pp. 78-79 ◽  
Author(s):  
Yohei Matoba ◽  
Yoko Aoki ◽  
Shizuka Tanaka ◽  
Kazue Yahagi ◽  
Tsutomu Itagaki ◽  
...  
Keyword(s):  
Cell Lines ◽  
Human Coronavirus ◽  
Cytopathic Effects ◽  
Human Coronavirus 229E

scholarly journals The ORF4a protein of human coronavirus 229E functions as a viroporin that regulates viral production

2014 ◽  
Vol 1838 (4) ◽  
pp. 1088-1095 ◽  
Author(s):  
Ronghua Zhang ◽  
Kai Wang ◽  
Wei Lv ◽  
Wenjing Yu ◽  
Shiqi Xie ◽  
...  
Keyword(s):  
Viral Production ◽  
Human Coronavirus ◽  
Human Coronavirus 229E

scholarly journals Analysis of human coronavirus 229E spike and nucleoprotein genes demonstrates genetic drift between chronologically distinct strains

2006 ◽  
Vol 87 (5) ◽  
pp. 1203-1208 ◽  
Author(s):  
Doris Chibo ◽  
Chris Birch
Keyword(s):  
Phylogenetic Analysis ◽  
Respiratory Infections ◽  
N Gene ◽  
Human Coronavirus ◽  
S Gene ◽  
Limited Variation ◽  
Contrast Analysis ◽  
Human Coronaviruses ◽  
Human Coronavirus 229E ◽  
S Genes

Historically, coronaviruses have been recognized as a cause of minor respiratory infections in humans. However, the recent identification of three novel human coronaviruses, one causing severe acute respiratory syndrome (SARS), has prompted further examination of these viruses. Previous studies of geographically and chronologically distinct Human coronavirus 229E (HCoV-229E) isolates have found only limited variation within S gene nucleotide sequences. In contrast, analysis of the S genes of contemporary Human coronavirus OC43 variants identified in Belgium revealed two distinct viruses circulating during 2003 and 2004. Here, the S and N gene sequences of 25 HCoV-229E variants identified in Victoria, Australia, between 1979 and 2004 in patients with symptomatic infections were determined. Phylogenetic analysis showed clustering of the isolates into four groups, with evidence of increasing divergence with time. Evidence of positive selection in the S gene was also established.

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