scholarly journals The association of CREBRF variant rs373863828 with body composition in adult Samoans

2021 ◽  
Author(s):  
Nicola L. Hawley ◽  
Rachel L. Duckham ◽  
Jenna C. Carlson ◽  
Take Naseri ◽  
Muagututia Sefuiva Reupena ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Body Composition ◽  
Body Fat ◽  
Lean Mass ◽  
Alternative Hypothesis ◽  
Missense Variant ◽  
Fat Distribution ◽  
Primary Role ◽  
Cross Sectional

AbstractObjectiveThe minor allele of rs373863828, a missense variant in CREBRF, is associated with higher BMI but lower odds of type 2 diabetes in Pacific Islanders.MethodsTo test if this protective effect operates through metabolically favorable body fat distribution, we examined the association of the minor A allele with body composition, measured using dual-energy x-ray absorptiometry (DXA), in a cross-sectional study of n=421 Samoan adults.ResultsWe replicated our earlier finding that this allele was associated with higher weight and BMI, although it was statistically significant only in women. There was no significant association of genotype with percent body fat, visceral adiposity or fat distribution, although in women, the A allele was associated with greater total fat mass (p=0.02), android (p=0.009) and trunk fat (p=0.01). In both sexes, age- and height-adjusted average lean mass was significantly greater per copy of the A allele: 2.16 kg/copy in women and 1.73 kg/copy in men.ConclusionsThese data do not support a primary role of fat distribution in mediating the association between rs373863828 genotype and type 2 diabetes risk. We suggest an alternative hypothesis: those with the A allele may more efficiently regulate blood glucose because of their greater absolute lean mass.

scholarly journals Body fat distribution, menopausal hormone therapy and incident type 2 diabetes in postmenopausal women of the MESA study

Maturitas ◽  
2016 ◽  
Vol 91 ◽  
pp. 147-152
Author(s):  
Imo A. Ebong ◽  
Karol E. Watson ◽  
Kristen G. Hairston ◽  
Mercedes R. Carnethon ◽  
Pamela Ouyang ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Hormone Therapy ◽  
Postmenopausal Women ◽  
Body Fat ◽  
Fat Distribution ◽  
Body Fat Distribution ◽  
Menopausal Hormone Therapy ◽  
Incident Type ◽  
Incident Type 2 Diabetes

Effects of rosiglitazone on body fat distribution and insulin sensitivity in Korean type 2 diabetes mellitus patients

Metabolism ◽  
2008 ◽  
Vol 57 (4) ◽  
pp. 479-487 ◽  
Author(s):  
You-Cheol Hwang ◽  
Eun Young Lee ◽  
Won Jae Lee ◽  
Bong Soo Cha ◽  
Kun-Ho Yoon ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Insulin Sensitivity ◽  
Body Fat ◽  
Fat Distribution ◽  
Body Fat Distribution ◽  
Korean Type

scholarly journals Visceral obesity is associated with increased soluble CD163 concentration in men with type 2 diabetes mellitus

2015 ◽  
Vol 4 (1) ◽  
pp. 27-36 ◽  
Author(s):  
Lars Peter Sørensen ◽  
Tina Parkner ◽  
Esben Søndergaard ◽  
Bo Martin Bibby ◽  
Holger Jon Møller ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Adipose Tissue ◽  
Body Fat ◽  
Fat Distribution ◽  
Normal Weight ◽  
Healthy Men ◽  
Soluble Cd163

Monocyte/macrophage-specific soluble CD163 (sCD163) concentration is associated with insulin resistance and increases with deteriorating glycemic control independently of BMI. This led to the proposal of the hypothesis that obesity-associated white adipose tissue inflammation varies between individuals. The objective was to examine the effect of male overweight/obesity and type 2 diabetes mellitus (T2DM) on associations between adiposity parameters and sCD163. A total of 23 overweight/obese non-diabetic men, 16 overweight/obese men with T2DM, and a control group of 20 normal-weight healthy men were included. Body composition and regional body fat distribution were determined by whole-body dual X-ray absorptiometry scan and abdominal computed tomography (CT) scan. Serum sCD163 concentrations were determined by ELISA. Associations between adiposity parameters and sCD163 were investigated using multiple linear regression analysis. In the normal-weight healthy men, there was no significant association between adiposity parameters and sCD163, whereas in the overweight/obese non-diabetic men, measures of general and regional adiposity were positively associated with sCD163. In the overweight/obese men with T2DM, only visceral adipose tissue (VAT) and the ratio of VAT to abdominal subcutaneous adipose tissue (SAT), a measure of relative body fat distribution between VAT and SAT depots, were positively associated with sCD163. In a multivariate analysis, including VAT, upper-body SAT, and lower-body fat, adjusted for BMI and age, VAT remained a significant predictor of sCD163 in the overweight/obese T2DM men, but not in the overweight/obese non-diabetic men. Our results indicate that VAT inflammation is exaggerated in men with T2DM, and that propensity to store excess body fat viscerally is particularly detrimental in men with T2DM.

scholarly journals The Relationship between Body Composition, Dietary Intake, Physical Activity, and Pulmonary Status in Adolescents and Adults with Cystic Fibrosis

Nutrients ◽  
2022 ◽  
Vol 14 (2) ◽  
pp. 310
Author(s):  
Kevin J. Scully ◽  
Laura T. Jay ◽  
Steven Freedman ◽  
Gregory S. Sawicki ◽  
Ahmet Uluer ◽  
...  
Keyword(s):  
Physical Activity ◽  
Cystic Fibrosis ◽  
Body Composition ◽  
Dietary Intake ◽  
Healthy Volunteers ◽  
Clinical Outcomes ◽  
Body Fat ◽  
Lean Mass ◽  
Cross Sectional ◽  
Adolescents And Adults

Measures of body fat and lean mass may better predict important clinical outcomes in patients with cystic fibrosis (CF) than body mass index (BMI). Little is known about how diet quality and exercise may impact body composition in these patients. Dual X-ray absorptiometry (DXA) body composition, 24-h dietary recall, and physical activity were assessed in a cross-sectional analysis of 38 adolescents and adults with CF and 19 age-, race-, and gender-matched healthy volunteers. Compared with the healthy volunteers, participants with CF had a lower appendicular lean mass index (ALMI), despite no observed difference in BMI, and their diets consisted of higher glycemic index foods with a greater proportion of calories from fat and a lower proportion of calories from protein. In participants with CF, pulmonary function positively correlated with measures of lean mass, particularly ALMI, and negatively correlated with multiple measures of body fat after controlling for age, gender, and BMI. Higher physical activity levels were associated with greater ALMI and lower body fat. In conclusion, body composition measures, particularly ALMI, may better predict key clinical outcomes in individuals with CF than BMI. Future longitudinal studies analyzing the effect of dietary intake and exercise on body composition and CF-specific clinical outcomes are needed.

scholarly journals Causal Associations of Adiposity and Body Fat Distribution With Coronary Heart Disease, Stroke Subtypes, and Type 2 Diabetes Mellitus

Circulation ◽  
2017 ◽  
Vol 135 (24) ◽  
pp. 2373-2388 ◽  
Author(s):  
Caroline E. Dale ◽  
Ghazaleh Fatemifar ◽  
Tom M. Palmer ◽  
Jon White ◽  
David Prieto-Merino ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Coronary Heart Disease ◽  
Type 2 Diabetes Mellitus ◽  
Heart Disease ◽  
Body Fat ◽  
Fat Distribution ◽  
Body Fat Distribution ◽  
Stroke Subtypes
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