scholarly journals “Effect of the intervention with omega-3 fatty acids on nutritional and clinical aspects in patients with breast cancer receiving medical treatment”

Author(s):  
Palma-Gutierrez Edgardo ◽  
Espinoza-Rado Erika ◽  
Zafra-Tanaka Jessica Hanae

ABSTRACTBackgroundIt is known that cancer can cause loss of body weight and muscle protein wasting, which leads to a state of malnutrition, which in turn worsens the prognosis and health of the cancer patient. It has been suggested that the promoting mechanism of this state is systemic inflammation, for which reason several clinical trials have used omega-3 fatty acids, especially eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), as adjuvants to antineoplastic treatment, mainly due to its anti-inflammatory effects. However, few systematic reviews and meta-analyzes have analyzed the effects of omega-3s in patients with breast cancer.ObjectiveThe aim of this study is to assess the effect of the supplementation with omega-3 fatty acids on nutritional and clinical outcomes in patients with breast cancer receiving medical treatment.MethodsA systematic review will be conducted, starting with a search in PubMed, CENTRAL and EMBASE using search terms related to omega-3 fatty acids and breast cancer. We will include only randomized controlled trials that assess the effects of omega-3 in patients with breast cancer receiving medical treatment.. Data will be extracted in a spread sheet. Study selection and data extraction will be conducted by two reviewers independently and the Cochrane Risk of Bias Tool for RCT will be used for assessment of risk of bias. Discrepancies will be reviewed with a third reviewer.ConclusionThis systematic review aims to provide an analysis on the outcomes of the usage of the intervention with omega-3 fatty acids on nutritional and clinical aspects in patients with breast cancer receiving medical treatment.

2019 ◽  
Vol 3 (Supplement_1) ◽  
Author(s):  
Lisa Moloney ◽  
Mary Rozga ◽  
Kathleen Gura ◽  
Camilia Martin

Abstract Objectives To investigate the evidence for the effect of omega 3 fatty acids via enteral nutrition on identified outcomes in the very low birthweight preterm infant population. Methods A literature search was conducted in EMBASE, CINAHL, Cochrane Central, PubMed databases for the period of January 1980-November 2017 for all peer-reviewed articles examining preterm infant nutrition. A multidisciplinary volunteer expert Workgroup and staff screened articles according to defined inclusion criteria (randomized controlled trials, enteral fed preterm infants < 1500 gm, economically developed nations). Data was extracted and risk of bias was evaluated for each included article using the Academy's Quality Criteria Checklist and Cochrane's Risk of Bias Tool. Data was summarized and conclusion statements were developed and graded for each identified outcome using the GRADE framework and Academy methodology. Results The search identified in 25,264 articles, and six studies published in 13 articles were included. Two included studies had low risk of bias. Remaining studies had bias in the following Cochrane domains: attrition (2), detection (3), selection (2), performance (2), and reporting (1). Eleven conclusion statements were developed, 4 were graded as good, 2 as fair, 5 as limited. Though evidence quality describing the effect of 64mg of omega 3s daily on mortality and retinopathy of prematurity was good, there were no significant effects reported [RR (95% CI) was 1.31 (0.88 to 1.96) and 0.96 (0.61, 1.50), respectively]. Similarly, there were no significant effects found for type of fat intake by VLBW infants on bronchopulmonary disease, atopy, necrotizing enterocolitis, anthropometrics, neuro- or visual development or gastrointestinal health. Conclusions This systematic review revealed high heterogeneity amongst interventions, including in feeding types (formula, formula or human milk, or human milk), mode of supplementation, and amount and composition of supplement (DHA, EPA, ARA, MCT). Funding Sources Academy of Nutrition and Dietetics.


2021 ◽  
Vol 5 (Supplement_2) ◽  
pp. 24-24
Author(s):  
Eun young Kang ◽  
Hyun Kyung Kim ◽  
Gwang-woong Go

Abstract Objectives The prevalence of neurodegenerative disorders such as dementia is positively correlated to aging. As there is insufficient evidence for the medicinal remedies of dementia, focusing on prevention strategies to use nutraceuticals could provide positive results. Therefore, this systematic review aimed to evaluate the effect of various nutraceuticals on age-associated cognitive decline. Methods Literature was searched using PubMed, EMBASE, Cochrane, and PsycINFO databases with the search terms being nutraceuticals in cognitive dysfunction. The literature was limited to human studies, randomized controlled trials, and a single material. Selection of literature, evaluation of the risk of bias, and assessment of the quality of evidence was conducted independently by two reviewers. Results We finally included 17 studies of literature after excluding the risk of bias ‘high.’ The evidence was rated ‘high’ quality for both omega-3 fatty acids and vitamin Bs. Other materials, including vitamins D & E, anserine/carnosine, and chromium were identified as ‘moderate’ quality. Omega-3 fatty acids (0.48–2.2 g of DHA and 203–720 mg of EPA) relieved cognitive decline and amyloid β related proteins in participants with mild cognitive impairment. However, the cognitive decline did not have an effect on dementia patients. Vitamin B (25–500 µg of B12 and 20 mg of B6) group exhibited decreased homocysteine levels, followed by enhanced cognitive function. However, vitamin D & E, anserine/carnosine, and chromium showed a shred of limited evidence owing to limited studies. Conclusions This study suggests that omega-3 fatty acids and vitamin B have protective effects against age-associated cognitive decline. Funding Sources This research was funded by Ottogi, grant number HY-201900000670003.


Author(s):  
Sydne J Newberry ◽  
Mei Chung ◽  
Marika Booth ◽  
Margaret A Maglione ◽  
Alice M Tang ◽  
...  

Author(s):  
Maiana da Costa Vieira ◽  
Sylvio Andre Garcia Vieira ◽  
Jovito Adiel Skupien ◽  
Carina Rodrigues Boeck

Nutrients ◽  
2018 ◽  
Vol 10 (6) ◽  
pp. 758 ◽  
Author(s):  
Bárbara Brayner ◽  
Gunveen Kaur ◽  
Michelle Keske ◽  
Katherine Livingstone

2021 ◽  
pp. 100997
Author(s):  
Safi U. Khan ◽  
Ahmad N. Lone ◽  
Muhammad Shahzeb Khan ◽  
Salim S. Virani ◽  
Roger S. Blumenthal ◽  
...  

2009 ◽  
Vol 41 (1) ◽  
pp. 36-66 ◽  
Author(s):  
Lefkothea-Stella Kremmyda ◽  
Maria Vlachava ◽  
Paul S. Noakes ◽  
Norma D. Diaper ◽  
Elizabeth A. Miles ◽  
...  

2013 ◽  
Vol 46 (3) ◽  
pp. 226 ◽  
Author(s):  
Sewon Jeong ◽  
Ji Yeon Kim ◽  
Ju Eun Paek ◽  
Joohee Kim ◽  
Jin Sook Kwak ◽  
...  

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